Faster perceptual learning through excitotoxic neurodegeneration
Open accessAbstract
Glutamatergic neural transmission is involved in both neural plasticity and neurodegeneration. This combination of roles could result in ambivalent effects in which excitotoxic neurodegeneration augments neural plasticity in parallel. Neural plasticity can be induced by exposure-based learning (EBL) that resembles timing properties of long-term potentiation (LTP) protocols (i.e., LTP-like learning). Even though it has not been demonstrated so far in animal models that perceptual effects of such stimulation protocols are mediated by typical LTP mechanisms, it has been shown that exposure-based learning exerts strong effects on cognitive brain functioning and is modulated by glutamatergic neural transmission. We reveal that exposure-based perceptual learning is more efficient in a human model of excitotoxic neurodegeneration than in healthy participants. Premanifest Huntington's disease gene mutation carriers showed faster increases in perceptual sensitivities than controls. This in turn changed attentional processing in extrastriate visual areas objectified using electroencephalogram data. The emergence of faster learning correlated positively with genetic disease load. Our results confirm an ambivalent action of increased glutamatergic transmission, implying that the process of excitotoxic neurodegeneration is associated with enhanced perceptual learning, which can be used to improve attentional and behavioral control via the alteration of perceptual sensitivities.
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An excessively plastic status may precede the progressive degenerative process as in other brain disorders.
“An excessively plastic status may precede the progressive degenerative process as in other brain disorders (29, 54).”
From Prolonged Period of Cortical Plasticity upon Redox Dysregulation in Fast-Spiking Interneurons (2015) · cites this paper as [54]
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Do, K. Q., Cuenod, M., & Hensch, T. K. (2015) · Schizophrenia Bulletin · doi:10.1093/schbul/sbv065 · Cited by 158 · see citing works
Prolonged Period of Cortical Plasticity upon Redox Dysregulation in Fast-Spiking Interneurons
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- Authors
- Beste, C., Wascher, E., Dinse, H. R., & Saft, C.
- Affiliations
- Ruhr University Bochum (DE)
- Corresponding author
- Beste, Christian
- Venue
- Current Biology
- Publisher
- Elsevier BV
- Published
- 2012-10
- Volume
- 22
- Issue
- 20
- Pages
- 1914-1917
- ISSN
- 0960-9822 (ISSN-L)
- OpenAlex
- W1991873473
- Cited by
- 33
- References
- 27
- Citations by year
- 2024: 1 · 2023: 1 · 2020: 5 · 2019: 3 · 2018: 3 · 2017: 3 · 2016: 6 · 2015: 4 · 2014: 2 · 2013: 4 · 2012: 1
- FWCI
- 1.45
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Current Biology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Deutsche Forschungsgemeinschaft
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Cognitive Neuroscience › Visual perception and processing mechanisms
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Genetic Neurodegenerative Diseases
- Keywords
- perceptual learning, excitotoxic neurodegeneration, glutamatergic neurotransmission, long-term potentiation, neuroplasticity, premanifest Huntington's disease, attention, visual perception, extrastriate visual areas
- MeSH terms
- Attention, Brain, Electroencephalography, Humans, Huntington Disease, Learning, Synaptic Transmission, Neuronal Plasticity, Long-Term Potentiation
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