Cited by 74Olfactory and Sensory Function StudiesNeurobiology and Insect Physiology ResearchNeurogenesis and neuroplasticity mechanisms

Experience-Dependent Plasticity of Odor Representations in the Telencephalon of Zebrafish

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Jacobson, Gilad A., Rupprecht, Peter, Friedrich, Rainer W.·2018·Current Biology

Abstract

Sensory systems balance stability and plasticity to optimize stimulus representations in dynamic environments. We studied these processes in the olfactory system of adult zebrafish. Activity patterns evoked by repeated odor stimulation were measured by multiphoton calcium imaging in the olfactory bulb (OB) and in telencephalic area Dp, the homolog of olfactory cortex. Whereas odor responses in the OB were highly reproducible, responses of Dp neurons adapted over trials and exhibited substantial variability that could be attributed to ongoing activity and to systematic changes in neuronal representations following each stimulus. An NMDA receptor antagonist did not affect the magnitude of odor responses but strongly reduced the variability and experience-dependent modification of odor responses in Dp. As a consequence, odor representations became stable over trials. These results demonstrate that odor representations in higher brain areas are continuously modified by experience, supporting the view that olfactory processing is inseparable from memory, even in the absence of reinforcement.

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Crossref · 10.1016/j.cub.2017.11.007

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  • Present day muskoxen are challenged by low genetic variability and extremely low diversity in the major histocompatibility complex, potentially impacting their ability to respond to infectious disease.

    “This has left present day muskoxen challenged by low genetic variability (Hansen et al. 2018) and extremely low diversity in the major histocompatibility complex, potentially impacting their ability to respond to infectious disease (Gordeeva et al. 2009; Cooley et al. 2011; Thulin et al. 2011).”

    From Muskox status, recent variation, and uncertain future (2020) · cites this paper as Hansen et al. 2018

  • Two subspecies O.m. wardi and O.m. moschatus are commonly recognized and recent studies have identified genetic separation between them.

    “Two subspecies, O.m. wardi and O.m. moschatus, are commonly recognized and referred to as ‘White-Faced’ and ‘Barren-Ground,’ respectively (van Coeverden de Groot 2001), and recent studies have identified genetic separation between the two (Hansen et al. 2018).”

    From Muskox status, recent variation, and uncertain future (2020) · cites this paper as Hansen et al. 2018

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Authors
Jacobson, G. A., Rupprecht, P., & Friedrich, R. W.
Affiliations
  • Friedrich Miescher Institute (CH)
  • University of Basel (CH)
Corresponding author
  • Jacobson, Gilad A.
  • Friedrich, Rainer W.
Venue
Current Biology
Publisher
Elsevier BV
Published
2018-01
Volume
28
Issue
1
Pages
1-14.e3
ISSN
0960-9822 (ISSN-L)
OpenAlex
W2771478208
Cited by
74
References
87
Citations by year
2026: 5 · 2025: 7 · 2024: 10 · 2023: 6 · 2022: 6 · 2021: 17 · 2020: 9 · 2019: 8 · 2018: 6
FWCI
3.93
Type
journal article
Language
en
Open access
Locations
  • Current Biology (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • Novartis Research Foundation
  • Swiss National Science Foundation (31003A_135196, 310030B_1528331)
  • Boehringer Ingelheim Fonds
  • EMBO (ALTF 338-2009)
  • Marie Curie Intra European (PIEF-GA-2009-255211)
Topics
  • Life Sciences › Neuroscience › Sensory Systems › Olfactory and Sensory Function Studies
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurobiology and Insect Physiology Research
  • Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
Keywords
experience-dependent plasticity, odor representation, olfactory system, zebrafish, olfactory bulb, olfactory cortex, NMDA receptor, neural activity patterns, olfactory memory, stability-plasticity balance
MeSH terms
Action Potentials, Animals, Female, Male, Neuronal Plasticity, Neurons, Odorants, Olfactory Bulb, Telencephalon, Zebrafish, Recognition, Psychology, Olfactory Perception

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