Experience-Dependent Plasticity of Odor Representations in the Telencephalon of Zebrafish
Open accessAbstract
Sensory systems balance stability and plasticity to optimize stimulus representations in dynamic environments. We studied these processes in the olfactory system of adult zebrafish. Activity patterns evoked by repeated odor stimulation were measured by multiphoton calcium imaging in the olfactory bulb (OB) and in telencephalic area Dp, the homolog of olfactory cortex. Whereas odor responses in the OB were highly reproducible, responses of Dp neurons adapted over trials and exhibited substantial variability that could be attributed to ongoing activity and to systematic changes in neuronal representations following each stimulus. An NMDA receptor antagonist did not affect the magnitude of odor responses but strongly reduced the variability and experience-dependent modification of odor responses in Dp. As a consequence, odor representations became stable over trials. These results demonstrate that odor representations in higher brain areas are continuously modified by experience, supporting the view that olfactory processing is inseparable from memory, even in the absence of reinforcement.
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Present day muskoxen are challenged by low genetic variability and extremely low diversity in the major histocompatibility complex, potentially impacting their ability to respond to infectious disease.
“This has left present day muskoxen challenged by low genetic variability (Hansen et al. 2018) and extremely low diversity in the major histocompatibility complex, potentially impacting their ability to respond to infectious disease (Gordeeva et al. 2009; Cooley et al. 2011; Thulin et al. 2011).”
From Muskox status, recent variation, and uncertain future (2020) · cites this paper as Hansen et al. 2018
Two subspecies O.m. wardi and O.m. moschatus are commonly recognized and recent studies have identified genetic separation between them.
“Two subspecies, O.m. wardi and O.m. moschatus, are commonly recognized and referred to as ‘White-Faced’ and ‘Barren-Ground,’ respectively (van Coeverden de Groot 2001), and recent studies have identified genetic separation between the two (Hansen et al. 2018).”
From Muskox status, recent variation, and uncertain future (2020) · cites this paper as Hansen et al. 2018
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Self-citation
- Authors
- Jacobson, G. A., Rupprecht, P., & Friedrich, R. W.
- Affiliations
- Friedrich Miescher Institute (CH)
- University of Basel (CH)
- Corresponding author
- Jacobson, Gilad A.
- Friedrich, Rainer W.
- Venue
- Current Biology
- Publisher
- Elsevier BV
- Published
- 2018-01
- Volume
- 28
- Issue
- 1
- Pages
- 1-14.e3
- ISSN
- 0960-9822 (ISSN-L)
- OpenAlex
- W2771478208
- Cited by
- 74
- References
- 87
- Citations by year
- 2026: 5 · 2025: 7 · 2024: 10 · 2023: 6 · 2022: 6 · 2021: 17 · 2020: 9 · 2019: 8 · 2018: 6
- FWCI
- 3.93
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Current Biology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Novartis Research Foundation
- Swiss National Science Foundation (31003A_135196, 310030B_1528331)
- Boehringer Ingelheim Fonds
- EMBO (ALTF 338-2009)
- Marie Curie Intra European (PIEF-GA-2009-255211)
- Topics
- Life Sciences › Neuroscience › Sensory Systems › Olfactory and Sensory Function Studies
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurobiology and Insect Physiology Research
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Keywords
- experience-dependent plasticity, odor representation, olfactory system, zebrafish, olfactory bulb, olfactory cortex, NMDA receptor, neural activity patterns, olfactory memory, stability-plasticity balance
- MeSH terms
- Action Potentials, Animals, Female, Male, Neuronal Plasticity, Neurons, Odorants, Olfactory Bulb, Telencephalon, Zebrafish, Recognition, Psychology, Olfactory Perception
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