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Active Properties of Neocortical Pyramidal Neuron Dendrites
Abstract
Dendrites are the main recipients of synaptic inputs and are important sites that determine neurons' input-output functions. This review focuses on thin neocortical dendrites, which receive the vast majority of synaptic inputs in cortex but also have specialized electrogenic properties. We present a simplified working-model biophysical scheme of pyramidal neurons that attempts to capture the essence of their dendritic function, including the ability to behave under plausible conditions as dynamic computational subunits. We emphasize the electrogenic capabilities of NMDA receptors (NMDARs) because these transmitter-gated channels seem to provide the major nonlinear depolarizing drive in thin dendrites, even allowing full-blown NMDA spikes. We show how apparent discrepancies in experimental findings can be reconciled and discuss the current status of dendritic spikes in vivo; a dominant NMDAR contribution would indicate that the input-output relations of thin dendrites are dynamically set by network activity and cannot be fully predicted by purely reductionist approaches.
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“Moreover, the NMDA-current has slow dynamics, promoting integration over a time window of tens of milliseconds (Major, Larkum, and Schiller 2013; Doron et al. 2017).”
From Single cortical neurons as deep artificial neural networks (2021) · cites this paper as Major, Larkum, and Schiller 2013
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Metadata
- Authors
- Major, G., Larkum, M. E., & Schiller, J.
- Affiliations
- Cardiff University (GB)
- Charité – Universitätsmedizin Berlin (DE)
- Technion – Israel Institute of Technology (IL)
- Corresponding author
- Larkum, Matthew E.
- Schiller, Jackie
- Venue
- Annual Review of Neuroscience
- Publisher
- Annual Reviews
- Published
- 2013-07-08
- Volume
- 36
- Issue
- 1
- Pages
- 1-24
- ISSN
- 0147-006X (ISSN-L)
- 1545-4126
- OpenAlex
- W2152781875
- Cited by
- 443
- References
- 15
- Citations by year
- 2026: 25 · 2025: 37 · 2024: 33 · 2023: 43 · 2022: 39 · 2021: 34 · 2020: 39 · 2019: 32 · 2018: 34 · 2017: 38 · 2016: 37 · 2015: 31 · 2014: 19 · 2013: 1
- FWCI
- 2.93
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Annual Review of Neuroscience (publishedVersion)
- PubMed (publishedVersion)
- ORCA Online Research @Cardiff (Cardiff University) (submittedVersion)
- Funders
- Biotechnology and Biological Sciences Research Council (BB/F016484/1)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
- Physical Sciences › Engineering › Electrical and Electronic Engineering › Advanced Memory and Neural Computing
- Keywords
- neocortical pyramidal neurons, NMDA receptor, dendritic spikes, dendritic computation, input-output function, synaptic integration
- MeSH terms
- Action Potentials, Animals, Dendrites, Receptors, N-Methyl-D-Aspartate, Pyramidal Cells, Neocortex
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