Direct Electrical Stimulation of Lateral Orbitofrontal Cortex Acutely Improves Mood in Individuals with Symptoms of Depression

The PHQ-9: Validity of a brief depression severity measure

Kroenke, K., Spitzer, R. L., & Williams, J. B. W. (2001) · Journal of General Internal Medicine · doi:10.1046/j.1525-1497.2001.016009606.x · Cited by 44,910

EEGLAB: an open source toolbox for analysis of single-trial EEG dynamics including independent component analysis

Delorme, A., & Makeig, S. (2004) · Journal of Neuroscience Methods · doi:10.1016/j.jneumeth.2003.10.009 · Cited by 24,371

FreeSurfer

Fischl, B. (2012) · NeuroImage · doi:10.1016/j.neuroimage.2012.01.021 · Cited by 9,526

Comparison of Beck Depression Inventories -IA and -II in psychiatric outpatients

Beck, A. T., Steer, R. A., Ball, R., & Ranieri, W. F. (1996) · Journal of Personality Assessment · doi:10.1207/s15327752jpa6703_13 · Cited by 5,965

Deep Brain Stimulation for Treatment-Resistant Depression

Mayberg, H. S., Lozano, A. M., Voon, V., McNeely, H. E., Seminowicz, D., Hamani, C., Schwalb, J. M., & Kennedy, S. H. (2005) · Neuron · doi:10.1016/j.neuron.2005.02.014 · Cited by 4,059

Resting-State Functional Connectivity in Major Depression: Abnormally Increased Contributions from Subgenual Cingulate Cortex and Thalamus

Greicius, M. D., Flores, B. H., Menon, V., Glover, G. H., Solvason, H. B., Kenna, H., Reiss, A. L., & Schatzberg, A. F. (2007) · Biological Psychiatry · doi:10.1016/j.biopsych.2006.09.020 · Cited by 2,214

The human orbitofrontal cortex: linking reward to hedonic experience

Kringelbach, M. L. (2005) · Nature Reviews Neuroscience · doi:10.1038/nrn1747 · Cited by 2,180

Resting-state connectivity biomarkers define neurophysiological subtypes of depression

Drysdale, A. T., Grosenick, L., Downar, J., Dunlop, K., Mansouri, F., Meng, Y., Fetcho, R. N., Zebley, B., Oathes, D. J., Etkin, A., et al. (2017) · Nature Medicine · doi:10.1038/nm.4246 · Cited by 2,170

The functional neuroanatomy of the human orbitofrontal cortex: Evidence from neuroimaging and neuropsychology

KRINGELBACH, M. (2004) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2004.03.006 · Cited by 1,977

A functional anatomical study of unipolar depression

Drevets, W., Videen, T., Price, J., Preskorn, S., Carmichael, S., & Raichle, M. (1992) · The Journal of Neuroscience · doi:10.1523/jneurosci.12-09-03628.1992 · Cited by 1,266

Closed-loop neuromodulation in an individual with treatment-resistant depression

Scangos, K. W., Khambhati, A. N., Daly, P. M., Makhoul, G. S., Sugrue, L. P., Zamanian, H., Liu, T. X., Rao, V. R., Sellers, K. K., Dawes, H. E., et al. (2021) · Nature Medicine · doi:10.1038/s41591-021-01480-w · Cited by 535

The orbitofrontal cortex: reward, emotion and depression

Rolls, E. T., Cheng, W., & Feng, J. (2020) · Brain Communications · doi:10.1093/braincomms/fcaa196 · Cited by 474

Identification of common neural circuit disruptions in emotional processing across psychiatric disorders

McTeague, L. M., Rosenberg, B. M., Lopez, J. W., Carreon, D. M., Huemer, J., Jiang, Y., Chick, C. F., Eickhoff, S. B., & Etkin, A. (2020) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2019.18111271 · Cited by 388

Using brain imaging to improve spatial targeting of transcranial magnetic stimulation for depression

Cash, R. F. H., Weigand, A., Zalesky, A., Siddiqi, S. H., Downar, J., Fitzgerald, P. B., & Fox, M. D. (2021) · Biological Psychiatry · doi:10.1016/j.biopsych.2020.05.033 · Cited by 366

Brain–machine interfaces from motor to mood

Shanechi, M. M. (2019) · Nature Neuroscience · doi:10.1038/s41593-019-0488-y · Cited by 263

State-dependent responses to intracranial brain stimulation in a patient with depression

Scangos, K. W., Makhoul, G. S., Sugrue, L. P., Chang, E. F., & Krystal, A. D. (2021) · Nature Medicine · doi:10.1038/s41591-020-01175-8 · Cited by 243

Lesion Studies in Contemporary Neuroscience

Vaidya, A. R., Pujara, M. S., Petrides, M., Murray, E. A., & Fellows, L. K. (2019) · Trends in Cognitive Sciences · doi:10.1016/j.tics.2019.05.009 · Cited by 243

Development of a neural interface for high-definition, long-term recording in rodents and nonhuman primates

Chiang, C.-H., Won, S. M., Orsborn, A. L., Yu, K. J., Trumpis, M., Bent, B., Wang, C., Xue, Y., Min, S., Woods, V., et al. (2020) · Science Translational Medicine · doi:10.1126/scitranslmed.aay4682 · Cited by 211

New and emerging approaches to treat psychiatric disorders

Scangos, K. W., State, M. W., Miller, A. H., Baker, J. T., & Williams, L. M. (2023) · Nature Medicine · doi:10.1038/s41591-022-02197-0 · Cited by 164

First-in-human prediction of chronic pain state using intracranial neural biomarkers

Shirvalkar, P. R., Prosky, J., Chin, G., Ahmadipour, P., Sani, O. G., Desai, M., Schmitgen, A., Dawes, H. E., Shanechi, M. M., Starr, P. A., et al. (2023) · Nature Neuroscience · doi:10.1038/s41593-023-01338-z · Cited by 151

Affective Brain–Computer Interfaces (aBCIs): A Tutorial

Wu, D., Lu, B., Hu, B., & Zeng, Z. (2023) · Proceedings of the IEEE · doi:10.1109/jproc.2023.3277471 · Cited by 135

Modelling and prediction of the dynamic responses of large-scale brain networks during direct electrical stimulation

Yang, Y., Qiao, S., Sani, O. G., Sedillo, J. I., Ferrentino, B., Pesaran, B., & Shanechi, M. M. (2021) · Nature Biomedical Engineering · doi:10.1038/s41551-020-00666-w · Cited by 139

The RNS System: brain-responsive neurostimulation for the treatment of epilepsy

Jarosiewicz, B., & Morrell, M. J. (2020) · Expert Review of Medical Devices · doi:10.1080/17434440.2019.1683445 · Cited by 113

Does the Prefrontal Cortex Play an Essential Role in Consciousness? Insights from Intracranial Electrical Stimulation of the Human Brain

Raccah, O., Block, N., & Fox, K. C. R. (2021) · The Journal of Neuroscience · doi:10.1523/jneurosci.1141-20.2020 · Cited by 96

Roles of the medial and lateral orbitofrontal cortex in major depression and its treatment

Zhang, B., Rolls, E. T., Wang, X., Xie, C., Cheng, W., & Feng, J. (2024) · Molecular Psychiatry · doi:10.1038/s41380-023-02380-w · Cited by 107

Field potential 1/f activity in the subcallosal cingulate region as a candidate signal for monitoring deep brain stimulation for treatment-resistant depression

Veerakumar, A., Tiruvadi, V., Howell, B., Waters, A. C., Crowell, A. L., Voytek, B., Riva-Posse, P., Denison, L., Rajendra, J. K., Edwards, J. A., et al. (2019) · Journal of Neurophysiology · doi:10.1152/jn.00875.2018 · Cited by 89

Cortical-subcortical structural connections support transcranial magnetic stimulation engagement of the amygdala

Sydnor, V. J., Cieslak, M., Duprat, R., Deluisi, J. A., Flounders, M. W., Long, H., Scully, M., Balderston, N. L., Sheline, Y. I., Bassett, D. S., et al. (2022) · Science Advances · doi:10.1126/sciadv.abn5803 · Cited by 103

Non-invasive transcranial brain modulation for neurological disorders treatment: A narrative review

Mosilhy, E. A., Alshial, E. E., Eltaras, M. M., Rahman, M. M. A., Helmy, H. I., Elazoul, A. H., Hamdy, O., & Mohammed, H. S. (2022) · Life Sciences · doi:10.1016/j.lfs.2022.120869 · Cited by 77

Local and distant cortical responses to single pulse intracranial stimulation in the human brain are differentially modulated by specific stimulation parameters

Paulk, A. C., Zelmann, R., Crocker, B., Widge, A. S., Dougherty, D. D., Eskandar, E. N., Weisholtz, D. S., Richardson, R. M., Cosgrove, G. R., Williams, Z. M., et al. (2022) · Brain stimulation · doi:10.1016/j.brs.2022.02.017 · Cited by 68

Emerging medical applications based on non-ionizing electromagnetic fields from 0 Hz to 10 THz

Mattsson, M., & Simkó, M. (2019) · Medical Devices Evidence and Research · doi:10.2147/mder.s214152 · Cited by 67

The Case for Adaptive Neuromodulation to Treat Severe Intractable Mental Disorders

Provenza, N. R., Matteson, E., Allawala, A. B., Barrios-Anderson, A., Sheth, S. A., Viswanathan, A., McIngvale, E., Storch, E. A., Frank, M. J., McLaughlin, N. C. R., et al. (2019) · Frontiers in Neuroscience · doi:10.3389/fnins.2019.00152 · Cited by 68

The neuroscience of emotional disorders.

Rolls, E. (2021) · Handbook of Clinical Neurology · doi:10.1016/b978-0-12-822290-4.00002-5 · Cited by 29

Theta-burst stimulation entrains frequency-specific oscillatory responses

Solomon, E. A., Sperling, M. R., Sharan, A. D., Wanda, P. A., Levy, D. F., Lyalenko, A., Pedisich, I., Rizzuto, D. S., & Kahana, M. J. (2021) · Brain stimulation · doi:10.1016/j.brs.2021.08.014 · Cited by 59

Closed-loop neurostimulation for the treatment of psychiatric disorders

Sellers, K. K., Cohen, J. L., Khambhati, A. N., Fan, J. M., Lee, A. M., Chang, E. F., & Krystal, A. D. (2023) · Neuropsychopharmacology · doi:10.1038/s41386-023-01631-2 · Cited by 58

Mechanisms of Action of TMS in the Treatment of Depression

Downar, J. H., Siddiqi, S., Mitra, A., Williams, N., & Liston, C. M. (2024) · Current topics in behavioral neurosciences · doi:10.1007/7854_2024_483 · Cited by 59

Intracortical Dynamics Underlying Repetitive Stimulation Predicts Changes in Network Connectivity

Huang, Y., Hajnal, B., Entz, L., Fabó, D., Herrero, J. L., Mehta, A. D., & Keller, C. J. (2019) · Journal of Neuroscience · doi:10.1523/jneurosci.0535-19.2019 · Cited by 54

Decoding task engagement from distributed network electrophysiology in humans

Provenza, N. R., Paulk, A. C., Peled, N., Restrepo, M. I., Cash, S. S., Dougherty, D. D., Eskandar, E. N., Borton, D. A., & Widge, A. S. (2019) · Journal of Neural Engineering · doi:10.1088/1741-2552/ab2c58 · Cited by 51

Decoding Depression Severity From Intracranial Neural Activity

Xiao, J., Provenza, N. R., Asfouri, J., Myers, J. C., Mathura, R. K., Metzger, B. A., Adkinson, J. A., Allawala, A. B., Pirtle, V., Oswalt, D. N., et al. (2023) · Biological Psychiatry · doi:10.1016/j.biopsych.2023.01.020 · Cited by 50

Decoding naturalistic affective behaviour from spectro-spatial features in multiday human iEEG

Bijanzadeh, M., Khambhati, A. N., Desai, M., Wallace, D. L., Shafi, A., Dawes, H. E., Sturm, V. E., & Chang, E. F. (2022) · Nature Human Behaviour · doi:10.1038/s41562-022-01310-0 · Cited by 49

Flexible, high-resolution thin-film electrodes for human and animal neural research

Chiang, C., Wang, C., Barth, K. J., Rahimpour, S., Trumpis, M., Duraivel, S., Rachinskiy, I., Dubey, A., Wingel, K., Wong, M. K., et al. (2021) · Journal of Neural Engineering · doi:10.1088/1741-2552/ac02dc · Cited by 47

Structuro-functional surrogates of response to subcallosal cingulate deep brain stimulation for depression

Elias, G. J. B., Germann, J., Boutet, A., Pancholi, A., Beyn, M. E., Bhatia, K. D., Neudorfer, C., Loh, A., Rizvi, S. J., Bhat, V., et al. (2021) · Brain · doi:10.1093/brain/awab284 · Cited by 49

From bed to bench side: Reverse translation to optimize neuromodulation for mood disorders

Rudebeck, P. H., Rich, E. L., & Mayberg, H. S. (2019) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1902287116 · Cited by 42

Human Responses to Visually Evoked Threat

Yilmaz Balban, M., Cafaro, E., Saue-Fletcher, L., Washington, M. J., Bijanzadeh, M., Lee, A. M., Chang, E. F., & Huberman, A. D. (2021) · Current Biology · doi:10.1016/j.cub.2020.11.035 · Cited by 48

Neural basis responsible for self-control association with procrastination: Right MFC and bilateral OFC functional connectivity with left dlPFC

Xu, T., Sirois, F. M., Zhang, L., Yu, Z., & Feng, T. (2021) · Journal of Research in Personality · doi:10.1016/j.jrp.2021.104064 · Cited by 48

Brain–computer interfaces for neuropsychiatric disorders

Oganesian, L. L., & Shanechi, M. M. (2024) · Nature Reviews Bioengineering · doi:10.1038/s44222-024-00177-2 · Cited by 47

Cortical thickness following electroconvulsive therapy in patients with depression: a longitudinal MRI study

Gbyl, K., Rostrup, E., Raghava, J. M., Carlsen, J. F., Schmidt, L. S., Lindberg, U., Ashraf, A., Jørgensen, M. B., Larsson, H. B. W., Rosenberg, R., et al. (2019) · Acta Psychiatrica Scandinavica · doi:10.1111/acps.13068 · Cited by 36

Glucocorticoid ultradian rhythmicity differentially regulates mood and resting state networks in the human brain: A randomised controlled clinical trial

Kalafatakis, K., Russell, G. M., Ferguson, S. G., Grabski, M., Harmer, C. J., Munafo, M. R., Marchant, N., Wilson, A., Brooks, J. C. W., Thakrar, J., et al. (2020) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2020.105096 · Cited by 33

Frequency dependent emotion differentiation and directional coupling in amygdala, orbitofrontal and medial prefrontal cortex network with intracranial recordings

Sonkusare, S., Ding, Q., Zhao, Y., Liu, W., Yang, R., Mandali, A., Manssuer, L. R., Zhang, C., Cao, C., Sun, B., et al. (2022) · Molecular Psychiatry · doi:10.1038/s41380-022-01883-2 · Cited by 36

Beta and theta oscillations track effort and previous reward in the human basal ganglia and prefrontal cortex during decision making

Hoy, C. W., de Hemptinne, C., Wang, S. S., Harmer, C. J., Apps, M. A. J., Husain, M., Starr, P. A., & Little, S. J. (2024) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2322869121 · Cited by 34

Ketamine Normalizes the Structural Alterations of Inferior Frontal Gyrus in Depression

Dai, D., Lacadie, C. M., Holmes, S. E., Cool, R., Anticevic, A., Averill, C., Abdallah, C., & Esterlis, I. (2020) · Chronic Stress · doi:10.1177/2470547020980681 · Cited by 34

Speech emotion recognition based on emotion perception

Liu, G., Cai, S., & Wang, C. (2023) · EURASIP Journal on Audio Speech and Music Processing · doi:10.1186/s13636-023-00289-4 · Cited by 33

Orbitofrontal cortex: a ‘non-rewarding’ new treatment target in depression?

Downar, J. (2019) · Current Biology · doi:10.1016/j.cub.2018.11.057 · Cited by 31

Deep brain stimulation of the orbitofrontal cortex prevents the development and reinstatement of morphine place preference

Fakhrieh‐Asl, G., Sadr, S. S., Karimian, S. M., & Riahi, E. (2019) · Addiction Biology · doi:10.1111/adb.12780 · Cited by 30

Machine Learning Identifies Large-Scale Reward-Related Activity Modulated by Dopaminergic Enhancement in Major Depression

Liu, Y., Admon, R., Mellem, M. S., Belleau, E. L., Kaiser, R. H., Clegg, R. A., Beltzer, M., Goer, F., Vitaliano, G. D., Ahammad, P., et al. (2019) · Biological Psychiatry Cognitive Neuroscience and Neuroimaging · doi:10.1016/j.bpsc.2019.10.002 · Cited by 32

Prefrontal Physiomarkers of Anxiety and Depression in Parkinson’s Disease

de Hemptinne, C., Chen, W., Racine, C. A., Seritan, A. L., Miller, A. M., Yaroshinsky, M. S., Wang, S. S., Gilron, R., Little, S. J., Bledsoe, I. O., et al. (2021) · Frontiers in Neuroscience · doi:10.3389/fnins.2021.748165 · Cited by 32

Deep brain stimulation of the “medial forebrain bundle”: sustained efficacy of antidepressant effect over years

Fenoy, A. J., Schulz, P. E., Sanches, M., Selvaraj, S., Burrows, C. L., Asir, B., Conner, C. R., Quevedo, J., & Soares, J. C. (2022) · Molecular Psychiatry · doi:10.1038/s41380-022-01504-y · Cited by 32

Intracerebral mechanisms explaining the impact of incidental feedback on mood state and risky choice

Cecchi, R., Vinckier, F., Hammer, J., Marusič, P., Nica, A., Rheims, S., Trébuchon, A., Barbeau, E. J., Denuelle, M., Maillard, L. G., et al. (2022) · eLife · doi:10.7554/elife.72440 · Cited by 32

Heightened Defensive Responses Following Subtotal Lesions of Macaque Orbitofrontal Cortex

Pujara, M. S., Rudebeck, P. H., Ciesinski, N. K., & Murray, E. A. (2019) · Journal of Neuroscience · doi:10.1523/jneurosci.2812-18.2019 · Cited by 30

Dorsomedial prefrontal rTMS for depression in borderline personality disorder: A pilot randomized crossover trial

Feffer, K., Lee, H. H., Wu, W., Etkin, A., Demchenko, I., Cairo, T., Mazza, F., Fettes, P., Mansouri, F., Bhui, K. S., et al. (2021) · Journal of Affective Disorders · doi:10.1016/j.jad.2021.12.038 · Cited by 30

A universal model of electrochemical safety limits in vivo for electrophysiological stimulation

Vatsyayan, R., & Dayeh, S. A. (2022) · Frontiers in Neuroscience · doi:10.3389/fnins.2022.972252 · Cited by 28

Adaptive tracking of human ECoG network dynamics

Ahmadipour, P., Yang, Y., Chang, E. F., & Shanechi, M. M. (2020) · Journal of Neural Engineering · doi:10.1088/1741-2552/abae42 · Cited by 30

Temporal interference electrical neurostimulation at 20 Hz beat frequency leads to increased fMRI BOLD activation in orbitofrontal cortex in humans

Modak, P., Fine, J. M., Colon, B., Need, E., Cheng, H., Hulvershorn, L. A., Finn, P., & Brown, J. W. (2024) · Brain stimulation · doi:10.1016/j.brs.2024.07.014 · Cited by 26

Clinical neuroprosthetics: Today and tomorrow

Lee, M. B., Kramer, D. R., Peng, T. D., Barbaro, M. F., Liu, C. Y., Kellis, S., & Lee, B. (2019) · Journal of Clinical Neuroscience · doi:10.1016/j.jocn.2019.07.056 · Cited by 29

A Causal Network Analysis of Neuromodulation in the Mood Processing Network

Qiao, S., Sedillo, J. I., Brown, K. A., Ferrentino, B., & Pesaran, B. (2020) · Neuron · doi:10.1016/j.neuron.2020.06.012 · Cited by 27

Attention bias modification through transcranial direct current stimulation (tDCS): A review

Nejati, V., Heyrani, R., & Nitsche, M. A. (2022) · Neurophysiologie Clinique · doi:10.1016/j.neucli.2022.09.002 · Cited by 27

Human intracranial recordings reveal distinct cortical activity patterns during invasive and non-invasive vagus nerve stimulation

Schuerman, W. L., Nourski, K. V., Rhone, A. E., Howard, M. A., Chang, E. F., & Leonard, M. K. (2021) · Scientific Reports · doi:10.1038/s41598-021-02307-x · Cited by 25

Myths, Misconceptions, and Invalid Assumptions About Counseling and Psychotherapy

Kottler, J. A., & Balkin, R. S. (2020) · doi:10.1093/oso/9780190090692.001.0001 · Cited by 24

A novel dual-site OFC-dlPFC accelerated repetitive transcranial magnetic stimulation for depression: a pilot randomized controlled study

Cui, H., Ding, H., Hu, L., Zhao, Y., Shu, Y., & Voon, V. (2024) · Psychological Medicine · doi:10.1017/s0033291724002289 · Cited by 25

Large-scale structural network change correlates with clinical response to rTMS in depression

Nestor, S. M., Mir-Moghtadaei, A., Vila‐Rodriguez, F., Giacobbe, P., Daskalakis, Z. J., Blumberger, D. M., & Downar, J. H. (2022) · Neuropsychopharmacology · doi:10.1038/s41386-021-01256-3 · Cited by 24

Multimodal Neural Evidence on the Corticostriatal Underpinning of Suicidality in Late-Life Depression

Shao, R., Gao, M., Lin, C., Huang, C., Liu, H., Toh, C., Wu, C. W., Tsai, Y., Qi, D., Lee, S., et al. (2021) · Biological Psychiatry Cognitive Neuroscience and Neuroimaging · doi:10.1016/j.bpsc.2021.11.011 · Cited by 24

Predictive neuromodulation of cingulo-frontal neural dynamics in major depressive disorder using a brain-computer interface system: A simulation study

Fang, H., & Yang, Y. (2023) · Frontiers in Computational Neuroscience · doi:10.3389/fncom.2023.1119685 · Cited by 23

Gamma knife capsulotomy for intractable OCD: Neuroimage analysis of lesion size, location, and clinical response

McLaughlin, N. C. R., Magnotti, J. F., Banks, G. P., Nanda, P., Hoexter, M. Q., Lopes, A. C., Batistuzzo, M. C., Asaad, W. F., Stewart, C., Paulo, D. L., et al. (2023) · Translational Psychiatry · doi:10.1038/s41398-023-02425-2 · Cited by 23

Neuromodulation for major depressive disorder: innovative measures to capture efficacy and outcomes

Rabin, J. S., Davidson, B., Giacobbe, P., Hamani, C., Cohn, M., Illes, J., & Lipsman, N. (2020) · The Lancet Psychiatry · doi:10.1016/s2215-0366(20)30187-5 · Cited by 23

ESTADOS DE ÁNIMO, ANSIEDAD Y DEPRESIÓN EN ESTUDIANTES DE MEDICINA DURANTE LA CRISIS SANITARIA COVID-19

Hernández, D. C. V., & Mayorga-Lascano, M. (2021) · PSICOLOGÍA UNEMI · doi:10.29076/issn.2602-8379vol5iss9.2021pp10-20p · Cited by 36

Major-depressive-disorder-associated dysregulation of ZBTB7A in orbitofrontal cortex promotes astrocyte-mediated stress susceptibility

Fulton, S. L., Bendl, J. M., Salvo, G. D., Fullard, J. F., Al-Kachak, A., Lepack, A. E., Stewart, A. F., Singh, S., Poller, W. C., Bastle, R. M., et al. (2025) · Neuron · doi:10.1016/j.neuron.2025.05.023 · Cited by 23

Distinct suppressing effects of deep brain stimulation in the orbitofrontal cortex on the development, extinction, and reinstatement of methamphetamine-seeking behaviors

Fattahi, M., Eskandari, K., Riahi, E., Khosrowabadi, R., & Haghparast, A. (2023) · Life Sciences · doi:10.1016/j.lfs.2023.121613 · Cited by 20

State-specific modulation of mood using intracranial electrical stimulation of the orbitofrontal cortex

Cao, D., Liu, Q., Zhang, J., Li, J., & Jiang, T. (2023) · Brain stimulation · doi:10.1016/j.brs.2023.07.049 · Cited by 20

Invasive Electrophysiology for Circuit Discovery and Study of Comorbid Psychiatric Disorders in Patients With Epilepsy: Challenges, Opportunities, and Novel Technologies

Balzekas, I., Sladky, V., Nejedlý, P., Brinkmann, B. H., Crepeau, D., Mívalt, F., Gregg, N. M., Attia, T. P., Marks, V. S., Wheeler, L., et al. (2021) · Frontiers in Human Neuroscience · doi:10.3389/fnhum.2021.702605 · Cited by 21

Intracranial directed connectivity links subregions of the prefrontal cortex to major depression

Myers, J. C., Xiao, J., Mathura, R. K., Shofty, B., Gates, V., Adkinson, J., Allawala, A. B., Anand, A., Gadot, R., Najera, R. A., et al. (2025) · Nature Communications · doi:10.1038/s41467-025-61487-6 · Cited by 18

Neuroanatomical Correlates of Emotion-Related Impulsivity

Elliott, M., Esmail, S. A. S., Weiner, K. S., & Johnson, S. L. (2022) · Biological Psychiatry · doi:10.1016/j.biopsych.2022.07.018 · Cited by 19

Brain metabolic changes and clinical response to superolateral medial forebrain bundle deep brain stimulation for treatment-resistant depression

Conner, C. R., Quevedo, J., Soares, J. C., & Fenoy, A. J. (2022) · Molecular Psychiatry · doi:10.1038/s41380-022-01726-0 · Cited by 17

Ruminative reflection is associated with anticorrelations between the orbitofrontal cortex and the default mode network in depression: implications for repetitive transcranial magnetic stimulation

Ehrlich, T. J., Bhat, J. V., Horwege, A. M., Mathalon, D. H., Glover, G. H., Roach, B. J., Badran, B. W., Forman, S. D., George, M. S., Scott, J. C., et al. (2021) · Brain Imaging and Behavior · doi:10.1007/s11682-021-00596-4 · Cited by 16

Cardiac–Brain Dynamics Depend on Context Familiarity and Their Interaction Predicts Experience of Emotional Arousal

Mishra, S., Srinivasan, N., & Tiwary, U. S. (2022) · Brain Sciences · doi:10.3390/brainsci12060702 · Cited by 15

Model-agnostic meta-learning for EEG-based inter-subject emotion recognition

Chen, C., Fang, H., Yang, Y., & Zhou, Y. (2024) · Journal of Neural Engineering · doi:10.1088/1741-2552/ad9956 · Cited by 18

1Hz right orbitofrontal TMS benefits depressed patients unresponsive to dorsolateral prefrontal cortex TMS

Prentice, A., Kolken, Y., Tuttle, C., van Neijenhof, J., Pitch, R. J., van Oostrom, I., Kruiver, V., Downar, J. H., Sack, A. T., Arns, M., et al. (2023) · Brain stimulation · doi:10.1016/j.brs.2023.10.005 · Cited by 16

Stereotactic electroencephalography in epilepsy patients for mapping of neural circuits related to emotional and psychiatric behaviors: a systematic review

Ramos, C. G. L., Tan, H., Yamamoto, E. A., Cleary, D. R., Mazur-Hart, D. J., Shahin, M. N., & Raslan, A. M. (2023) · Neurosurgical FOCUS · doi:10.3171/2022.11.focus22615 · Cited by 14

Wireless control of nerve growth using bipolar electrodes: a new paradigm in electrostimulation

Rajnicek, A. M., & Casañ-Pastor, N. (2024) · Biomaterials Science · doi:10.1039/d3bm01946b · Cited by 14

Mapping Symptom Clusters to Circuits: Toward Personalizing TMS Targets to Improve Treatment Outcomes in Depression

Nestor, S. M., & Blumberger, D. M. (2020) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2020.20030271 · Cited by 13

The role of left orbitofrontal cortex in selective attention during automatic emotion regulation: Evidence from transcranial direct current stimulation

Hua, Y. Q., Li, M., Qiaoting, W. A. N. G., Feng, C., & Zhang, J. (2020) · Acta Psychologica Sinica · doi:10.3724/sp.j.1041.2020.01048 · Cited by 14

Integration of the Cortical Haemodynamic Response Measured by Functional Near-Infrared Spectroscopy and Amino Acid Analysis to Aid in the Diagnosis of Major Depressive Disorder

Ong, S., Husain, S. F., Wee, H. N., Ching, J., Kovalik, J., Cheng, M. S., Schwarz, H., Tang, T. B., & Ho, C. S. H. (2021) · Diagnostics · doi:10.3390/diagnostics11111978 · Cited by 12

Neurostimulation for treatment-resistant posttraumatic stress disorder: an update on neurocircuitry and therapeutic targets

Larkin, M. B., McGinnis, J. P., Snyder, R. I., Storch, E. A., Goodman, W. K., Viswanathan, A., & Sheth, S. A. (2020) · Journal of neurosurgery · doi:10.3171/2020.4.jns2061 · Cited by 12

Terahertz photoneuromodulation of lateral orbitofrontal cortex neurons ameliorates stress-induced depression and cognitive impairment

Yuanyuan, H., Ma, J., Yu, Y., Yin, J., Gao, G., Yuan, Y., Ruan, H., Yan, X., Song, Z., & Chang, C. (2024) · Fundamental Research · doi:10.1016/j.fmre.2024.12.004 · Cited by 11

Electrical high frequency stimulation of the nucleus accumbens shell does not modulate depressive-like behavior in rats

Schumacher, A., Haegele, M., Spyth, J., & Moser, A. (2019) · Behavioural Brain Research · doi:10.1016/j.bbr.2019.112277 · Cited by 11

Abnormal Global Cortical Responses in Drug-Naïve Patients With Schizophrenia Following Orbitofrontal Cortex Stimulation: A Concurrent Transcranial Magnetic Stimulation–Electroencephalography Study

Jiao, X., Hu, Q., Tang, Y., Zhang, T., Zhang, J., Wang, X., Sun, J., & Wang, J. (2024) · Biological Psychiatry · doi:10.1016/j.biopsych.2024.05.024 · Cited by 10

The critical role of the orbitofrontal cortex for regret in an economic decision-making task

Zhang, T., Zhang, Q., Wu, J., Wang, M., Li, W., Yan, J., Zhang, J., Jin, Z., & Li, L. (2022) · Brain Structure and Function · doi:10.1007/s00429-022-02568-w · Cited by 10

Neurocomputational mechanisms underlying fear-biased adaptation learning in changing environments

Wang, Z., Nan, T., Goerlich, K. S., Li, Y., Aleman, A., Luo, Y., & Xu, P. (2023) · PLoS Biology · doi:10.1371/journal.pbio.3001724 · Cited by 10

Investigating EEG biomarkers of clinical response to low frequency rTMS in depression

Voetterl, H., Miron, J., Mansouri, F., Fox, L., Hyde, M., Blumberger, D. M., Daskalakis, Z. J., Vila‐Rodriguez, F., Sack, A. T., & Downar, J. H. (2021) · Journal of Affective Disorders Reports · doi:10.1016/j.jadr.2021.100250 · Cited by 10

Prefrontal–bed nucleus of the stria terminalis physiological and neuropsychological biomarkers predict therapeutic outcomes in depression

Wang, L., Zhang, Y., Wang, Y., Ding, Q., Dai, L., Hu, K., Ye, K., lv, X., Zhang, X., Mandali, A., et al. (2025) · Nature Communications · doi:10.1038/s41467-025-65179-z · Cited by 11

One-Shot Tagging During Wake and Cueing During Sleep With Spatiotemporal Patterns of Transcranial Electrical Stimulation Can Boost Long-Term Metamemory of Individual Episodes in Humans

Pilly, P. K., Skorheim, S. W., Hubbard, R. J., Ketz, N., Roach, S. M., Lerner, I., Jones, A. P., Robert, B. M., Bryant, N. B., Hartholt, A., et al. (2020) · Frontiers in Neuroscience · doi:10.3389/fnins.2019.01416 · Cited by 9

Identification of Reliable Target Brain Regions for Enhancing Object–Location Memory by Brain Stimulation

Abdelmotaleb, M., Niemann, F., Kocataş, H., Guevara, L. M. C., Shahbabaie, A., Malinowski, R., Riemann, S., Fromm, A. E., Hayek, D., Antonenko, D., et al. (2025) · Brain and Behavior · doi:10.1002/brb3.70658 · Cited by 7

A case series of a novel 1 Hz right-sided dorsolateral prefrontal cortex rTMS protocol in major depression

Miron, J., Voetterl, H., Mansouri, F., Blumberger, D. M., Daskalakis, Z. J., & Downar, J. H. (2019) · Brain stimulation · doi:10.1016/j.brs.2019.11.006 · Cited by 8

Prefrontal network engagement by deep brain stimulation in limbic hubs

Allawala, A. B., Bijanki, K. R., Oswalt, D. N., Mathura, R. K., Adkinson, J. A., Pirtle, V., Shofty, B., Robinson, M. E., Harrison, M. T., Mathew, S. J., et al. (2024) · Frontiers in Human Neuroscience · doi:10.3389/fnhum.2023.1291315 · Cited by 8

Intracranial Neural Biomarkers of Psychiatric Symptoms and Their Utility for Guiding Neuromodulation Therapy: A Systematic Review

Kabotyanski, K. E., Provenza, N. R., & Sheth, S. A. (2025) · Biological Psychiatry · doi:10.1016/j.biopsych.2025.10.005 · Cited by 6

The Effect of Transcranial Electrical Stimulation on the Recovery of Sleep Quality after Sleep Deprivation Based on an EEG Analysis

Wang, Y., Cao, Q., Wei, C., Xu, F., Zhang, P., Zeng, H., Shao, Y., Weng, X., & Meng, R. (2023) · Brain Sciences · doi:10.3390/brainsci13060933 · Cited by 7

Intracranial electrical stimulation of corticolimbic sites modulates arousal in humans

Fan, J. M., Lee, A. M., Sellers, K. K., Woodworth, K., Makhoul, G. S., Liu, T. X., Henderson, C., Maya, D. A., Martinez, R., Zamanian, H., et al. (2023) · Brain stimulation · doi:10.1016/j.brs.2023.06.017 · Cited by 8

Event detection and classification from multimodal time series with application to neural data

Sadras, N., Pesaran, B., & Shanechi, M. M. (2024) · Journal of Neural Engineering · doi:10.1088/1741-2552/ad3678 · Cited by 7

Differential activation of lateral parabrachial nuclei and their limbic projections during head compared with body pain: A 7-Tesla functional magnetic resonance imaging study

Robertson, R. V., Meylakh, N., Crawford, L. S., Mendoza, F. A. T., Macey, P. M., Macefield, V. G., Keay, K. A., & Henderson, L. A. (2024) · NeuroImage · doi:10.1016/j.neuroimage.2024.120832 · Cited by 8

Association between polygenic risk for Major Depression and brain structure in a mega-analysis of 50,975 participants across 11 studies

Shen, X., Toenders, Y. J., Han, L. K. M., Weihs, A., Alexander, N., Andlauer, T. F. M., Brosch, K., Forstner, A. J., Grotegerd, D., Hahn, T., et al. (2025) · Molecular Psychiatry · doi:10.1038/s41380-025-03136-4 · Cited by 8

Role and Functions of the Human Orbitofrontal Cortex

Robin, A., & Bastin, J. (2025) · Journal of Clinical Neurophysiology · doi:10.1097/wnp.0000000000001207 · Cited by 7

Developing Precision Invasive Neuromodulation for Psychiatry

Bormann, N. L., Trapp, N. T., Narayanan, N. S., & Boes, A. D. (2021) · Journal of Neuropsychiatry · doi:10.1176/appi.neuropsych.20100268 · Cited by 7

State-specific modulation of mood using intracranial electrical stimulation of the orbitofrontal cortex

Cao, D., Liu, Q., Zhang, J., Li, J., & Jiang, T. (2023) · Brain stimulation · doi:10.1016/j.brs.2023.07.049 · Cited by 20

Electrical stimulation alleviates depressive-like behaviors of rats: investigation of brain targets and potential mechanisms

Lim, L. W., Prickaerts, J., Huguet, G., Kadar, E., Hartung, H., Sharp, T., & Temel, Y. (2015) · Translational Psychiatry · doi:10.1038/tp.2015.24 · Cited by 116

Lateral habenula deep brain stimulation alleviates depression-like behaviors and reverses the oscillatory pattern in the nucleus accumbens in an animal model of depression

Akhoondian, M. J., Rashtiani, S., Khakpour-Taleghani, B., Rostampour, M., Jafari, A., & Rohampour, K. (2023) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2023.110745 · Cited by 8

Orbitofrontal cortex: a ‘non-rewarding’ new treatment target in depression?

Downar, J. (2019) · Current Biology · doi:10.1016/j.cub.2018.11.057 · Cited by 31

Deep brain stimulation for Parkinson’s disease dissociates mood and motor circuits: a functional MRI case study

Stefurak, T., Mikulis, D., Mayberg, H., Lang, A. E., Hevenor, S., Pahapill, P., Saint‐Cyr, J., & Lozano, A. (2003) · Movement Disorders · doi:10.1002/mds.10593 · Cited by 215