Identification of common neural circuit disruptions in emotional processing across psychiatric disorders
Open accessAbstract
OBJECTIVE: Disrupted emotional processing is a common feature of many psychiatric disorders. The authors investigated functional disruptions in neural circuitry underlying emotional processing across a range of tasks and across psychiatric disorders through a transdiagnostic quantitative meta-analysis of published neuroimaging data. METHODS: A PubMed search was conducted for whole-brain functional neuroimaging findings published through May 2018 that compared activation during emotional processing tasks in patients with psychiatric disorders (including schizophrenia, bipolar or unipolar depression, anxiety, and substance use) to matched healthy control participants. Activation likelihood estimation (ALE) meta-analyses were conducted on peak voxel coordinates to identify spatial convergence. RESULTS: The 298 experiments submitted to meta-analysis included 5,427 patients and 5,491 control participants. ALE across diagnoses and patterns of patient hyper- and hyporeactivity demonstrated abnormal activation in the amygdala, the hippocampal/parahippocampal gyri, the dorsomedial/pulvinar nuclei of the thalamus, and the fusiform gyri, as well as the medial and lateral dorsal and ventral prefrontal regions. ALE across disorders but considering directionality demonstrated patient hyperactivation in the amygdala and the hippocampal/parahippocampal gyri. Hypoactivation was found in the medial and lateral prefrontal regions, most pronounced during processing of unpleasant stimuli. More refined disorder-specific analyses suggested that these overall patterns were shared to varying degrees, with notable differences in patterns of hyper- and hypoactivation. CONCLUSIONS: These findings demonstrate a pattern of neurocircuit disruption across major psychiatric disorders in regions and networks key to adaptive emotional reactivity and regulation. More specifically, disruption corresponded prominently to the "salience" network, the ventral striatal/ventromedial prefrontal "reward" network, and the lateral orbitofrontal "nonreward" network. Consistent with the Research Domain Criteria initiative, these findings suggest that psychiatric illness may be productively formulated as dysfunction in transdiagnostic neurobehavioral phenotypes such as neurocircuit activation.
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Disruptions in this inhibitory control mechanism may underlie deficient emotion regulation across diagnostic categories.
“Disruptions in this inhibitory control mechanism may underlie deficient emotion regulation across diagnostic categories (McTeague et al., 2020, Zilverstand et al., 2017).”
From Rt-fMRI neurofeedback-guided cognitive reappraisal training modulates amygdala responsivity in posttraumatic stress disorder (2020) · cites this paper as McTeague et al., 2020
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Background
- Authors
- McTeague, L. M., Rosenberg, B. M., Lopez, J. W., Carreon, D. M., Huemer, J., Jiang, Y., Chick, C. F., Eickhoff, S. B., & Etkin, A.
- Affiliations
- Medical University of South Carolina (US)
- ORCID
- Venue
- American Journal of Psychiatry
- Published
- 2020-05-01
- Volume
- 177
- Issue
- 5
- Pages
- 411-421
- ISSN
- 0002-953X (ISSN-L)
- 1535-7228
- PMC
- PMC7280468
- OpenAlex
- W3001336471
- Cited by
- 388
- References
- 65
- Citations by year
- 2026: 34 · 2025: 64 · 2024: 125 · 2023: 54 · 2022: 51 · 2021: 45 · 2020: 15
- FWCI
- 22.02
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- American Journal of Psychiatry (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute of Mental Health (R01MH074457, DP1MH116506, R56MH074457, K23MH104849)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Life Sciences › Neuroscience › Cognitive Neuroscience › Functional Brain Connectivity Studies
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Keywords
- emotional processing, mental illness, amygdala, hippocampus, thalamus, prefrontal cortex, hyperactivation, hypoactivation, salience network, reward network, emotional reactivity, emotion regulation, schizophrenia, depression, anxiety, substance use disorders, Research Domain Criteria, neurobehavioral phenotype
- MeSH terms
- Adolescent, Adult, Aged, Mental Disorders, Child, Emotions, Female, Humans, Male, Middle Aged, Neural Pathways, Likelihood Functions, Young Adult, Functional Neuroimaging
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