Cited by 113Circadian rhythm and melatoninHypothalamic control of reproductive hormonesRegulation of Appetite and Obesity

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Kisspeptin Neurons in the Arcuate Nucleus of the Hypothalamus Orchestrate Circadian Rhythms and Metabolism

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Padilla, Stephanie L., Perez, Jazmine G., Ben-Hamo, Miriam, Johnson, Christopher W., Sanchez, Raymond E.A., Bussi, Ivana L., Palmiter, Richard D., de la Iglesia, Horacio O.·2019·Current Biology

DOI 10.1016/j.cub.2019.01.022PMC PMC7147454

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Abstract

Successful reproduction in female mammals is precisely timed and must be able to withstand the metabolic demand of pregnancy and lactation. We show that kisspeptin-expressing neurons in the arcuate hypothalamus (Kiss1 ARH) of female mice control the daily timing of food intake, along with the circadian regulation of locomotor activity, sleep, and core body temperature. Toxin-induced silencing of Kiss1 ARH neurons shifts wakefulness and food consumption to the light phase and induces weight gain. Toxin-silenced mice are less physically active and have attenuated temperature rhythms. Because the rhythm of the master clock in the suprachiasmatic nucleus (SCN) appears to be intact, we hypothesize that Kiss1 ARH neurons signal to neurons downstream of the master clock to modulate the output of the SCN. We conclude that, in addition to their well-established role in regulating fertility, Kiss1 ARH neurons are a critical component of the hypothalamic circadian oscillator network that times overt rhythms of physiology and behavior.

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Authors: Padilla, S. L., Perez, J. G., Ben-Hamo, M., Johnson, C. W., Sanchez, R. E. A., Bussi, I. L., Palmiter, R. D., & de la Iglesia, H. O.
Affiliations: University of Washington (US)
Howard Hughes Medical Institute (US)
ORCID: Sanchez, Raymond E.A.
Bussi, Ivana L.
Palmiter, Richard D.
Venue: Current Biology
Publisher: Elsevier BV
Published: 2019-02
Volume: 29
Issue: 4
Pages: 592-604.e4
ISSN: 0960-9822 (ISSN-L)
DOI: 10.1016/j.cub.2019.01.022
PMC: PMC7147454
OpenAlex: W2914272305
Cited by: 113
References: 90
Citations by year: 2026: 10 · 2025: 16 · 2024: 12 · 2023: 14 · 2022: 9 · 2021: 28 · 2020: 15 · 2019: 9
FWCI: 8.42
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
www.elsevier.com/open-access/userlicense/1.0/ (vor, 382 d)
Locations: Current Biology (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
Funders: National Institutes of Health (R01-NS094211, R01-DA24908)
Topics: Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
Health Sciences › Medicine › Reproductive Medicine › Hypothalamic control of reproductive hormones
Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
Keywords: kisspeptin neurons, KISS1, arcuate nucleus, hypothalamus, circadian rhythm, dietary intake, locomotor activity, sleep, core body temperature, suprachiasmatic nucleus, female reproduction, metabolism, weight gain
MeSH terms: Animals, Arcuate Nucleus of Hypothalamus, Body Temperature, Circadian Rhythm, Feeding Behavior, Female, Locomotion, Neurons, Sleep, Mice, Kisspeptins

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Kisspeptin Neurons in the Arcuate Nucleus of the Hypothalamus Orchestrate Circadian Rhythms and Metabolism

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