The DOI matches its Crossref record; 90 of the 90 references it cites were found in a registry or an index.
Kisspeptin Neurons in the Arcuate Nucleus of the Hypothalamus Orchestrate Circadian Rhythms and Metabolism
Open accessAbstract
Successful reproduction in female mammals is precisely timed and must be able to withstand the metabolic demand of pregnancy and lactation. We show that kisspeptin-expressing neurons in the arcuate hypothalamus (Kiss1 ARH) of female mice control the daily timing of food intake, along with the circadian regulation of locomotor activity, sleep, and core body temperature. Toxin-induced silencing of Kiss1 ARH neurons shifts wakefulness and food consumption to the light phase and induces weight gain. Toxin-silenced mice are less physically active and have attenuated temperature rhythms. Because the rhythm of the master clock in the suprachiasmatic nucleus (SCN) appears to be intact, we hypothesize that Kiss1 ARH neurons signal to neurons downstream of the master clock to modulate the output of the SCN. We conclude that, in addition to their well-established role in regulating fertility, Kiss1 ARH neurons are a critical component of the hypothalamic circadian oscillator network that times overt rhythms of physiology and behavior.
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“Indeed, given the substantial investment of energy required for fertility, pregnancy, and lactation, it is not surprising that there is a reciprocal interaction between neural circuits that regulate energy balance, body temperature, and reproduction. This interaction ensures an adequate energy reserve to meet the demands of reproduction [47].”
From Temperature regulation in women: Effects of the menstrual cycle (2020) · cites this paper as [47]
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Cites
Obesity and Metabolic Syndrome in Circadian Clock Mutant Mice
Turek, F. W., Joshu, C., Kohsaka, A., Lin, E., Ivanova, G., McDearmon, E., Laposky, A., Losee-Olson, S., Easton, A., Jensen, D. R., et al. (2005) · Science · doi:10.1126/science.1108750 · Cited by 2,485
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Central and Peripheral Circadian Clocks in Mammals
Mohawk, J. A., Green, C. B., & Takahashi, J. S. (2012) · Annual Review of Neuroscience · doi:10.1146/annurev-neuro-060909-153128 · Cited by 2,265
Hatori, M., Vollmers, C., Zarrinpar, A., DiTacchio, L., Bushong, E. A., Gill, S., Leblanc, M., Chaix, A., Joens, M., Fitzpatrick, J. A. J., et al. (2012) · Cell Metabolism · doi:10.1016/j.cmet.2012.04.019 · Cited by 1,986
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Physiology of Circadian Entrainment
Golombek, D. A., & Rosenstein, R. E. (2010) · Physiological Reviews · doi:10.1152/physrev.00009.2009 · Cited by 1,169
NPY/AgRP Neurons Are Essential for Feeding in Adult Mice but Can Be Ablated in Neonates
Luquet, S. H., Perez, F. A., Hnasko, T. S., & Palmiter, R. D. (2005) · Science · doi:10.1126/science.1115524 · Cited by 1,150
Self-citationRegulation of Kiss1 gene expression in the brain of the female mouse
Smith, J. T., Cunningham, M. J., Rissman, E. F., Clifton, D. K., & Steiner, R. A. (2005) · Endocrinology · doi:10.1210/en.2005-0488 · Cited by 1,102
Generation of circadian rhythms in the suprachiasmatic nucleus
Hastings, M. H., Maywood, E. S., & Brancaccio, M. (2018) · Nature Reviews Neuroscience · doi:10.1038/s41583-018-0026-z · Cited by 1,065
Light as a central modulator of circadian rhythms, sleep and affect
LeGates, T. A., Fernandez, D. C., & Hattar, S. (2014) · Nature Reviews Neuroscience · doi:10.1038/nrn3743 · Cited by 1,001
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Temperature regulation in women: Effects of the menstrual cycle
Baker, F. C., Siboza, F., & Fuller, A. (2020) · Temperature · doi:10.1080/23328940.2020.1735927 · Cited by 262
Metabolic regulation of kisspeptin — the link between energy balance and reproduction
Navarro, V. M. (2020) · Nature Reviews Endocrinology · doi:10.1038/s41574-020-0363-7 · Cited by 240
Circadian rhythms and obesity: Timekeeping governs lipid metabolism
Li, Y., Ma, J., Kang, Y., Su, W., Tan, B., Wu, X., Huang, X., Li, T., Yin, Y., Tosini, G., et al. (2020) · Journal of Pineal Research · doi:10.1111/jpi.12682 · Cited by 162
Circadian Rhythms of the Hypothalamus: From Function to Physiology
Drunen, R. V., & Eckel‐Mahan, K. L. (2021) · Clocks & Sleep · doi:10.3390/clockssleep3010012 · Cited by 146
Sen, A., & Hoffmann, H. M. (2019) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2019.110655 · Cited by 125
Metadata
- Authors
- Padilla, S. L., Perez, J. G., Ben-Hamo, M., Johnson, C. W., Sanchez, R. E. A., Bussi, I. L., Palmiter, R. D., & de la Iglesia, H. O.
- Affiliations
- University of Washington (US)
- Howard Hughes Medical Institute (US)
- Venue
- Current Biology
- Publisher
- Elsevier BV
- Published
- 2019-02
- Volume
- 29
- Issue
- 4
- Pages
- 592-604.e4
- ISSN
- 0960-9822 (ISSN-L)
- PMC
- PMC7147454
- OpenAlex
- W2914272305
- Cited by
- 113
- References
- 90
- Citations by year
- 2026: 10 · 2025: 16 · 2024: 12 · 2023: 14 · 2022: 9 · 2021: 28 · 2020: 15 · 2019: 9
- FWCI
- 8.42
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Current Biology (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health (R01-NS094211, R01-DA24908)
- Topics
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
- Health Sciences › Medicine › Reproductive Medicine › Hypothalamic control of reproductive hormones
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
- Keywords
- kisspeptin neurons, KISS1, arcuate nucleus, hypothalamus, circadian rhythm, dietary intake, locomotor activity, sleep, core body temperature, suprachiasmatic nucleus, female reproduction, metabolism, weight gain
- MeSH terms
- Animals, Arcuate Nucleus of Hypothalamus, Body Temperature, Circadian Rhythm, Feeding Behavior, Female, Locomotion, Neurons, Sleep, Mice, Kisspeptins
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