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Neonatal Immune Development in the Calf and Its Impact on Vaccine Response
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In this article we cover the immunologic response as it develops, the components of passive immunity, and the immune response of young calves. We discuss interference from maternal immunity in the development of specific immunity and vaccine strategies for developing protection against pathogens in calves.
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“At approximately 2–3 weeks of age calves experience an “immunity gap”, during which maternal antibodies acquired by transfer of passive immunity via colostrum decline before the calf’s active immune system is fully functional, leaving them particularly susceptible disease [20, 21].”
From Effects of age and feeding protocols on the metabolic and physiological condition of unweaned calves during and after long-distance transport (2026) · cites this paper as [21]
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Metadata
- Authors
- Chase, C. C. L., Hurley, D. J., & Reber, A. J.
- Affiliations
- South Dakota State University (US)
- University of Georgia (US)
- Corresponding author
- Chase, Christopher C.L.
- Venue
- Veterinary Clinics of North America: Food Animal Practice
- Publisher
- Elsevier BV
- Published
- 2008-03
- Volume
- 24
- Issue
- 1
- Pages
- 87-104
- ISSN
- 0749-0720 (ISSN-L)
- PMC
- PMC7127081
- OpenAlex
- W1996061587
- Cited by
- 482
- References
- 71
- Citations by year
- 2026: 32 · 2025: 51 · 2024: 55 · 2023: 44 · 2022: 38 · 2021: 48 · 2020: 39 · 2019: 19 · 2018: 27 · 2017: 16 · 2016: 18 · 2015: 14 · 2014: 25 · 2013: 8 · 2012: 11
- FWCI
- 3.17
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Veterinary Clinics of North America Food Animal Practice (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Open PRAIRIE (South Dakota State University) (submittedVersion)
- Funders
- University of Rochester
- Medical Center, University of Rochester
- Topics
- Life Sciences › Agricultural and Biological Sciences › Animal Science and Zoology › Animal health and immunology
- Life Sciences › Immunology and Microbiology › Immunology › Immune responses and vaccinations
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Neonatal and Maternal Infections
- Keywords
- neonatal immune development, calves, passive immunity, maternal immunity, vaccine response, neonatal calves, bovine pathogens
- MeSH terms
- Animals, Animals, Newborn, Antibody Formation, Cattle, Colostrum, Female, Immunity, Cellular, Immunity, Maternally-Acquired, Immunization, Passive, Vaccination
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