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Role of microRNA-155 in autoimmunity

Leng, Rui-Xue, Pan, Hai-Feng, Qin, Wei-Zi, Chen, Gui-Mei, Ye, Dong-Qing·2011·Cytokine & Growth Factor Reviews

Abstract

MicroRNAs (miRNAs) have recently emerged as a major class of gene expression regulators linked to most biological functions. MiR-155 is encoded within a region known as B cell integration cluster (Bic) gene, identified originally as a frequent integration site for the avian leukosis virus. Disregulation of endogenous miR-155 has been implicated in the pathogenesis of human cancers. Recently, aberrant expression of miR-155 was observed in many autoimmune conditions, including rheumatoid arthritis (RA), multiple sclerosis (MS), and systemic lupus erythematosus (SLE). Moreover, functional analysis demonstrated that miR-155 has powerful regulatory potential in a wide variety of immune cells through targeting specific mRNAs. Since pathogenic immune cells play a pivotal role in pathogenesis of human autoimmune diseases, miR-155 might be a versatile therapeutic target. This review will discuss the current understandings for the role of miR-155 in autoimmunity.

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Metadata

Authors
Leng, R.-X., Pan, H.-F., Qin, W.-Z., Chen, G.-M., & Ye, D.-Q.
Venue
Cytokine & Growth Factor Reviews
Publisher
Elsevier BV
Published
2011-06
Volume
22
Issue
3
Pages
141-147
ISSN
1359-6101
Cited by
118
References
3
Language
en

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