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Role of microRNA-155 in autoimmunity
Abstract
MicroRNAs (miRNAs) have recently emerged as a major class of gene expression regulators linked to most biological functions. MiR-155 is encoded within a region known as B cell integration cluster (Bic) gene, identified originally as a frequent integration site for the avian leukosis virus. Disregulation of endogenous miR-155 has been implicated in the pathogenesis of human cancers. Recently, aberrant expression of miR-155 was observed in many autoimmune conditions, including rheumatoid arthritis (RA), multiple sclerosis (MS), and systemic lupus erythematosus (SLE). Moreover, functional analysis demonstrated that miR-155 has powerful regulatory potential in a wide variety of immune cells through targeting specific mRNAs. Since pathogenic immune cells play a pivotal role in pathogenesis of human autoimmune diseases, miR-155 might be a versatile therapeutic target. This review will discuss the current understandings for the role of miR-155 in autoimmunity.
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“MiR-155 plays a critical role in both innate and adaptive immunity, thus regulating and modulating inflammation in autoimmune diseases such as MS (Leng et al. 2011).”
From MiR-124 and MiR-155 as Therapeutic Targets in Microglia-Mediated Inflammation in Multiple Sclerosis (2025) · cites this paper as Leng et al. 2011
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Requirement of bic/microRNA-155 for Normal Immune Function
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Metadata
- Authors
- Leng, R.-X., Pan, H.-F., Qin, W.-Z., Chen, G.-M., & Ye, D.-Q.
- Venue
- Cytokine & Growth Factor Reviews
- Publisher
- Elsevier BV
- Published
- 2011-06
- Volume
- 22
- Issue
- 3
- Pages
- 141-147
- ISSN
- 1359-6101
- Cited by
- 118
- References
- 3
- Language
- en
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