Cited by 513COVID-19 Clinical Research StudiesSARS-CoV-2 and COVID-19 ResearchRespiratory Support and Mechanisms

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Cytokine storm intervention in the early stages of COVID-19 pneumonia

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Sun, Xinjuan, Wang, Tianyuan, Cai, Dayong, Hu, Zhiwei, Chen, Jin’an, Liao, Hui, Zhi, Liming, Wei, Hongxia, Zhang, Zhihong, Qiu, Yuying, Wang, Jing, Wang, Aiping·2020·Cytokine & Growth Factor Reviews

DOI 10.1016/j.cytogfr.2020.04.002PMC PMC7182527

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Abstract

Clinical intervention in patients with corona virus disease 2019 (COVID-19) has demonstrated a strong upregulation of cytokine production in patients who are critically ill with SARS-CoV2-induced pneumonia. In a retrospective study of 41 patients with COVID-19, most patients with SARS-CoV-2 infection developed mild symptoms, whereas some patients later developed aggravated disease symptoms, and eventually passed away because of multiple organ dysfunction syndrome (MODS), as a consequence of a severe cytokine storm. Guidelines for the diagnosis and treatment of SARS-CoV-2 infected pneumonia were first published January 30th, 2020; these guidelines recommended for the first time that cytokine monitoring should be applied in severely ill patients to reduce pneumonia related mortality. The cytokine storm observed in COVID-19 illness is also an important component of mortality in other viral diseases, including SARS, MERS and influenza. In view of the severe morbidity and mortality of COVID-19 pneumonia, we review the current understanding of treatment of human coronavirus infections from the perspective of a dysregulated cytokine and immune response.

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Authors: Sun, X., Wang, T., Cai, D., Hu, Z., Chen, J., Liao, H., Zhi, L., Wei, H., Zhang, Z., Qiu, Y., Wang, J., & Wang, A.
Affiliations: Chinese People's Liberation Army (CN)
Nanjing University of Chinese Medicine (CN)
Jiangsu Province Hospital (CN)
Nanjing Drum Tower Hospital (CN)
Corresponding author: Wang, Jing
Wang, Aiping
ORCID: Wang, Tianyuan
Wei, Hongxia
Zhang, Zhihong
Wang, Jing
Wang, Aiping
Venue: Cytokine & Growth Factor Reviews
Publisher: Elsevier BV
Published: 2020-06
Volume: 53
Pages: 38-42
ISSN: 1359-6101 (ISSN-L)
DOI: 10.1016/j.cytogfr.2020.04.002
PMC: PMC7182527
OpenAlex: W3019663170
Cited by: 513
References: 36
Citations by year: 2026: 9 · 2025: 23 · 2024: 32 · 2023: 77 · 2022: 110 · 2021: 160 · 2020: 102
FWCI: 5.30
Type: journal article
Language: en
Open access: hybrid
doi.org
Licence: cc-by-nc-nd
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
creativecommons.org/licenses/by-nc-nd/4.0/ (vor)
Locations: Cytokine & Growth Factor Reviews (publishedVersion, cc-by-nc-nd)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Infectious Diseases › COVID-19 Clinical Research Studies
Health Sciences › Medicine › Infectious Diseases › SARS-CoV-2 and COVID-19 Research
Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Respiratory Support and Mechanisms
Keywords: cytokine storm, COVID-19 pandemic, SARS-CoV-2, COVID-19 pneumonia, cytokine monitoring, multiple organ failure, immune dysregulation, cytokine production, mortality, SARS, MERS, influenza, antiviral therapy
MeSH terms: Betacoronavirus, Continuous Renal Replacement Therapy, Cytokine Release Syndrome, COVID-19, SARS-CoV-2, Adrenal Cortex Hormones, Antibodies, Monoclonal, Female, Humans, Male, Multiple Organ Failure, Pneumonia, Viral, Polyethylene Glycols, Recombinant Proteins, Retrospective Studies, Cytokines, Interferon-alpha, Coronavirus Infections, Pandemics

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