Cited by 19Sirtuins and Resveratrol in MedicineTea Polyphenols and EffectsSARS-CoV-2 and COVID-19 Research

A comprehensive review on modulation of SIRT1 signaling pathways in the immune system of COVID ‐19 patients by phytotherapeutic melatonin and epigallocatechin‐3‐gallate

Open access
Chattree, Vineeta, Singh, Kamana, Singh, Kanishk, Goel, Aayush, Maity, Amritaparna, Lone, Asif·2022·Journal of Food Biochemistry

Abstract

SARS-CoV-2 infection has now become the world's most significant health hazard, with the World Health Organization declaring a pandemic on March 11, 2020. COVID-19 enters the lungs through angiotensin-converting enzyme 2 (ACE2) receptors, alters various signaling pathways, and causes immune cells to overproduce cytokines, resulting in mucosal inflammation, lung damage, and multiple organ failure in COVID-19 patients. Although several antiviral medications have been effective in managing the virus, they have not been effective in lowering the inflammation and symptoms of the illness. Several studies have found that epigallocatechin-3-gallate and melatonin upregulate sirtuins proteins, which leads to downregulation of pro-inflammatory gene transcription and NF-κB, protecting organisms from oxidative stress in autoimmune, respiratory, and cardiovascular illnesses. As a result, the purpose of this research is to understand more about the molecular pathways through which these phytochemicals affect COVID-19 patients' impaired immune systems, perhaps reducing hyperinflammation and symptom severity. PRACTICAL APPLICATIONS: Polyphenols are natural secondary metabolites that are found to be present in plants. EGCG a polyphenol belonging to the flavonoid family in tea has potent anti-inflammatory and antioxidative properties that helps to counter the inflammation and oxidative stress associated with many neurodegenerative diseases. Melatonin, another strong antioxidant in plants, has been shown to possess antiviral function and alleviate oxidative stress in many inflammatory diseases. In this review, we propose an alternative therapy for COVID-19 patients by supplementing their diet with these nutraceuticals that perhaps by modulating sirtuin signaling pathways counteract cytokine storm and oxidative stress, the root causes of severe inflammation and symptoms in these patients.

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Crossref · 10.1111/jfbc.14259

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  • There are initial indications that the antioxidant and anti-inflammatory actions of melatonin may work together with select polyphenols (e.g., resveratrol, epigallocatechin 3-gallate) for therapeutic indications.

    “There are initial indications that the antioxidant and anti-inflammatory actions of melatonin may work together with select polyphenols (e.g., resveratrol, epigallocatechin 3-gallate) for therapeutic indications [48,49,50,51,52,53,54].”

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Authors
Chattree, V., Singh, K., Singh, K., Goel, A., Maity, A., & Lone, A.
Affiliations
University of Delhi (IN)
Corresponding author
Chattree, Vineeta
Venue
Journal of Food Biochemistry
Publisher
Wiley
Published
2022-06-03
Volume
46
Issue
12
Pages
e14259-e14259
ISSN
  • 0145-8884 (ISSN-L)
  • 1745-4514
OpenAlex
W4281688941
Cited by
19
References
133
Citations by year
2026: 3 · 2025: 2 · 2024: 4 · 2023: 7 · 2022: 3
FWCI
0.57
Type
journal article
Language
en
Open access
Locations
  • Journal of Food Biochemistry (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Geriatrics and Gerontology › Sirtuins and Resveratrol in Medicine
  • Health Sciences › Medicine › Pathology and Forensic Medicine › Tea Polyphenols and Effects
  • Health Sciences › Medicine › Infectious Diseases › SARS-CoV-2 and COVID-19 Research
Keywords
COVID-19 pandemic, SARS-CoV-2, melatonin, epigallocatechin gallate, NF-κB, cytokine storm, hyperinflammation, oxidative stress, polyphenols, nutraceuticals, immunomodulation, flavonoids, anti-inflammatory activity, ACE2 receptor
MeSH terms
COVID-19, SARS-CoV-2, Antioxidants, Antiviral Agents, Catechin, Humans, Immune System, Inflammation, Melatonin, Signal Transduction, Sirtuin 1

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