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Canonical Wnt/β-Catenin Signaling Prevents Osteoblasts from Differentiating into Chondrocytes

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Hill, Theo P., Später, Daniela, Taketo, Makoto M., Birchmeier, Walter, Hartmann, Christine·2005·Developmental Cell

DOI 10.1016/j.devcel.2005.02.013

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Targeted Disruption of Results in a Complete Lack of Bone Formation owing to Maturational Arrest of Osteoblasts
Komori, T., Yagi, H., Nomura, S., Yamaguchi, A., Sasaki, K., Deguchi, K., Shimizu, Y., Bronson, R. T., Gao, Y.-H., Inada, M., et al. (1997) · Cell · doi:10.1016/s0092-8674(00)80258-5 · Cited by 4,244
The Novel Zinc Finger-Containing Transcription Factor Osterix Is Required for Osteoblast Differentiation and Bone Formation
Nakashima, K., Zhou, X., Kunkel, G., Zhang, Z., Deng, J. M., Behringer, R. R., & de Crombrugghe, B. (2002) · Cell · doi:10.1016/s0092-8674(01)00622-5 · Cited by 3,608
Developmental regulation of the growth plate
Kronenberg, H. M. (2003) · Nature · doi:10.1038/nature01657 · Cited by 2,849
Cbfa1, a Candidate Gene for Cleidocranial Dysplasia Syndrome, Is Essential for Osteoblast Differentiation and Bone Development
Otto, F., Thornell, A. P., Crompton, T., Denzel, A., Gilmour, K. C., Rosewell, I. R., Stamp, G. W. H., Beddington, R. S. P., Mundlos, S., Olsen, B. R., et al. (1997) · Cell · doi:10.1016/s0092-8674(00)80259-7 · Cited by 2,814
Sonic hedgehog mediates the polarizing activity of the ZPA
Riddle, R. D., Johnson, R. L., Laufer, E., & Tabin, C. (1993) · Cell · doi:10.1016/0092-8674(93)90626-2 · Cited by 2,307
LDL Receptor-Related Protein 5 (LRP5) Affects Bone Accrual and Eye Development
Gong, Y., Slee, R. B., Fukai, N., Rawadi, G., Roman-Roman, S., Reginato, A. M., Wang, H., Cundy, T., Glorieux, F. H., Lev, D., et al. (2001) · Cell · doi:10.1016/s0092-8674(01)00571-2 · Cited by 2,235
Sox9 is required for cartilage formation
Bi, W., Deng, J. M., Zhang, Z., Behringer, R. R., & de Crombrugghe, B. (1999) · Nature Genetics · doi:10.1038/8792 · Cited by 1,758
Indian hedgehog signaling regulates proliferation and differentiation of chondrocytes and is essential for bone formation
St-Jacques, B., Hammerschmidt, M., & McMahon, A. P. (1999) · Genes & Development · doi:10.1101/gad.13.16.2072 · Cited by 1,735
The transcription factor Sox9 has essential roles in successive steps of the chondrocyte differentiation pathway and is required for expression of Sox5 and Sox6
Akiyama, H., Chaboissier, M.-C., Martin, J. F., Schedl, A., & de Crombrugghe, B. (2002) · Genes & Development · doi:10.1101/gad.1017802 · Cited by 1,721
Reaching a Genetic and Molecular Understanding of Skeletal Development
Karsenty, G., & Wagner, E. F. (2002) · Developmental Cell · doi:10.1016/s1534-5807(02)00157-0 · Cited by 1,601
Canonical wnt signaling in differentiated osteoblasts controls osteoclast differentiation.
Glass, D. A., Bialek, P., Ahn, J. D., Starbuck, M., Patel, M. S., Clevers, H., Taketo, M. M., Long, F., McMahon, A. P., Lang, R. A., et al. (2005) · Developmental Cell · doi:10.1016/j.devcel.2005.02.017 · Cited by 1,558
Self-citation
β-Catenin Controls Hair Follicle Morphogenesis and Stem Cell Differentiation in the Skin
Huelsken, J., Vogel, R., Erdmann, B., Cotsarelis, G., & Birchmeier, W. (2001) · Cell · doi:10.1016/s0092-8674(01)00336-1 · Cited by 1,353
Self-citation
Intestinal polyposis in mice with a dominant stable mutation of the beta -catenin gene
Harada, N. (1999) · The EMBO Journal · doi:10.1093/emboj/18.21.5931 · Cited by 1,212
The biology of fracture healing in long bones
McKibbin, B. (1978) · The Journal of Bone and Joint Surgery. British volume · doi:10.1302/0301-620x.60b2.350882 · Cited by 1,180
Cbfa1-independent decrease in osteoblast proliferation, osteopenia, and persistent embryonic eye vascularization in mice deficient in Lrp5, a Wnt coreceptor
Kato, M., Patel, M. S., Levasseur, R., Lobov, I., Chang, B. H.-J., Glass, D. A., Hartmann, C., Li, L., Hwang, T.-H., Brayton, C. F., et al. (2002) · The Journal of Cell Biology · doi:10.1083/jcb.200201089 · Cited by 1,086
Self-citation
Expression of Cre recombinase in the developing mouse limb bud driven by a Prxl enhancer
Logan, M., Martin, J. F., Nagy, A., Lobe, C., Olson, E. N., & Tabin, C. J. (2002) · genesis · doi:10.1002/gene.10092 · Cited by 1,005
Low-Density Lipoprotein Receptor-Related Protein-5 Binds to Axin and Regulates the Canonical Wnt Signaling Pathway
Mao, J., Wang, J., Liu, B., Pan, W., Farr, G. H., Flynn, C., Yuan, H., Takada, S., Kimelman, D., Li, L., et al. (2001) · Molecular Cell · doi:10.1016/s1097-2765(01)00224-6 · Cited by 839 · cited 2×
“…osteoblasto- l sgenesis came from the finding that loss-of-function mutations in the Lrp5 gene, encoding a coreceptor of d ocanonical Wnt signaling (Mao et al., 2001), result in a decrease in bone density associated with defects in os- n wteoblast differentiation and proliferation (Gong et al.,…”
Background
BMP-2 Controls Alkaline Phosphatase Expression and Osteoblast Mineralization by a Wnt Autocrine Loop
Rawadi, G., Vayssière, B., Dunn, F., Baron, R., & Roman-Roman, S. (2003) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.2003.18.10.1842 · Cited by 764
Interactions between Sox9 and β-catenin control chondrocyte differentiation
Akiyama, H., Lyons, J. P., Mori-Akiyama, Y., Yang, X., Zhang, R., Zhang, Z., Deng, J. M., Taketo, M. M., Nakamura, T., Behringer, R. R., et al. (2004) · Genes & Development · doi:10.1101/gad.1171104 · Cited by 754
Self-citation
Sequential roles of Hedgehog and Wnt signaling in osteoblast development
Hu, H., Hilton, M. J., Tu, X., Yu, K., Ornitz, D. M., & Long, F. (2005) · Development · doi:10.1242/dev.01564 · Cited by 682
A Twist Code Determines the Onset of Osteoblast Differentiation
Bialek, P., Kern, B., Yang, X., Schrock, M., Sosic, D., Hong, N., Wu, H., Yu, K., Ornitz, D. M., Olson, E. N., et al. (2004) · Developmental Cell · doi:10.1016/s1534-5807(04)00058-9 · Cited by 674
Requirement for β-Catenin in Anterior-Posterior Axis Formation in Mice
Huelsken, J., Vogel, R., Brinkmann, V., Erdmann, B., Birchmeier, C., & Birchmeier, W. (2000) · The Journal of Cell Biology · doi:10.1083/jcb.148.3.567 · Cited by 660
Self-citation
Differential staining of cartilage and bone in whole mouse fetuses by alcian blue and alizarin red S
McLeod, M. J. (1980) · Teratology · doi:10.1002/tera.1420220306 · Cited by 613
Runx2 and Runx3 are essential for chondrocyte maturation, and Runx2 regulates limb growth through induction of Indian hedgehog
Yoshida, C. A., Yamamoto, H., Fujita, T., Furuichi, T., Ito, K., Inoue, K.-I., Yamana, K., Zanma, A., Takada, K., Ito, Y., et al. (2004) · Genes & Development · doi:10.1101/gad.1174704 · Cited by 587
Maturational disturbance of chondrocytes inCbfa1-deficient mice
Inada, M., Yasui, T., Nomura, S., Miyake, S., Deguchi, K., Himeno, M., Sato, M., Yamagiwa, H., Kimura, T., Yasui, N., et al. (1999) · Developmental Dynamics · doi:10.1002/(sici)1097-0177(199904)214:4<279::aid-aja1>3.0.co;2-w · Cited by 570
SOX9 is an intestine crypt transcription factor, is regulated by the Wnt pathway, and represses the CDX2 and MUC2 genes
Blache, P., van de Wetering, M., Duluc, I., Domon, C., Berta, P., Freund, J.-N., Clevers, H., & Jay, P. (2004) · The Journal of Cell Biology · doi:10.1083/jcb.200311021 · Cited by 506
Wnt-14 Plays a Pivotal Role in Inducing Synovial Joint Formation in the Developing Appendicular Skeleton
Hartmann, C., & Tabin, C. J. (2001) · Cell · doi:10.1016/s0092-8674(01)00222-7 · Cited by 490
Self-citation
Dual roles of Wnt signaling during chondrogenesis in the chicken limb
Hartmann, C., & Tabin, C. J. (2000) · Development · doi:10.1242/dev.127.14.3141 · Cited by 472
Self-citation
β-catenin–sensitive isoforms of lymphoid enhancer factor-1 are selectively expressed in colon cancer
Hovanes, K., Li, T. W. H., Munguia, J. E., Truong, T., Milovanovic, T., Lawrence Marsh, J., Holcombe, R. F., & Waterman, M. L. (2001) · Nature Genetics · doi:10.1038/ng0501-53 · Cited by 458
Regulation of chondrocyte differentiation by Cbfa1
Kim, I. S., Otto, F., Zabel, B., & Mundlos, S. (1999) · Mechanisms of Development · doi:10.1016/s0925-4773(98)00210-x · Cited by 452
The Wnt Antagonist Secreted Frizzled-Related Protein-1 Is a Negative Regulator of Trabecular Bone Formation in Adult Mice
Bodine, P. V. N., Zhao, W., Kharode, Y. P., Bex, F. J., Lambert, A.-J., Goad, M. B., Gaur, T., Stein, G. S., Lian, J. B., & Komm, B. S. (2004) · Molecular Endocrinology · doi:10.1210/me.2003-0498 · Cited by 449
Transcriptional mechanisms in osteoblast differentiation and bone formation
Nakashima, K., & de Crombrugghe, B. (2003) · Trends in Genetics · doi:10.1016/s0168-9525(03)00176-8 · Cited by 432
Sox9 is required for determination of the chondrogenic cell lineage in the cranial neural crest
Mori-Akiyama, Y., Akiyama, H., Rowitch, D. H., & de Crombrugghe, B. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1631288100 · Cited by 429
FGF-, BMP- and Shh-mediated signalling pathways in the regulation of cranial suture morphogenesis and calvarial bone development
Kim, H.-J., Rice, D. P. C., Kettunen, P. J., & Thesleff, I. (1998) · Development · doi:10.1242/dev.125.7.1241 · Cited by 412
Distinct WNT Pathways Regulating AER Formation and Dorsoventral Polarity in the Chick Limb Bud
Kengaku, M., Capdevila, J., Rodriguez-Esteban, C., De La Peña, J., Johnson, R. L., Belmonte, J. C. I., & Tabin, C. J. (1998) · Science · doi:10.1126/science.280.5367.1274 · Cited by 411
Integration of FGF and TWIST in calvarial bone and suture development
Rice, D. P. C., Åberg, T., Chan, Y.-S., Tang, Z., J. Kettunen, P., Pakarinen, L., Maxson, R. E., & Thesleff, I. (2000) · Development · doi:10.1242/dev.127.9.1845 · Cited by 407
A transcriptional response to Wnt protein in human embryonic carcinoma cells
Willert, J., Epping, M., Pollack, J. R., Brown, P. O., & Nusse, R. (2002) · BMC Developmental Biology · doi:10.1186/1471-213x-2-8 · Cited by 401
Wnt/β-catenin signaling is sufficient and necessary for synovial joint formation
Guo, X., Day, T. F., Jiang, X., Garrett-Beal, L., Topol, L., & Yang, Y. (2004) · Genes & Development · doi:10.1101/gad.1230704 · Cited by 391
L-Sox5, Sox6 and Sox9 control essential steps of the chondrocyte differentiation pathway
Lefebvre, V., Behringer, R. R., & de Crombrugghe, B. (2001) · Osteoarthritis and Cartilage · doi:10.1053/joca.2001.0447 · Cited by 365
Tissue specific regulation of VEGF expression during bone development requires Cbfa1/Runx2
Zelzer, E., Glotzer, D. J., Hartmann, C., Thomas, D., Fukai, N., Soker, S., & Olsen, B. R. (2001) · Mechanisms of Development · doi:10.1016/s0925-4773(01)00428-2 · Cited by 339
Self-citation
Hepatocyte growth factor induces Wnt-independent nuclear translocation of beta-catenin after Met-beta-catenin dissociation in hepatocytes.
Monga, S. P., Mars, W. M., Pediaditakis, P., Bell, A. W., Mulé, K., Bowen, W. C., Wang, X., Zarnegar, R., & Michalopoulos, G. K. (2002) · PubMed · Cited by 304
Sonic hedgehog promotes somitic chondrogenesis by altering the cellular response to BMP signaling
Murtaugh, L. C., Chyung, J. H., & Lassar, A. B. (1999) · Genes & Development · doi:10.1101/gad.13.2.225 · Cited by 290
TCF transcription factors: molecular switches in carcinogenesis
Roose, J., & Clevers, H. (1999) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/s0304-419x(99)00026-8 · Cited by 281
Fibroblast growth factor signaling controlling osteoblast differentiation
Marie, P. J. (2003) · Gene · doi:10.1016/s0378-1119(03)00748-0 · Cited by 274
Activated β-catenin induces osteoblast differentiation of C3H10T1/2 cells and participates in BMP2 mediated signal transduction
Bain, G., Müller, T., Wang, X., & Papkoff, J. (2003) · Biochemical and Biophysical Research Communications · doi:10.1016/s0006-291x(02)02951-0 · Cited by 262
Wnt regulation of chondrocyte differentiation
Church, V., Nohno, T., Linker, C., Marcelle, C., & Francis-West, P. (2002) · Journal of Cell Science · doi:10.1242/jcs.00152 · Cited by 254
Twist is up-regulated in response to Wnt1 and inhibits mouse mammary cell differentiation.
Howe, L. R., Watanabe, O., Leonard, J. N., & Brown, A. M. C. (2003) · PubMed · Cited by 245
Stabilization of β-catenin by a Wnt-independent mechanism regulates cardiomyocyte growth
Haq, S., Michael, A., Andreucci, M., Bhattacharya, K., Dotto, P., Walters, B., Woodgett, J., Kilter, H., & Force, T. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0835895100 · Cited by 227
?-Catenin and BMP-2 synergize to promote osteoblast differentiation and new bone formation
Mbalaviele, G., Sheikh, S., Stains, J. P., Salazar, V. S., Cheng, S.-L., Chen, D., & Civitelli, R. (2005) · Journal of Cellular Biochemistry · doi:10.1002/jcb.20253 · Cited by 220
WNT targets: repression and activation
Nusse, R. (1999) · Trends in Genetics · doi:10.1016/s0168-9525(98)01634-5 · Cited by 216
LRP5 and Wnt Signaling: A Union Made for Bone
Johnson, M. L., Harnish, K., Nusse, R., & Hul, W. V. (2004) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.040816 · Cited by 211
Inhibition of Chondrogenesis byWntGene Expressionin Vivoandin Vitro
Rudnicki, J. A., & Brown, A. M. C. (1997) · Developmental Biology · doi:10.1006/dbio.1997.8536 · Cited by 184
Wnt-3A Enhances Bone Morphogenetic Protein-2-mediated Chondrogenesis of Murine C3H10T1/2 Mesenchymal Cells
Fischer, L. M., Boland, G. M., & Tuan, R. S. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m109330200 · Cited by 154
Regulation of the chondrocyte phenotype by beta-catenin
Ryu, J., Kim, S. J., Kim, S., Oh, C., Hwang, S., Chun, C. H., Oh, S.-H., Seong, J. K., Huh, T., & Chun, J. (2002) · Development · doi:10.1242/dev.129.23.5541 · Cited by 152
Activation of β-catenin signaling in differentiated mammary secretory cells induces transdifferentiation into epidermis and squamous metaplasias
Miyoshi, K., Shillingford, J. M., Provost, F. L., Gounari, F., Bronson, R. T., von Boehmer, H., Taketo, M. M., Cardiff, R. D., Hennighausen, L. G., & Khazaie, K. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.012414099 · Cited by 132
Self-citation
Activation of β-catenin in prostate epithelium induces hyperplasias and squamous transdifferentiation
Bierie, B., Nozawa, M., Renou, J., Shillingford, J. M., Morgan, F., Oka, T., Taketo, M. M., Cardiff, R. D., Miyoshi, K., Wagner, K., et al. (2003) · Oncogene · doi:10.1038/sj.onc.1206426 · Cited by 132
Self-citation
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Ryu, J. (2002) · Development · doi:10.1242/dev.00110 · Cited by 99
Chondrogenic cell differentiation from membrane bone periostea
Fang, J., & Hall, B. K. (1997) · Anatomy and Embryology · doi:10.1007/s004290050104 · Cited by 93
Successive formative stages of precartilaginous mesenchymal condensations in vitro: Modulation of cell adhesion by Wnt-7A and BMP-2
Stott, N. S., Jiang, T. X., & Chuong, C. (1999) · Journal of Cellular Physiology · Cited by 88
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Glass, D. A., & Karsenty, G. (2006) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1346.015 · Cited by 75
Secondary chondrocyte-derived Ihh stimulates proliferation of periosteal cells during chick development
Buxton, P., Hall, B. K., Archer, C. W., & Francis‐West, P. H. (2003) · Development · doi:10.1242/dev.00610 · Cited by 41

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Glass, D. A., Bialek, P., Ahn, J. D., Starbuck, M., Patel, M. S., Clevers, H., Taketo, M. M., Long, F., McMahon, A. P., Lang, R. A., et al. (2005) · Developmental Cell · doi:10.1016/j.devcel.2005.02.017 · Cited by 1,558
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Authors: Hill, T. P., Später, D., Taketo, M. M., Birchmeier, W., & Hartmann, C.
Venue: Developmental Cell
Publisher: Elsevier BV
Published: 2005-05
Volume: 8
Issue: 5
Pages: 727-738
ISSN: 1534-5807 (ISSN-L)
DOI: 10.1016/j.devcel.2005.02.013
OpenAlex: W2014362480
Cited by: 1,084
References: 61
FWCI: 22.01
Type: journal article
Language: en
Open access: bronze

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Canonical Wnt/β-Catenin Signaling Prevents Osteoblasts from Differentiating into Chondrocytes

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