The DOI matches its Crossref record; 7 of the 7 references it cites were found in a registry or an index.
Drosophila rasiRNA Pathway Mutations Disrupt Embryonic Axis Specification through Activation of an ATR/Chk2 DNA Damage Response
Open accessAbstract
Small repeat-associated siRNAs (rasiRNAs) mediate silencing of retrotransposons and the Stellate locus. Mutations in the Drosophila rasiRNA pathway genes armitage and aubergine disrupt embryonic axis specification, triggering defects in microtubule polarization as well as asymmetric localization of mRNA and protein determinants in the developing oocyte. Mutations in the ATR/Chk2 DNA damage signal transduction pathway dramatically suppress these axis specification defects, but do not restore retrotransposon or Stellate silencing. Furthermore, rasiRNA pathway mutations lead to germline-specific accumulation of gamma-H2Av foci characteristic of DNA damage. We conclude that rasiRNA-based gene silencing is not required for axis specification, and that the critical developmental function for this pathway is to suppress DNA damage signaling in the germline.
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Cites
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A novel class of small RNAs bind to MILI protein in mouse testes
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MicroRNAs Regulate Brain Morphogenesis in Zebrafish
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The Human LINE-1 Retrotransposon Creates DNA Double-strand Breaks
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Cited by
Transposable elements and the epigenetic regulation of the genome
Slotkin, R. K., & Martienssen, R. (2007) · Nature Reviews Genetics · doi:10.1038/nrg2072 · Cited by 2,044
PIWI-interacting small RNAs: the vanguard of genome defence
Siomi, M. C., Sato, K., Pezic, D., & Aravin, A. A. (2011) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm3089 · Cited by 1,319
The Piwi-piRNA Pathway Provides an Adaptive Defense in the Transposon Arms Race
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Small RNAs as Guardians of the Genome
Malone, C. D., & Hannon, G. J. (2009) · Cell · doi:10.1016/j.cell.2009.01.045 · Cited by 836
Maternal mRNA deadenylation and decay by the piRNA pathway in the early Drosophila embryo
Rouget, C., Papin, C., Boureux, A., Meunier, A.-C., Franco, B., Robine, N., Lai, E. C., Pelisson, A., & Simonelig, M. (2010) · Nature · doi:10.1038/nature09465 · Cited by 438
Metadata
- Authors
- Klattenhoff, C., Bratu, D. P., McGinnis-Schultz, N., Koppetsch, B. S., Cook, H. A., & Theurkauf, W. E.
- Venue
- Developmental Cell
- Publisher
- Elsevier BV
- Published
- 2007-01
- Volume
- 12
- Issue
- 1
- Pages
- 45-55
- ISSN
- 1534-5807 (ISSN-L)
- OpenAlex
- W2037570580
- Cited by
- 287
- References
- 7
- FWCI
- 8.14
- Type
- journal article
- Language
- en
- Open access
- bronze
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