Glypican-3 Inhibits Hedgehog Signaling during Development by Competing with Patched for Hedgehog Binding

Cyclopia and defective axial patterning in mice lacking Sonic hedgehog gene function

Chiang, C., Litingtung, Y., Lee, E., Young, K. E., Corden, J. L., Westphal, H., & Beachy, P. A. (1996) · Nature · doi:10.1038/383407a0 · Cited by 3,062

Mutations of the Human Homolog of Drosophila patched in the Nevoid Basal Cell Carcinoma Syndrome

Hahn, H., Wicking, C., Zaphiropoulos, P. G., Gailani, M. R., Shanley, S., Chidambaram, A., Vorechovsky, I., Holmberg, E., Unden, A. B., Gillies, S., et al. (1996) · Cell · doi:10.1016/s0092-8674(00)81268-4 · Cited by 2,022

Indian hedgehog signaling regulates proliferation and differentiation of chondrocytes and is essential for bone formation

St-Jacques, B., Hammerschmidt, M., & McMahon, A. P. (1999) · Genes & Development · doi:10.1101/gad.13.16.2072 · Cited by 1,735

Dual Roles for Patched in Sequestering and Transducing Hedgehog

Chen, Y., & Struhl, G. (1996) · Cell · doi:10.1016/s0092-8674(00)81374-4 · Cited by 900

Communicating with Hedgehogs

Hooper, J. E., & Scott, M. P. (2005) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm1622 · Cited by 804

Vertebrate Hedgehog signalling modulated by induction of a Hedgehog-binding protein

Chuang, P.-T., & McMahon, A. P. (1999) · Nature · doi:10.1038/17611 · Cited by 795

Mutations in GPC3, a glypican gene, cause the Simpson-Golabi-Behmel overgrowth syndrome

Pilia, G., Hughes-Benzie, R. M., MacKenzie, A., Baybayan, P., Chen, E. Y., Huber, R., Neri, G., Cao, A., Forabosco, A., & Schlessinger, D. (1996) · Nature Genetics · doi:10.1038/ng0396-241 · Cited by 761

Functions of heparan sulfate proteoglycans in cell signaling during development

Lin, X. (2004) · Development · doi:10.1242/dev.01522 · Cited by 678

Smoothened Mutants Reveal Redundant Roles for Shh and Ihh Signaling Including Regulation of L/R Asymmetry by the Mouse Node

Zhang, X. M., Ramalho-Santos, M., & McMahon, A. P. (2001) · Cell · doi:10.1016/s0092-8674(01)00385-3 · Cited by 606

Identification of Hedgehog Pathway Components by RNAi in Drosophila Cultured Cells

Lum, L., Yao, S., Mozer, B., Rovescalli, A., Von Kessler, D., Nirenberg, M., & Beachy, P. A. (2003) · Science · doi:10.1126/science.1081403 · Cited by 532

Genome-wide Prediction of Mammalian Enhancers Based on Analysis of Transcription-Factor Binding Affinity

Hallikas, O., Palin, K., Sinjushina, N., Rautiainen, R., Partanen, J., Ukkonen, E., & Taipale, J. (2006) · Cell · doi:10.1016/j.cell.2005.10.042 · Cited by 472

Glypican-3 Promotes the Growth of Hepatocellular Carcinoma by Stimulating Canonical Wnt Signaling

Capurro, M. I., Xiang, Y.-Y., Lobe, C., & Filmus, J. (2005) · Cancer Research · doi:10.1158/0008-5472.can-04-4244 · Cited by 469

The Zebrafish Glypican Knypek Controls Cell Polarity during Gastrulation Movements of Convergent Extension

Topczewski, J., Sepich, D. S., Myers, D. C., Walker, C., Amores, A., Lele, Z., Hammerschmidt, M., Postlethwait, J., & Solnica-Krezel, L. (2001) · Developmental Cell · doi:10.1016/s1534-5807(01)00005-3 · Cited by 455

QSulf1 remodels the 6-O sulfation states of cell surface heparan sulfate proteoglycans to promote Wnt signaling

Ai, X., Do, A.-T., Lozynska, O., Kusche-Gullberg, M., Lindahl, U., & Emerson, C. P. (2003) · The Journal of Cell Biology · doi:10.1083/jcb.200212083 · Cited by 444

Glypicans: proteoglycans with a surprise

Filmus, J., & Selleck, S. B. (2001) · Journal of Clinical Investigation · doi:10.1172/jci13712 · Cited by 441

Glypican-3 as a Serum Marker for Hepatocellular Carcinoma

Capurro, M., & Filmus, J. (2005) · Cancer Research · doi:10.1158/0008-5472.372.65.1 · Cited by 432

Nevoid Basal Cell Carcinoma Syndrome

Gorlin, R. J. (1995) · Dermatologic Clinics · doi:10.1016/s0733-8635(18)30114-1 · Cited by 419

The cell-surface proteoglycan Dally regulates Wingless signalling in Drosophila

Tsuda, M., Kamimura, K., Nakato, H., Archer, M., Staatz, W., Fox, B., Humphrey, M., Olson, S., Futch, T., Kaluza, V., et al. (1999) · Nature · doi:10.1038/22336 · Cited by 387

Heparan sulfate proteoglycans are critical for the organization of the extracellular distribution of Wingless

Baeg, G.-H., Lin, X., Khare, N., Baumgartner, S., & Perrimon, N. (2001) · Development · doi:10.1242/dev.128.1.87 · Cited by 371

Wnts and Hedgehogs: lipid-modified proteins and similarities in signaling mechanisms at the cell surface

Nusse, R. (2003) · Development · doi:10.1242/dev.00821 · Cited by 336

Glypican-3–Deficient Mice Exhibit Developmental Overgrowth and Some of the Abnormalities Typical of Simpson-Golabi-Behmel Syndrome

Cano-Gauci, D. F., Song, H. H., Yang, H., McKerlie, C., Choo, B., Shi, W., Pullano, R., Piscione, T. D., Grisaru, S., Soon, S., et al. (1999) · The Journal of Cell Biology · doi:10.1083/jcb.146.1.255 · Cited by 331

Feedback control of mammalian Hedgehog signaling by the Hedgehog-binding protein, Hip1, modulates Fgf signaling during branching morphogenesis of the lung

Chuang, P.-T., Kawcak, T., & McMahon, A. P. (2003) · Genes & Development · doi:10.1101/gad.1026303 · Cited by 315

The Hedgehog-binding proteins Gas1 and Cdo cooperate to positively regulate Shh signaling during mouse development

Allen, B. L., Tenzen, T., & McMahon, A. P. (2007) · Genes & Development · doi:10.1101/gad.1543607 · Cited by 284

Stimulation of fibroblast growth factor receptor-1 occupancy and signaling by cell surface-associated syndecans and glypican.

Steinfeld, R., Van Den Berghe, H., & David, G. (1996) · The Journal of cell biology · doi:10.1083/jcb.133.2.405 · Cited by 267

Cdo Functions at Multiple Points in the Sonic Hedgehog Pathway, and Cdo-Deficient Mice Accurately Model Human Holoprosencephaly

Zhang, W., Kang, J.-S., Cole, F., Yi, M.-J., & Krauss, R. S. (2006) · Developmental Cell · doi:10.1016/j.devcel.2006.04.005 · Cited by 260

The division abnormally delayed (dally) gene: a putative integral membrane proteoglycan required for cell division patterning during postembryonic development of the nervous system in Drosophila

Nakato, H., Futch, T. A., & Selleck, S. B. (1995) · Development · doi:10.1242/dev.121.11.3687 · Cited by 259

Drosophila glypicans control the cell-to-cell movement of Hedgehog by a dynamin-independent process

Han, C., Belenkaya, T. Y., Wang, B., & Lin, X. (2004) · Development · doi:10.1242/dev.00958 · Cited by 238

The Ihog Cell-Surface Proteins Bind Hedgehog and Mediate Pathway Activation

Yao, S., Lum, L., & Beachy, P. (2006) · Cell · doi:10.1016/j.cell.2006.02.040 · Cited by 235

Growth and pattern of the mammalian neural tube are governed by partially overlapping feedback activities of the hedgehog antagonists patched 1 and Hhip1

Jeong, J., & McMahon, A. P. (2005) · Development · doi:10.1242/dev.01566 · Cited by 223

Dally regulates Dpp morphogen gradient formation in the Drosophila wing

Fujise, M., Takeo, S., Kamimura, K., Matsuo, T., Aigaki, T., Izumi, S., & Nakato, H. (2003) · Development · doi:10.1242/dev.00379 · Cited by 223

The Loss of Glypican-3 Induces Alterations in Wnt Signaling

Song, H. H., Shi, W., Xiang, Y.-Y., & Filmus, J. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m410090200 · Cited by 215

Opposing Activities of Dally-like Glypican at High and Low Levels of Wingless Morphogen Activity

Kreuger, J., Perez, L., Giraldez, A. J., & Cohen, S. M. (2004) · Developmental Cell · doi:10.1016/j.devcel.2004.08.005 · Cited by 211

Megalin Functions as an Endocytic Sonic Hedgehog Receptor

McCarthy, R. A., Barth, J. L., Chintalapudi, M. R., Knaak, C., & Argraves, W. S. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m201933200 · Cited by 209

Receptor-mediated endocytosis of soluble and membrane-tethered Sonic hedgehog by Patched-1

Incardona, J. P., Lee, J. H., Robertson, C. P., Enga, K., Kapur, R. P., & Roelink, H. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.220251997 · Cited by 199

Role of glypican 4 in the regulation of convergent extension movements during gastrulation in Xenopus laevis

Ohkawara, B., Yamamoto, T. S., Tada, M., & Ueno, N. (2003) · Development · doi:10.1242/dev.00435 · Cited by 184

Clinical and molecular aspects of the Simpson-Golabi-Behmel syndrome

Neri, G., Gurrieri, F., Zanni, G., & Lin, A. (1998) · American Journal of Medical Genetics · doi:10.1002/(sici)1096-8628(19981002)79:4<279::aid-ajmg9>3.0.co;2-h · Cited by 182

OCI-5/GPC3, a Glypican Encoded by a Gene That Is Mutated in the Simpson-Golabi-Behmel Overgrowth Syndrome, Induces Apoptosis in a Cell Line–specific Manner

Gonzalez, A. D., Kaya, M., Shi, W., Song, H., Testa, J. R., Penn, L. Z., & Filmus, J. (1998) · The Journal of Cell Biology · doi:10.1083/jcb.141.6.1407 · Cited by 181

Hedgehog signaling and congenital malformations

Nieuwenhuis, E., & Hui, C. (2004) · Clinical Genetics · doi:10.1111/j.1399-0004.2004.00360.x · Cited by 154

The glypican Dally-like is required for Hedgehog signalling in the embryonic epidermis ofDrosophila

Desbordes, S. C., & Sanson, B. (2003) · Development · doi:10.1242/dev.00874 · Cited by 146

The role of glypicans in mammalian development

Song, H. H., & Filmus, J. (2002) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/s0304-4165(02)00390-2 · Cited by 145

OCI-5/Rat Glypican-3 Binds to Fibroblast Growth Factor-2 but Not to Insulin-like Growth Factor-2

Song, H. H., Shi, W., & Filmus, J. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.12.7574 · Cited by 133

Shifting paradigms in Hedgehog signaling

Wang, Y., McMahon, A. P., & Allen, B. L. (2007) · Current Opinion in Cell Biology · doi:10.1016/j.ceb.2007.02.005 · Cited by 124

Mouse patched1 controls body size determination and limb patterning

Milenković, L., Goodrich, L. V., Higgins, K. M., & Scott, M. P. (1999) · Development · doi:10.1242/dev.126.20.4431 · Cited by 123

Regulation of Hedgehog signaling: a complex story

Ogden, S. K., Ascano, M., Stegman, M. A., & Robbins, D. J. (2004) · Biochemical Pharmacology · doi:10.1016/j.bcp.2004.01.002 · Cited by 116

Gpc3 expression correlates with the phenotype of the Simpson-Golabi-Behmel syndrome

Pellegrini, M., Pilia, G., Pantano, S., Lucchini, F., Uda, M., Fumi, M., Cao, A., Schlessinger, D., & Forabosco, A. (1998) · Developmental Dynamics · doi:10.1002/(sici)1097-0177(199812)213:4<431::aid-aja8>3.0.co;2-7 · Cited by 110

Functional binding of secreted molecules to heparan sulfate proteoglycans in Drosophila

Baeg, G., & Perrimon, N. (2000) · Current Opinion in Cell Biology · doi:10.1016/s0955-0674(00)00134-4 · Cited by 104

Identification of Glypican as a Dual Modulator of the Biological Activity of Fibroblast Growth Factors

Bonneh‐Barkay, D., Shlissel, M., Berman, B., Shaoul, E., Admon, A., Vlodavsky, I., Carey, D. J., Asundi, V. K., Reich‐Slotky, R., & Ron, D. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.19.12415 · Cited by 103

Overgrowth of a Mouse Model of the Simpson–Golabi–Behmel Syndrome Is Independent of IGF Signaling

Chiao, E. T., Fisher, P. E., Crisponi, L., Deiana, M., Dragatsis, I., Schlessinger, D., Pilia, G., & Efstratiadis, A. (2002) · Developmental Biology · doi:10.1006/dbio.2001.0554 · Cited by 93

Hex expression suggests a role in the development and function of organs derived from foregut endoderm

Bogue, C. W., Ganea, G. R., Sturm, E., Iannucci, R., & Jacobs, H. C. (2000) · Developmental Dynamics · doi:10.1002/1097-0177(2000)9999:9999<::aid-dvdy1059>3.0.co;2-# · Cited by 93

Kinetic and Structural Studies on Interactions between Heparin or Heparan Sulfate and Proteins of the Hedgehog Signaling Pathway

Zhang, F., McLellan, J. S., Ayala, A. M., Leahy, D. J., & Linhardt, R. J. (2007) · Biochemistry · doi:10.1021/bi6025424 · Cited by 73

GPC6, a Novel Member of the Glypican Gene Family, Encodes a Product Structurally Related to GPC4 and Is Colocalized withGPC5on Human Chromosome 13

Paine‐Saunders, S., Viviano, B. L., & Saunders, S. (1999) · Genomics · doi:10.1006/geno.1999.5793 · Cited by 67

Regulatory Variation at Glypican-3 Underlies a Major Growth QTL in Mice

Oliver, F., Christians, J. K., Liu, X., Rhind, S. M., Verma, V., Davison, C., Brown, S. D. M., Denny, P., & Keightley, P. D. (2005) · PLoS Biology · doi:10.1371/journal.pbio.0030135 · Cited by 52

A Spontaneous Mouse Mutation, mesenchymal dysplasia (mes), Is Caused by a Deletion of the Most C-Terminal Cytoplasmic Domain of patched (ptc)

Makino, S., Masuya, H., Ishijima, J., Yada, Y., & Shiroishi, T. (2001) · Developmental Biology · doi:10.1006/dbio.2001.0419 · Cited by 52

Extracellular matrix structure

Theocharis, A. D., Skandalis, S. S., Gialeli, C., & Karamanos, N. K. (2016) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2015.11.001 · Cited by 2,598

Heparan Sulfate Proteoglycans

Sarrazin, S., Lamanna, W. C., & Esko, J. D. (2011) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a004952 · Cited by 1,516

Heparan sulfate proteoglycan as a cell-surface endocytosis receptor

Christianson, H. C., & Belting, M. (2014) · Matrix Biology · doi:10.1016/j.matbio.2013.10.004 · Cited by 429

Proteoglycans in health and disease: novel roles for proteoglycans in malignancy and their pharmacological targeting

Theocharis, A. D., Skandalis, S. S., Tzanakakis, G. N., & Karamanos, N. K. (2010) · The FEBS Journal · doi:10.1111/j.1742-4658.2010.07800.x · Cited by 403

Proteoglycan Chemical Diversity Drives Multifunctional Cell Regulation and Therapeutics

Karamanos, N. K., Piperigkou, Z., Theocharis, A. D., Watanabe, H., Franchi, M., Baud, S., Brézillon, S., Götte, M., Passi, A., Vigetti, D., et al. (2018) · Chemical Reviews · doi:10.1021/acs.chemrev.8b00354 · Cited by 367