The DOI matches its Crossref record; 9 of the 9 references it cites were found in a registry or an index.
Mouse Maelstrom, a Component of Nuage, Is Essential for Spermatogenesis and Transposon Repression in Meiosis
Open accessAbstract
Summary Tight control of transposon activity is essential for the integrity of the germline. Recently, a germ cell-specific organelle, nuage, was proposed to play a role in transposon repression. To test this hypothesis, we disrupted a murine homolog of a Drosophila nuage protein Maelstrom. Effects on male meiotic chromosome synapsis and derepression of transposable elements (TEs) were observed. In the adult Mael−/− testes, LINE-1 (L1) derepression occurred at the onset of meiosis. As a result, Mael−/− spermatocytes were flooded with L1 ribonucleoproteins (RNPs) that accumulated in large cytoplasmic enclaves and nuclei. Mael−/− spermatocytes with nuclear L1 RNPs exhibited massive DNA damage and severe chromosome asynapsis even in the absence of SPO11-generated meiotic double strand breaks. This study demonstrates that MAEL, a nuage component, is indispensable for the silencing of TEs and identifies the initiation of meiosis as an important step in TE control in the male germline.
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Initial sequencing and comparative analysis of the mouse genome
Mouse Genome Sequencing Consortium (2002) · Nature · doi:10.1038/nature01262 · Cited by 7,187
Transposable elements and the epigenetic regulation of the genome
Slotkin, R. K., & Martienssen, R. (2007) · Nature Reviews Genetics · doi:10.1038/nrg2072 · Cited by 2,044
Mobile Elements: Drivers of Genome Evolution
Kazazian, H. H. (2004) · Science · doi:10.1126/science.1089670 · Cited by 1,922
A novel class of small RNAs bind to MILI protein in mouse testes
Aravin, A., Gaidatzis, D., Pfeffer, S., Lagos-Quintana, M., Landgraf, P., Iovino, N., Morris, P., Brownstein, M. J., Kuramochi-Miyagawa, S., Nakano, T., et al. (2006) · Nature · doi:10.1038/nature04916 · Cited by 1,516
Genomic Instability in Mice Lacking Histone H2AX
Celeste, A., Petersen, S., Romanienko, P. J., Fernandez-Capetillo, O., Chen, H. T., Sedelnikova, O. A., Reina-San-Martin, B., Coppola, V., Meffre, E., Difilippantonio, M. J., et al. (2002) · Science · doi:10.1126/science.1069398 · Cited by 1,385
Human L1 retrotransposon encodes a conserved endonuclease required for retrotransposition
Feng, Q., Moran, J. V., Kazazian, H. H., & Boeke, J. D. (1996) · Cell · doi:10.1016/s0092-8674(00)81997-2 · Cited by 1,139
The Piwi-piRNA Pathway Provides an Adaptive Defense in the Transposon Arms Race
Aravin, A. A., Hannon, G. J., & Brennecke, J. (2007) · Science · doi:10.1126/science.1146484 · Cited by 1,096
The Human LINE-1 Retrotransposon Creates DNA Double-strand Breaks
Gasior, S. L., Wakeman, T. P., Xu, B., & Deininger, P. L. (2006) · Journal of Molecular Biology · doi:10.1016/j.jmb.2006.01.089 · Cited by 519
Human LINE-1 retrotransposon induces DNA damage and apoptosis in cancer cells
Belgnaoui, S. M., Gosden, R. G., Semmes, O. J., & Haoudi, A. (2006) · Cancer Cell International · doi:10.1186/1475-2867-6-13 · Cited by 219
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Stallmeyer, B., Bühlmann, C., Stakaitis, R., Dicke, A.-K., Ghieh, F., Meier, L., Zoch, A., MacKenzie MacLeod, D., Steingröver, J., Okutman, Ö., et al. (2024) · Nature Communications · doi:10.1038/s41467-024-50930-9 · Cited by 71
Self-citationRibonuclease activity of MARF1 controls oocyte RNA homeostasis and genome integrity in mice
Yao, Q., Cao, G., Li, M., Wu, B., Zhang, X., Zhang, T., Guo, J., Yin, H., Shi, L., Chen, J., et al. (2018) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1809744115 · Cited by 41
LINE-1 of evidence for fetal oocyte attrition by retrotransposon
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Metadata
- Authors
- Soper, S. F. C., van der Heijden, G. W., Hardiman, T. C., Goodheart, M., Martin, S. L., de Boer, P., & Bortvin, A.
- Venue
- Developmental Cell
- Publisher
- Elsevier BV
- Published
- 2008-08
- Volume
- 15
- Issue
- 2
- Pages
- 285-297
- ISSN
- 1534-5807 (ISSN-L)
- OpenAlex
- W2080722280
- Cited by
- 341
- References
- 9
- FWCI
- 31.24
- Type
- journal article
- Language
- en
- Open access
- bronze
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