The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Sequential Transphosphorylation of the BRI1/BAK1 Receptor Kinase Complex Impacts Early Events in Brassinosteroid Signaling
Open accessAbstract
Brassinosteroids (BRs) regulate plant development through a signal transduction pathway involving the BRI1 and BAK1 transmembrane receptor kinases. The detailed molecular mechanisms of phosphorylation, kinase activation, and oligomerization of the BRI1/BAK1 complex in response to BRs are uncertain. We demonstrate that BR-dependent activation of BRI1 precedes association with BAK1 in planta, and that BRI1 positively regulates BAK1 phosphorylation levels in vivo. BRI1 transphosphorylates BAK1 in vitro on specific kinase-domain residues critical for BAK1 function. BAK1 also transphosphorylates BRI1, thereby quantitatively increasing BRI1 kinase activity toward a specific substrate. We propose a sequential transphosphorylation model in which BRI1 controls signaling specificity by direct BR binding followed by substrate phosphorylation. The coreceptor BAK1 is then activated by BRI1-dependent transphosphorylation and subsequently enhances signaling output through reciprocal BRI1 transphosphorylation. This model suggests both conservation and distinct differences between the molecular mechanisms regulating phosphorylation-dependent kinase activation in plant and animal receptor kinases.
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Cites
BRASSINOSTEROIDS: Essential Regulators of Plant Growth and Development
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Self-citationBRI1/BAK1, a Receptor Kinase Pair Mediating Brassinosteroid Signaling
Nam, K. H., & Li, J. (2002) · Cell · doi:10.1016/s0092-8674(02)00814-0 · Cited by 1,217
Self-citation
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Brassinosteroids control meristem size by promoting cell cycle progression in Arabidopsis roots
González-García, M.-P., Vilarrasa-Blasi, J., Zhiponova, M., Divol, F., Mora-García, S., Russinova, E., & Caño-Delgado, A. I. (2011) · Development · doi:10.1242/dev.057331 · Cited by 522
Modulators of Protein–Protein Interactions
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SERKing Coreceptors for Receptors
Ma, X., Xu, G., He, P., & Shan, L. (2016) · Trends in Plant Science · doi:10.1016/j.tplants.2016.08.014 · Cited by 266
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The molecular circuitry of brassinosteroid signaling
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Obergfell, E., Hohmann, U., Moretti, A., Chen, H., & Hothorn, M. (2024) · Plant And Cell Physiology · doi:10.1093/pcp/pcae056 · Cited by 10
Allosteric activation of the co-receptor BAK1 by the EFR receptor kinase initiates immune signaling
Mühlenbeck, H., Tsutsui, Y., Lemmon, M. A., Bender, K. W., & Zipfel, C. (2023) · doi:10.1101/2023.08.23.554490 · Cited by 3
Metadata
- Authors
- Wang, X., Kota, U., He, K., Blackburn, K., Li, J., Goshe, M. B., Huber, S. C., & Clouse, S. D.
- Venue
- Developmental Cell
- Publisher
- Elsevier BV
- Published
- 2008-08
- Volume
- 15
- Issue
- 2
- Pages
- 220-235
- ISSN
- 1534-5807 (ISSN-L)
- OpenAlex
- W2024443524
- Cited by
- 575
- References
- 2
- FWCI
- 43.96
- Type
- journal article
- Language
- en
- Open access
- bronze
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