The DOI matches its Crossref record; 67 of the 67 references it cites were found in a registry or an index.
Establishment of Intestinal Identity and Epithelial-Mesenchymal Signaling by Cdx2
Open accessAbstract
SUMMARY We demonstrate that conditional ablation of the homeobox transcription factor Cdx2 from early endoderm results in the replacement of the posterior intestinal epithelium with keratinocytes, a dramatic cell fate conversion caused by ectopic activation of the foregut/esophageal differentiation program. This anterior homeotic transformation is first evident in the early embryonic Cdx2-deficient gut as expression of several key foregut endoderm regulators was shifted caudally. While the intestinal transcriptome was severely affected, Cdx2-deficiency only transiently modified selected posterior Hox genes and the primary enteric Hox code was maintained. Further, we demonstrate that Cdx2-directed intestinal cell fate adoption plays an important role in the establishment of normal epithelial-mesenchymal interactions, as multiple signaling pathways involved in this process were severely affected. We conclude that Cdx2 controls important aspects of intestinal identity and development, and that this function is largely independent of the enteric Hox code.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
1 retracted
RETRACTED: Cdx2 Gene Expression and Trophectoderm Lineage Specification in Mouse Embryos
Deb, K. D., Sivaguru, M., Yong, H. Y., et al. (2006) · Science · doi:10.1126/science.1120925 · Cited by 97
RetractedDAVID: Database for Annotation, Visualization, and Integrated Discovery
Dennis, G., Sherman, B. T., Hosack, D. A., Yang, J., Gao, W., Lane, H. C., & Lempicki, R. A. (2003) · Genome Biology · doi:10.1186/gb-2003-4-5-p3 · Cited by 9,327
Bolstad, B. M., Irizarry, R. A., Åstrand, M., & Speed, T. P. (2003) · Bioinformatics · doi:10.1093/bioinformatics/19.2.185 · Cited by 8,266
TM4: a free, open-source system for microarray data management and analysis
Saeed, A. I., Sharov, V., White, J., Li, J., Liang, W., Bhagabati, N., Braisted, J., Klapa, M., Currier, T., Thiagarajan, M., et al. (2003) · BioTechniques · doi:10.2144/03342mt01 · Cited by 4,837
Homeobox genes and axial patterning
McGinnis, W., & Krumlauf, R. (1992) · Cell · doi:10.1016/0092-8674(92)90471-n · Cited by 2,674
Pvclust: an R package for assessing the uncertainty in hierarchical clustering
Suzuki, R., & Shimodaira, H. (2006) · Bioinformatics · doi:10.1093/bioinformatics/btl117 · Cited by 2,451
Hox genes in vertebrate development
Krumlauf, R. (1994) · Cell · doi:10.1016/0092-8674(94)90290-9 · Cited by 2,073
High-efficiency deleter mice show that FLPe is an alternative to Cre-loxP
Rodríguez, C. I., Buchholz, F., Galloway, J., Sequerra, R., Kasper, J., Ayala, R., Stewart, A. F., & Dymecki, S. M. (2000) · Nature Genetics · doi:10.1038/75973 · Cited by 1,159
Stoffers, D. A., Zinkin, N. T., Stanojevic, V., Clarke, W. L., & Habener, J. F. (1997) · Nature Genetics · doi:10.1038/ng0197-106 · Cited by 1,106
Requirement of Math1 for Secretory Cell Lineage Commitment in the Mouse Intestine
Yang, Q., Bermingham, N. A., Finegold, M. J., & Zoghbi, H. Y. (2001) · Science · doi:10.1126/science.1065718 · Cited by 919
Cited by
Vertebrate Endoderm Development and Organ Formation
Zorn, A. M., & Wells, J. M. (2009) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev.cellbio.042308.113344 · Cited by 812
Distinct Lineage Specification Roles for NANOG, OCT4, and SOX2 in Human Embryonic Stem Cells
Wang, Z., Oron, E., Nelson, B., Razis, S., & Ivanova, N. (2012) · Cell Stem Cell · doi:10.1016/j.stem.2012.02.016 · Cited by 554
Phenotypic landscape of intestinal organoid regeneration
Lukonin, I., Serra, D., Challet Meylan, L., Volkmann, K., Baaten, J., Zhao, R., Meeusen, S., Colman, K., Maurer, F., Stadler, M. B., et al. (2020) · Nature · doi:10.1038/s41586-020-2776-9 · Cited by 283
Guts and Gall: Bile Acids in Regulation of Intestinal Epithelial Function in Health and Disease
Hegyi, P., Maléth, J., Walters, J. R., Hofmann, A. F., & Keely, S. J. (2018) · Physiological Reviews · doi:10.1152/physrev.00054.2017 · Cited by 269
Stomach development, stem cells and disease
Kim, T.-H., & Shivdasani, R. A. (2016) · Development · doi:10.1242/dev.124891 · Cited by 175
Le Guen, L., Marchal, S., Faure, S., & de Santa Barbara, P. (2015) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-015-1975-2 · Cited by 95
Improving stem cell-derived pancreatic islets using single-cell multiome-inferred regulomes
Zhu, H., Wang, G., Nguyen-Ngoc, K.-V., Kim, D., Miller, M., Goss, G., Kovsky, J., Harrington, A. R., Saunders, D., Melton, R., et al. (2022) · doi:10.1101/2022.09.25.509355 · Cited by 85
Control of Cell Identity by the Nuclear Receptor HNF4 in Organ Pathophysiology
Dubois, V., Staels, B., Lefebvre, P., Verzi, M., & Eeckhoute, J. (2020) · Cells · doi:10.3390/cells9102185 · Cited by 63
De La Cena, K. O. C., Ho, R. X.-Y., Amraei, R., Woolf, N., Tashjian, J. Y., Zhao, Q., Richards, S., Walker, J., Huang, J., Chitalia, V. C., et al. (2021) · The American Journal of Pathology · doi:10.1016/j.ajpath.2020.09.015 · Cited by 23
Metadata
- Authors
- Gao, N., White, P., & Kaestner, K. H.
- Venue
- Developmental Cell
- Publisher
- Elsevier BV
- Published
- 2009-04
- Volume
- 16
- Issue
- 4
- Pages
- 588-599
- ISSN
- 1534-5807 (ISSN-L)
- OpenAlex
- W2113284270
- Cited by
- 381
- References
- 67
- FWCI
- 11.16
- Type
- journal article
- Language
- en
- Open access
- bronze
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
