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Cited by 381

The DOI matches its Crossref record; 67 of the 67 references it cites were found in a registry or an index.

Establishment of Intestinal Identity and Epithelial-Mesenchymal Signaling by Cdx2

Open access
Gao, Nan, White, Peter, Kaestner, Klaus H.·2009·Developmental Cell
DOI 10.1016/j.devcel.2009.02.010
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Abstract

SUMMARY We demonstrate that conditional ablation of the homeobox transcription factor Cdx2 from early endoderm results in the replacement of the posterior intestinal epithelium with keratinocytes, a dramatic cell fate conversion caused by ectopic activation of the foregut/esophageal differentiation program. This anterior homeotic transformation is first evident in the early embryonic Cdx2-deficient gut as expression of several key foregut endoderm regulators was shifted caudally. While the intestinal transcriptome was severely affected, Cdx2-deficiency only transiently modified selected posterior Hox genes and the primary enteric Hox code was maintained. Further, we demonstrate that Cdx2-directed intestinal cell fate adoption plays an important role in the establishment of normal epithelial-mesenchymal interactions, as multiple signaling pathways involved in this process were severely affected. We conclude that Cdx2 controls important aspects of intestinal identity and development, and that this function is largely independent of the enteric Hox code.

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Metadata

Authors
Gao, N., White, P., & Kaestner, K. H.
Venue
Developmental Cell
Publisher
Elsevier BV
Published
2009-04
Volume
16
Issue
4
Pages
588-599
ISSN
1534-5807 (ISSN-L)
DOI
10.1016/j.devcel.2009.02.010
OpenAlex
W2113284270
Cited by
381
References
67
FWCI
11.16
Type
journal article
Language
en
Open access
bronze

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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.

Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.