The DOI matches its Crossref record; 7 of the 7 references it cites were found in a registry or an index.
Reciprocal Requirements for EDA/EDAR/NF-κB and Wnt/β-Catenin Signaling Pathways in Hair Follicle Induction
Open accessAbstract
SUMMARY Wnt/β-catenin and NF-κB signaling mechanisms provide central controls in development and disease, but how these pathways intersect is unclear. Using hair follicle induction as a model system, we show that patterning of dermal Wnt/β-catenin signaling requires epithelial β-catenin activity. We find that Wnt/β-catenin signaling is absolutely required for NF-κB activation, and that Edar is a direct Wnt target gene. Wnt/β-catenin signaling is initially activated independently of Eda/Edar/NF-κB activity in primary hair follicle primordia. However, Eda/Edar/NF-κB signaling is required to refine the pattern of Wnt/β-catenin activity, and to maintain this activity at later stages of placode development. We show that maintenance of localized expression of Wnt10b and Wnt10a requires NF-κB signaling, providing a molecular explanation for the latter observation, and identify Wnt10b as a direct NF-κB target. These data reveal a complex interplay and inter-dependence of Wnt/β-catenin and Eda/Edar/NF-κB signaling pathways in initiation and maintenance of primary hair follicle placodes.
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Cites
WNT Signals Are Required for the Initiation of Hair Follicle Development
Andl, T., Reddy, S. T., Gaddapara, T., & Millar, S. E. (2002) · Developmental Cell · doi:10.1016/s1534-5807(02)00167-3 · Cited by 1,088
Self-citationScratching the surface of skin development
Fuchs, E. (2007) · Nature · doi:10.1038/nature05659 · Cited by 930
Reddy, S., Andl, T., Bagasra, A., Lu, M. M., Epstein, D. J., Morrisey, E. E., & Millar, S. E. (2001) · Mechanisms of Development · doi:10.1016/s0925-4773(01)00452-x · Cited by 489
Self-citationAndl, T., Murchison, E. P., Liu, F., Zhang, Y., Yunta-Gonzalez, M., Tobias, J. W., Andl, C. D., Seykora, J. T., Hannon, G. J., & Millar, S. E. (2006) · Current Biology · doi:10.1016/j.cub.2006.04.005 · Cited by 359
Self-citationAdaimy, L., Chouery, E., Mégarbané, H., Mroueh, S., Delague, V., Nicolas, E., Belguith, H., de Mazancourt, P., & Mégarbané, A. (2007) · The American Journal of Human Genetics · doi:10.1086/520064 · Cited by 248
Generation of the primary hair follicle pattern.
Mou, C., Jackson, B., Schneider, P., Overbeek, P. A., & Headon, D. J. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0600825103 · Cited by 206
Self-citationTucker, A. S., Headon, D. J., Courtney, J.-M., Overbeek, P., & Sharpe, P. T. (2004) · Developmental Biology · doi:10.1016/j.ydbio.2003.12.019 · Cited by 146
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Cited by
The senescence-associated secretory phenotype induces cellular plasticity and tissue regeneration.
Ritschka, B., Storer, M., Mas, A., Heinzmann, F., Ortells, M. C., Morton, J. P., Sansom, O. J., Zender, L., & Keyes, W. M. (2017) · Genes & Development · doi:10.1101/gad.290635.116 · Cited by 650
Crosstalk between Wnt/β-Catenin and NF-κB Signaling Pathway during Inflammation
Ma, B., & Hottiger, M. O. (2016) · Frontiers in Immunology · doi:10.3389/fimmu.2016.00378 · Cited by 563
β-catenin Activity in the Dermal Papilla Regulates Morphogenesis and Regeneration of Hair
Enshell-Seijffers, D., Lindon, C., Kashiwagi, M., & Morgan, B. A. (2010) · Developmental Cell · doi:10.1016/j.devcel.2010.01.016 · Cited by 411
Mesenchymal–epithelial interactions during hair follicle morphogenesis and cycling
Sennett, R., & Rendl, M. (2012) · Seminars in Cell & Developmental Biology · doi:10.1016/j.semcdb.2012.08.011 · Cited by 388
Wnt Signaling in Skin Development, Homeostasis, and Disease
Lim, X., & Nusse, R. (2013) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a008029 · Cited by 268
Metadata
- Authors
- Zhang, Y., Tomann, P., Andl, T., Gallant, N. M., Huelsken, J., Jerchow, B., Birchmeier, W., Paus, R., Piccolo, S., Mikkola, M. L., Morrisey, E. E., Overbeek, P. A., Scheidereit, C., Millar, S. E., & Schmidt-Ullrich, R.
- Venue
- Developmental Cell
- Publisher
- Elsevier BV
- Published
- 2009-07
- Volume
- 17
- Issue
- 1
- Pages
- 49-61
- ISSN
- 1534-5807 (ISSN-L)
- OpenAlex
- W2062336866
- Cited by
- 367
- References
- 7
- FWCI
- 15.87
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Zhang, Y., Tomann, P., Andl, T., Gallant, N. M., Huelsken, J., Jerchow, B., Birchmeier, W., Paus, R., Piccolo, S., Mikkola, M. L., Morrisey, E. E., Overbeek, P. A., Scheidereit, C., Millar, S. E., & Schmidt-Ullrich, R. (2009). Reciprocal Requirements for EDA/EDAR/NF-κB and Wnt/β-Catenin Signaling Pathways in Hair Follicle Induction. Developmental Cell. https://doi.org/10.1016/j.devcel.2009.05.011
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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