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Cited by 930Hair Growth and DisordersSkin and Cellular Biology ResearchDevelopmental Biology and Gene Regulation

Scratching the surface of skin development

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Fuchs, Elaine·2007·Nature
DOI 10.1038/nature05659PMC PMC2405926
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Abstract

The epidermis and its appendages develop from a single layer of multipotent embryonic progenitor keratinocytes. Embryonic stem cells receive cues from their environment that instruct them to commit to a particular differentiation programme and generate a stratified epidermis, hair follicles or sebaceous glands. Exciting recent developments have focused on how adult skin epithelia maintain populations of stem cells for use in the natural cycles of hair follicle regeneration and for re-epithelialization in response to wounding.

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  • In early gestation, HF patterning is initiated by mesenchymal signals together with epithelial Wnt signaling to induce hair placodes.

    “In early gestation, HF patterning is initiated by signals from the mesenchyme, in conjunction with epithelial Wnt signaling, to induce the formation of thickened regions of epithelium, known as hair placodes [11, 12].”

    From The empowering influence of air-liquid interface culture on skin organoid hair follicle development (2025) · cites this paper as [12]

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Cited by

Sorted by citations

Authors
Fuchs, E.
Affiliations
Howard Hughes Medical Institute (US)
Corresponding author
Fuchs, Elaine
ORCID
Fuchs, Elaine
Venue
Nature
Publisher
Springer Science and Business Media LLC
Published
2007-02
Volume
445
Issue
7130
Pages
834-842
ISSN
  • 0028-0836 (ISSN-L)
  • 1476-4687
DOI
10.1038/nature05659
PMC
PMC2405926
OpenAlex
W2081588299
Cited by
930
References
11
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FWCI
11.61
Type
journal article
Language
en
Open access
Licence
www.springer.com/tdm (tdm)
Locations
  • Nature (publishedVersion)
  • PubMed (publishedVersion)
  • PubMed Central (acceptedVersion)
  • RePEc: Research Papers in Economics (submittedVersion)
Funders
National Institute of Arthritis and Musculoskeletal and Skin Diseases (R01AR027883)
Topics
  • Health Sciences › Medicine › Urology › Hair Growth and Disorders
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Skin and Cellular Biology Research
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
Keywords
skin development, epidermis, keratinocytes, embryonic stem cells, hair follicle, sebaceous glands, stratified epithelium, stem cell maintenance, hair follicle regeneration, re-epithelialization, wound healing, cell differentiation
MeSH terms
Animals, Hair, Humans, Sebaceous Glands, Skin, Stem Cells, Hair Follicle, Regenerative Medicine

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

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