The DOI matches its Crossref record; 7 of the 7 references it cites were found in a registry or an index.
Reciprocal Requirements for EDA/EDAR/NF-κB and Wnt/β-Catenin Signaling Pathways in Hair Follicle Induction
Open accessAbstract
SUMMARY Wnt/β-catenin and NF-κB signaling mechanisms provide central controls in development and disease, but how these pathways intersect is unclear. Using hair follicle induction as a model system, we show that patterning of dermal Wnt/β-catenin signaling requires epithelial β-catenin activity. We find that Wnt/β-catenin signaling is absolutely required for NF-κB activation, and that Edar is a direct Wnt target gene. Wnt/β-catenin signaling is initially activated independently of Eda/Edar/NF-κB activity in primary hair follicle primordia. However, Eda/Edar/NF-κB signaling is required to refine the pattern of Wnt/β-catenin activity, and to maintain this activity at later stages of placode development. We show that maintenance of localized expression of Wnt10b and Wnt10a requires NF-κB signaling, providing a molecular explanation for the latter observation, and identify Wnt10b as a direct NF-κB target. These data reveal a complex interplay and inter-dependence of Wnt/β-catenin and Eda/Edar/NF-κB signaling pathways in initiation and maintenance of primary hair follicle placodes.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
WNT Signals Are Required for the Initiation of Hair Follicle Development
Andl, T., Reddy, S. T., Gaddapara, T., & Millar, S. E. (2002) · Developmental Cell · doi:10.1016/s1534-5807(02)00167-3 · Cited by 1,088
Self-citationScratching the surface of skin development
Fuchs, E. (2007) · Nature · doi:10.1038/nature05659 · Cited by 930
Reddy, S., Andl, T., Bagasra, A., Lu, M. M., Epstein, D. J., Morrisey, E. E., & Millar, S. E. (2001) · Mechanisms of Development · doi:10.1016/s0925-4773(01)00452-x · Cited by 489
Self-citationAndl, T., Murchison, E. P., Liu, F., Zhang, Y., Yunta-Gonzalez, M., Tobias, J. W., Andl, C. D., Seykora, J. T., Hannon, G. J., & Millar, S. E. (2006) · Current Biology · doi:10.1016/j.cub.2006.04.005 · Cited by 359
Self-citationAdaimy, L., Chouery, E., Mégarbané, H., Mroueh, S., Delague, V., Nicolas, E., Belguith, H., de Mazancourt, P., & Mégarbané, A. (2007) · The American Journal of Human Genetics · doi:10.1086/520064 · Cited by 248
Generation of the primary hair follicle pattern.
Mou, C., Jackson, B., Schneider, P., Overbeek, P. A., & Headon, D. J. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0600825103 · Cited by 206
Self-citationTucker, A. S., Headon, D. J., Courtney, J.-M., Overbeek, P., & Sharpe, P. T. (2004) · Developmental Biology · doi:10.1016/j.ydbio.2003.12.019 · Cited by 146
Self-citation
Cited by
The senescence-associated secretory phenotype induces cellular plasticity and tissue regeneration.
Ritschka, B., Storer, M., Mas, A., Heinzmann, F., Ortells, M. C., Morton, J. P., Sansom, O. J., Zender, L., & Keyes, W. M. (2017) · Genes & Development · doi:10.1101/gad.290635.116 · Cited by 650
Crosstalk between Wnt/β-Catenin and NF-κB Signaling Pathway during Inflammation
Ma, B., & Hottiger, M. O. (2016) · Frontiers in Immunology · doi:10.3389/fimmu.2016.00378 · Cited by 563
β-catenin Activity in the Dermal Papilla Regulates Morphogenesis and Regeneration of Hair
Enshell-Seijffers, D., Lindon, C., Kashiwagi, M., & Morgan, B. A. (2010) · Developmental Cell · doi:10.1016/j.devcel.2010.01.016 · Cited by 411
Mesenchymal–epithelial interactions during hair follicle morphogenesis and cycling
Sennett, R., & Rendl, M. (2012) · Seminars in Cell & Developmental Biology · doi:10.1016/j.semcdb.2012.08.011 · Cited by 388
Wnt Signaling in Skin Development, Homeostasis, and Disease
Lim, X., & Nusse, R. (2013) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a008029 · Cited by 268
Chen, D., Jarrell, A., Guo, C., Lang, R., & Atit, R. (2012) · Development · doi:10.1242/dev.076463 · Cited by 260
Single cell transcriptomics of human epidermis identifies basal stem cell transition states
Wang, S., Drummond, M. L., Guerrero-Juarez, C. F., Tarapore, E., MacLean, A. L., Stabell, A. R., Wu, S. C., Gutierrez, G., That, B. T., Benavente, C. A., et al. (2020) · Nature Communications · doi:10.1038/s41467-020-18075-7 · Cited by 218
Sennett, R., Wang, Z., Rezza, A., Grisanti, L., Roitershtein, N., Sicchio, C., Mok, K. W., Heitman, N. J., Clavel, C., Ma’ayan, A., et al. (2015) · Developmental Cell · doi:10.1016/j.devcel.2015.06.023 · Cited by 211
Hierarchical patterning modes orchestrate hair follicle morphogenesis
Glover, J. D., Wells, K. L., Matthäus, F., Painter, K. J., Ho, W., Riddell, J., Johansson, J. A., Ford, M. J., Jahoda, C. A. B., Klika, V., et al. (2017) · PLOS Biology · doi:10.1371/journal.pbio.2002117 · Cited by 155
Spatiotemporal antagonism in mesenchymal-epithelial signaling in sweat versus hair fate decision
Lu, C. P., Polak, L., Keyes, B. E., & Fuchs, E. (2016) · Science · doi:10.1126/science.aah6102 · Cited by 149
The developmental basis of fingerprint pattern formation and variation
Glover, J. D., Sudderick, Z. R., Shih, B. B.-J., Batho-Samblas, C., Charlton, L., Krause, A. L., Anderson, C., Riddell, J., Balic, A., Li, J., et al. (2023) · Cell · doi:10.1016/j.cell.2023.01.015 · Cited by 136
Epidermal Development in Mammals: Key Regulators, Signals from Beneath, and Stem Cells
Liu, S., Zhang, H., & Duan, E. (2013) · International Journal of Molecular Sciences · doi:10.3390/ijms140610869 · Cited by 110
Ectodysplasin A (EDA) – EDA receptor signalling and its pharmacological modulation
Kowalczyk-Quintas, C., & Schneider, P. (2014) · Cytokine & Growth Factor Reviews · doi:10.1016/j.cytogfr.2014.01.004 · Cited by 97
Involvement of Wnt, Eda and Shh at defined stages of sweat gland development
Cui, C.-Y., Yin, M., Sima, J., Childress, V., Michel, M., Piao, Y., & Schlessinger, D. (2014) · Development · doi:10.1242/dev.109231 · Cited by 80
Dynamic signals for hair follicle development and regeneration
Wang, X., Tredget, E. E., & Wu, Y. (2012) · Stem Cells and Development · doi:10.1089/scd.2011.0230 · Cited by 80
Bioengineered skin organoids: from development to applications
Hong, Z.-X., Zhu, S.-T., Li, H., Luo, J.-Z., Yang, Y., An, Y., Wang, X., & Wang, K. (2023) · Military Medical Research · doi:10.1186/s40779-023-00475-7 · Cited by 77
Peled, A., Sarig, O., Samuelov, L., Bertolini, M., Ziv, L., Weissglas-Volkov, D., Eskin-Schwartz, M., Adase, C. A., Malchin, N., Bochner, R., et al. (2016) · PLOS Genetics · doi:10.1371/journal.pgen.1006369 · Cited by 55
Self-citationSun, S., Xiao, J., Huo, J., Geng, Z., Ma, K., Sun, X., & Fu, X. (2018) · Stem Cell Research & Therapy · doi:10.1186/s13287-017-0758-0 · Cited by 36
Back to the Future: From Appendage Development Toward Future Human Hair Follicle Neogenesis
de Groot, S. C., Ulrich, M. M. W., Gho, C. G., & Huisman, M. A. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.661787 · Cited by 33
Whole-Genome Resequencing Reveals Selection Signal Related to Sheep Wool Fineness
Zhang, W., Jin, M., Li, T., Lu, Z., Wang, H., Yuan, Z., & Wei, C. (2023) · Animals · doi:10.3390/ani13182944 · Cited by 30
LEF1 haploinsufficiency causes ectodermal dysplasia
Lévy, J., Capri, Y., Rachid, M., Dupont, C., Vermeesch, J. R., Devriendt, K., Verloes, A., Tabet, A., & Bailleul‐Forestier, I. (2020) · Clinical Genetics · doi:10.1111/cge.13714 · Cited by 25
Bao, D.-Y., Yang, Y., Tong, X., & Qin, H.-Y. (2024) · Heliyon · doi:10.1016/j.heliyon.2023.e23057 · Cited by 3
Metadata
- Authors
- Zhang, Y., Tomann, P., Andl, T., Gallant, N. M., Huelsken, J., Jerchow, B., Birchmeier, W., Paus, R., Piccolo, S., Mikkola, M. L., Morrisey, E. E., Overbeek, P. A., Scheidereit, C., Millar, S. E., & Schmidt-Ullrich, R.
- Venue
- Developmental Cell
- Publisher
- Elsevier BV
- Published
- 2009-07
- Volume
- 17
- Issue
- 1
- Pages
- 49-61
- ISSN
- 1534-5807 (ISSN-L)
- OpenAlex
- W2062336866
- Cited by
- 367
- References
- 7
- FWCI
- 15.87
- Type
- journal article
- Language
- en
- Open access
- bronze
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
