The DOI matches its Crossref record; 11 of the 11 references it cites were found in a registry or an index.
Actin Filament Turnover Drives Leading Edge Growth during Myelin Sheath Formation in the Central Nervous System
Open accessAbstract
Summary During central nervous system development, oligodendrocytes wrap their plasma membrane around axons to generate multi-lamellar myelin sheaths. To drive growth at the leading edge of myelin at the interface with the axon, mechanical forces are necessary, but the underlying mechanisms are not known. Using an interdisciplinary approach that combines morphological, genetic and biophysical analyses, we identified a key role for actin filament network turnover in myelin growth. At the onset of myelin biogenesis, F-actin is redistributed to the leading edge, where its polymerization-based forces push out non-adhesive and motile protrusions. F-actin disassembly converts protrusions into sheets by reducing surface tension and in turn inducing membrane spreading and adhesion. We identified the actin depolymerizing factor ADF/Cofilin1, which mediates high F-actin turnover rates, as essential factor in this process. We propose that F-actin turnover is the driving force in myelin wrapping by regulating repetitive cycles of leading edge protrusion and spreading.
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Rapid leukocyte migration by integrin-independent flowing and squeezing
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White matter in learning, cognition, and psychiatric disorders
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Disruption of Cnp1 uncouples oligodendroglial functions in axonal support and myelination
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ADF/Cofilin: a functional node in cell biology
Bernstein, B. W., & Bamburg, J. R. (2010) · Trends in Cell Biology · doi:10.1016/j.tcb.2010.01.001 · Cited by 704
Mechanisms of axon ensheathment and myelin growth
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Retinoid X receptor gamma signaling accelerates CNS remyelination
Huang, J. K., Jarjour, A. A., Nait Oumesmar, B., Kerninon, C., Williams, A., Krezel, W., Kagechika, H., Bauer, J., Zhao, C., Evercooren, A. B.-V., et al. (2011) · Nature Neuroscience · doi:10.1038/nn.2702 · Cited by 547
Synaptic vesicle release regulates myelin sheath number of individual oligodendrocytes in vivo
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Self-citationAxin2 as regulatory and therapeutic target in newborn brain injury and remyelination
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Dynamics and Mechanisms of CNS Myelination
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Cited by
Myelin in the Central Nervous System: Structure, Function, and Pathology
Stadelmann, C., Timmler, S., Barrantes-Freer, A., & Simons, M. (2019) · Physiological Reviews · doi:10.1152/physrev.00031.2018 · Cited by 728
Self-citationMicroglia phagocytose myelin sheaths to modify developmental myelination
Hughes, A. N., & Appel, B. (2020) · Nature Neuroscience · doi:10.1038/s41593-020-0654-2 · Cited by 344
Glia in mammalian development and disease
Zuchero, J. B., & Barres, B. A. (2015) · Development · doi:10.1242/dev.129304 · Cited by 304
Autophagy is essential for oligodendrocyte differentiation, survival, and proper myelination
Bankston, A. N., Forston, M. D., Howard, R. M., Andres, K. R., Smith, A. E., Ohri, S. S., Bates, M. L., Bunge, M. B., & Whittemore, S. R. (2019) · Glia · doi:10.1002/glia.23646 · Cited by 112
Mathews, E. S., & Appel, B. (2016) · Journal of Neuroscience · doi:10.1523/jneurosci.0726-16.2016 · Cited by 97
Metadata
- Authors
- Nawaz, S., Sánchez, P., Schmitt, S., Snaidero, N., Mitkovski, M., Velte, C., Brückner, B. R., Alexopoulos, I., Czopka, T., Jung, S. Y., Rhee, J. S., Janshoff, A., Witke, W., Schaap, I. A. T., Lyons, D. A., & Simons, M.
- Venue
- Developmental Cell
- Publisher
- Elsevier BV
- Published
- 2015-07
- Volume
- 34
- Issue
- 2
- Pages
- 139-151
- ISSN
- 1534-5807 (ISSN-L)
- OpenAlex
- W1839988640
- Cited by
- 249
- References
- 11
- FWCI
- 8.47
- Type
- journal article
- Language
- en
- Open access
- bronze
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- CoChat. (2026). Citation check: Actin Filament Turnover Drives Leading Edge Growth during Myelin Sheath Formation in the Central Nervous System. https://app.cochat.ai/papers/10.1016/j.devcel.2015.05.013
- The paper
- Nawaz, S., Sánchez, P., Schmitt, S., Snaidero, N., Mitkovski, M., Velte, C., Brückner, B. R., Alexopoulos, I., Czopka, T., Jung, S. Y., Rhee, J. S., Janshoff, A., Witke, W., Schaap, I. A. T., Lyons, D. A., & Simons, M. (2015). Actin Filament Turnover Drives Leading Edge Growth during Myelin Sheath Formation in the Central Nervous System. Developmental Cell. https://doi.org/10.1016/j.devcel.2015.05.013
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
