Synaptic vesicle release regulates myelin sheath number of individual oligodendrocytes in vivo
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The myelination of axons by oligodendrocytes markedly affects CNS function, but how this is regulated by neuronal activity in vivo is not known. We found that blocking synaptic vesicle release impaired CNS myelination by reducing the number of myelin sheaths made by individual oligodendrocytes during their short period of formation. We also found that stimulating neuronal activity increased myelin sheath formation by individual oligodendrocytes. These data indicate that neuronal activity regulates the myelinating capacity of single oligodendrocytes.
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Inhibition of vesicular release from neurons to mature oligodendrocytes impairs myelination in vivo.
“Inhibition of vesicular release from neurons to mature oligodendrocytes impairs myelination, both in vitro (Wake et al., 2015 ; Wake, Lee, & Fields, 2011 ) and in vivo (Hines, Ravanelli, Schwindt, Scott, & Appel, 2015 ; Mensch et al., 2015 ).”
From Motor learning requires myelination to reduce asynchrony and spontaneity in neural activity (2020) · cites this paper as Mensch et al., 2015
The paper reports that blocking neuronal synaptic vesicle release impaired myelination in vivo in zebrafish. But it locates the effect during oligodendrocytes’ initial period of sheath formation, not specifically in mature oligodendrocytes; it also presents direct signaling from axons to oligodendrocytes as a possible mechanism rather than an established one. The indexed passages have no page numbers. (LLM, conf=0.88)
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BackgroundLife-long oligodendrocyte development and plasticity
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- Authors
- Mensch, S., Baraban, M., Almeida, R., Czopka, T., Ausborn, J., El Manira, A., & Lyons, D. A.
- Affiliations
- Euan MacDonald Centre for Motor Neuron Disease Research (GB)
- Karolinska Institutet (SE)
- Corresponding author
- Lyons, David A
- Venue
- Nature Neuroscience
- Published
- 2015-04-06
- Volume
- 18
- Issue
- 5
- Pages
- 628-630
- ISSN
- 1097-6256 (ISSN-L)
- 1546-1726
- PMC
- PMC4427868
- OpenAlex
- W2001188679
- Cited by
- 398
- References
- 33
- Citations by year
- 2026: 16 · 2025: 24 · 2024: 26 · 2023: 25 · 2022: 27 · 2021: 37 · 2020: 50 · 2019: 49 · 2018: 39 · 2017: 43 · 2016: 45 · 2015: 15
- FWCI
- 19.19
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature Neuroscience (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- mediaTUM – the media and publications repository of the Technical University Munich (Technical University Munich) (submittedVersion)
- Funders
- Wellcome Trust (102836/Z/13/Z, 102836)
- Medical Research Council (MR/K015710/1)
- Biotechnology and Biological Sciences Research Council (BB/F023243/1)
- Topics
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Health Sciences › Medicine › Pathology and Forensic Medicine › Multiple Sclerosis Research Studies
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Keywords
- synaptic vesicle release, oligodendrocytes, myelination, neuronal activity, CNS myelination, zebrafish, axonal myelination
- MeSH terms
- Animals, Cell Count, Chimera, Embryo, Nonmammalian, Myelin Sheath, Neurons, Oligodendroglia, Pentylenetetrazole, Spinal Cord, Synaptic Vesicles, Tetanus Toxin, Zebrafish, GABA-A Receptor Antagonists
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