Brain lipid sensing and nervous control of energy balance

Fatty acylation of proteins: new insights into membrane targeting of myristoylated and palmitoylated proteins

Resh, M. D. (1999) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/s0167-4889(99)00075-0 · Cited by 1,247 · see citing works

Central Administration of Oleic Acid Inhibits Glucose Production and Food Intake

Obici, S., Feng, Z., Morgan, K., Stein, D., Karkanias, G., & Rossetti, L. (2002) · Diabetes · doi:10.2337/diabetes.51.2.271 · Cited by 654 · see citing works

Inhibition of hypothalamic carnitine palmitoyltransferase-1 decreases food intake and glucose production

Obici, S., Feng, Z., Arduini, A., Conti, R., & Rossetti, L. (2003) · Nature Medicine · doi:10.1038/nm873 · Cited by 548 · see citing works

Hypothalamic sensing of fatty acids

Lam, T. K. T., Schwartz, G. J., & Rossetti, L. (2005) · Nature Neuroscience · doi:10.1038/nn1456 · Cited by 478 · see citing works

Body Fat and the Activity of the Autonomic Nervous System

Peterson, H. R., Rothschild, M. A., Weinberg, C. R., Fell, R. D., McLeish, K. R., & Pfeifer, M. A. (1988) · New England Journal of Medicine · doi:10.1056/nejm198804283181701 · Cited by 411 · see citing works

Palmitic acid mediates hypothalamic insulin resistance by altering PKC-θ subcellular localization in rodents

Benoit, S. C., Kemp, C. J., Elias, C. F., Abplanalp, W., Herman, J. P., Migrenne, S., Lefevre, A.-L., Cruciani-Guglielmacci, C., Magnan, C., Yu, F., et al. (2009) · Journal of Clinical Investigation · doi:10.1172/jci36714 · Cited by 351 · see citing works

Delivery and turnover of plasma-derived essential PUFAs in mammalian brain

Rapoport, S. I., Chang, M., & Spector, A. A. (2001) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)31629-1 · Cited by 330 · see citing works

Hypothalamic nutrient sensing in the control of energy homeostasis

Blouet, C., & Schwartz, G. J. (2009) · Behavioural Brain Research · doi:10.1016/j.bbr.2009.12.024 · Cited by 321 · see citing works

Distribution and phenotype of neurons containing the ATP-sensitive K+ channel in rat brain

Dunn-Meynell, A. A., Rawson, N. E., & Levin, B. E. (1998) · Brain Research · doi:10.1016/s0006-8993(98)00956-1 · Cited by 256 · see citing works

The gustatory pathway is involved in CD36‐mediated orosensory perception of long‐chain fatty acids in the mouse

Gaillard, D., Laugerette, F., Darcel, N., El-Yassimi, A., Passilly‐Degrace, P., Hichami, A., Khan, N. A., Montmayeur, J., & Besnard, P. (2007) · The FASEB Journal · doi:10.1096/fj.07-8415com · Cited by 233 · see citing works

Essential Polyunsaturated Fatty Acids and the Barrier to the Brain: The Components of a Model for Transport

Edmond, J. (2001) · Journal of Molecular Neuroscience · doi:10.1385/jmn:16:2-3:181 · Cited by 174 · see citing works

Eating Elicited by Orexin-A, But Not Melanin-Concentrating Hormone, Is Opioid Mediated

Clegg, D. J., Air, E. L., Woods, S. C., & Seeley, R. J. (2002) · Endocrinology · doi:10.1210/endo.143.8.8977 · Cited by 160 · see citing works

Inhibition of Na,K-ATPase and sodium pump by protein kinase C regulators sphingosine, lysophosphatidylcholine, and oleic acid.

Oishi, K., Zheng, B., & Kuo, J. F. (1990) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)40196-8 · Cited by 159 · see citing works

Characteristics and mechanisms of hypothalamic neuronal fatty acid sensing

Le Foll, C., Irani, B. G., Magnan, C., Dunn-Meynell, A. A., & Levin, B. E. (2009) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00223.2009 · Cited by 159 · cited 14× · see citing works

Fasted to Fed Trafficking of Fatty Acids in Human Adipose Tissue Reveals a Novel Regulatory Step for Enhanced Fat Storage

Ruge, T., Hodson, L., Cheeseman, J., Dennis, A., Fielding, B. A., Humphreys, S. M., Frayn, K. N., & Karpe, F. (2009) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2008-2090 · Cited by 156 · see citing works

Effect of free fatty acid on the rat lateral hypothalamic neurons

Oomura, Y., Nakamura, T., Sugimori, M., & Yamada, Y. (1975) · Physiology & Behavior · doi:10.1016/0031-9384(75)90015-3 · Cited by 144 · see citing works

Fatty acid metabolism as a target for obesity treatment.

Ronnett, G., Kim, E.-K., Landree, L. E., & Tu, Y.-J. (2005) · Physiology and Behavior · doi:10.1016/j.physbeh.2005.04.014 · Cited by 133 · see citing works

Altered sympathetic activity during development of diet-induced obesity in rat

Levin, B. E., Triscari, J. M., & Sullivan, A. C. (1983) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.1983.244.3.r347 · Cited by 133 · see citing works

Effects of Oleic Acid on Distinct Populations of Neurons in the Hypothalamic Arcuate Nucleus Are Dependent on Extracellular Glucose Levels

Wang, R., Cruciani‐Guglielmacci, C., Migrenne, S., Magnan, C., Cotero, V. E., & Routh, V. H. (2005) · Journal of Neurophysiology · doi:10.1152/jn.00697.2005 · Cited by 131 · see citing works

Activation of Astrocytes by CNTF Induces Metabolic Plasticity and Increases Resistance to Metabolic Insults

Escartin, C., Pierre, K., Colin, A., Brouillet, E., Delzescaux, T., Guillermier, M., Dhénain, M., Déglon, N., Hantraye, P., Pellerin, L., et al. (2007) · Journal of Neuroscience · doi:10.1523/jneurosci.0174-07.2007 · Cited by 126 · see citing works

Lipid infusion lowers sympathetic nervous activity and leads to increased β-cell responsiveness to glucose

Magnan, C., Collins, S. C., Berthault, M., Kassis, N., Vincent, M., Gilbert, M., Pénicaud, L., Ktorza, A., & Assimacopoulos‐Jeannet, F. (1999) · Journal of Clinical Investigation · doi:10.1172/jci3883 · Cited by 115 · see citing works

Oleic Acid Directly Regulates POMC Neuron Excitability in the Hypothalamus

Jo, Y., Su, Y., Juárez, R. G., & Chua, S. C. (2009) · Journal of Neurophysiology · doi:10.1152/jn.91294.2008 · Cited by 104 · see citing works

Brain glucose sensing mechanism and glucose homeostasis

Pénicaud, L., Leloup, C., Lorsignol, A., Alquier, T., & Guillod, E. (2002) · Current opinion in clinical nutrition and metabolic care · doi:10.1097/00075197-200209000-00013 · Cited by 101 · see citing works

Fatty Acid Uptake and Incorporation in Brain: Studies with the Perfusion Model

Smith, Q. R., & Nagura, H. (2001) · Journal of Molecular Neuroscience · doi:10.1385/jmn:16:2-3:167 · Cited by 99 · see citing works

MONITORING ENERGY BALANCE: Metabolites of Fatty Acid Synthesis as Hypothalamic Sensors

Dowell, P., Hu, Z., & Lane, M. D. (2005) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.73.011303.074027 · Cited by 82 · see citing works

Effects of central administration of distinct fatty acids on hypothalamic neuropeptide expression and energy metabolism

Schwinkendorf, D. R., Tsatsos, N. G., Gosnell, B. A., & Mashek, D. G. (2010) · International Journal of Obesity · doi:10.1038/ijo.2010.159 · Cited by 81 · see citing works

Beta oxidation in the brain is required for the effects of non-esterified fatty acids on glucose-induced insulin secretion in rats

Cruciani‐Guglielmacci, C., Hervalet, A., Douared, L., Sanders, N. M., Levin, B. E., Ktorza, A., & Magnan, C. (2004) · Diabetologia · doi:10.1007/s00125-004-1569-2 · Cited by 76 · see citing works

PKA and arachidonic acid activation of human recombinant ClC-2 chloride channels

Tewari, K. P., Malinowska, D. H., Sherry, A. M., et al. (2000) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.2000.279.1.c40 · Cited by 74 · see citing works

C75 Alters Central and Peripheral Gene Expression to Reduce Food Intake and Increase Energy Expenditure

Tu, Y., Thupari, J. N., Kim, E. K., Pinn, M. L., Moran, T. H., Ronnett, G. V., & Kuhajda, F. P. (2004) · Endocrinology · doi:10.1210/en.2004-0976 · Cited by 73 · see citing works

Rethinking the central causes of diabetes

Elmquist, J. K., & Marcus, J. (2003) · Nature Medicine · doi:10.1038/nm0603-645 · Cited by 65 · see citing works

Dietary Docosahexaenoic Acid [22: 6(n-3)] as a Phospholipid or a Triglyceride Enhances the Potassium Chloride–Evoked Release of Acetylcholine in Rat Hippocampus

Aïd, S., Vancassel, S., Linard, A., Lavialle, M., & Guesnet, P. (2005) · Journal of Nutrition · doi:10.1093/jn/135.5.1008 · Cited by 62 · see citing works

Pharmacological stimulation of brain carnitine palmitoyl-transferase-1 decreases food intake and body weight

Aja, S. M., Landree, L. E., Kleman, A. M., Medghalchi, S. M., Vadlamudi, A., McFadden, J. M., Aplasca, A., Hyun, J., Plummer, E. R., Daniels, K., et al. (2007) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00862.2006 · Cited by 58 · see citing works

Fatty Acid Synthase Inhibitors Modulate Energy Balance via Mammalian Target of Rapamycin Complex 1 Signaling in the Central Nervous System

Proulx, K., Cota, D., Woods, S. C., & Seeley, R. J. (2008) · Diabetes · doi:10.2337/db07-1690 · Cited by 57 · see citing works

Suppression of Calcium Sparks in Rat Ventricular Myocytes and Direct Inhibition of Sheep Cardiac RyR Channels by EPA, DHA and Oleic Acid

Honen, B. N., Saint, D. A., & Laver, D. R. (2003) · The Journal of Membrane Biology · doi:10.1007/s00232-003-0628-9 · Cited by 55 · see citing works

Fatty Acid Signaling in the Hypothalamus and the Neural Control of Insulin Secretion

Migrenne, S., Cruciani‐Guglielmacci, C., Kang, L., Wang, R., Rouch, C., Lefèvre, A.-L., Ktorza, A., Routh, V. H., Levin, B. E., & Magnan, C. (2006) · Diabetes · doi:10.2337/db06-s017 · Cited by 55 · see citing works

Intracerebroventricular infusion of a triglyceride emulsion leads to both altered insulin secretion and hepatic glucose production in rats

Clément, L., Cruciani‐Guglielmacci, C., Magnan, C., Vincent, M., Douared, L., Orosco, M., Assimacopoulos‐Jeannet, F., Pénicaud, L., & Ktorza, A. (2002) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/s00424-002-0937-3 · Cited by 53 · see citing works

Brain Uptake and Utilization of Fatty Acids: Applications to Peroxisomal Biogenesis Diseases

Watkins, P. A., Hamilton, J. A., Leaf, A., Spector, A. A., Moore, S. A., Anderson, R. E., Moser, H. W., Noetzel, M. J., & Katz, R. (2001) · Journal of Molecular Neuroscience · doi:10.1385/jmn:16:2-3:87 · Cited by 53 · see citing works

Differential effects of dietary fats on sympathetic nervous system activity in the rat

Young, J. B., & Walgren, M. C. (1994) · Metabolism · doi:10.1016/0026-0495(94)90157-0 · Cited by 50 · see citing works

Differential effects of hypothalamic long-chain fatty acid infusions on suppression of hepatic glucose production

Ross, R., Rossetti, L., Lam, T. K. T., & Schwartz, G. J. (2010) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00190.2010 · Cited by 48 · see citing works

Body fat and sympathetic nerve activity

Scherrer, U., Owlya, R., & Leport, M. (1996) · Cardiovascular Drugs and Therapy · doi:10.1007/bf00120490 · Cited by 36 · see citing works

Effects of omega-3 fatty acids on orexigenic and anorexigenic modulators at the onset of anorexia

Ramos, E. J. B., Romanova, I. V., Suzuki, S., Chen, C., Ugrumov, M. V., Sato, T., Gonçalves, C. G., & Meguid, M. M. (2005) · Brain Research · doi:10.1016/j.brainres.2005.03.052 · Cited by 32 · see citing works

The Regulation of Energy Balance by the Central Nervous System

Proulx, K., & Seeley, R. J. (2005) · Psychiatric Clinics of North America · doi:10.1016/j.psc.2004.09.005 · Cited by 20 · see citing works

Mitochondrial fatty acid oxidation in obesity

Serra, D., Mera, P., Malandrino, M. I., Mir, J. F., & Herrero, L. (2013) · Antioxidants & Redox Signaling · doi:10.1089/ars.2012.4875 · Cited by 246 · see citing works

Gene-Environment Interactions Controlling Energy and Glucose Homeostasis and the Developmental Origins of Obesity

Bouret, S., Levin, B. E., & Ozanne, S. E. (2015) · Physiological Reviews · doi:10.1152/physrev.00007.2014 · Cited by 157 · see citing works

Long Term Improvement of Glucose Homeostasis by Vanadate in Obese Hyperinsulinemic fa/fa Rats*

Brichard, S., Pottier, A. M., & Henquin, J. C. (1989) · Endocrinology · doi:10.1210/endo-125-5-2510 · Cited by 125 · see citing works

Sleep deprivation alters energy homeostasis through non-compensatory alterations in hypothalamic insulin receptors in Wistar rats

de Moraes, D. A., Venâncio, D. P., & Suchecki, D. (2014) · Hormones and Behavior · doi:10.1016/j.yhbeh.2014.08.015 · Cited by 29 · see citing works

Arcuate AgRP, but not POMC neurons, modulate paraventricular CRF synthesis and release in response to fasting

Fernandes, A. C. A., de Oliveira, F. P., Fernández, G., Vieira, L. D. G., Rosa, C. G., do Nascimento, T., França, S. D. C., Donato, J., Vella, K. R., Antunes‐Rodrigues, J., et al. (2022) · Cell & Bioscience · doi:10.1186/s13578-022-00853-z · Cited by 22 · see citing works

Taurine supplementation ameliorates glucose homeostasis, prevents insulin and glucagon hypersecretion, and controls β, α, and δ-cell masses in genetic obese mice

Santos-Silva, J., Ribeiro, R. A., Vettorazzi, J., Irles, E., Rickli, S., Borck, P., Porciúncula, P. M., Quesada, I., Nadal, A., Boschero, A., et al. (2015) · Amino Acids · doi:10.1007/s00726-015-1988-z · Cited by 54 · see citing works

Disrupted Leptin Signaling in the Lateral Hypothalamus and Ventral Premammillary Nucleus Alters Insulin and Glucagon Secretion and Protects Against Diet-Induced Obesity

Denroche, H. C., Glavas, M. M., Tudurí, E., Karunakaran, S., Quong, W. L., Philippe, M., Britton, H. M., Clee, S. M., & Kieffer, T. J. (2016) · Endocrinology · doi:10.1210/en.2015-1998 · Cited by 17 · see citing works