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Cited by 176Metabolism, Diabetes, and CancerPancreatic and Hepatic Oncology ResearchDiabetes Treatment and Management

The DOI matches its Crossref record; 47 of the 48 references it cites were found in a registry or an index.

Metformin is associated with reduced risk of pancreatic cancer in patients with type 2 diabetes mellitus: A systematic review and meta-analysis

Wang, Zheng, Lai, Song-tao, Xie, Li, Zhao, Jian-dong, Ma, Ning-yi, Zhu, Ji, Ren, Zhi-gang, Jiang, Guo-liang·2014·Diabetes Research and Clinical Practice
DOI 10.1016/j.diabres.2014.04.007
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Abstract

Aims Recent epidemiological studies indicated that use of metformin might decrease the risk of various cancers among patients with type 2 diabetes mellitus (T2DM). However, its influence on pancreatic cancer was controversial. Therefore, we did a meta-analysis of currently available observational studies on the issue.Methods We did a PubMed and ISI Web of Science search for observational articles. The pooled relative risk (RR) was estimated using a random-effect model. Heterogeneity was evaluated using I(2) statistic. Subgroup analysis was performed to explore the source of heterogeneity and confirm the overall estimates. Publication bias was also examined.Results The analysis included 11 articles (13 studies) comprising 10 cohort studies and 3 case-control studies. Use of metformin was associated with a significant lower risk of pancreatic cancer [RR 0.63, 95% confidence internal (CI) 0.46-0.86, p=0.003]. In a total 11 subgroup analyses, 5 provided the consistent result with pooled effect estimates of overall analysis. No publication bias was detected by Begg's (Z=-0.79, p=0.428) and Egger's test (t=-0.92, p=0.378).Conclusions From present observational studies, use of metformin appears to be associated with a reduced risk of pancreatic cancer in patients with T2DM. Further investigation is needed.

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Metadata

Authors
Wang, Z., Lai, S.-T., Xie, L., Zhao, J.-D., Ma, N.-Y., Zhu, J., Ren, Z.-G., & Jiang, G.-L.
Affiliations
Shanghai Medical College of Fudan University (CN)
ORCID
Venue
Diabetes Research and Clinical Practice
Publisher
Elsevier BV
Published
2014-10
Volume
106
Issue
1
Pages
19-26
ISSN
0168-8227 (ISSN-L)
DOI
10.1016/j.diabres.2014.04.007
OpenAlex
W2160695284
Cited by
176
References
48
Citations by year
2026: 5 · 2025: 6 · 2024: 7 · 2023: 17 · 2022: 14 · 2021: 14 · 2020: 21 · 2019: 15 · 2018: 18 · 2017: 19 · 2016: 19 · 2015: 19 · 2014: 2
FWCI
1.85
Type
journal article
Language
en
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • Diabetes Research and Clinical Practice (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Metabolism, Diabetes, and Cancer
  • Health Sciences › Medicine › Oncology › Pancreatic and Hepatic Oncology Research
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Treatment and Management
Keywords
metformin, pancreatic cancer, type 2 diabetes, cancer risk reduction
MeSH terms
Diabetes Mellitus, Type 2, Humans, Hypoglycemic Agents, Metformin, Pancreatic Neoplasms, Prognosis, Case-Control Studies, Risk Assessment

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