Metformin

The Effect of Intensive Treatment of Diabetes on the Development and Progression of Long-Term Complications in Insulin-Dependent Diabetes Mellitus

(1993) · New England Journal of Medicine · doi:10.1056/nejm199309303291401 · Cited by 24,667 · see citing works

Insulin Resistance: A Multifaceted Syndrome Responsible for NIDDM, Obesity, Hypertension, Dyslipidemia, and Atherosclerotic Cardiovascular Disease

DeFronzo, R. A., & Ferrannini, E. (1991) · Diabetes Care · doi:10.2337/diacare.14.3.173 · Cited by 4,555 · see citing works

Banting lecture 1988. Role of insulin resistance in human disease.

Reaven, G. (1988) · Diabetes · doi:10.2337/diabetes.37.12.1595 · Cited by 3,801 · see citing works

Intensive insulin therapy prevents the progression of diabetic microvascular complications in Japanese patients with non-insulin-dependent diabetes mellitus: a randomized prospective 6-year study.

Ohkubo, Y., Kishikawa, H., Araki, E., Miyata, T., Isami, S., Motoyoshi, S., Kojima, Y., Furuyoshi, N., & Shichiri, M. (1995) · Diabetes Research and Clinical Practice · doi:10.1016/0168-8227(95)01064-k · Cited by 3,079 · see citing works

Pathogenesis of NIDDM. A balanced overview.

DeFronzo, R. A., Bonadonna, R. C., & Ferrannini, E. (1992) · Diabetes Care · doi:10.2337/diacare.15.3.318 · Cited by 2,085 · see citing works

Morbidity and mortality in diabetics in the Framingham population. Sixteen year follow-up study

Garcia, M. J., McNamara, P. M., Gordon, T., & Kannell, W. B. (1974) · Diabetes · doi:10.2337/diab.23.2.105 · Cited by 1,608 · see citing works

Long-Term Complications of Diabetes Mellitus

Nathan, D. M. (1993) · New England Journal of Medicine · doi:10.1056/nejm199306103282306 · Cited by 1,495 · see citing works

Efficacy of Metformin in Patients with Non-Insulin-Dependent Diabetes Mellitus

DeFronzo, R. A., & Goodman, A. M. (1995) · New England Journal of Medicine · doi:10.1056/nejm199508313330902 · Cited by 1,368 · see citing works

Quantitation of Muscle Glycogen Synthesis in Normal Subjects and Subjects with Non-Insulin-Dependent Diabetes by¹³C Nuclear Magnetic Resonance Spectroscopy

Shulman, G. I., Rothman, D. L., Jue, T., Stein, P., DeFronzo, R. A., & Shulman, R. G. (1990) · New England Journal of Medicine · doi:10.1056/nejm199001253220403 · Cited by 1,248 · see citing works

Metabolic effects of metformin in non-insulin-dependent diabetes mellitus

Stumvoll, M., Nurjhan, N., Perriello, G., Dailey, G., & Gerich, J. E. (1995) · New England Journal of Medicine · doi:10.1056/nejm199508313330903 · Cited by 1,148 · see citing works

Traditional Plant Medicines as Treatments for Diabetes

Bailey, C. J., & Day, C. (1989) · Diabetes Care · doi:10.2337/diacare.12.8.553 · Cited by 833 · see citing works

U.K. prospective diabetes study 16. Overview of 6 years' therapy of type II diabetes: a progressive disease. U.K. Prospective Diabetes Study Group

(1995) · Diabetes · doi:10.2337/diabetes.44.11.1249 · Cited by 796 · see citing works

Biguanides and NIDDM

Bailey, C. J. (1992) · Diabetes Care · doi:10.2337/diacare.15.6.755 · Cited by 596 · see citing works

Insulin and Atheroma: 20-Yr Perspective

Stout, R. W. (1990) · Diabetes Care · doi:10.2337/diacare.13.6.631 · Cited by 570 · see citing works

Mortality and survival in Type 2 (non-insulin-dependent) diabetes mellitus

Panzram, G. (1987) · Diabetologia · doi:10.1007/bf00274216 · Cited by 541 · see citing works

United Kingdom prospective diabetes study (UKPDS) 13: relative efficacy of randomly allocated diet, sulphonylurea, insulin, or metformin in patients with newly diagnosed non-insulin dependent diabetes followed for three years

(1995) · BMJ · doi:10.1136/bmj.310.6972.83 · Cited by 478 · see citing works

Oral Hypoglycemic Agents

Oates, J. A., Wood, A. J. J., & Gerich, J. E. (1989) · New England Journal of Medicine · doi:10.1056/nejm198911023211805 · Cited by 476 · see citing works

Mechanism of metformin action in obese and lean noninsulin-dependent diabetic subjects

DEFRONZO, R. A., BARZILAI, N., & SIMONSON, D. C. (1991) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-73-6-1294 · Cited by 408 · see citing works

Sulfonylureas in NIDDM

Groop, L. C. (1992) · Diabetes Care · doi:10.2337/diacare.15.6.737 · Cited by 408 · see citing works

Effects of Metformin on Insulin Resistance, Risk Factors for Cardiovascular Disease, and Plasminogen Activator Inhibitor in NIDDM Subjects: A study of two ethnic groups

Nagi, D. K., & Yudkin, J. S. (1993) · Diabetes Care · doi:10.2337/diacare.16.4.621 · Cited by 353 · see citing works

Prevalence of micro- and macroalbuminuria, arterial hypertension, retinopathy and large vessel disease in European Type 2 (non-insulin-dependent) diabetic patients

Gall, M. ‐., Rossing, P. R., Sk�tt, P., Damsbo, P., Vaag, A. A., Bech, K., Dejgaard, A., Lauritzen, M., Lauritzen, E., Hougaard, P., et al. (1991) · Diabetologia · doi:10.1007/bf00400995 · Cited by 351 · see citing works

Therapeutic Comparison of Metformin and Sulfonylurea, Alone and in Various Combinations: A double-blind controlled study

Hermann, L. S., Scherstén, B., Bitzén, P.-O., Kjellström, T., Lindgärde, F., & Melander, A. (1994) · Diabetes Care · doi:10.2337/diacare.17.10.1100 · Cited by 343 · see citing works

UK Prospective Diabetes Study 7: response of fasting plasma glucose to diet therapy in newly presenting type II diabetic patients

(1990) · Metabolism · doi:10.1016/0026-0495(90)90299-r · Cited by 288 · see citing works

Prevalence of diabetes and impaired glucose tolerance and plasma glucose levels in U.S. population aged 20-74 yr

Harris, M. I., Hadden, W. C., Knowler, W. C., et al. (1987) · Diabetes · doi:10.2337/diabetes.36.4.523 · Cited by 288 · see citing works

Reduction of metformin renal tubular secretion by cimetidine in man.

Somogyi, A. A., Stockley, C. S., Keal, J., Rolan, P. E., & Bochner, F. (1987) · British Journal of Clinical Pharmacology · doi:10.1111/j.1365-2125.1987.tb03090.x · Cited by 281 · see citing works

Effect of Metformin on Carbohydrate and Lipoprotein Metabolism in NIDDM Patients

Wu, M. ‐., Johnston, P., Sheu, W. H., Hollenbeck, C. B., Jeng, C., Goldfine, I. D., Chen, Y. D., & Reaven, G. M. (1990) · Diabetes Care · doi:10.2337/diacare.13.1.1 · Cited by 257 · see citing works

Cellular mechanism of metformin action involves glucose transporter translocation from an intracellular pool to the plasma membrane in L6 muscle cells

Hundal, H. S., Ramlal, T., Reyes, R., Leiter, L. A., & Klip, A. (1992) · Endocrinology · doi:10.1210/endo.131.3.1505458 · Cited by 243 · see citing works

Comparative Tolerability Profiles of Oral Antidiabetic Agents

Krentz, A. J., Ferner, R. E., & Bailey, C. J. (1994) · Drug Safety · doi:10.2165/00002018-199411040-00002 · Cited by 209 · see citing works

Banting lecture 1990. Beta-cells in type II diabetes mellitus

Porte, D. (1991) · Diabetes · doi:10.2337/diabetes.40.2.166 · Cited by 150 · see citing works

Effect of metformin on glucose metabolism in the splanchnic bed

Bailey, C. J., Wilcock, C., & Day, C. (1992) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.1992.tb09093.x · Cited by 129 · see citing works

Biguanide-associated lactic acidosis. Case report and review of the literature

Gan, S. C. (1992) · Archives of Internal Medicine · doi:10.1001/archinte.152.11.2333 · Cited by 129 · see citing works

Predominant role of gluconeogenesis in increased hepatic glucose production in NIDDM

Consoli, A., Nurjhan, N., Capani, F., et al. (1989) · Diabetes · doi:10.2337/diabetes.38.5.550 · Cited by 126 · see citing works

Similar reduction of first- and second-phase B-cell responses at three different glucose levels in type II diabetes and the effect of gliclazide therapy

Hosker, J. P., Rudenski, A. S., Burnett, M. A., Matthews, D. R., & Turner, R. C. (1989) · Metabolism · doi:10.1016/0026-0495(89)90064-4 · Cited by 125 · see citing works

Effect of metformin on insulin-stimulated glucose transport in isolated skeletal muscle obtained from patients with NIDDM

Galuska, D., Nolte, L. A., Zierath, J. R., & Wallberg‐Henriksson, H. (1994) · Diabetologia · doi:10.1007/bf00404340 · Cited by 121 · see citing works

Effect of metformin treatment on insulin action in diabetic rats: In vivo and in vitro correlations

Rossetti, L., DeFronzo, R. A., Gherzi, R., Stein, P., Andraghetti, G., Falzetti, G., Shulman, G. I., Klein-Robbenhaar, E., & Cordera, R. (1990) · Metabolism · doi:10.1016/0026-0495(90)90259-f · Cited by 111 · see citing works

Metformin—An update

Bailey, C. J. (1993) · General Pharmacology The Vascular System · doi:10.1016/0306-3623(93)90411-p · Cited by 110 · see citing works

Inhibition of hepatic gluconeogenesis by metformin

Wollen, N., & Bailey, C. J. (1988) · Biochemical Pharmacology · doi:10.1016/0006-2952(88)90617-x · Cited by 109 · see citing works

Diarrhea and Metformin in a Diabetic Clinic

Dandona, P., Fonseca, V., Mier, A., & Beckett, A. G. (1983) · Diabetes Care · doi:10.2337/diacare.6.5.472 · Cited by 109 · see citing works

Hypoglycaemic effect of metformin in genetically obese (fa/fa) rats results from an increased utilization of blood glucose by intestine

Pénicaud, L., Hitier, Y., Ferré, P., & Girard, J. R. (1989) · Biochemical Journal · doi:10.1042/bj2620881 · Cited by 105 · see citing works

Natural History of Pancreatic Islet B‐Cell Function in Type 2 Diabetes Mellitus Studied over Six Years by Homeostasis Model Assessment

Rudenski, A. S., Hadden, D. R., Atkinson, A. B., Kennedy, L., Matthews, D. R., Merrett, J. D., Pockaj, B. A., & Turner, R. C. (1988) · Diabetic Medicine · doi:10.1111/j.1464-5491.1988.tb00938.x · Cited by 97 · see citing works

Different effects of insulin and oral antidiabetic agents on glucose and energy metabolism in Type 2 (non-insulin-dependent) diabetes mellitus

Groop, L., Wid�n, E., Franssila-Kallunki, A., Ekstrand, A., Saloranta, C., Schalin, C., & Eriksson, J. G. (1989) · Diabetologia · doi:10.1007/bf00285334 · Cited by 96 · see citing works

Combined metformin-sulfonylurea treatment of patients with noninsulin- dependent diabetes in fair to poor glycemic control

Reaven, G. M., Johnston, P., Hollenbeck, C. B., Skowroński, R., Zhang, J. C., Goldfine, I. D., & Chen, Y. I. (1992) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.74.5.1569149 · Cited by 96 · see citing works

Standards of Medical Care for Patients With Diabetes Mellitus: American Diabetes Association

(1994) · Diabetes Care · doi:10.2337/diacare.17.6.616 · Cited by 95 · see citing works

Biguanides

Nattrass, M., & Alberti, K. G. M. M. (1978) · Diabetologia · doi:10.1007/bf01263443 · Cited by 91 · see citing works

Comparison of metformin and chlorpropamide in non-obese, maturity-onset diabetics uncontrolled by diet.

Clarke, B. F., & Campbell, I. W. (1977) · BMJ · doi:10.1136/bmj.2.6102.1576 · Cited by 89 · see citing works

In vivo metformin treatment ameliorates insulin resistance: evidence for potentiation of insulin-induced translocation and increased functional activity of glucose transporters in obese (fa/fa) Zucker rat adipocytes

Matthaei, S., Reibold, J. P., Hamann, A., Benecke, H., Häring, H.-U., Greten, H., & Klein, H. H. (1993) · Endocrinology · doi:10.1210/endo.133.1.8391425 · Cited by 83 · see citing works

Metformin Causes a Reduction in Basal and Post‐venous Occlusion Plasminogen Activator Inhibitor‐1 in Type 2 Diabetic Patients

Grant, P. J., Stickland, M. H., Booth, N. A., et al. (1991) · Diabetic Medicine · doi:10.1111/j.1464-5491.1991.tb01610.x · Cited by 78 · see citing works

Mechanism of metformin action in non-insulin-dependent diabetes

Jackson, R. A., Hawa, M. I., Jaspan, J. B., et al. (1987) · Diabetes · doi:10.2337/diabetes.36.5.632 · Cited by 70 · see citing works

11 Treatment—metformin

Bailey, C. J., & Nattrass, M. (1988) · Baillière s Clinical Endocrinology and Metabolism · doi:10.1016/s0950-351x(88)80043-0 · Cited by 68 · see citing works

Influence of oxidation polymorphism on phenformin kinetics and dynamics

Oates, N. S., Shah, R. R., Idle, J. R., & Smith, R. L. (1983) · Clinical Pharmacology & Therapeutics · doi:10.1038/clpt.1983.257 · Cited by 62 · see citing works

Biguanides and Sulfonylureas as Combination Therapy in NIDDM

Hermann, L. S. (1990) · Diabetes Care · doi:10.2337/diacare.13.3.37 · Cited by 61 · see citing works

Acute antihyperglycemic mechanisms of metformin in NIDDM. Evidence for suppression of lipid oxidation and hepatic glucose production

Perriello, G., Misericordia, P., Volpi, E., et al. (1994) · Diabetes · doi:10.2337/diabetes.43.7.920 · Cited by 60 · see citing works

Metformin and glibenclamide: comparative risks.

Campbell, I. W. (1984) · BMJ · doi:10.1136/bmj.289.6440.289 · Cited by 42 · see citing works

Dual effect of metformin in cultured rat hepatocytes: Potentiation of insulin action and prevention of insulin-induced resistance

Melin, B., Cherqui, G., Eggelpoël, M.-J. B.-V., Caron, M., Lascols, O., Capeau, J., & Picard, J. (1990) · Metabolism · doi:10.1016/0026-0495(90)90171-8 · Cited by 38 · see citing works

Association of Metformin's effect to increase insulin-stimulated glucose transport with potentiation of insulin-induced translocation of glucose transporters from intracellular pool to plasma membrane in rat adipocytes

Matthaei, S., Hamann, A., Klein, H. H., et al. (1991) · Diabetes · doi:10.2337/diabetes.40.7.850 · Cited by 32 · see citing works

Metformin blocks downregulation of cell surface GLUT4 caused by chronic insulin treatment of rat adipocytes

Kozka, I. J., & Holman, G. D. (1993) · Diabetes · doi:10.2337/diabetes.42.8.1159 · Cited by 13 · see citing works

Hypoglycaemic, Antihyperglycaemic and Antidiabetic Drugs

Bailey, C. J. (1992) · Diabetic Medicine · doi:10.1111/j.1464-5491.1992.tb01822.x · Cited by 12 · see citing works

Effect of intensive blood-glucose control with metformin on complications in overweight patients with type 2 diabetes (UKPDS 34)

(1998) · The Lancet · doi:10.1016/s0140-6736(98)07037-8 · Cited by 8,247 · see citing works

Management of hyperglycaemia in type 2 diabetes: a patient-centered approach. Position statement of the American Diabetes Association (ADA) and the European Association for the Study of Diabetes (EASD)

Inzucchi, S. E., Bergenstal, R. M., Buse, J. B., Diamant, M., Ferrannini, E., Nauck, M., Peters, A. L., Tsapas, A., Wender, R., & Matthews, D. R. (2012) · Diabetologia · doi:10.1007/s00125-012-2534-0 · Cited by 3,919 · see citing works

Medical Management of Hyperglycemia in Type 2 Diabetes: A Consensus Algorithm for the Initiation and Adjustment of Therapy

Nathan, D. M., Buse, J. B., Davidson, M. B., Ferrannini, E., Holman, R. R., Sherwin, R., & Zinman, B. (2009) · Diabetes Care · doi:10.2337/dc08-9025 · Cited by 3,834 · see citing works

Management of Hyperglycemia in Type 2 Diabetes: A Patient-Centered Approach

Inzucchi, S. E., Bergenstal, R. M., Buse, J. B., Diamant, M., Ferrannini, E., Nauck, M., Peters, A. L., Tsapas, A., Wender, R., & Matthews, D. R. (2012) · Diabetes Care · doi:10.2337/dc12-0413 · Cited by 3,207 · see citing works

Type 2 diabetes: principles of pathogenesis and therapy

Stumvoll, M., Goldstein, B. J., & van Haeften, T. W. (2005) · The Lancet · doi:10.1016/s0140-6736(05)61032-x · Cited by 2,662 · see citing works

Diabetic nephropathy: diagnosis, prevention, and treatment

Gross, J. L., de Azevedo, M. J., Silveiro, S. P., Canani, L. H., Caramori, M. L., & Zelmanovitz, T. (2005) · Diabetes Care · doi:10.2337/diacare.28.1.164 · Cited by 1,839 · see citing works

A graphene-based electrochemical device with thermoresponsive microneedles for diabetes monitoring and therapy

Lee, H., Choi, T. K., Lee, Y. B., Cho, H. R., Ghaffari, R., Wang, L., Choi, H. J., Chung, T. D., Lu, N., Hyeon, T., et al. (2016) · Nature Nanotechnology · doi:10.1038/nnano.2016.38 · Cited by 1,802 · see citing works

An increase in the <i>Akkermansia</i> spp. population induced by metformin treatment improves glucose homeostasis in diet-induced obese mice

Shin, N.-R., Lee, J.-C., Lee, H.-Y., Kim, M.-S., Whon, T. W., Lee, M.-S., & Bae, J.-W. (2014) · Gut · doi:10.1136/gutjnl-2012-303839 · Cited by 1,550 · see citing works

Dimethylbiguanide inhibits cell respiration via an indirect effect targeted on the respiratory chain complex I

El-Mir, M.-Y., Nogueira, V., Fontaine, E., Avéret, N., Rigoulet, M., & Leverve, X. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.275.1.223 · Cited by 1,399 · see citing works

KDIGO 2020 Clinical practice guideline for diabetes management in chronic kidney disease

de Boer, I. H., Caramori, M. L., Chan, J. C. N., Heerspink, H. J. L., Hurst, C., Khunti, K., Liew, A., Michos, E. D., Navaneethan, S. D., Olowu, W. A., et al. (2020) · Kidney International · doi:10.1016/j.kint.2020.06.019 · Cited by 1,399 · see citing works

KDIGO 2022 Clinical Practice Guideline for Diabetes Management in Chronic Kidney Disease

Rossing, P., Caramori, M. L., Chan, J. C. N., Heerspink, H. J. L., Hurst, C., Khunti, K., Liew, A., Michos, E. D., Navaneethan, S. D., Olowu, W. A., et al. (2022) · Kidney International · doi:10.1016/j.kint.2022.06.008 · Cited by 1,373 · see citing works

Metformin Inhibits Hepatic Gluconeogenesis in Mice Independently of the LKB1/AMPK Pathway via a Decrease in Hepatic Energy State

Foretz, M., Hébrard, S., Leclerc, J., Zarrinpashneh, E., Soty, M., Mithieux, G., Sakamoto, K., Andreelli, F., & Viollet, B. (2010) · Journal of Clinical Investigation · doi:10.1172/jci40671 · Cited by 1,181 · see citing works

Pharmacologic Therapy for Type 2 Diabetes Mellitus

DeFronzo, R. A. (1999) · Annals of Internal Medicine · doi:10.7326/0003-4819-131-4-199908170-00008 · Cited by 1,173 · see citing works

Metformin inhibits mitochondrial complex I of cancer cells to reduce tumorigenesis

Wheaton, W. W., Weinberg, S. E., Hamanaka, R. B., Soberanes, S., Sullivan, L. B., Anso, E., Glasauer, A., Dufour, E., Mutlu, G. M., Budigner, G. S., et al. (2014) · eLife · doi:10.7554/elife.02242 · Cited by 1,105 · see citing works

Mechanism by which metformin reduces glucose production in type 2 diabetes.

Hundal, R. S., Krssak, M., Dufour, S., Laurent, D., Lebon, V, Chandramouli, V, Inzucchi, S. E., Schumann, W. C., Petersen, K. F., Landau, B. R., et al. (2000) · Diabetes · doi:10.2337/diabetes.49.12.2063 · Cited by 1,052 · see citing works

Metformin: An Update

Kirpichnikov, D., McFarlane, S. I., & Sowers, J. R. (2002) · Annals of Internal Medicine · doi:10.7326/0003-4819-137-1-200207020-00009 · Cited by 1,084 · see citing works

Increased Cancer-Related Mortality for Patients With Type 2 Diabetes Who Use Sulfonylureas or Insulin

Bowker, S. L., Majumdar, S. R., Veugelers, P., & Johnson, J. A. (2006) · Diabetes Care · doi:10.2337/diacare.29.02.06.dc05-1558 · Cited by 933 · see citing works

Single phosphorylation sites in Acc1 and Acc2 regulate lipid homeostasis and the insulin-sensitizing effects of metformin

Fullerton, M. D., Galic, S., Marcinko, K., Sikkema, S., Pulinilkunnil, T., Chen, Z.-P., O'Neill, H. M., Ford, R. J., Palanivel, R., O'Brien, M., et al. (2013) · Nature Medicine · doi:10.1038/nm.3372 · Cited by 893 · see citing works

Metformin, independent of AMPK, inhibits mTORC1 in a rag GTPase-dependent manner

Kalender, A., Selvaraj, A., Kim, S. Y., Gulati, P., Brûlé, S., Viollet, B., Kemp, B. E., Bardeesy, N., Dennis, P., Schlager, J. J., et al. (2010) · Cell Metabolism · doi:10.1016/j.cmet.2010.03.014 · Cited by 889 · see citing works

The Diabetes Prevention Program. Design and methods for a clinical trial in the prevention of type 2 diabetes

(1999) · Diabetes Care · doi:10.2337/diacare.22.4.623 · Cited by 725 · see citing works

Medical management of hyperglycaemia in type 2 diabetes mellitus: a consensus algorithm for the initiation and adjustment of therapy: A consensus statement from the American Diabetes Association and the European Association for the Study of Diabetes

Nathan, D. M., Buse, J. B., Davidson, M. B., Ferrannini, E., Holman, R. R., Sherwin, R., & Zinman, B. (2009) · Diabetologia · doi:10.1007/s00125-008-1157-y · Cited by 712 · see citing works

Metformin-associated lactic acidosis: current perspectives on causes and risk

DeFronzo, R., Fleming, G. A., Chen, K., & Bicsak, T. A. (2016) · Metabolism · doi:10.1016/j.metabol.2015.10.014 · Cited by 658 · see citing works

Consensus statement by the American Association of Clinical Endocrinologists and American College of Endocrinology on the comprehensive type 2 diabetes management algorithm - 2020 executive summary

Garber, A. J., Handelsman, Y., Grunberger, G., Einhorn, D., Abrahamson, M. J., Barzilay, J. I., Blonde, L., Bush, M. A., DeFronzo, R. A., Garber, J. R., et al. (2020) · Endocrine Practice · doi:10.4158/cs-2019-0472 · Cited by 598 · see citing works

Metformin: An Old But Still the Best Treatment for Type 2 Diabetes

Rojas, L. B. A., & Gomes, M. B. (2013) · Diabetology &amp; Metabolic Syndrome · doi:10.1186/1758-5996-5-6 · Cited by 567 · see citing works

American Association of Clinical Endocrinologists and American College of Endocrinology - clinical practice guidelines for developing a diabetes mellitus comprehensive care plan - 2015

Handelsman, Y., Bloomgarden, Z. T., Grunberger, G., Umpierrez, G., Zimmerman, R. S., Bailey, T. S., Blonde, L., Bray, G. A., Cohen, A. J., Dagogo-Jack, S., et al. (2015) · Endocrine Practice · doi:10.4158/ep15672.glsuppl · Cited by 559 · see citing works

Improved Endothelial Function With Metformin in Type 2 Diabetes Mellitus

Mather, K. J., Verma, S., & Anderson, T. J. (2001) · Journal of the American College of Cardiology · doi:10.1016/s0735-1097(01)01129-9 · Cited by 513 · see citing works

American Association of Clinical Endocrinology Clinical Practice Guideline: Developing a Diabetes Mellitus Comprehensive Care Plan-2022 Update.

Blonde, L., Umpierrez, G. E., Reddy, S. S., McGill, J. B., Berga, S. L., Bush, M., Chandrasekaran, S., DeFronzo, R. A., Einhorn, D., Galindo, R. J., et al. (2022) · Endocrine Practice · doi:10.1016/j.eprac.2022.08.002 · Cited by 507 · see citing works

Molecular mechanism of action of metformin: old or new insights?

Rena, G., Pearson, E. R., & Sakamoto, K. (2013) · Diabetologia · doi:10.1007/s00125-013-2991-0 · Cited by 479 · see citing works

Consensus statement by the American Association of Clinical Endocrinologists and American College of Endocrinology on the comprehensive type 2 diabetes management algorithm – 2017 executive summary

Garber, A. J., Abrahamson, M. J., Barzilay, J. I., Blonde, L., Bloomgarden, Z. T., Bush, M. A., Dagogo-Jack, S., DeFronzo, R. A., Einhorn, D., Fonseca, V. A., et al. (2017) · Endocrine Practice · doi:10.4158/ep161682.cs · Cited by 435 · see citing works

Evidence-based and potential benefits of metformin in the polycystic ovary syndrome: A comprehensive review

Palomba, S., Falbo, A., Zullo, F., & Orio, F. (2009) · Endocrine Reviews · doi:10.1210/er.2008-0030 · Cited by 426 · see citing works

Use of Metformin in the Setting of Mild-to-Moderate Renal Insufficiency

Lipska, K. J., Bailey, C. J., & Inzucchi, S. E. (2011) · Diabetes Care · doi:10.2337/dc10-2361 · Cited by 432 · see citing works

Metformin Inhibits Hepatic Gluconeogenesis Through AMP-Activated Protein Kinase–Dependent Regulation of the Orphan Nuclear Receptor SHP

Kim, Y. D., Park, K.-G., Lee, Y.-S., Park, Y.-Y., Kim, D.-K., Nedumaran, B., Jang, W. G., Cho, W.-J., Ha, J., Lee, I.-K., et al. (2008) · Diabetes · doi:10.2337/db07-0381 · Cited by 422 · see citing works

Management of hyperglycaemia in type 2 diabetes: a consensus algorithm for the initiation and adjustment of therapy: A consensus statement from the American Diabetes Association and the European Association for the Study of Diabetes

Nathan, D. M., Buse, J. B., Davidson, M. B., Heine, R. J., Holman, R. R., Sherwin, R., & Zinman, B. (2006) · Diabetologia · doi:10.1007/s00125-006-0316-2 · Cited by 420 · see citing works

Pharmacology and therapeutic implications of current drugs for type 2 diabetes mellitus

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Metformin reduces endogenous reactive oxygen species and associated DNA damage

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