Diabetes, pancreatogenic diabetes, and pancreatic cancer
Open accessAbstract
The relationships between diabetes and pancreatic ductal adenocarcinoma (PDAC) are complex. Longstanding type 2 diabetes (T2DM) is a risk factor for pancreatic cancer, but increasing epidemiological data point to PDAC as also a cause of diabetes due to unknown mechanisms. New-onset diabetes is of particular interest to the oncology community as the differentiation of new-onset diabetes caused by PDAC as distinct from T2DM may allow for earlier diagnosis of PDAC. To address these relationships and raise awareness of the relationships between PDAC and diabetes, a symposium entitled Diabetes, Pancreatogenic Diabetes, and Pancreatic Cancer was held at the American Diabetes Association’s 76th Scientific Sessions in June 2016. This article summarizes the data presented at that symposium, describing the current understanding of the interrelationships between diabetes, diabetes management, and pancreatic cancer, and identifies areas where additional research is needed.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
A distinguishing feature of pancreatic diabetes is concurrent pancreatic exocrine insufficiency, pathological pancreatic imaging, and absence of type 1 diabetes-associated autoimmunity.
“A distinguishing feature is concurrent pancreatic exocrine insuf fi ciency (consider screening individuals with acute and chronic pancreatitis for exocrine pancreatic insuf fi ciency by measuring fecal elastase), pathological pancreatic imaging (endoscopic ultrasound, MRI, and computed tomography), and absence of type 1 diabetes -associated autoimmunity (116 -120).”
From 2. Diagnosis and Classification of Diabetes: <i>Standards of Care in Diabetes—2024</i> (2024) · cites this paper as [119]
New-onset diabetes can be considered an early warning sign of pancreatic ductal adenocarcinoma.
“Thus, new-onset diabetes can be considered an early warning sign of pancreatic ductal adenocarcinoma,22”
From Early detection of pancreatic cancer (2020) · cites this paper as [22]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Siegel, R. L., Miller, K. D., & Jemal, A. (2016) · CA: A Cancer Journal for Clinicians · doi:10.3322/caac.21332 · Cited by 16,003 · see citing works
The metabolic phenotype in obesity: Fat mass, body fat distribution, and adipose tissue function
Goossens, G. H. (2017) · Obesity Facts · doi:10.1159/000471488 · Cited by 8,481 · see citing works
Rahib, L., Smith, B. D., Aizenberg, R., Rosenzweig, A. B., Fleshman, J. M., & Matrisian, L. M. (2014) · Cancer Research · doi:10.1158/0008-5472.can-14-0155 · Cited by 7,094 · see citing works
Prevalence of and Trends in Diabetes Among Adults in the United States, 1988-2012
Menke, A., Casagrande, S., Geiss, L., & Cowie, C. C. (2015) · JAMA · doi:10.1001/jama.2015.10029 · Cited by 2,362 · see citing works
Kahn, S. E. (2003) · Diabetologia · doi:10.1007/s00125-002-1009-0 · Cited by 2,166 · cited 1× · see citing works
“Concomitantly, there is failure to enhance peripheral (predominantly skeletal muscle) glucose utilization, with initially increased insulin levels, as the b-cell attempts to overcome the insulin resistance (9).”
BackgroundWellcome Trust Case Control Consortium, Zeggini, E., Scott, L. J., Saxena, R., Voight, B. F., Marchini, J. L., Hu, T., de Bakker, P. I., Abecasis, G. R., Almgren, P., et al. (2008) · Nature Genetics · doi:10.1038/ng.120 · Cited by 1,864 · see citing works
Metformin suppresses gluconeogenesis by inhibiting mitochondrial glycerophosphate dehydrogenase
Madiraju, A. K., Erion, D. M., Rahimi, Y., Zhang, X.-M., Braddock, D. T., Albright, R. A., Prigaro, B. J., Wood, J. L., Bhanot, S., MacDonald, M. J., et al. (2014) · Nature · doi:10.1038/nature13270 · Cited by 1,284 · see citing works
The genetic architecture of type 2 diabetes
Fuchsberger, C., Flannick, J., Teslovich, T. M., Mahajan, A., Agarwala, V., Gaulton, K. J., Ma, C., Fontanillas, P., Moutsianas, L., McCarthy, D. J., et al. (2016) · Nature · doi:10.1038/nature18642 · Cited by 1,051 · see citing works
Exomic Sequencing Identifies <i>PALB2</i> as a Pancreatic Cancer Susceptibility Gene
Jones, S., Hruban, R. H., Kamiyama, M., Borges, M., Zhang, X., Parsons, D. W., Lin, J. C.-H., Palmisano, E., Brune, K., Jaffee, E. M., et al. (2009) · Science · doi:10.1126/science.1171202 · Cited by 826 · cited 2× · see citing works
“Susceptibility genes that have been identified range from rare mutations in genes associated with cancer syndromes to common SNPs. Designs that include familybased and case-control studies have uncovered mutations in known syndrome-related genes, such as BRCA1, BRCA2, CDKN2A, and CFTR. Next-generation sequencing has i…”
BackgroundObesity and cancer—mechanisms underlying tumour progression and recurrence
Park, J., Morley, T. S., Kim, M. G., Clegg, D. J., & Scherer, P. E. (2014) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2014.94 · Cited by 792 · see citing works
Genotype score in addition to common risk factors for prediction of type 2 diabetes
Meigs, J. B., Shrader, P., Sullivan, L. M., McAteer, J. B., Fox, C. S., Dupuis, J., Manning, A. K., Florez, J. C., Wilson, P. W. F., D'Agostino, R. B., et al. (2008) · New England Journal of Medicine · doi:10.1056/nejmoa0804742 · Cited by 759 · cited 1× · see citing works
“Interestingly, despite these efforts, the genetic variants do not significantly improve risk assessment over common risk factors such as age, sex, family history, BMI, and clinical measures (16).”
BackgroundDiabetes mellitus as a risk factor for pancreatic cancer. A meta-analysis
Everhart, J. (1995) · JAMA · doi:10.1001/jama.273.20.1605 · Cited by 747 · see citing works
Adiposity and cancer risk: new mechanistic insights from epidemiology
Renehan, A. G., Zwahlen, M., & Egger, M. (2015) · Nature Reviews Cancer · doi:10.1038/nrc3967 · Cited by 654 · see citing works
Prevalence and Clinical Profile of Pancreatic Cancer–Associated Diabetes Mellitus
Pannala, R., Leirness, J. B., Bamlet, W. R., Basu, A., Petersen, G. M., & Chari, S. T. (2008) · Gastroenterology · doi:10.1053/j.gastro.2008.01.039 · Cited by 621 · see citing works
Self-citation<i>ATM</i> Mutations in Patients with Hereditary Pancreatic Cancer
Roberts, N. J., Jiao, Y., Yu, J., Kopelovich, L., Petersen, G. M., Bondy, M. L., Gallinger, S., Schwartz, A. G., Syngal, S., Cote, M. L., et al. (2012) · Cancer Discovery · doi:10.1158/2159-8290.cd-11-0194 · Cited by 491 · see citing works
Self-citationWhitcomb, D. C., LaRusch, J., Krasinskas, A. M., Klei, L., Smith, J. P., Brand, R. E., Neoptolemos, J. P., Lerch, M. M., Tector, M., Sandhu, B. S., et al. (2012) · Nature Genetics · doi:10.1038/ng.2466 · Cited by 352 · see citing works
New insights into pancreatic cancer-induced paraneoplastic diabetes
Sah, R. P., Nagpal, S. J. S., Mukhopadhyay, D., & Chari, S. T. (2013) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/nrgastro.2013.49 · Cited by 336 · see citing works
Self-citationPrevalence of diabetes mellitus secondary to pancreatic diseases (type 3c)
Ewald, N., Kaufmann, C., Raspe, A., Kloer, H. U., Bretzel, R. G., & Hardt, P. D. (2011) · Diabetes/Metabolism Research and Reviews · doi:10.1002/dmrr.2260 · Cited by 307 · see citing works
Pancreatogenic Diabetes: Special Considerations for Management
Cui, Y., & Andersen, D. K. (2011) · Pancreatology · doi:10.1159/000329188 · Cited by 255 · see citing works
Self-citationPhilip, B., Roland, C. L., Daniluk, J., Liu, Y., Chatterjee, D., Gomez, S., Ji, B., Huang, H., Wang, H., Fleming, J. B., et al. (2013) · Gastroenterology · doi:10.1053/j.gastro.2013.08.018 · Cited by 249 · see citing works
Rickels, M. R., Bellin, M., Toledo, F. G. S., Robertson, R. P., Andersen, D. K., Chari, S. T., Brand, R., Frulloni, L., Anderson, M. A., & Whitcomb, D. C. (2013) · Pancreatology · doi:10.1016/j.pan.2013.05.002 · Cited by 249 · see citing works
Self-citationImproved glucose metabolism after subtotal pancreatectomy for pancreatic cancer
Permert, J., Ihse, I., Jorfeldt, L., von Schenck, H., Arnquist, H. J., & Larsson, D. G. J. (1993) · British journal of surgery · doi:10.1002/bjs.1800800841 · Cited by 241 · see citing works
Diabetes mellitus secondary to pancreatic diseases (type 3c)—are we neglecting an important disease?
Ewald, N., & Bretzel, R. G. (2013) · European Journal of Internal Medicine · doi:10.1016/j.ejim.2012.12.017 · Cited by 235 · see citing works
RAGE Regulates the Metabolic and Inflammatory Response to High-Fat Feeding in Mice
Song, F., del Pozo, C. H., Rosario, R., Zou, Y. S., Ananthakrishnan, R., Xu, X., Patel, P. R., Benoit, V. M., Yan, S. F., Li, H., et al. (2014) · Diabetes · doi:10.2337/db13-1636 · Cited by 205 · see citing works
Is pancreatic diabetes (type 3c diabetes) underdiagnosed and misdiagnosed?
Hardt, P. D., Brendel, M. D., Kloer, H. U., & Bretzel, R. G. (2008) · Diabetes Care · doi:10.2337/dc08-s244 · Cited by 194 · see citing works
Pelaez-Luna, M., Takahashi, N., Fletcher, J. G., & Chari, S. T. (2007) · The American Journal of Gastroenterology · doi:10.1111/j.1572-0241.2007.01480.x · Cited by 180 · see citing works
Self-citationWolpin, B. M., Bao, Y., Qian, Z. R., Wu, C. H., Kraft, P., Ogino, S., Stampfer, M. J., Sato, K., Ma, J., Buring, J. E., et al. (2013) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/djt123 · Cited by 178 · see citing works
Wang, Z., Lai, S.-T., Xie, L., Zhao, J.-D., Ma, N.-Y., Zhu, J., Ren, Z.-G., & Jiang, G.-L. (2014) · Diabetes Research and Clinical Practice · doi:10.1016/j.diabres.2014.04.007 · Cited by 176 · see citing works
Genetic Aspects of Pancreatitis
Whitcomb, D. C. (2010) · Annual Review of Medicine · doi:10.1146/annurev.med.041608.121416 · Cited by 175 · see citing works
Genetics of type 2 diabetes: pathophysiologic and clinical relevance
Herder, C., & Roden, M. (2010) · European Journal of Clinical Investigation · doi:10.1111/j.1365-2362.2010.02454.x · Cited by 174 · see citing works
Prevalence of Diabetes Mellitus in Pancreatic Cancer Compared to Common Cancers
Aggarwal, G., Kamada, P., & Chari, S. T. (2013) · Pancreas · doi:10.1097/mpa.0b013e3182592c96 · Cited by 167 · see citing works
Self-citationDawson, D. W., Hertzer, K. M., Moro, A., Donald, G. W., Chang, H.-H., Go, V. L. W., Pandol, S. J., Lugea, A., Gukovskaya, A. S., Li, G., et al. (2013) · Cancer Prevention Research · doi:10.1158/1940-6207.capr-13-0065 · Cited by 155 · see citing works
Self-citationKlein, A. P., Lindström, S., Mendelsohn, J. B., Steplowski, E., Arslan, A. A., Bueno-de-Mesquita, H. B., Fuchs, C. S., Gallinger, S., Gross, M., Helzlsouer, K., et al. (2013) · PLoS ONE · doi:10.1371/journal.pone.0072311 · Cited by 148 · see citing works
Self-citationGenetic predisposition for beta cell fragility underlies type 1 and type 2 diabetes
Dooley, J., Tian, L., Schönefeldt, S., Delghingaro‐Augusto, V., Garcia‐Perez, J. E., Pasciuto, E., Marino, D. D., Carr, E. J., Oskolkov, N., Lyssenko, V., et al. (2016) · Nature Genetics · doi:10.1038/ng.3531 · Cited by 147 · see citing works
Cancer Risk for Patients Using Thiazolidinediones for Type 2 Diabetes: A Meta-Analysis
Bosetti, C., Rosato, V., Buniato, D., Zambon, A., Vecchia, C. L., & Corrao, G. (2013) · The Oncologist · doi:10.1634/theoncologist.2012-0302 · Cited by 144 · see citing works
Prevalence of pathogenic mutations in cancer predisposition genes among pancreatic cancer patients
Hu, C., Hart, S. N., Bamlet, W. R., Moore, R. M., Nandakumar, K., Eckloff, B. W., Lee, Y. K., Petersen, G. M., McWilliams, R. R., & Couch, F. J. (2016) · Cancer Epidemiology, Biomarkers & Prevention · doi:10.1158/1055-9965.epi-15-0455 · Cited by 137 · see citing works
Self-citationRelationship between the exocrine and endocrine pancreas after acute pancreatitis
Das, S. L. M. (2014) · World Journal of Gastroenterology · doi:10.3748/wjg.v20.i45.17196 · Cited by 116 · see citing works
Funahashi, H., Satake, M., Dawson, D. W., Huynh, N.-A., Reber, H. A., Hines, O. J., & Eibl, G. (2007) · Cancer Research · doi:10.1158/0008-5472.can-07-0970 · Cited by 116 · see citing works
Self-citationHuang, H., Dong, X., Kang, M. X., Xu, B., Chen, Y., Zhang, B., Chen, J., Xie, Q. P., & Wu, Y. (2010) · The American Journal of Gastroenterology · doi:10.1038/ajg.2010.32 · Cited by 110 · see citing works
The role of S100 proteins and their receptor RAGE in pancreatic cancer
Leclerc, E., & Vetter, S. W. (2015) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2015.09.022 · Cited by 93 · see citing works
Body Mass Index and Obesity- and Diabetes-Associated Genotypes and Risk for Pancreatic Cancer
Tang, H., Dong, X., Hassan, M. M., Abbruzzese, J. L., & Li, D. (2011) · Cancer Epidemiology Biomarkers & Prevention · doi:10.1158/1055-9965.epi-10-0845 · Cited by 89 · see citing works
Self-citationColmers-Gray, I. N., Bowker, S. L., Tjosvold, L., & Johnson, J. A. (2012) · Diabetes & Metabolism · doi:10.1016/j.diabet.2012.08.011 · Cited by 86 · see citing works
Pancreatic cancer-derived S-100A8 N-terminal peptide: A diabetes cause?
Basso, D., Greco, E., Fogar, P., Pucci, P., Flagiello, A., Baldo, G., Giunco, S., Valerio, A., Navaglia, F., Zambon, C., et al. (2006) · Clinica Chimica Acta · doi:10.1016/j.cca.2006.03.027 · Cited by 85 · see citing works
Advances in pancreatic cancer research: Moving towards early detection
He, X. (2014) · World Journal of Gastroenterology · doi:10.3748/wjg.v20.i32.11241 · Cited by 80 · see citing works
Visceral adiposity in gastrointestinal and hepatic carcinogenesis
Vongsuvanh, R., George, J., Qiao, L., & van der Poorten, D. (2012) · Cancer Letters · doi:10.1016/j.canlet.2012.11.038 · Cited by 72 · see citing works
Hart, P. A., Baichoo, E., Bi, Y., Hinton, A., Kudva, Y. C., & Chari, S. T. (2015) · Pancreatology · doi:10.1016/j.pan.2015.02.006 · Cited by 51 · see citing works
Self-citationHertzer, K. M., Xu, M., Moro, A., Dawson, D. W., Du, L., Li, G., Chang, H.-H., Stark, A. P., Jung, X., Hines, O. J., et al. (2015) · Pancreas · doi:10.1097/mpa.0000000000000497 · Cited by 50 · see citing works
Self-citationPfeffer, F., Koczan, D., Adam, U., Benz, S. R., von Dobschuetz, E., Prall, F., Nizze, H., Thiesen, H., Hopt, U. T., & Löbler, M. (2004) · Pancreas · doi:10.1097/00006676-200411000-00007 · Cited by 49 · see citing works
The practical importance of recognizing pancreatogenic or type 3c diabetes
Andersen, D. K. (2012) · Diabetes/Metabolism Research and Reviews · doi:10.1002/dmrr.2285 · Cited by 41 · see citing works
Self-citationBeta-cell reserve capacity in chronic pancreatitis.
Domschke, S., Stock, K.-P., Pichl, J., Schneider, M., & Domschke, W. (1985) · PubMed · Cited by 41 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
2. Classification and Diagnosis of Diabetes: <i>Standards of Medical Care in Diabetes—2022</i>
American Diabetes Association Professional Practice Committee (2022) · Diabetes Care · doi:10.2337/dc22-s002 · Cited by 4,792 · see citing works
2. Classification and Diagnosis of Diabetes: <i>Standards of Medical Care in Diabetes—2020</i>
American Diabetes Association (2020) · Diabetes Care · doi:10.2337/dc20-s002 · Cited by 3,187 · see citing works
2. Classification and Diagnosis of Diabetes: <i>Standards of Medical Care in Diabetes—2021</i>
American Diabetes Association (2021) · Diabetes Care · doi:10.2337/dc21-s002 · Cited by 3,116 · see citing works
2. Classification and Diagnosis of Diabetes: Standards of Care in Diabetes—2023
ElSayed, N. A., Aleppo, G., Aroda, V. R., Bannuru, R. R., Brown, F. M., Bruemmer, D., Collins, B. S., Gaglia, J. L., Hilliard, M. E., Isaacs, D. M., et al. (2022) · Diabetes Care · doi:10.2337/dc23-s002 · Cited by 2,646 · see citing works
Mizrahi, J. D., Surana, R., Valle, J. W., & Shroff, R. T. (2020) · The Lancet · doi:10.1016/s0140-6736(20)30974-0 · Cited by 2,559 · see citing works
2. Diagnosis and Classification of Diabetes: <i>Standards of Care in Diabetes—2024</i>
American Diabetes Association Professional Practice Committee, ElSayed, N. A., Aleppo, G., Bannuru, R. R., Bruemmer, D., Collins, B. S., Ekhlaspour, L., Gaglia, J. L., Hilliard, M. E., Johnson, E. L., et al. (2024) · Diabetes Care · doi:10.2337/dc24-s002 · Cited by 2,086 · see citing works
2. Diagnosis and classification of diabetes: standards of care in diabetes-2025
American Diabetes Association Professional Practice Committee, ElSayed, N. A., McCoy, R. G., Aleppo, G., Balapattabi, K., Beverly, E. A., Briggs Early, K., Bruemmer, D., Ebekozien, O., Echouffo-Tcheugui, J. B., et al. (2025) · Diabetes Care · doi:10.2337/dc25-s002 · Cited by 1,393 · see citing works
Pourshams, A., Sepanlou, S. G., Ikuta, K. S., Bisignano, C., Safiri, S., Roshandel, G., Sharif, M., Khatibian, M., Fitzmaurice, C., Nixon, M. R., et al. (2019) · The Lancet. Gastroenterology & hepatology · doi:10.1016/s2468-1253(19)30347-4 · Cited by 666 · see citing works
Kamangar, F., Nasrollahzadeh, D., Safiri, S., Sepanlou, S. G., Fitzmaurice, C., Ikuta, K. S., Bisignano, C., Islami, F., Roshandel, G., Lim, S. S., et al. (2020) · The Lancet. Gastroenterology & hepatology · doi:10.1016/s2468-1253(20)30007-8 · Cited by 648 · see citing works
Pancreatic cancer: A review of epidemiology, trend, and risk factors
Hu, J.-X., Zhao, C., Chen, W.-B., Liu, Q., Li, Q.-W., Lin, Y., & Gao, F. (2021) · World Journal of Gastroenterology · doi:10.3748/wjg.v27.i27.4298 · Cited by 602 · see citing works
Beyer, G., Habtezion, A., Werner, J., Lerch, M., & Mayerle, J. (2020) · The Lancet · doi:10.1016/s0140-6736(20)31318-0 · Cited by 237 · see citing works
Multidisciplinary standards of care and recent progress in pancreatic ductal adenocarcinoma
Grossberg, A. J., Chu, L. C. H., Deig, C. R., Fishman, E. K., Hwang, W. L., Maitra, A., Marks, D. L., Mehta, A., Nabavizadeh, N., Simeone, D. M., et al. (2020) · CA A Cancer Journal for Clinicians · doi:10.3322/caac.21626 · Cited by 491 · see citing works
Early detection of pancreatic cancer
Pereira, S. P., Oldfield, L., Ney, A., Hart, P. A., Keane, M. G., Pandol, S. J., Li, D., Greenhalf, W., Jeon, C. Y., Koay, E. J., et al. (2020) · The Lancet Gastroenterology & Hepatology · doi:10.1016/s2468-1253(19)30416-9 · Cited by 482 · see citing works
Self-citation2. Diagnosis and Classification of Diabetes: Standards of Care in Diabetes—2026
American Diabetes Association Professional Practice Committee for Diabetes*, Bajaj, M., McCoy, R. G., Balapattabi, K., Bannuru, R. R., Bellini, N. J., Bennett, A. K., Beverly, E. A., Briggs Early, K., ChallaSivaKanaka, S., et al. (2026) · Diabetes Care · doi:10.2337/dc26-s002 · Cited by 473 · see citing works
The Role of the Pentose Phosphate Pathway in Diabetes and Cancer
Ge, T., Yang, J., Zhou, S., Wang, Y., Li, Y., & Tong, X. (2020) · Frontiers in Endocrinology · doi:10.3389/fendo.2020.00365 · Cited by 413 · see citing works
Inflammation and Pancreatic Cancer: Focus on Metabolism, Cytokines, and Immunity
Padoan, A., Plebani, M., & Basso, D. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20030676 · Cited by 356 · see citing works
Matrix viscoelasticity promotes liver cancer progression in the pre-cirrhotic liver
Fan, W., Adebowale, K., Váncza, L., Li, Y., Rabbi, M. F., Kunimoto, K., Chen, D., Mozes, G., Chiu, D. K.-C., Li, Y., et al. (2024) · Nature · doi:10.1038/s41586-023-06991-9 · Cited by 263 · see citing works
Song, X., Liu, J., Kuang, F., Chen, X., Zeh, H. J., Kang, R., Kroemer, G., Xie, Y., & Tang, D. (2021) · Cell Reports · doi:10.1016/j.celrep.2021.108767 · Cited by 258 · see citing works
Bharucha, A. E., Kudva, Y. C., & Prichard, D. O. (2019) · Endocrine Reviews · doi:10.1210/er.2018-00161 · Cited by 252 · see citing works
Gallagher, E. J., & LeRoith, D. (2020) · Nature Reviews Cancer · doi:10.1038/s41568-020-0295-5 · Cited by 241 · see citing works
Yang, S., Liu, Q., & Liao, Q. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2020.607209 · Cited by 202 · see citing works
Yuan, S., Kar, S., Carter, P., Vithayathil, M. K., Mason, A. M., Burgess, S., & Larsson, S. C. (2020) · Diabetes · doi:10.2337/db20-0084 · Cited by 150 · see citing works
Glucose Metabolism in Pancreatic Cancer
Liang, Y., Raj, P. S., Yao, W., & Ying, H. (2019) · Cancers · doi:10.3390/cancers11101460 · Cited by 122 · see citing works
Insulin Resistance: The Increased Risk of Cancers
Szablewski, L. (2024) · Current Oncology · doi:10.3390/curroncol31020075 · Cited by 107 · see citing works
Akimoto, M., Maruyama, R., Kawabata, Y., Tajima, Y., & Takenaga, K. (2018) · Cell Death & Disease · doi:10.1038/s41419-018-0851-z · Cited by 104 · see citing works
The involvement of exosomes in the diagnosis and treatment of pancreatic cancer
Gabriel, A. N. A., Wang, F., Jiao, Q., Umwali, Y., Yang, X., Al-Ameri, S. A. A.-E., Du, L., Wang, Y., & Wang, C. (2020) · Molecular Cancer · doi:10.1186/s12943-020-01245-y · Cited by 104 · see citing works
Diabetes and pancreatic cancer: Exploring the two-way traffic
Roy, A., Sahoo, J., Kamalanathan, S., Naik, D., Mohan, P., & Kalayarasan, R. (2021) · World Journal of Gastroenterology · doi:10.3748/wjg.v27.i30.4939 · Cited by 104 · see citing works
Diabetes of the exocrine pancreas
Wynne, K., Devereaux, B., & Dornhorst, A. (2018) · Journal of Gastroenterology and Hepatology · doi:10.1111/jgh.14451 · Cited by 87 · see citing works
Huang, B. Z., Pandol, S. J., Jeon, C. Y., Chari, S. T., Sugar, C. A., Chao, C. R., Zhang, Z.-F., Wu, B. U., & Setiawan, V. W. (2020) · Clinical Gastroenterology and Hepatology · doi:10.1016/j.cgh.2019.11.043 · Cited by 87 · see citing works
Self-citationBeta cell dysfunction in diabetes: the islet microenvironment as an unusual suspect
Almaça, J., Caicedo, A., & Landsman, L. (2020) · Diabetologia · doi:10.1007/s00125-020-05186-5 · Cited by 84 · see citing works
Wang, G., Yao, H., Gong, Y., Lu, Z., Pang, R., Li, Y., Yuan, Y., Song, H., Liu, J., Jin, Y., et al. (2021) · Science Advances · doi:10.1126/sciadv.abh2724 · Cited by 85 · see citing works
Min, X., Guo, S., Lu, Y., & Xu, X. (2024) · Journal of Luminescence · doi:10.1016/j.jlumin.2024.120437 · Cited by 82 · see citing works
The intricate relationship between diabetes, obesity and pancreatic cancer
Paternoster, S., & Falasca, M. (2019) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2019.188326 · Cited by 79 · see citing works
Inflammatory Cytokine: An Attractive Target for Cancer Treatment
Lee, H., Lee, H.-J., & Chang, J. (2022) · Biomedicines · doi:10.3390/biomedicines10092116 · Cited by 79 · see citing works
Pancreatic cancer cachexia: three dimensions of a complex syndrome
Kordes, M., Larsson, L., Engstrand, L., & Löhr, M. J. (2021) · British Journal of Cancer · doi:10.1038/s41416-021-01301-4 · Cited by 78 · see citing works
Garcia, P. L., Miller, A. L., & Yoon, K. J. (2020) · Cancers · doi:10.3390/cancers12051327 · Cited by 77 · see citing works
Diabetes and Pancreatic Cancer—A Dangerous Liaison Relying on Carbonyl Stress
Menini, S., Iacobini, C., Vitale, M., Pesce, C. M., & Pugliese, G. (2021) · Cancers · doi:10.3390/cancers13020313 · Cited by 75 · see citing works
Adipose tissue and skeletal muscle wasting precede clinical diagnosis of pancreatic cancer
Babić, A., Rosenthal, M. H., Sundaresan, T. K., Khalaf, N. I., Lee, V., Brais, L. K., Loftus, M., Caplan, L. R., Denning, S. L., Gurung, A., et al. (2023) · Nature Communications · doi:10.1038/s41467-023-40024-3 · Cited by 77 · see citing works
Obesity and Pancreatic Cancer: Insight into Mechanisms
Eibl, G., & Rozengurt, E. (2021) · Cancers · doi:10.3390/cancers13205067 · Cited by 72 · see citing works
Self-citationDeveloping effective combination therapy for pancreatic cancer: An overview
Miller, A. L., Garcia, P. L., & Yoon, K. J. (2020) · Pharmacological Research · doi:10.1016/j.phrs.2020.104740 · Cited by 71 · see citing works
Type-3c Diabetes Mellitus, Diabetes of Exocrine Pancreas - An Update
Bhattamisra, S. K., Siang, T. C., Rong, C. Y., Annan, N. C., Sean, E. H. Y., Xi, L. W., Lyn, O. S., Liew, H. S., Choudhury, H., Pandey, M., et al. (2019) · Current Diabetes Reviews · doi:10.2174/1573399815666190115145702 · Cited by 72 · see citing works
Current Approaches to Pancreatic Cancer Screening
Chhoda, A., Lu, L., Clerkin, B. M., Risch, H. A., & Farrell, J. J. (2018) · American Journal Of Pathology · doi:10.1016/j.ajpath.2018.09.013 · Cited by 64 · see citing works
Hu, Y., Zeng, N., Ge, Y., Wang, D., Qin, X., Zhang, W., Jiang, F., & Liu, Y. (2022) · Frontiers in Endocrinology · doi:10.3389/fendo.2022.847760 · Cited by 64 · see citing works
Pancreatic Cancer: Challenges and Opportunities in Locoregional Therapies
Bazeed, A. Y., Day, C. M., & Garg, S. (2022) · Cancers · doi:10.3390/cancers14174257 · Cited by 65 · see citing works
Risk of the Watch-and-Wait Concept in Surgical Treatment of Intraductal Papillary Mucinous Neoplasm
Tjaden, C., Sandini, M., Mihaljević, A. L., Kaiser, J., Khristenko, E., Mayer, P., Hinz, U., Gaida, M. M., Berchtold, C., Diener, M. K., et al. (2021) · JAMA Surgery · doi:10.1001/jamasurg.2021.0950 · Cited by 61 · see citing works
The evolving view of thermogenic fat and its implications in cancer and metabolic diseases
Yin, X., Chen, Y., Ruze, R., Xu, R., Song, J., Wang, C., & Xu, Q. (2022) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-022-01178-6 · Cited by 68 · see citing works
Guideline for the Management of Diabetes Mellitus in the Elderly in China (2024 Edition)
Guo, L., & Xiao, X. (2024) · Aging Medicine · doi:10.1002/agm2.12294 · Cited by 65 · see citing works
Gabriel, A. N. A., Jiao, Q., Umwali, Y., Yang, X., Al-Ameri, S. A. A.-E., Du, L., Wang, Y., & Wang, C. (2019) · Pancreatology · doi:10.1016/j.pan.2019.11.006 · Cited by 59 · see citing works
Feola, T., Puliani, G., Sesti, F. F., Modica, R., Centello, R., Minotta, R., Cannavale, G., Meglio, S. D., Vito, V. D., Lauretta, R., et al. (2022) · Journal of Endocrinological Investigation · doi:10.1007/s40618-021-01715-0 · Cited by 60 · see citing works
KRAS mutation: The booster of pancreatic ductal adenocarcinoma transformation and progression
Zhang, Z., Zhang, H., Liao, X., & Tsai, H. (2023) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2023.1147676 · Cited by 62 · see citing works
Zhang, J., Gong, S., Liu, Y., Zheng, Z., & Feng, G. (2024) · Sensors and Actuators B Chemical · doi:10.1016/j.snb.2024.135432 · Cited by 60 · see citing works
A tale of two pancreases: exocrine pathology and endocrine dysfunction
Rickels, M. R., Norris, A. W., & Hull, R. L. (2020) · Diabetologia · doi:10.1007/s00125-020-05210-8 · Cited by 60 · see citing works
Self-citationYe, Z., Zhu, Z., Xie, J., Feng, Z., Li, Y., Xu, X., Li, W., & Chen, W. (2020) · International Journal of Nanomedicine · doi:10.2147/ijn.s279258 · Cited by 58 · see citing works
Abnormal exocrine–endocrine cell cross-talk promotes β-cell dysfunction and loss in MODY8
Kahraman, S., Dirice, E., Basile, G., Diegisser, D., Alam, J., Johansson, B. B., Gupta, M. K., Hu, J., Huang, L., Soh, C.-L., et al. (2022) · Nature Metabolism · doi:10.1038/s42255-021-00516-2 · Cited by 57 · see citing works
Farr, K. P., Moses, D. A., Haghighi, K. S., Phillips, P. A., Hillenbrand, C. M., & Chua, B. H. (2022) · Cancers · doi:10.3390/cancers14102539 · Cited by 57 · see citing works
Wu, S., Zhang, H., Gao, C., Chen, J., Li, H., Meng, Z., Bai, J., Shen, Q., Wu, H., & Yin, T. (2022) · Cellular and Molecular Gastroenterology and Hepatology · doi:10.1016/j.jcmgh.2022.07.008 · Cited by 57 · see citing works
Sharib, J. M., Fonseca, A. L., Swords, D. S., Jaradeh, K., Bracci, P. M., Firpo, M. A., Hatcher, S., Scaife, C. L., Wang, H., Kim, G. E., et al. (2018) · Surgery · doi:10.1016/j.surg.2018.07.014 · Cited by 55 · see citing works
Lee, M., Sun, J., Han, M., Cho, Y., Lee, J., Nam, C. M., & Kang, E. S. (2019) · Diabetes Care · doi:10.2337/dc18-2195 · Cited by 53 · see citing works
Pancreatic Cancer and Diabetes Mellitus
Sharma, A., & Chari, S. T. (2018) · Current Treatment Options in Gastroenterology · doi:10.1007/s11938-018-0197-8 · Cited by 52 · see citing works
Self-citationPancreatic endocrine and exocrine signaling and crosstalk in physiological and pathological status
Hu, C., Chen, Y., Yin, X., Xu, R., Yin, C., Wang, C., & Zhao, Y. (2025) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-024-02098-3 · Cited by 59 · see citing works
New-Onset Diabetes Mellitus After Chronic Pancreatitis Diagnosis
Zhu, X., Liu, D., Wei, Q., Lin, H., Zhi, M., Chen, Y., Qi, L., Waldron, R. T., Lugea, A., Pandol, S. J., et al. (2019) · Pancreas · doi:10.1097/mpa.0000000000001359 · Cited by 51 · see citing works
Metformin: review of epidemiology and mechanisms of action in pancreatic cancer
Eibl, G., & Rozengurt, E. (2021) · Cancer and Metastasis Reviews · doi:10.1007/s10555-021-09977-z · Cited by 49 · see citing works
Self-citationEffects of Berberine against Pancreatitis and Pancreatic Cancer
Vlavcheski, F., O’Neill, E. J., Gagacev, F., & Tsiani, E. (2022) · Molecules · doi:10.3390/molecules27238630 · Cited by 48 · see citing works
Validation of the ENDPAC model: Identifying new-onset diabetics at risk of pancreatic cancer
Khan, S. A., Safarudin, R., & Kupec, J. T. (2021) · Pancreatology · doi:10.1016/j.pan.2021.02.001 · Cited by 46 · see citing works
Diabetes and Pancreatic Cancer: Both Cause and Effect
Risch, H. A. (2018) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/djy093 · Cited by 46 · see citing works
Multidisciplinary consensus statement on the clinical management of patients with pancreatic cancer
Martín‐Pérez, E., Domínguez‐Muñoz, J. E., Romero, F. B., Cerezo, L., Teresa, F. M., Serrano, T., & Vera, R. (2020) · Clinical & Translational Oncology · doi:10.1007/s12094-020-02350-6 · Cited by 46 · see citing works
Zhang, Y., Huang, S., Li, P., Chen, Q., Li, Y., Zhou, Y., Wang, L., Kang, M., Zhang, B., Yang, B. J., et al. (2018) · Cancer Letters · doi:10.1016/j.canlet.2018.05.027 · Cited by 45 · see citing works
Chang, H.-H., & Eibl, G. (2019) · Cells · doi:10.3390/cells8070673 · Cited by 47 · see citing works
Self-citationThe relationship between pancreatic cancer and type 2 diabetes: cause and consequence
Li, Y., Bian, X., Wei, S., He, M., & Yang, Y. (2019) · Cancer Management and Research · doi:10.2147/cmar.s211972 · Cited by 47 · see citing works
The Metabolic Interplay between Cancer and Other Diseases
Le, A., Udupa, S., & Zhang, C. (2019) · Trends in cancer · doi:10.1016/j.trecan.2019.10.012 · Cited by 48 · see citing works
Obesity, obesities and gastrointestinal cancers
Zou, Y., & Pitchumoni, C. S. (2023) · Disease-a-Month · doi:10.1016/j.disamonth.2023.101592 · Cited by 44 · see citing works
Nucci, D., Santangelo, O. E., Provenzano, S., Fatigoni, C., Nardi, M., Ferrara, P., & Gianfredi, V. (2021) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph182111556 · Cited by 44 · see citing works
Luo, J. M., Xiang, Y., Xu, X., Fang, D., Ding, L., Ni, F., Zhu, X., Chen, B., & Zhou, M. (2018) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2018/6917206 · Cited by 42 · see citing works
Shivaprasad, C., Aiswarya, Y., Shah, K., Atluri, S., Anupam, B., Barure, R., Gautham, K., & Premchander, A. (2019) · Journal of Diabetes Science and Technology · doi:10.1177/1932296819860133 · Cited by 45 · see citing works
Jentzsch, V., Davis, J., & Djamgoz, M. B. A. (2020) · Cancers · doi:10.3390/cancers12113096 · Cited by 44 · see citing works
Mannucci, A., & Goel, A. (2025) · CA A Cancer Journal for Clinicians · doi:10.3322/caac.70035 · Cited by 53 · see citing works
Pediatric chronic pancreatitis: Updates in the 21st century
Abu‐El‐Haija, M. A., & Nathan, J. D. (2018) · Pancreatology · doi:10.1016/j.pan.2018.04.013 · Cited by 41 · see citing works
Endocrine and Metabolic Insights from Pancreatic Surgery
Mezza, T., CEFALO, C. M. A., Cinti, F., Quero, G., Pontecorvi, A., Alfieri, S., Holst, J. J., & Giaccari, A. (2020) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2020.07.003 · Cited by 41 · see citing works
Comorbidity of patients with noncommunicable diseases in general practice. Eurasian guidelines
Drapkina, O. M., Васильевна, К. А., Калинина, А. М., Avdeev, S. N., Викторович, А. М., Алексеева, Л. И., Almazova, I. I., Andreenko, Е. Y., Antipushina, D. N., Balanova, Y. А., et al. (2024) · CARDIOVASCULAR THERAPY AND PREVENTION · doi:10.15829/1728-8800-2024-3996 · Cited by 49 · see citing works
Chen, Z., Yue, L., Guo, Y., Huang, H., & Lin, W. (2024) · Analytica Chimica Acta · doi:10.1016/j.aca.2024.342748 · Cited by 40 · see citing works
Understanding Necroptosis in Pancreatic Diseases
He, R., Wang, Z., Dong, S., Chen, Z., & Zhou, W. (2022) · Biomolecules · doi:10.3390/biom12060828 · Cited by 38 · see citing works
Exploring the link between diabetes and pancreatic cancer
Pizzato, M., Turati, F., Rosato, V., & Vecchia, C. L. (2019) · Expert Review of Anticancer Therapy · doi:10.1080/14737140.2019.1642109 · Cited by 37 · see citing works
Modifiable and Non-Modifiable Risk Factors for the Development of Non-Hereditary Pancreatic Cancer
Olakowski, M., & Bułdak, Ł. (2022) · Medicina · doi:10.3390/medicina58080978 · Cited by 37 · see citing works
Effects and mechanisms of anti-diabetic dietary natural products: an updated review
Jin, C., Li, J., Xiong, R.-G., Wu, S.-X., Xu, X., Tang, G., Huang, S., Zhou, D.-D., Li, H., Feng, Y., et al. (2024) · Food & Function · doi:10.1039/d3fo04505f · Cited by 36 · see citing works
Childhood Pancreatitis and Risk for Incident Diabetes in Adulthood
Bendor, C. D., Bardugo, A., Zucker, I., Cukierman‐Yaffe, T., Lutski, M., Derazne, E., Shohat, T., Mosenzon, O., Tzur, D., Sapir, A., et al. (2019) · Diabetes Care · doi:10.2337/dc19-1562 · Cited by 36 · see citing works
Pusceddu, S., Vernieri, C., Prinzi, N., Torchio, M., Coppa, J. C., Antista, M., Niger, M., Milione, M., Giacomelli, L., Corti, F., et al. (2020) · Therapeutic Advances in Gastroenterology · doi:10.1177/1756284820927271 · Cited by 33 · see citing works
Protein Biomarkers for Early Detection of Pancreatic Ductal Adenocarcinoma: Progress and Challenges
Root, A., Allen, P. J., Tempst, P., & Yu, K. H. (2018) · Cancers · doi:10.3390/cancers10030067 · Cited by 33 · see citing works
Li, X., Zhou, J., Wang, X., Li, C., Ma, Z., Wan, Q., & Fu, P. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1152312 · Cited by 33 · see citing works
Oguma, T., Kanazawa, T., Kaneko, Y. K., Sato, R., Serizawa, M., Ooka, A., Yamaguchi, M., Ishikawa, T., & Kondo, H. (2024) · Journal of Controlled Release · doi:10.1016/j.jconrel.2024.07.059 · Cited by 32 · see citing works
Gallo, M., Adinolfi, V., Morviducci, L., Acquati, S., Tuveri, E., Ferrari, P., Zatelli, M. C., Faggiano, A., Argentiero, A., Natalicchio, A., et al. (2021) · ESMO Open · doi:10.1016/j.esmoop.2021.100155 · Cited by 33 · see citing works
Kan, C., Liu, N., Zhang, K., Wu, D., liang, Y., Cai, W., Jing, Q., Han, F., Xing, S.-J., & Sun, X. (2023) · Annals of Global Health · doi:10.5334/aogh.4019 · Cited by 31 · see citing works
Xu, W., Lu, Z., Wang, X., Cheung, M. H., Lin, M., Li, C., Dong, Y., Liang, C., & Chen, Y. (2020) · Nutrition and Diabetes · doi:10.1038/s41387-020-00134-z · Cited by 31 · see citing works
Deng, J., Guo, Y., Du, J., Gu, J., Kong, L., Tao, B., Li, J., & Fu, D. (2022) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2022.844028 · Cited by 31 · see citing works
Association between pancreatic cancer and diabetes: insights from a retrospective cohort study
Amri, F., Belkhayat, C., Yeznasni, A., Koulali, H., Jabi, R., Zazour, A., Abda, N., Bouziane, M., Ismaili, Z., & Kharrasse, G. (2023) · BMC Cancer · doi:10.1186/s12885-023-11344-w · Cited by 31 · see citing works
The Cause and Effect Relationship of Diabetes after Acute Pancreatitis
Śliwińska‐Mossoń, M., Bil‐Lula, I., & Marek, G. (2023) · Biomedicines · doi:10.3390/biomedicines11030667 · Cited by 30 · see citing works
Review of Associations Between Type 2 Diabetes and Cancer
Bonagiri, P. R., & Shubrook, J. H. (2020) · Clinical Diabetes · doi:10.2337/cd19-0077 · Cited by 30 · see citing works
Immune-related somatic mutation genes are enriched in PDACs with diabetes
Wang, K., Zhou, W., Meng, P., Wang, P., Zhou, C., Yao, Y., Wu, S., Wang, Y., Zhao, J., Zou, D., et al. (2019) · Translational Oncology · doi:10.1016/j.tranon.2019.03.006 · Cited by 29 · see citing works
Genetics of diabetes and its complications: a comprehensive review
Sami, A., Javed, A., Ozsahin, D. U., Özşahin, İ., Muhammad, K., & Waheed, Y. (2025) · Diabetology & Metabolic Syndrome · doi:10.1186/s13098-025-01748-y · Cited by 38 · see citing works
A Serum Marker for Early Pancreatic Cancer With a Possible Link to Diabetes
Nam, H., Hong, S., Jung, K. H., Kang, S., Park, M. S., Kang, S., Kim, H. S., Mai, V.-H., Kim, J., Lee, H., et al. (2021) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/djab191 · Cited by 29 · see citing works
Vonderau, J. S., & Desai, C. S. (2022) · JAAPA · doi:10.1097/01.jaa.0000885140.47709.6f · Cited by 30 · see citing works
- Authors
- Andersen, D. K., Korc, M., Petersen, G. M., Eibl, G., Li, D., Rickels, M. R., Chari, S. T., & Abbruzzese, J. L.
- Affiliations
- National Institutes of Health (US)
- Indiana University Indianapolis (US)
- Mayo Clinic (US)
- University of California, Los Angeles (US)
- The University of Texas MD Anderson Cancer Center (US)
- University of Pennsylvania (US)
- Duke University (US)
- Corresponding author
- Abbruzzese, James L.
- ORCID
- Venue
- Diabetes
- Publisher
- American Diabetes Association
- Published
- 2017-04-13
- Volume
- 66
- Issue
- 5
- Pages
- 1103-1110
- ISSN
- 0012-1797 (ISSN-L)
- 1939-327X
- PMC
- PMC5399609
- OpenAlex
- W2615250694
- Cited by
- 516
- References
- 50
- Citations by year
- 2026: 43 · 2025: 55 · 2024: 78 · 2023: 71 · 2022: 79 · 2021: 61 · 2020: 59 · 2019: 40 · 2018: 24 · 2017: 5
- FWCI
- 15.43
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Diabetes (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- eScholarship (California Digital Library) (submittedVersion)
- IUScholarWorks (Indiana University) (submittedVersion)
- Funders
- National Institutes of Health
- Topics
- Health Sciences › Medicine › Oncology › Pancreatic and Hepatic Oncology Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Metabolism, Diabetes, and Cancer
- Health Sciences › Medicine › Surgery › Pancreatitis Pathology and Treatment
- Keywords
- pancreatic ductal adenocarcinoma, type 2 diabetes, pancreatic diabetes, new-onset diabetes, pancreatic cancer risk factors, diabetes management, early cancer detection
- MeSH terms
- Blood Glucose, Diabetes Mellitus, Diabetes Mellitus, Type 2, Humans, Hypoglycemic Agents, Inflammation, Obesity, Pancreatic Neoplasms, Risk Factors, Causality, Genetic Predisposition to Disease, Carcinoma, Pancreatic Ductal, Pancreatitis, Chronic
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
