Depression and chronic liver diseases: are there shared underlying mechanisms?

Huang, Xiaoqin; Liu, Xiaoyun; Yu, Yongqiang

doi:10.3389/fnmol.2017.00134

Cited by 121Tryptophan and brain disordersLiver Disease and TransplantationAlcohol Consumption and Health Effects

Depression and chronic liver diseases: are there shared underlying mechanisms?

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Huang, Xiaoqin, Liu, Xiaoyun, Yu, Yongqiang·2017·Frontiers in Molecular Neuroscience

DOI 10.3389/fnmol.2017.00134PMC PMC5420567

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Abstract

The occurrence of depression is higher in patients with chronic liver disease (CLD) than that in the general population. The mechanism described in previous studies mainly focused on inflammation and stress, which not only exists in CLD, but also emerges in common chronic diseases, leaving the specific mechanism unknown. This review was to summarize the prevalence and risk factors of depression in CLD including chronic hepatitis B, chronic hepatitis, alcoholic liver disease, and non-alcoholic fatty liver disease, and to point out the possible underlying mechanism of this potential link. Clarifying the origins of this common comorbidity (depression and CLD) may provide more information to understand both diseases.

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Integrating behavioral health services within care of patients with noncommunicable diseases has become a national priority.
“Integrating behavioral health services within care of patients with noncommunicable diseases, such as heart failure, diabetes, and cancer, has become a national priority.28”
From A Behavioral Health Program for Alcohol Use Disorder, Substance Abuse, and Depression in Chronic Liver Disease (2019) · cites this paper as [28]
The Conclusion (page unavailable) calls for studies of depression screening in chronic liver disease management, but does not say that integrating behavioral health services into care has become a national priority. Searches for that priority and for integrated care across noncommunicable diseases found no passage addressing the claim. (LLM, conf=0.72)
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“Interestingly, Smith et al. (2012) found that in 800 Caucasians with CH-C, a polymorphism (rs9657182) in the promoter region of the gene encoding IDO was markedly associated with moderate or severe IFN-α-induced depression symptoms, whereas it did not predict depression in African Americans, who…”
Background
Depressive symptoms predict long-term mortality after liver transplantation
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Depression and obesity: evidence of shared biological mechanisms
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Nonalcoholic Fatty Liver Disease Increases the Risk of Anxiety and Depression
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Matrine ameliorates anxiety and depression-like behaviour by targeting hyperammonemia-induced neuroinflammation and oxidative stress in CCl4 model of liver injury
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Depression is associated with non‐alcoholic fatty liver disease among adults in the United States
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Peripheral Dopamine Controlled by Gut Microbes Inhibits Invariant Natural Killer T Cell-Mediated Hepatitis
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Association between nonalcoholic fatty liver disease and depression: A systematic review and meta-analysis of observational studies
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Non-alcoholic fatty liver disease and coexisting depression, anxiety and/or stress in adults: a systematic review and meta-analysis
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Gut microbiome-brain-cirrhosis axis
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Depression and risk of gastrointestinal disorders: a comprehensive two-sample Mendelian randomization study of European ancestry
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Nootkatone improves anxiety‐ and depression‐like behavior by targeting hyperammonemia‐induced oxidative stress in D‐galactosamine model of liver injury
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Gut microbiota promotes macrophage M1 polarization in hepatic sinusoidal obstruction syndrome via regulating intestinal barrier function mediated by butyrate
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Socioeconomic Vulnerability to Depressive Symptoms in Patients with Chronic Hepatitis B
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N-acetyl cysteine in the treatment of alcohol use disorder in patients with liver disease: Rationale for further research
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Comparison of health-related quality of life after transarterial chemoembolization and transarterial radioembolization in patients with unresectable hepatocellular carcinoma
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Prevalence of nonalcoholic fatty liver disease in mental disorder inpatients in China: an observational study
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Depression-like phenotypes in mice with hepatic ischemia/reperfusion injury: A role of gut–microbiota–liver–brain axis via vagus nerve
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Depression-like phenotypes in mice following common bile duct ligation: Insights into the gut–liver–brain axis via the vagus nerve
Yang, Y. H., Eguchi, A., Mori, C., & Hashimoto, K. (2024) · Neurobiology of Disease · doi:10.1016/j.nbd.2024.106433 · Cited by 29 · see citing works
Electroacupuncture Alleviates Depressive-like Behavior by Modulating the Expression of P2X7/NLRP3/IL-1β of Prefrontal Cortex and Liver in Rats Exposed to Chronic Unpredictable Mild Stress
Pang, F., Yang, Y., Huang, S., Yang, Z., Zhu, Z., Liao, D., Guo, X., Zhou, M., Li, Y., & Tang, C. (2023) · Brain Sciences · doi:10.3390/brainsci13030436 · Cited by 25 · see citing works
Symptom-based network classification identifies distinct clinical subgroups of liver diseases with common molecular pathways
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Disease severity predicts higher healthcare costs among hospitalized nonalcoholic fatty liver disease/nonalcoholic steatohepatitis (NAFLD/NASH) patients in Spain
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A Behavioral Health Program for Alcohol Use Disorder, Substance Abuse, and Depression in Chronic Liver Disease
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“Depression and CLD are known to have some common underlying biological mechanisms.(30)”
Background
Depression in non-alcoholic fatty liver disease is associated with an increased risk of complications and mortality
Ng, C. H., Xiao, J., Chew, N., Chin, Y. H., Chan, K. E., Quek, J., Lim, W. H., Tan, D. J. H., Loke, R. W. K., Tan, C., et al. (2022) · Frontiers in Medicine · doi:10.3389/fmed.2022.985803 · Cited by 25 · see citing works
Liver and inflammatory biomarker relationships to depression symptoms in healthy older adults
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Self-citation

Authors: Huang, X., Liu, X., & Yu, Y.
Affiliations: Anhui Medical University (CN)
Corresponding author: Huang, Xiaoqin
Yu, Yongqiang
ORCID: Liu, Xiaoyun
Yu, Yongqiang
Venue: Frontiers in Molecular Neuroscience
Publisher: Frontiers Media SA
Published: 2017-05-08
Volume: 10
Pages: 134-134
ISSN: 1662-5099 (ISSN-L)
DOI: 10.3389/fnmol.2017.00134
PMC: PMC5420567
OpenAlex: W2612640743
Cited by: 121
References: 134
Citations by year: 2026: 9 · 2025: 11 · 2024: 18 · 2023: 22 · 2022: 9 · 2021: 19 · 2020: 16 · 2019: 8 · 2018: 9
FWCI: 0.61
Type: journal article
Language: en
Open access: gold
doi.org
Licence: cc-by
Locations: Frontiers in Molecular Neuroscience (publishedVersion, cc-by)
PubMed Central (publishedVersion, cc-by)
PubMed (publishedVersion)
DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
Funders: National Natural Science Foundation of China (81571308)
Topics: Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
Health Sciences › Medicine › Hepatology › Liver Disease and Transplantation
Health Sciences › Medicine › Pathology and Forensic Medicine › Alcohol Consumption and Health Effects
Keywords: depression, chronic liver disease, comorbidities, chronic hepatitis B, chronic hepatitis, alcoholic liver disease, non-alcoholic fatty liver disease, inflammation, stress, risk factors, prevalence

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Depression and chronic liver diseases: are there shared underlying mechanisms?

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