Symptom prevalence and quality of life of patients with end-stage liver disease: A systematic review and meta-analysis
Open accessAbstract
Background: End-stage liver disease is a common cause of morbidity and mortality worldwide, yet little is known about its symptomatology and impact on health-related quality of life. Aim: To describe symptom prevalence and health-related quality of life of patients with end-stage liver disease to improve care. Design: Systematic review. Data sources: We searched eight electronic databases from January 1980 to June 2018 for studies investigating symptom prevalence or health-related quality of life of adult patients with end-stage liver disease. No language restrictions were applied. Meta-analyses were performed where appropriate. Results: We included 80 studies: 35 assessing symptom prevalence, 41 assessing health-related quality of life, and 4 both. The instruments assessing symptoms varied across studies. The most frequently reported symptoms were as follows: pain (prevalence range 30%–79%), breathlessness (20%–88%), muscle cramps (56%–68%), sleep disturbance (insomnia 26%–77%, daytime sleepiness 29.5%–71%), and psychological symptoms (depression 4.5%–64%, anxiety 14%–45%). Erectile dysfunction was prevalent (53%–93%) in men. The health-related quality of life of patients with end-stage liver disease was significantly impaired when compared to healthy controls or patients with chronic liver disease. Compared with compensated cirrhosis, decompensation led to significant worsening of both components of the 36-Item Short Form Survey although to a larger degree for the Physical Component Summary score (decrease from average 6.4 (95% confidence interval: 4.0–8.8); p < 0.001) than for the Mental Component Summary score (4.5 (95% confidence interval: 2.4–6.6); p < 0.001). Conclusion: The symptom prevalence of patients with end-stage liver disease resembled that of patients with other advanced conditions. Given the diversity of symptoms and significantly impaired health-related quality of life, multidisciplinary approach and timely intervention are crucial.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In patients diagnosed with chronic liver disease, the prevalence of depression symptoms was 63% in studies using self-report inventories and 4.5% in studies using diagnostic clinical interviews.
“For example, the prevalence of DEP symptoms in patients diagnosed with chronic LD was 63% in studies using selfreport inventories, with far lower rates (4.5%) observed in studies using diagnostic clinical interviews.[2]”
From Prevalence of depression and anxiety symptoms by liver disease etiology (2023) · cites this paper as [2]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Preferred Reporting Items for Systematic Reviews and Meta-Analyses: the PRISMA statement
Moher, D., Liberati, A., Tetzlaff, J., Altman, D. G., & for the PRISMA Group (2009) · BMJ · doi:10.1136/bmj.b2535 · Cited by 83,823 · see citing works
Measuring inconsistency in meta-analyses
Higgins, J. P. T., Thompson, S. G., Deeks, J. J., & Altman, D. G. (2003) · BMJ · doi:10.1136/bmj.327.7414.557 · Cited by 63,139 · see citing works
(1992) · PubMed · Cited by 33,716 · see citing works
The MOS 36-ltem Short-Form Health Survey (SF-36): I. Conceptual Framework and Item Selection
Ware, J. E., & Sherbourne, C. D. (1992) · Medical Care · doi:10.1097/00005650-199206000-00002 · Cited by 30,033 · see citing works
Preferred Reporting Items for Systematic Reviews and Meta-Analyses: The PRISMA Statement
Moher, D., Liberati, A., Tetzlaff, J., & Altman, D. G. (2009) · Journal of Clinical Epidemiology · doi:10.1016/j.jclinepi.2009.06.005 · Cited by 19,575 · see citing works
Erdogan, D., Heijnen, B. H. M., Bennink, R. J., Kok, M., Dinant, S., Straatsburg, I. H., Gouma, D. J., & van Gulik, T. M. (2004) · Liver International · doi:10.1111/j.1478-3231.2004.00901.x · Cited by 11,656 · see citing works
Transection of the oesophagus for bleeding oesophageal varices
Pugh, R. N. H., Murray-Lyon, I. M., Dawson, J. L., Pietroni, M. C., & Williams, R. (1973) · Journal of British Surgery · doi:10.1002/bjs.1800600817 · Cited by 7,941 · see citing works
Mazzaferro, V., Regalia, E., Doci, R., Andreola, S. A., Pulvirenti, A., Bozzetti, F., Montalto, F., Ammatuna, M., Morabito, A., & Gennari, L. (1996) · New England Journal of Medicine · doi:10.1056/nejm199603143341104 · Cited by 7,173 · see citing works
MCHORNEY, C. A., JOHNE, W., & ANASTASIAE, R. (1993) · Medical Care · doi:10.1097/00005650-199303000-00006 · Cited by 6,681 · see citing works
Acute Abdomen: A Rare Case of Ruptured Hepatocellular Carcinoma
Gloor, S., Jensen, K. O., Breitenstein, S., Binkert, C. A., Angst, E., & Hetzer, F. H. (2017) · Case Reports in Gastroenterology · doi:10.1159/000463378 · Cited by 5,370 · see citing works
Malinchoc, M., Kamath, P. S., Gordon, F. D., Peine, C. J., Rank, J., & ter Borg, P. C. J. (2000) · Hepatology · doi:10.1053/he.2000.5852 · Cited by 2,893 · see citing works
Model for end-stage liver disease (MELD) and allocation of donor livers
Wiesner, R. H., Edwards, E. B., Freeman, R. B., Harper, A., Kim, W. R., Kamath, P. S., Kremers, W. K., Lake, J. R., Howard, T. K., Merion, R. M., et al. (2003) · Gastroenterology · doi:10.1053/gast.2003.50016 · Cited by 2,524 · see citing works
Schuppan, D., & Afdhal, N. H. (2008) · The Lancet · doi:10.1016/s0140-6736(08)60383-9 · Cited by 2,089 · see citing works
Kaplan, M. M. (1987) · New England Journal of Medicine · doi:10.1056/nejm198702263160907 · Cited by 2,015 · see citing works
Standard Quality Assessment Criteria for Evaluating Primary Research Papers from a Variety of Fields
Kmet, L. M., Cook, L. S., & Lee, R. C. (2004) · University of Alberta Library · doi:10.7939/r37m04f16 · Cited by 1,682 · see citing works
Schwab, M. (2011) · Springer eBooks · doi:10.1007/978-3-642-16483-5_4730 · Cited by 1,241 · see citing works
Kaplan, M. M., & Gershwin, M. E. (2005) · New England Journal of Medicine · doi:10.1056/nejmra043898 · Cited by 1,144 · see citing works
Liver cirrhosis mortality in 187 countries between 1980 and 2010: a systematic analysis
Mokdad, A. A., Lopez, A. D., Shahraz, S., Lozano, R., Mokdad, A. H., Stanaway, J., Murray, C. J., & Naghavi, M. (2014) · BMC Medicine · doi:10.1186/s12916-014-0145-y · Cited by 1,129 · see citing works
MELD and PELD: Application of survival models to liver allocation
Wiesner, R., Mcdiarmid, S., Kamath, P., Edwards, E., Malinchoc, M., Kremers, W. K., Krom, R., & Kim, W. (2001) · Liver transplantation · doi:10.1053/jlts.2001.25879 · Cited by 881 · see citing works
Younossi, Z. M., Guyatt, G. H., Kiwi, M. L., Boparai, N., & King, D. (1999) · Gut · doi:10.1136/gut.45.2.295 · Cited by 670 · see citing works
Development of a novel frailty index to predict mortality in patients with end‐stage liver disease
Lai, J. C., Covinsky, K. E., Dodge, J. L., Boscardin, W. J., Segev, D. L., Roberts, J. P., & Feng, S. (2017) · Hepatology · doi:10.1002/hep.29219 · Cited by 556 · see citing works
Primary Sclerosing Cholangitis
Lazaridis, K. N., & LaRusso, N. F. (2016) · New England Journal of Medicine · doi:10.1056/nejmra1506330 · Cited by 528 · see citing works
Subclinical hepatic encephalopathy impairs daily functioning
Groeneweg, M., Quero, J. C., Bruijn, I. D., Hartmann, I. J. C., Essink‐Bot, M., Hop, W. C. J., & Schalm, S. W. (1998) · Hepatology · doi:10.1002/hep.510280108 · Cited by 506 · see citing works
Factors associated with poor health-related quality of life of patients with cirrhosis
Marchesini, G., Bianchi, G. P., Amodio, P., Salerno, F., Merli, M., Panella, C., Loguercio, C., Apolone, G., Niero, M., & Abbiati, R. A. (2001) · Gastroenterology · doi:10.1053/gast.2001.21193 · Cited by 500 · see citing works
Moens, K., Higginson, I. J., Harding, R., Brearley, S. G., Caraceni, A. T., Cohen, J., Costantini, M., Deliëns, L., Francke, A. L., Kaasa, S., et al. (2014) · Journal of Pain and Symptom Management · doi:10.1016/j.jpainsymman.2013.11.009 · Cited by 444 · see citing works
Self-citationHealth-related quality of life in chronic liver disease: the impact of type and severity of disease
Younossi, Z., Boparai, N., Price, L., Kiwi, M. L., McCormick, M., & Guyatt, G. (2001) · American Journal of Gastroenterology · doi:10.1111/j.1572-0241.2001.03956.x · Cited by 345 · see citing works
[Primary sclerosing cholangitis].
Molina Jurado, M., Ferrer, J., & Gómez, N. (1984) · PubMed · Cited by 335 · see citing works
Impact of Hepatopulmonary Syndrome on Quality of Life and Survival in Liver Transplant Candidates
Fallon, M. B., Krowka, M. J., Brown, R. S., Trotter, J. F., Zacks, S., Roberts, K. E., Shah, V. H., Kaplowitz, N., Forman, L., Wille, K. M., et al. (2008) · Gastroenterology · doi:10.1053/j.gastro.2008.06.038 · Cited by 307 · see citing works
Jacoby, A., Rannard, A., Buck, D., Bhala, N. B., Newton, J. L., James, O., & Jones, D. E. J. (2005) · Gut · doi:10.1136/gut.2005.065862 · Cited by 270 · see citing works
Influence of Hepatic Encephalopathy on Health-Related Quality of Life in Patients with Cirrhosis
Arguedas, M. R., DeLawrence, T. G., & McGuire, B. M. (2003) · Digestive Diseases and Sciences · doi:10.1023/a:1024784327783 · Cited by 229 · see citing works
Poonja, Z., Brisebois, A., van Zanten, S. V., Tandon, P., Meeberg, G., & Karvellas, C. J. (2013) · Clinical Gastroenterology and Hepatology · doi:10.1016/j.cgh.2013.08.027 · Cited by 226 · see citing works
Liver transplantation: a systematic review of long‐term quality of life
Yang, L., Shan, L. L., Saxena, A., & Morris, D. L. (2014) · Liver International · doi:10.1111/liv.12553 · Cited by 216 · see citing works
Quality of life and cognitive function in hepatitis C at different stages of liver disease
Córdoba, J., Flavià, M., Jacas, C., Sauleda, S., Esteban, J. I., Vargas, V., Esteban, R., & Guàrdia, J. (2003) · Journal of Hepatology · doi:10.1016/s0168-8278(03)00189-2 · Cited by 214 · see citing works
Gralnek, I. M., Hays, R. D., Kilbourne, A. M., Rosen, H. R., Keeffe, E. B., Artinian, L., Kim, S., Lazarovici, D., Jensen, D. M., Busuttil, R. W., et al. (2000) · The American Journal of Gastroenterology · doi:10.1016/s0002-9270(00)02168-7 · Cited by 206 · see citing works
Psychological status and depression in patients with liver cirrhosis
Bianchi, G., Marchesini, G., Nicolino, F., Graziani, R., Sgarbi, D., Loguercio, C., Abbiati, R., & Zoli, M. (2005) · Digestive and Liver Disease · doi:10.1016/j.dld.2005.01.020 · Cited by 187 · see citing works
Baumann, A. J., Wheeler, D., James, M., Turner, R., Siegel, A., & Navarro, V. J. (2015) · Journal of Pain and Symptom Management · doi:10.1016/j.jpainsymman.2015.07.014 · Cited by 162 · see citing works
Predictors of health‐related quality of life in patients with chronic liver disease
Afendy, A., Kallman, J. B., Stepanova, M., Younoszai, Z., Aquino, R. D., Bianchi, G. P., Marchesini, G., & Younossi, Z. M. (2009) · Alimentary Pharmacology & Therapeutics · doi:10.1111/j.1365-2036.2009.04061.x · Cited by 161 · see citing works
Gralnek, I. M., Hays, R. D., Kilbourne, A. M., et al. (2000) · The American Journal of Gastroenterology · doi:10.1111/j.1572-0241.2000.03375.x · Cited by 157 · see citing works
Cirrhosis and muscle cramps: Evidence of a causal relationship
Angeli, P., Albino, G., Carraro, P., Pria, M. D., Merkel, C., Caregaro, L., Bei, E. D., Bortoluzzi, A., Plebani, M., & Gatta, A. (1996) · Hepatology · doi:10.1002/hep.510230211 · Cited by 148 · see citing works
Quality of life in cirrhosis is related to potentially treatable factors
Les, Í., Doval, E., Flavià, M., Jacas, C., Cárdenas, G., Esteban, R., Guàrdia, J., & Córdoba, J. (2010) · European Journal of Gastroenterology & Hepatology · doi:10.1097/meg.0b013e3283319975 · Cited by 147 · see citing works
Solà, E., Watson, H., Graupera, I., Turón, F., Barreto, R., Rodríguez, E., Pavesi, M., Arroyo, V., Guevara, M., & Ginès, P. (2012) · Journal of Hepatology · doi:10.1016/j.jhep.2012.07.020 · Cited by 139 · see citing works
Integration of Palliative Care in End-Stage Liver Disease and Liver Transplantation
Potosek, J., Curry, M. P., Buss, M. K., & Chittenden, E. (2014) · Journal of Palliative Medicine · doi:10.1089/jpm.2013.0167 · Cited by 133 · see citing works
Health‐related quality of life in chronic hepatitis B patients†
Ong, S. C., Mak, B., Aung, M. O., Li, S., & Lim, S. G. (2008) · Hepatology · doi:10.1002/hep.22138 · Cited by 127 · see citing works
MELD fails to measure quality of life in liver transplant candidates
Saab, S., Ibrahim, A. B., Shpaner, A., Younossi, Z. M., Lee, C., Durazo, F. A., Han, S. H. B., Esrason, K. T., Wu, V., Hiatt, J. R., et al. (2005) · Liver Transplantation · doi:10.1002/lt.20345 · Cited by 124 · see citing works
Depression in Patients with Cirrhosis (Impact on Outcome)
Singh, N., Gayowski, T., Wagener, M. M., & Marino, I. R. (1997) · Digestive Diseases and Sciences · doi:10.1023/a:1018898106656 · Cited by 116 · see citing works
Integrating Palliative Care for Liver Transplant Candidates
Larson, A. M., & Curtis, J. R. (2006) · JAMA · doi:10.1001/jama.295.18.2168 · Cited by 114 · see citing works
Dying with End Stage Liver Disease with Cirrhosis: Insights from SUPPORT
Roth, K. E., Lynn, J., Zhong, Z. J., Borum, M. L., & Dawson, N. V. (2000) · Journal of the American Geriatrics Society · doi:10.1111/j.1532-5415.2000.tb03121.x · Cited by 110 · see citing works
Montagnese, S., Middleton, B., Skene, D. J., & Morgan, M. Y. (2009) · Liver International · doi:10.1111/j.1478-3231.2009.02089.x · Cited by 103 · see citing works
Roth, K. E., Lynn, J., Zhong, Z., Borum, M. L., & Dawson, N. V. (2000) · PubMed · Cited by 99 · see citing works
A Psychiatric Study of 247 Liver Transplantation Candidates
Trzepacz, P. T., Brenner, R., & Thiel, D. H. V. (1989) · Psychosomatics · doi:10.1016/s0033-3182(89)72295-7 · Cited by 99 · see citing works
Sleep disturbance and daytime sleepiness in patients with cirrhosis: a case control study
Mostacci, B., Ferlisi, M., Antognini, A. B., Sama, C., Morelli, M. C., Mondini, S., & Cirignotta, F. (2008) · Neurological Sciences · doi:10.1007/s10072-008-0973-7 · Cited by 98 · see citing works
Beyond scoring: a modern interpretation of disease progression in chronic liver disease
Rosselli, M., MacNaughtan, J., Jalan, R., & Pinzani, M. (2013) · Gut · doi:10.1136/gutjnl-2012-302826 · Cited by 96 · see citing works
Sexual Functioning in Patients With End-Stage Liver Disease Before and After Transplantation
Sorrell, J. H., & Brown, J. R. (2006) · Liver Transplantation · doi:10.1002/lt.20812 · Cited by 90 · see citing works
Assessment of health-related quality of life in Chinese patients with minimal hepatic encephalopathy
Bao, Z.-J. (2007) · World Journal of Gastroenterology · doi:10.3748/wjg.v13.i21.3003 · Cited by 84 · see citing works
Kanwal, F., Hays, R. D., Kilbourne, A. M., Dulai, G. S., & Gralnek, I. M. (2004) · The American Journal of Gastroenterology · doi:10.1111/j.1572-0241.2004.30300.x · Cited by 84 · see citing works
van der Plas, S. M., Hansen, B. E., de Boer, J. B., Stijnen, T., Passchier, J., de Man, R. A., & Schalm, S. W. (2003) · BMC Gastroenterology · doi:10.1186/1471-230x-3-33 · Cited by 83 · see citing works
Pretransplant depression, antidepressant use, and outcomes of orthotopic liver transplantation
Rogal, S. S., Landsittel, D. P., Surman, O. S., Chung, R. T., & Rutherford, A. (2010) · Liver Transplantation · doi:10.1002/lt.22231 · Cited by 76 · see citing works
Ghabril, M., Jackson, M., Gotur, R., Weber, R., Orman, E. S., Vuppalanchi, R., & Chalasani, N. (2017) · Clinical Gastroenterology and Hepatology · doi:10.1016/j.cgh.2017.01.027 · Cited by 76 · see citing works
Health State Utilities and Quality of Life in Patients with Hepatitis B
Woo, G. W., TOMLINSON, G. A., Yim, C., Lilly, L. B., Therapondos, G., Wong, D., Ungar, W. J., Einarson, T. R., Sherman, M., Heathcote, E. J., et al. (2012) · Canadian Journal of Gastroenterology · doi:10.1155/2012/736452 · Cited by 75 · see citing works
Quality of Life in Liver Transplant Candidates
Derck, J., Thelen, A. E., Cron, D. C., Friedman, J. F., Gerebics, A., Englesbe, M. J., & Sonnenday, C. J. (2015) · Transplantation · doi:10.1097/tp.0000000000000593 · Cited by 74 · see citing works
Pain and Opioid Use in Chronic Liver Disease
Rogal, S. S., Winger, D., Bielefeldt, K., & Szigethy, E. (2013) · Digestive Diseases and Sciences · doi:10.1007/s10620-013-2638-5 · Cited by 70 · see citing works
Prevalence and Morbidity Associated with Muscle Cramps in Patients with Cirrhosis
Chatrath, H., Liangpunsakul, S., Ghabril, M., Otte, J. L., Chalasani, N., & Vuppalanchi, R. (2012) · The American Journal of Medicine · doi:10.1016/j.amjmed.2012.03.012 · Cited by 65 · see citing works
Wang, J. (2013) · World Journal of Gastroenterology · doi:10.3748/wjg.v19.i30.4984 · Cited by 65 · see citing works
Guenther F. Wiesinger, M. Q. (2001) · Journal of Rehabilitation Medicine · doi:10.1080/165019701753236446 · Cited by 64 · see citing works
Björnsson, E., Verbaan, H., Oksanen, A., Frydén, A., Johansson, J., Friberg, S., Dalgård, O., & Kalaitzakis, E. (2009) · Scandinavian Journal of Gastroenterology · doi:10.1080/00365520902898135 · Cited by 64 · see citing works
Sexual Dysfunction in Chronic Liver Disease: Is Liver Transplantation an Effective Cure?
Burra, P., Germani, G., Masier, A., Martin, E. D., Gambato, M., Salonia, A., Bo, P., Vitale, A., Cillo, U., Russo, F. P., et al. (2010) · Transplantation · doi:10.1097/tp.0b013e3181e1f1f6 · Cited by 61 · see citing works
Mina, A., Morán, S., Ortiz-Olvera, N. X., Mera, R. M., & Uribe, M. (2013) · Hepatology Research · doi:10.1111/hepr.12227 · Cited by 61 · see citing works
Rogal, S. S., Bielefeldt, K., Wasan, A. D., Lotrich, F. E., Zickmund, S. L., Szigethy, E., & DiMartini, A. F. (2014) · Clinical Gastroenterology and Hepatology · doi:10.1016/j.cgh.2014.10.029 · Cited by 60 · see citing works
Muscle cramps in patients with cirrhosis.
Abrams, G. A., Concato, J., & Fallon, M. (1996) · PubMed · Cited by 56 · see citing works
Ahluwalia, V., Wade, J. B., Thacker, L. R., Kraft, K. A., Sterling, R. K., Stravitz, R. T., Fuchs, M. A., Bouneva, I., Puri, P., Luketic, V. A., et al. (2013) · Journal of Hepatology · doi:10.1016/j.jhep.2013.04.023 · Cited by 56 · see citing works
Falls and cognitive dysfunction impair health-related quality of life in patients with cirrhosis
Román, E. M., Córdoba, J., Torrens, M., Guarner, C., & Soriano, G. (2012) · European Journal of Gastroenterology & Hepatology · doi:10.1097/meg.0b013e3283589f49 · Cited by 55 · see citing works
Kim, S. H., Oh, E. G., & Lee, W. H. (2006) · International Journal of Nursing Studies · doi:10.1016/j.ijnurstu.2005.11.012 · Cited by 52 · see citing works
Šumskienė, J. (2006) · World Journal of Gastroenterology · doi:10.3748/wjg.v12.i48.7792 · Cited by 49 · see citing works
Chronic Pain among Liver Transplant Candidates
Madan, A., Barth, K. S., Balliet, W. E., Hernandez‐Tejada, M. A., Borckardt, J. J., Malcolm, R. J., Willner, I. R., Koch, D., & Reuben, A. (2012) · Progress in Transplantation · doi:10.7182/pit2012535 · Cited by 49 · see citing works
Moscucci, F., Nardelli, S., Pentassuglio, I., Pasquale, C., Ridola, L., Merli, M., & Riggio, O. (2011) · Liver International · doi:10.1111/j.1478-3231.2011.02598.x · Cited by 49 · see citing works
Zhuang, G., Zhang, M., Liu, Y., Guo, Y., Wu, Q., Zhou, K., Ji, Z., & Zhang, X. (2014) · Health and Quality of Life Outcomes · doi:10.1186/1477-7525-12-101 · Cited by 48 · see citing works
Erectile Dysfunction in End-Stage Liver Disease Men
Huyghe, É., Kamar, N., Wagner, F., Capietto, A.-H., El-Kahwaji, L., Muscari, F., Plante, P., & Rostaing, L. P. E. (2009) · The Journal of Sexual Medicine · doi:10.1111/j.1743-6109.2008.01169.x · Cited by 48 · see citing works
Excessive daytime sleepiness and hepatic encephalopathy: it is worth asking
Rui, M. D., Schiff, S., Aprile, D., Angeli, P., Bombonato, G., Bolognesi, M., Sacerdoti, D., Gatta, A., Merkel, C., Amodio, P., et al. (2012) · Metabolic Brain Disease · doi:10.1007/s11011-012-9360-4 · Cited by 45 · see citing works
Fritz, E. M., & Hammer, J. (2009) · European Journal of Gastroenterology & Hepatology · doi:10.1097/meg.0b013e328318ed19 · Cited by 44 · see citing works
Parkash, O., Iqbal, R., Jafri, F., Azam, I., & Jafri, W. (2012) · BMC Research Notes · doi:10.1186/1756-0500-5-446 · Cited by 43 · see citing works
Stepanova, M., Nader, F., Bureau, C., Adebayo, D., Elkrief, L., Valla, D. C., Peck‐Radosavljevic, M., McCune, A., Vargas, V., Simón‐Talero, M., et al. (2018) · Quality of Life Research · doi:10.1007/s11136-018-1813-8 · Cited by 43 · see citing works
Başkol, M., Özbakır, Ö., Coşkun, R., Başkol, G., Saraymen, R., & Yücesoy, M. (2004) · Journal of Clinical Gastroenterology · doi:10.1097/01.mcg.0000129059.69524.d9 · Cited by 41 · see citing works
Condição funcional, força muscular respiratória e qualidade de vida em pacientes cirróticos
Galant, L. H., Forgiarini, L. A., Dias, A. S., & Marroni, C. A. (2012) · Brazilian Journal of Physical Therapy · doi:10.1590/s1413-35552012000100006 · Cited by 39 · see citing works
ZHU, H.-P., GU, Y.-R., ZHANG, G.-L., Su, Y., WANG, K., Zheng, Y., & Gao, Z. (2016) · Experimental and Therapeutic Medicine · doi:10.3892/etm.2016.3271 · Cited by 39 · see citing works
Fatigue and Sleep Quality before and after Liver Transplantation
Rodrigue, J. R., Nelson, D. R., Reed, A., Hanto, D. W., & Curry, M. P. (2010) · Progress in Transplantation · doi:10.7182/prtr.20.3.x82q1832184j4733 · Cited by 37 · see citing works
Stewart, K. E., Hart, R. P., Gibson, D. P., & Fisher, R. A. (2013) · Psychosomatics · doi:10.1016/j.psym.2013.10.002 · Cited by 36 · see citing works
The Transition to End-of-Life Care in End-Stage Liver Disease
Cox‐North, P., Doorenbos, A. Z., Shannon, S. E., Scott, J., & Curtis, J. R. (2013) · Journal of Hospice and Palliative Nursing · doi:10.1097/njh.0b013e318289f4b0 · Cited by 36 · see citing works
Functional status, respiratory muscle strength, and quality of life in patients with cirrhosis.
Galant, L. H., Forgiarini, L. A., Dias, A. S., & Marroni, C. A. (2012) · PubMed · Cited by 36 · see citing works
Dyspnea and respiratory muscle strength in end-stage liver disease
Kaltsakas, G. (2013) · World Journal of Hepatology · doi:10.4254/wjh.v5.i2.56 · Cited by 35 · see citing works
Oral Health and Quality of Life in Candidates for Liver Transplantation
Lins-Kusterer, L., Aguiar, I., Carvalho, F. M., Souza, L. S., Sarmento, V. A., Codés, L., Bittencourt, P. L., Paraná, R., & Bastos, J. (2017) · Transplantation Proceedings · doi:10.1016/j.transproceed.2017.01.049 · Cited by 35 · see citing works
Wunsch, E., Szymanik, B., Post, M. H., Marlicz, W. M., Mydłowska, M., & Milkiewicz, P. (2011) · Liver International · doi:10.1111/j.1478-3231.2011.02465.x · Cited by 33 · see citing works
Kalaitzakis, E., Josefsson, A., & Bjornsson, E. S. (2008) · BMC Gastroenterology · doi:10.1186/1471-230x-8-46 · Cited by 32 · see citing works
Trajectories of anxiety and depression in liver transplant candidates during the waiting‐list period
Annema, C., Roodbol, P. F., Van den Heuvel, E. R., Metselaar, H. J., Van Hoek, B., Porte, R. J., & Ranchor, A. V. (2017) · British Journal of Health Psychology · doi:10.1111/bjhp.12241 · Cited by 32 · see citing works
Waiting for a Liver Transplant: Psychosocial Well-Being, Spirituality, and Need for Counselling
Goetzmann, L., Wagner-Huber, R., Klaghofer, R., Muellhaupt, B., Clavien, P., Buddeberg, C., & Scheuer, E. (2006) · Transplantation Proceedings · doi:10.1016/j.transproceed.2006.08.171 · Cited by 31 · see citing works
Does cirrhosis affect quality of life in hepatitis C virus‐infected patients?
Hsu, P. C., Krajden, M., Yoshida, E. M., Anderson, F., TOMLINSON, G. A., & Krahn, M. D. (2009) · Liver International · doi:10.1111/j.1478-3231.2008.01865.x · Cited by 31 · see citing works
Palliative care for patients with end‐stage liver disease: An overview
Rakoski, M. O., & Volk, M. L. (2015) · Clinical Liver Disease · doi:10.1002/cld.478 · Cited by 30 · see citing works
How to tackle rising rates of liver disease in the UK
Bhala, N. B., Aithal, G. P., & Ferguson, J. (2013) · BMJ · doi:10.1136/bmj.f807 · Cited by 30 · see citing works
Coping strategies and quality of life among liver transplantation candidates.
Barba, R. J., Morales, I., Taboada, D., Denia, F., Mingote, J. C., Jiménez, M. Á. C., Palomo, T., & Rubio, G. (2011) · PubMed · Cited by 30 · see citing works
Health-Related Quality of Life in Chinese Patients with Chronic Liver Disease
Gao, R., Gao, F., Li, G., & Hao, J. Y. (2012) · Gastroenterology Research and Practice · doi:10.1155/2012/516140 · Cited by 29 · see citing works
Symptoms of Daytime Sleepiness and Sleep Apnea in Liver Cirrhosis Patients
Abdullah, A. E., Al-Jahdali, F., Ahmed, A. E., Shirbini, N., Abdullah, A.-H., Salim, B., Ali, Y. Z., Aljumah, A. A., Khan, M., Abdullah, K., et al. (2017) · Annals of Hepatology · doi:10.5604/01.3001.0010.0304 · Cited by 28 · see citing works
Assessment of sexual function and conjugal satisfaction prior to and after liver transplantation
Klein, J., Tran, S., Mentha‐Dugerdil, A., Giostra, E., Majno, P. E., Morard, I., Berney, T., Dendauw, P., Morel, P., Mentha, G., et al. (2013) · Annals of Transplantation · doi:10.12659/aot.883860 · Cited by 27 · see citing works
Study of the sleep quality and psychological state of patients with hepatitis B liver cirrhosis
Xiao, G., Ye, Q., Han, T., Yan, J., Sun, L., & Wang, F. (2017) · Hepatology Research · doi:10.1111/hepr.12981 · Cited by 27 · see citing works
The Transition to End-of-Life Care in End-Stage Liver Disease
&NA; (2013) · Journal of Hospice and Palliative Nursing · doi:10.1097/njh.0b013e318295ea27 · Cited by 25 · see citing works
Assessment of depression and anxiety in patients with chronic liver disease
Popovic, D. D., Culafic, D., Kisić-Tepavčević, D., Kovacevic, N., Špuran, M., Djuranovic, S. P., Jovicic, I., Krstic, M. N., Perišić, M., & Pekmezovic, T. D. (2015) · Vojnosanitetski pregled · doi:10.2298/vsp130904007p · Cited by 24 · see citing works
Identifying palliative care needs in a Portuguese liver unit
Carvalho, J. R., Vasconcelos, M., da Costa, P. M., Marinho, R. T., Fatela, N., Raimundo, M., Carvalhana, S. C., Ramalho, F. J., Cortez‐Pinto, H., & Velosa, J. (2018) · Liver International · doi:10.1111/liv.13865 · Cited by 24 · see citing works
Gutteling, J. J., de Man, R. A., Busschbach, J. J. V., & Darlington, A. (2007) · Hepatology International · doi:10.1007/s12072-007-9035-0 · Cited by 23 · see citing works
The burden of alcoholism in fifteen years of cirrhosis hospital admissions in P ortugal
Marinho, R. T., Duarte, H., Gíria, J., Nunes, J., Ferreira, A. O., & Velosa, J. (2014) · Liver International · doi:10.1111/liv.12569 · Cited by 22 · see citing works
Benzing, C., Krezdorn, N., Forster, J. I., Hinz, A., Krenzien, F., Atanasov, G., Schmelzle, M., Hau, H., & Bartels, M. J. (2016) · HPB · doi:10.1016/j.hpb.2016.01.546 · Cited by 22 · see citing works
Predictors of quality of life in patients evaluated for liver transplantation
Jara, M., Bednarsch, J., Malinowski, M. B., Lüttgert, K., Orr, J. G., Puhl, G., Seehofer, D., Neuhaus, P., & Stockmann, M. (2014) · Clinical Transplantation · doi:10.1111/ctr.12426 · Cited by 21 · see citing works
Sleep disorders in cirrhotics; How can we detect ?
Gençdal, G., Günşar, F., Meral, C. E., Salman, E., Gürsel, B., Oruç, N., Karasu, Z. A., Ersöz, G., & Akarca, U. S. (2014) · Liver International · doi:10.1111/liv.12485 · Cited by 20 · see citing works
Kalaitzakis, E., Josefsson, A., Castedal, M., Henfridsson, P., Bengtsson, M., Andersson, B. A., & Bjornsson, E. S. (2013) · Scandinavian Journal of Gastroenterology · doi:10.3109/00365521.2013.836755 · Cited by 20 · see citing works
Chien, Y.-C., Chiang, H.-C., Lin, P., & Chen, Y. (2015) · BMC Urology · doi:10.1186/s12894-015-0078-6 · Cited by 19 · see citing works
Che, Y., You, J., Chongsuvivatwong, V., Li, L., Sriplung, H., Yan, Y.-Z., Ma, S., Zhang, X., Shen, T., Chen, H.-M., et al. (2014) · Asian Pacific Journal of Cancer Prevention · doi:10.7314/apjcp.2014.15.12.4765 · Cited by 19 · see citing works
Mortality Associated with Hepatobiliary Disease in Portugal between 2006 and 2012
da Rocha, M. C., Marinho, R. T., & Rodrigues, T. (2017) · GE Portuguese Journal of Gastroenterology · doi:10.1159/000484868 · Cited by 18 · see citing works
Sogolow, E. D., Lasker, J. N., Sharim, R. R., Weinrieb, R. M., & Sass, D. A. (2010) · Illness Crisis & Loss · doi:10.2190/il.18.3.e · Cited by 17 · see citing works
[Prevalence of dyspepsia in liver cirrhosis: a clinical and epidemiological investigation].
Grassi, M., Albiani, B., Matteis, A. D., Fontana, M., Mc, L., & Raffa, S. (2001) · PubMed · Cited by 16 · see citing works
HRQOL using SF36 (generic specific) in liver cirrhosis
Janani, K., Varghese, J., Jain, M., Harika, K., Srinivasan, V., Michael, T., & Jayanthi, V. (2017) · Indian Journal of Gastroenterology · doi:10.1007/s12664-017-0773-1 · Cited by 14 · see citing works
Tsai, L., Lin, C., Chiang, S.-C., Chen, C., Lan, S.-J., & See, L. (2014) · Gastroenterology Nursing · doi:10.1097/sga.0000000000000020 · Cited by 11 · see citing works
Wunsch, E., Naprawa, G., Koziarska, D., Milkiewicz, M., Nowacki, P., & Milkiewicz, P. (2013) · Annals of Hepatology · doi:10.1016/s1665-2681(19)31008-7 · Cited by 9 · see citing works
Wang, G., Yang, J., Li, M.-R., Liu, B., Jiang, N., Fu, B., Jin, H., Li, H., Yang, Y., & Chen, G. (2013) · Experimental and Clinical Transplantation · doi:10.6002/ect.2012.0102 · Cited by 8 · see citing works
Smith, A. K., Ladner, D. P., & McCarthy, E. P. (2008) · American Journal of Hospice and Palliative Medicine® · doi:10.1177/1049909108315914 · Cited by 7 · see citing works
Respiratory muscle strength, hypoxemia and dyspnea in liver cirrhosis patients
Abdel-bary, S. A., Yousif, M., & Hussein, H. A. (2014) · Egyptian Journal of Chest Diseases and Tuberculosis · doi:10.1016/j.ejcdt.2014.06.016 · Cited by 7 · see citing works
Lower urinary tract symptoms in patients with liver cirrhosis
Margreiter, M., Heinisch, B. B., Schwarzer, R., Klatte, T., Shariat, S. F., & Ferlitsch, A. (2014) · World Journal of Urology · doi:10.1007/s00345-014-1313-6 · Cited by 6 · see citing works
Current status of pruritus in chronic liver diseases and efficacy of nalfurafine hydrochloride
Sumi, R., Fukuda, K., Irishio, K., Hattori, M., Sawai, Y., Kogita, S., Igura, T., Yamaguchi, Y., Matsumoto, Y., Nakahara, M., et al. (2017) · Kanzo · doi:10.2957/kanzo.58.486 · Cited by 4 · see citing works
Flagged first, then by citations
Research works printed but not linked: 1
- [6]Kotzeva M (ed.). European social statistics (Eurostat Pocketbooks). 2013 ed. Luxembourg: European Union, 2013, https://annazavaritt.blog.ilsole24ore.com/wp-content/uploads/sites/54/files/eurostat-social-stats-2013-complete-edition.pdf
Cited by
Sorted by citations
Guidelines on the management of ascites in cirrhosis
Aithal, G. P., Palaniyappan, N., China, L., Härmälä, S., Macken, L., Ryan, J. M., Wilkes, E. A., Moore, K., Leithead, J. A., Hayes, P. C., et al. (2021) · Gut · doi:10.1136/gutjnl-2020-321790 · Cited by 680 · see citing works
Diagnosis and Management of Cirrhosis and Its Complications
Tapper, E. B., & Parikh, N. D. (2023) · JAMA · doi:10.1001/jama.2023.5997 · Cited by 422 · see citing works
AASLD Practice Guidance: Palliative care and symptom‐based management in decompensated cirrhosis
Rogal, S. S., Hansen, L., Patel, A., Ufere, N. N., Verma, M., Woodrell, C. D., & Kanwal, F. (2022) · Hepatology · doi:10.1002/hep.32378 · Cited by 226 · see citing works
Sarcopenia in chronic liver disease: mechanisms and countermeasures
Allen, S., Quinlan, J. I., Dhaliwal, A., Armstrong, M. J., Elsharkawy, A. M., Greig, C. A., Lord, J. M., Lavery, G. G., & Breen, L. (2020) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00373.2020 · Cited by 124 · see citing works
Depression and anxiety are common among patients with cirrhosis
Hernaez, R., Kramer, J. R., Khan, A., Phillips, J., McCallister, K., Chaffin, K., Hernandez, A. P., Fullington, H., Ortiz, C., Blackwell, J.-M., et al. (2022) · Clinical Gastroenterology and Hepatology · doi:10.1016/j.cgh.2020.08.045 · Cited by 77 · see citing works
Suddle, A. R., Reeves, H. L., Hubner, R. A., Marshall, A., Rowe, I. A. C., TINIAKOS, D. G., Hübscher, S. G., Callaway, M. P., Sharma, D., See, T. C., et al. (2024) · Gut · doi:10.1136/gutjnl-2023-331695 · Cited by 78 · see citing works
AGA Clinical Practice Update on Palliative Care Management in Cirrhosis: Expert Review
Tandon, P., Walling, A. M., Patton, H. M., & Taddei, T. H. (2020) · Clinical Gastroenterology and Hepatology · doi:10.1016/j.cgh.2020.11.027 · Cited by 63 · see citing works
Health-Related Quality of Life: A Rapid Predictor of Hospitalization in Patients With Cirrhosis
Kok, B., Whitlock, R. H., Ferguson, T. W., Bailey, R. J., Burak, K. W., Kowalczewski, J. A., Tangri, N., & Tandon, P. (2020) · The American Journal of Gastroenterology · doi:10.14309/ajg.0000000000000545 · Cited by 64 · see citing works
Macken, L., Bremner, S. A., Gage, H., Touray, M., Williams, P., Crook, D., Mason, L. D., Lambert, D., Evans, C., Cooper, M., et al. (2020) · Alimentary Pharmacology & Therapeutics · doi:10.1111/apt.15802 · Cited by 62 · see citing works
Integrated Care of Alcohol-Related Liver Disease
Winder, G. S., Fernandez, A. C., & Mellinger, J. L. (2022) · Journal of Clinical and Experimental Hepatology · doi:10.1016/j.jceh.2022.01.010 · Cited by 51 · see citing works
Vidot, H., Cvejic, E., Finegan, L., Shores, E. A., Bowen, D. G., Strasser, S. I., McCaughan, G. W., Carey, S., Allman-Farinelli, M. A., & Shackel, N. A. (2019) · Nutrients · doi:10.3390/nu11081810 · Cited by 48 · see citing works
Nonhospice Palliative Care Within the Treatment of End‐Stage Liver Disease
Verma, M., Tapper, E. B., Singal, A. G., & Navarro, V. J. (2020) · Hepatology · doi:10.1002/hep.31226 · Cited by 48 · see citing works
Palliative care in liver disease: what does good look like?
Woodland, H., Hudson, B., Forbes, K., McCune, A., & Wright, M. (2019) · Frontline Gastroenterology · doi:10.1136/flgastro-2019-101180 · Cited by 47 · see citing works
Yamamura, S., Nakano, D., Hashida, R., Tsutsumi, T., Kawaguchi, T., Okada, M., Isoda, H., Takahashi, H., Matsuse, H., Eguchi, Y., et al. (2020) · Journal of Gastroenterology and Hepatology · doi:10.1111/jgh.15172 · Cited by 46 · see citing works
Yoo, H. J., Jung, K. J., Kim, M., Kim, M., Kang, M., Jee, S. H., Choi, Y. J., & Lee, J. H. (2019) · Frontiers in Physiology · doi:10.3389/fphys.2019.01421 · Cited by 43 · see citing works
Lai, J. C., Ufere, N. N., & Bucuvalas, J. C. (2020) · Liver Transplantation · doi:10.1002/lt.25792 · Cited by 41 · see citing works
Wang, C. W., Lebsack, A. E., Sudore, R. L., & Lai, J. C. (2020) · Digestive Diseases and Sciences · doi:10.1007/s10620-020-06369-1 · Cited by 38 · see citing works
Review article: current and emerging therapies for the management of cirrhosis and its complications
Tapper, E. B., Ufere, N. N., Huang, D. Q., & Loomba, R. S. (2022) · Alimentary Pharmacology & Therapeutics · doi:10.1111/apt.16831 · Cited by 39 · see citing works
Santos, F. C. D., Macieira, T. G. R., Yao, Y., Hunter, S., Madandola, O. O., Cho, H., Bjarnadóttir, R. I., Lopez, K. D., Wilkie, D. J., & Keenan, G. M. (2022) · Journal of Palliative Medicine · doi:10.1089/jpm.2021.0578 · Cited by 37 · see citing works
Macrophages and the development and progression of non-alcoholic fatty liver disease
Alabdulaali, B., Al‐Rashed, F., Al‐Onaizi, M., Kandari, A., Razafiarison, J., Tonui, D., Williams, M. R., Blériot, C., Ahmad, R., & Alzaïd, F. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1195699 · Cited by 35 · see citing works
Patient and Caregiver Perspectives on Palliative Care in End-Stage Liver Disease
Donlan, J., Ufere, N. N., Indriolo, T., Jackson, V. A., Chung, R. T., El-Jawahri, A. R., & Traeger, L. N. (2020) · Journal of Palliative Medicine · doi:10.1089/jpm.2020.0551 · Cited by 35 · see citing works
Global Assessment of Palliative Care Need: Serious Health-Related Suffering Measurement Methodology
Kwete, X. J., Bhadelia, A., Arreola‐Ornelas, H., Mendez, O., Rosa, W. E., Connor, S. R., Downing, J. D., Jamison, D. T. T., Watkins, D., Calderón, R., et al. (2024) · Journal of Pain and Symptom Management · doi:10.1016/j.jpainsymman.2024.03.027 · Cited by 35 · see citing works
Nursing care for patients with cirrhosis
Fabrellas, N., Künzler‐Heule, P., Olofson, A. E., Jack, K., & Carol, M. (2023) · Journal of Hepatology · doi:10.1016/j.jhep.2023.01.029 · Cited by 32 · see citing works
Burdensome Transitions of Care for Patients with End-Stage Liver Disease and Their Caregivers
Ufere, N. N., Donlan, J., Indriolo, T., Richter, J. M., Thompson, R., Jackson, V. A., Volandes, A. E., Chung, R. T., Traeger, L. N., & El-Jawahri, A. R. (2020) · Digestive Diseases and Sciences · doi:10.1007/s10620-020-06617-4 · Cited by 31 · see citing works
Patel, A., Woodrell, C. D., Ufere, N. N., Hansen, L., Tandon, P., Verma, M., Lai, J. C., Pinotti, R., & Rakoski, M. O. (2021) · Hepatology Communications · doi:10.1002/hep4.1743 · Cited by 30 · see citing works
Cognitive Impairment and Physical Frailty in Patients With Cirrhosis
Berry, K., Duarte‐Rojo, A., Grab, J. D., Dunn, M. A., Boyarsky, B. J., Verna, E. C., Kappus, M. R., Volk, M. L., McAdams‐DeMarco, M., Segev, D. L., et al. (2021) · Hepatology Communications · doi:10.1002/hep4.1796 · Cited by 28 · see citing works
Macken, L., Corrigan, M., Prentice, W. M., Finlay, F., McDonagh, J., Rajoriya, N., Salmon, C., Donnelly, M. C., Evans, C., Ganai, B., et al. (2022) · Frontline Gastroenterology · doi:10.1136/flgastro-2022-102128 · Cited by 28 · see citing works
Cooper, M., Pollard, A., Pandey, A., Bremner, S. A., Macken, L., Evans, C., Austin, M. J., Parnell, N., Steer, S., Thomson, S. J., et al. (2020) · Journal of Pain and Symptom Management · doi:10.1016/j.jpainsymman.2020.12.007 · Cited by 28 · see citing works
Hui, Y., Li, N., Yu, Z., Li, C., Wang, X., Li, Y., Sun, M., Yang, W., Guo, G., Fan, X., et al. (2021) · Hepatology Communications · doi:10.1002/hep4.1827 · Cited by 26 · see citing works
Palliative Care for Patients with End-Stage Liver Disease
Philips, C. A., & Kedarisetty, C. K. (2022) · Journal of Clinical and Experimental Hepatology · doi:10.1016/j.jceh.2022.08.003 · Cited by 26 · see citing works
The Prevalence of Pain in Chronic Diseases: An Umbrella Review of Systematic Reviews
Viderman, D., Tapinova, K., Aubakirova, M., & Abdildin, Y. G. (2023) · Journal of Clinical Medicine · doi:10.3390/jcm12237302 · Cited by 28 · see citing works
Short‐Term Safety of Repeated Acetaminophen Use in Patients With Compensated Cirrhosis
McGill, M. R., James, L. P., McCullough, S. S., Moran, J. H., Mathews, S. E., Peterson, E. C., Fleming, D. P., Tripod, M., Vazquez, J. H., Kennon‐McGill, S., et al. (2021) · Hepatology Communications · doi:10.1002/hep4.1810 · Cited by 25 · see citing works
Fukazawa, K., Rodriguez, P. J., Fong, C. T., & Gologorsky, E. (2019) · Journal of Cardiothoracic and Vascular Anesthesia · doi:10.1053/j.jvca.2019.12.024 · Cited by 25 · see citing works
Identifying palliative care needs in a Portuguese liver unit
Carvalho, J. R., Vasconcelos, M., da Costa, P. M., Marinho, R. T., Fatela, N., Raimundo, M., Carvalhana, S. C., Ramalho, F. J., Cortez‐Pinto, H., & Velosa, J. (2018) · Liver International · doi:10.1111/liv.13865 · Cited by 24 · see citing works
Clarke, G., Chapman, E., Crooks, J., Koffman, J., Ahmed, S., & Bennett, M. (2022) · BMC Palliative Care · doi:10.1186/s12904-022-00923-6 · Cited by 18 · see citing works
Palliative clinical trials in advanced chronic liver disease: Challenges and opportunities
Verma, S., Hingwala, J. P., Low, J., Patel, A., Verma, M., Bremner, S. A., Haddadin, Y., Shinall, M. C., Komenda, P. V. J., & Ufere, N. N. (2023) · Journal of Hepatology · doi:10.1016/j.jhep.2023.06.018 · Cited by 24 · see citing works
Patient-centered care: Key elements applicable to chronic liver disease
Verma, M., Brahmania, M., Fortune, B. E., Asrani, S. K., Fuchs, M., & Volk, M. L. (2023) · Hepatology · doi:10.1002/hep.32618 · Cited by 24 · see citing works
Symptom Frequency and Distress Underestimated in Decompensated Cirrhosis
Hansen, L., Chang, M. F., Hiatt, S. O., Dieckmann, N. F., Lyons, K. S., & Lee, C. S. (2021) · Digestive Diseases and Sciences · doi:10.1007/s10620-021-07216-7 · Cited by 23 · see citing works
Waqar, W., Asghar, S., & Manzoor, S. (2021) · PLoS ONE · doi:10.1371/journal.pone.0256739 · Cited by 23 · see citing works
Hepatic Hydrothorax: A Narrative Review
Pippard, B. J., Bhatnagar, M., McNeill, L., Donnelly, M. C., Frew, K., & Aujayeb, A. (2022) · Pulmonary Therapy · doi:10.1007/s41030-022-00195-8 · Cited by 23 · see citing works
Fasoula, N., Karlas, A., Prokopchuk, O., Katsouli, N., Bariotakis, M., Liapis, E., Goetz, A., Kallmayer, M. A., Reber, J., Novotny, A., et al. (2023) · Photoacoustics · doi:10.1016/j.pacs.2023.100454 · Cited by 23 · see citing works
Patel, A., Tapper, E. B., Kanwal, F., Woodrell, C. D., Hansen, L., Lai, J. C., Rogal, S. S., McDermott, C. L., Rakoski, M. O., & Ufere, N. N. (2023) · Hepatology Communications · doi:10.1097/hc9.0000000000000135 · Cited by 24 · see citing works
Hsu, W., Tsai, P., Chen, C.-Y., Tseng, K., Lai, H., Kuo, H., Hung, C., Tung, S., Wang, J., Chen, J.-J., et al. (2021) · Journal of Gastroenterology and Hepatology · doi:10.1111/jgh.15538 · Cited by 23 · see citing works
Carbonneau, M., Eboreime, E., Hyde, A. M., Campbell-Scherer, D. L., Faris, P., Gramlich, L. M., Tsuyuki, R. T., Congly, S. E., Shaheen, A. A., Sadler, M. D., et al. (2020) · BMC Health Services Research · doi:10.1186/s12913-020-05427-8 · Cited by 22 · see citing works
Palliative Care Always: Hepatology—Virtual Primary Palliative Care Training for Hepatologists
DeNofrio, J. C., Verma, M., Kosinski, A. S., Navarro, V. J., Taddei, T. H., Volk, M. L., Bakitas, M. A., & Ramchandran, K. J. (2021) · Hepatology Communications · doi:10.1002/hep4.1849 · Cited by 22 · see citing works
Testing and Management of Iron Overload After Genetic Screening–Identified Hemochromatosis
Savatt, J. M., Johns, A. M., Schwartz, M. L. B., McDonald, W. S., Salvati, Z. M., Oritz, N. M., Masnick, M. F., Hatchell, K. E., Hao, J., Buchanan, A. H., et al. (2023) · JAMA Network Open · doi:10.1001/jamanetworkopen.2023.38995 · Cited by 21 · see citing works
Shehadah, A., Naing, L. Y., Bapaye, J., Malik, S., Mohamed, M., Khalid, N., Munoz, A., Jadhav, N., Mushtaq, A., Okolo, P. I., III, et al. (2023) · The American Journal of the Medical Sciences · doi:10.1016/j.amjms.2023.10.006 · Cited by 21 · see citing works
Zhu, C., Zhang, D.-H., Zhu, C.-W., Xu, J., Guo, C., Wu, X., Cao, Q.-L., & Di, G. (2021) · Stem Cell Research & Therapy · doi:10.1186/s13287-021-02625-x · Cited by 20 · see citing works
Yoo, H. J., Lee, B., Jung, E., Kim, S. G., Kim, Y. S., & Yoo, J. (2021) · Hepatology International · doi:10.1007/s12072-021-10270-y · Cited by 20 · see citing works
Iacob, S., Mina, V., Mandea, M., Iacob, R. A., Vădan, R., Boar, V., Ionescu, G. D., Buzescu, D., Gheorghe, C., & Gheorghe, L. S. (2022) · Frontiers in Nutrition · doi:10.3389/fnut.2022.774044 · Cited by 20 · see citing works
Shinall, M. C., Bonnet, K. R., Schlundt, D. G., & Verma, M. (2021) · Liver Transplantation · doi:10.1002/lt.26364 · Cited by 19 · see citing works
Atreya, S. Y., Datta, S. S., & Salins, N. S. (2022) · Indian Journal of Palliative Care · doi:10.25259/ijpc_9_2022 · Cited by 19 · see citing works
Palliative care and end-stage liver disease
Rakoski, M. O., & Volk, M. L. (2019) · Current Opinion in Gastroenterology · doi:10.1097/mog.0000000000000530 · Cited by 20 · see citing works
Eftekar, M. (2019) · Australasian Psychiatry · doi:10.1177/1039856219875054 · Cited by 18 · see citing works
Whitsett, M. P., Ufere, N. N., Patel, A., Shea, J. A., Jones, C. A., Fix, O. K., & Serper, M. (2022) · Hepatology Communications · doi:10.1002/hep4.1939 · Cited by 18 · see citing works
Xu, W., Zhu, Z., Yu, J., Li, J., & Lu, H. (2023) · Asia-Pacific Journal of Oncology Nursing · doi:10.1016/j.apjon.2023.100361 · Cited by 17 · see citing works
Creating Effective Models for Delivering Palliative Care in Advanced Liver Disease
Verma, M., & Bakitas, M. A. (2021) · Current Hepatology Reports · doi:10.1007/s11901-021-00562-0 · Cited by 16 · see citing works
Treatment of Muscle Cramps in Patients With Cirrhosis of Liver: A Systematic Review
Kalia, S., Nath, P., Pathak, M., & Anand, A. C. (2021) · Journal of Clinical and Experimental Hepatology · doi:10.1016/j.jceh.2021.10.147 · Cited by 16 · see citing works
Symptom Classes in Decompensated Liver Disease
Hansen, L., Chang, M. F., Hiatt, S. O., Dieckmann, N. F., Mitra, A., Lyons, K. S., & Lee, C. S. (2021) · Clinical Gastroenterology and Hepatology · doi:10.1016/j.cgh.2021.11.023 · Cited by 16 · see citing works
Donlan, J., Zeng, C., Indriolo, T., Li, L., Zhu, E. V., Zhou, J., Pintro, K., Horick, N., Edelen, M. O., Chung, R. T., et al. (2024) · Hepatology Communications · doi:10.1097/hc9.0000000000000385 · Cited by 16 · see citing works
Rubin, J. B., Lai, J. C., Shui, A. M., Hohmann, S. F., & Auerbach, A. D. (2021) · Hepatology Communications · doi:10.1002/hep4.1694 · Cited by 16 · see citing works
Characterizing patient-reported outcomes in veterans with cirrhosis
Rogal, S. S., Yakovchenko, V., Gonzalez, R. I., Park, A., Lamorte, C., Gibson, S. P., Chartier, M., Ross, D. B., Comstock, E., Bajaj, J. S., et al. (2020) · PLoS ONE · doi:10.1371/journal.pone.0238712 · Cited by 14 · see citing works
Barber, T., Toon, L., Tandon, P., & Green, L. A. (2021) · Canadian Journal of Gastroenterology and Hepatology · doi:10.1155/2021/5582297 · Cited by 14 · see citing works
Improving end of life care in liver disease
Berry, P., & Kotha, S. (2022) · Journal of Hepatology · doi:10.1016/j.jhep.2021.10.001 · Cited by 14 · see citing works
Verma, M., Horrow, J. C., Carmody, S., & Navarro, V. J. (2023) · American Journal of Hospice and Palliative Medicine® · doi:10.1177/10499091231176297 · Cited by 14 · see citing works
Serra, S., Spampinato, M. D., Riccardi, A., Guarino, M., Fabbri, A., Orsi, L., & Iaco, F. D. (2023) · Journal of Clinical Medicine · doi:10.3390/jcm12134357 · Cited by 14 · see citing works
Inequity in end‐of‐life care for patients with chronic liver disease in England
Woodland, H., Buchanan, R. M., Pring, A., Dancox, M., McCune, A., Forbes, K., & Verne, J. (2023) · Liver International · doi:10.1111/liv.15684 · Cited by 14 · see citing works
Beresford, C. J., Gelling, L., Baron, S., & Thompson, L. (2023) · Health Expectations · doi:10.1111/hex.13893 · Cited by 14 · see citing works
Association between Sarcopenia and Depression in Patients with Chronic Liver Diseases
Nishikawa, H., Enomoto, H., Yoh, K., Iwata, Y., Sakai, Y., Kishino, K., Ikeda, N., Takashima, T., Aizawa, N., Takata, R., et al. (2019) · Journal of Clinical Medicine · doi:10.3390/jcm8050634 · Cited by 14 · see citing works
Integrating Palliative Care in the Management of Patients With Advanced Liver Disease
Patel, A., & Ufere, N. N. (2020) · Clinical Liver Disease · doi:10.1002/cld.936 · Cited by 13 · see citing works
Palliative care and end of life care in decompensated cirrhosis
Miller, K., Barman, P. M., & Kappus, M. R. (2023) · Clinical Liver Disease · doi:10.1097/cld.0000000000000044 · Cited by 13 · see citing works
Thuluvath, A. J., Duarte‐Rojo, A., Lai, J. C., Peipert, J. D., Dietch, Z. C., Siddiqui, O., Morrissey, S., Belfanti, K., Zhao, L., Guo, K., et al. (2023) · Transplantation · doi:10.1097/tp.0000000000004741 · Cited by 13 · see citing works
Barriers to palliative care in hepatocellular carcinoma: A review of the literature
Abasseri, M., Hoque, S., Kochovska, S., Caldwell, K., Sheahan, L., & Zekry, A. (2023) · Journal of Gastroenterology and Hepatology · doi:10.1111/jgh.16107 · Cited by 12 · see citing works
Nathiya, D., Raj, P., Singh, P., Bareth, H., Tejavath, A. S., Suman, S., Tomar, B. S., & Rai, R. R. (2023) · Journal of Clinical Medicine · doi:10.3390/jcm12165348 · Cited by 12 · see citing works
Kearney, A., Tiwari, N., Cullen, O., Legg, A., Arbi, I., Douglas, C. M., Leggett, B., Fenech, M., Mina, J., Hoey, P., et al. (2023) · Internal Medicine Journal · doi:10.1111/imj.16248 · Cited by 12 · see citing works
Validation of the Hospital Anxiety and Depression Scale in patients with decompensated cirrhosis
Zeng, C., Donlan, J., Indriolo, T., Li, L., Zhu, E. V., Zhou, J., Armstrong, M. E., Pintro, K., Horick, N., Chung, R. T., et al. (2024) · Hepatology Communications · doi:10.1097/hc9.0000000000000588 · Cited by 12 · see citing works
Palliative Care in End-Stage Liver Disease Patients Awaiting Liver Transplantation: Review
Silva, S. V., Freire, E., & Miranda, H. (2020) · GE Portuguese Journal of Gastroenterology · doi:10.1159/000507336 · Cited by 12 · see citing works
Hospice care for end stage liver disease in the United States
Orman, E. S., Johnson, A. W., Ghabril, M., & Sachs, G. A. (2021) · Expert Review of Gastroenterology & Hepatology · doi:10.1080/17474124.2021.1892487 · Cited by 11 · see citing works
The Safe Use of Analgesics in Patients with Cirrhosis: A Narrative Review
Ma, J., Bjornsson, E. S., & Chalasani, N. (2023) · The American Journal of Medicine · doi:10.1016/j.amjmed.2023.10.022 · Cited by 11 · see citing works
Zhao, F.-J., Huo, R., Li, F.-R., & You, X.-M. (2024) · Supportive Care in Cancer · doi:10.1007/s00520-024-08790-y · Cited by 11 · see citing works
Top Ten Tips Palliative Care Clinicians Should Know About End-Stage Liver Disease
Waterman, B. L., Ramsey, S. U., Whitsett, M. P., Patel, A., Radcliff, J. A., Kotler, D. L., Winters, A. C., Woodrell, C. D., Ufere, N. N., Serper, M., et al. (2021) · Journal of Palliative Medicine · doi:10.1089/jpm.2021.0097 · Cited by 11 · see citing works
Dang, T. T., Patel, K., Farhat, K., Abraldeṣ, J. G., Ma, M. M., Bailey, R. J., Burak, K. W., Mitchell, N., & Tandon, P. (2021) · European Journal of Gastroenterology & Hepatology · doi:10.1097/meg.0000000000002301 · Cited by 11 · see citing works
Medical referral criteria for palliative care in adults: a scoping review
Grądalski, T. (2022) · Polskie Archiwum Medycyny Wewnętrznej · doi:10.20452/pamw.16223 · Cited by 11 · see citing works
Deng, L. X., Kent, D. S., O’Riordan, D. L., Pantilat, S. Z., Lai, J. C., & Bischoff, K. E. (2021) · Journal of Palliative Medicine · doi:10.1089/jpm.2021.0219 · Cited by 11 · see citing works
Jordan, R. I., ElMokhallalati, Y., Corless, L., & Bennett, M. (2022) · Liver International · doi:10.1111/liv.15428 · Cited by 10 · see citing works
Zhou, K., Huang, X., Chen, M., Li, Z., Qin, J., Ji, Y., Yu, X., & Yan, F. (2024) · Journal of Advanced Nursing · doi:10.1111/jan.16044 · Cited by 10 · see citing works
Frailty and transplant-free survival of patients with liver cirrhosis: A meta-analysis
Yuan, C., Li, W., Liu, J., & Li, J. (2024) · PLoS ONE · doi:10.1371/journal.pone.0302836 · Cited by 10 · see citing works
Rubin, J. B., Loeb, R., Fenton, C. L., Huang, C., Keyhani, S., Seal, K. H., & Lai, J. C. (2024) · Hepatology Communications · doi:10.1097/hc9.0000000000000432 · Cited by 10 · see citing works
Koo, S., Sharp, L., Hull, M. A., Rushton, S., Neilson, L. J., The OSCAR study team, McPherson, S., & Rees, C. J. (2021) · BMJ Open Gastroenterology · doi:10.1136/bmjgast-2021-000638 · Cited by 10 · see citing works
Ihle, A., de Gouveia, B. R. F. O., Gouveia, É. R., Cheval, B., Nascimento, M. D. M., Conceição, L., Marconcin, P., Peralta, M., Ferrari, G., Oliveira, D., et al. (2021) · Sustainability · doi:10.3390/su132313370 · Cited by 10 · see citing works
Cammarota, A., Zanuso, V., Pressiani, T., Personeni, N., & Rimassa, L. (2022) · Journal of Hepatocellular Carcinoma · doi:10.2147/jhc.s268293 · Cited by 10 · see citing works
Zhang, Y., Xiao, L., Liu, Q., Zhang, X., Li, M., Xu, Y., Dai, M., Zhao, F., Shen, Y., Salvador, J. T., et al. (2025) · Scientific Reports · doi:10.1038/s41598-024-81943-5 · Cited by 10 · see citing works
Kieffer, S., Tanaka, T., Ogilvie, A. C., Gilbertson‐White, S., & Hagiwara, Y. (2022) · American Journal of Hospice and Palliative Medicine® · doi:10.1177/10499091221142841 · Cited by 9 · see citing works
Luk, J. W., Ha, N. B., Shui, A. M., Snyder, H. R., Batki, S. L., Ostacher, M. J., Monto, A., Wong, R. J., Cheung, R. C., Parekh, P. I., et al. (2024) · Alcoholism Clinical and Experimental Research · doi:10.1111/acer.15500 · Cited by 9 · see citing works
Emerging Role of Palliative Care in Patients with Advanced Liver Disease
Jordan, R. I., & Tandon, P. (2019) · Seminars in Liver Disease · doi:10.1055/s-0039-3400259 · Cited by 9 · see citing works
Oral Health‐Related Quality of Life in Chronic Liver Failure Patients Measured by OHIP‐14 and GOHAI
Zahed, M., Ranjbar, M. A., & Azad, A. (2020) · BioMed Research International · doi:10.1155/2020/8835824 · Cited by 9 · see citing works
The Impact of Social Workers in Cirrhosis Care: a Systematic Review
Ufere, N. N., Hinson, J., Finnigan, S., Powell, E. E., Donlan, J., Martin, C., Clark, P., & Valery, P. C. (2022) · Current Treatment Options in Gastroenterology · doi:10.1007/s11938-022-00381-2 · Cited by 9 · see citing works
Léniz, J., Domínguez, A., Bone, A. E., Etkind, S. N., Perez‐Cruz, P. E., & Sleeman, K. E. (2024) · BMC Medicine · doi:10.1186/s12916-024-03570-1 · Cited by 11 · see citing works
Commonly encountered symptoms and their management in patients with cirrhosis
Philips, C. A. (2024) · Frontiers in Medicine · doi:10.3389/fmed.2024.1442525 · Cited by 9 · see citing works
Palliative Care Intervention for Patients With End-Stage Liver Disease
Verma, M., Navarro, V. J., Kosinski, A. S., Taddei, T. H., Kalman, R. S., Barritt, A. S., Jakab, S., Serper, M., Orman, E. S., Balakrishnan, M., et al. (2026) · JAMA Internal Medicine · doi:10.1001/jamainternmed.2026.0571 · Cited by 8 · see citing works
- Authors
- Peng, J.-K., Hepgul, N., Higginson, I. J., & Gao, W.
- Affiliations
- National Taiwan University (TW)
- King's College London (GB)
- Corresponding author
- Peng, Jen-Kuei
- Venue
- Palliative Medicine
- Publisher
- SAGE Publications
- Published
- 2018-10-22
- Volume
- 33
- Issue
- 1
- Pages
- 24-36
- ISSN
- 0269-2163 (ISSN-L)
- 1477-030X
- PMC
- PMC6291907
- OpenAlex
- W2897616048
- Cited by
- 283
- References
- 123
- Citations by year
- 2026: 30 · 2025: 31 · 2024: 57 · 2023: 47 · 2022: 42 · 2021: 41 · 2020: 24 · 2019: 10 · 2018: 1
- FWCI
- 2.56
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Locations
- Palliative Medicine (publishedVersion, cc-by-nc)
- Europe PMC (PubMed Central) (publishedVersion, cc-by-nc)
- PubMed Central (publishedVersion, cc-by-nc)
- PubMed (publishedVersion)
- Research Portal (King's College London) (publishedVersion, cc-by-nc)
- Funders
- Ministry of Education of Taiwan (educational grant for JKP)
- National Institute for Health Research (CLAHRC South London at King’s College Hospital NHS)
- Topics
- Health Sciences › Medicine › Hepatology › Liver Disease and Transplantation
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Palliative Care and End-of-Life Issues
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Heart Failure Treatment and Management
- Keywords
- end-stage liver disease, symptom prevalence, health-related quality of life, pain, dyspnea, muscle cramps, sleep disorders, depression, anxiety, erectile dysfunction, liver cirrhosis, decompensated cirrhosis, chronic liver disease, SF-36
- MeSH terms
- Adult, Aged, Aged, 80 and over, Female, Humans, Liver Cirrhosis, Male, Middle Aged, Palliative Care, Quality of Life, Severity of Illness Index, Prevalence, End Stage Liver Disease
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
