DNA double-strand break repair pathway choice and cancer

A Programmable Dual-RNA–Guided DNA Endonuclease in Adaptive Bacterial Immunity

Jinek, M., Chylinski, K., Fonfara, I., Hauer, M., Doudna, J. A., & Charpentier, E. (2012) · Science · doi:10.1126/science.1225829 · Cited by 17,116

The mechanism of double-strand DNA break repair by the nonhomologous DNA end-joining pathway

Lieber, M. R. (2010) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.052308.093131 · Cited by 2,882

Massive genomic rearrangement acquired in a single catastrophic event during cancer development

Stephens, P. J., Greenman, C. D., Fu, B., Yang, F., Bignell, G. R., Mudie, L. J., Pleasance, E. D., Lau, K. W., Beare, D., Stebbings, L. A., et al. (2011) · Cell · doi:10.1016/j.cell.2010.11.055 · Cited by 2,414

DNA damage, aging, and Cancer

Hoeijmakers, J. H. J. (2009) · New England Journal of Medicine · doi:10.1056/nejmra0804615 · Cited by 2,239

A TALE nuclease architecture for efficient genome editing

Miller, J. C., Tan, S., Qiao, G., Barlow, K. A., Wang, J., Xia, D. F., Meng, X., Paschon, D. E., Leung, E., Hinkley, S. J., et al. (2011) · Nature Biotechnology · doi:10.1038/nbt.1755 · Cited by 2,098

53BP1 Inhibits Homologous Recombination in Brca1-Deficient Cells by Blocking Resection of DNA Breaks

Bunting, S. F., Callén, E., Wong, N., Chen, H.-T., Polato, F., Gunn, A., Bothmer, A., Feldhahn, N., Fernandez-Capetillo, O., Cao, L., et al. (2010) · Cell · doi:10.1016/j.cell.2010.03.012 · Cited by 1,671

Highly efficient endogenous human gene correction using designed zinc-finger nucleases

Urnov, F. D., Miller, J. C., Lee, Y.-L., Beausejour, C. M., Rock, J. M., Augustus, S., Jamieson, A. C., Porteus, M. H., Gregory, P. D., & Holmes, M. C. (2005) · Nature · doi:10.1038/nature03556 · Cited by 1,642

Double-Strand Break End Resection and Repair Pathway Choice

Symington, L. S., & Gautier, J. (2011) · Annual Review of Genetics · doi:10.1146/annurev-genet-110410-132435 · Cited by 1,556

Hairpin opening and overhang processing by an Artemis/DNA-dependent protein kinase complex in nonhomologous end joining and V(D)J recombination

Ma, Y., Pannicke, U., Schwarz, K., & Lieber, M. R. (2002) · Cell · doi:10.1016/s0092-8674(02)00671-2 · Cited by 1,166

DNA interstrand crosslink repair and cancer

Deans, A. J., & West, S. C. (2011) · Nature reviews. Cancer · doi:10.1038/nrc3088 · Cited by 1,063

Prediction and Investigation of Novel Proteins in DNA Double Stranded Break Repair

Hooshyar, M. (2016) · doi:10.22215/etd/2016-11472

Faculty Opinions recommendation of Phage Mu Gam protein promotes NHEJ in concert with Escherichia coli ligase.

Courcelle, J. (2019) · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature · doi:10.3410/f.734522415.793558747

E2F transcription factors: master controllers of genomic integrity throughout the cell cycle

Liu, Q. (2022) · Utrecht University Repository (Utrecht University) · doi:10.33540/1573

Efecto del resveratrol como radiosensibilizador en líneas celulares de cáncer cervicouterino a través de la inhibición de las vías de reparación de daño a DNA por Recombinación Homóloga (HR) y No Homóloga (NHEJ)

Acosta, A. T. (2022) · doi:10.24275/uami.w6634381v

Réparations de l'ADN

Robert, J. (2023) · Elsevier eBooks · doi:10.1016/b978-2-294-77967-1.00016-4

Data from Multicellular Complex Tumor Spheroid Response to DNA Repair Inhibitors in Combination with DNA-damaging Drugs

Dexheimer, T. S., Coussens, N. P., Silvers, T. E., Wright, J., Morris, J., Doroshow, J. H., & Teicher, B. A. (2023) · doi:10.1158/2767-9764.c.6767408

In Silico design and characterization of RAD51 protein inhibitors targeting homologous recombination repair for cancer therapy

Kaur, H., Kaur, H., Rajesh, P., & Rajesh, C. (2023) · Genome Instability & Disease · doi:10.1007/s42764-023-00106-4

Association study of rs323344 in TEX15 with non-obstructive azoospermia in Iranian population

Aliasghar, B., Sane, S., Sheidai, M., Koohdar, F., & Kalhor, N. (2023) · Genetika · doi:10.2298/gensr2302689a

An Estimation of some DNA Repair Genes Polymorphisms APE1, XRCC1, and RAD18) in X-Ray Technicians

Najjar, Z. S. R. (2022) · International Journal of Medical Research · doi:10.61705/g1mgfc98

Up-Regulation of Non-Homologous End-Joining by MUC1

Bessho, T. (2024) · Genes · doi:10.3390/genes15060808

Translational Research: Bridging the Gap Between Bench and Bedside

Marima, R. M., Sambo, E., Basera, A., Gabada, L., Ambele, M. A., Moela, P., Kaufmann, A. M., & Dlamini, Z. (2024) · Springer eBooks · doi:10.1007/978-3-031-64388-0_12

Additional file 2 of Identification of a RAD51B enhancer variant for susceptibility and progression to glioma

Huang, L., Xu, W., Yan, D., Shi, X., Zhang, S., Chen, M., & Dai, L. (2024) · Figshare · doi:10.6084/m9.figshare.24406883

Additional file 4 of Identification of a RAD51B enhancer variant for susceptibility and progression to glioma

Huang, L., Xu, W., Yan, D., Shi, X., Zhang, S., Chen, M., & Dai, L. (2024) · Figshare · doi:10.6084/m9.figshare.26628832

Additional file 6 of Identification of a RAD51B enhancer variant for susceptibility and progression to glioma

Huang, L., Xu, W., Yan, D., Shi, X., Zhang, S., Chen, M., & Dai, L. (2024) · Figshare · doi:10.6084/m9.figshare.26628838

Additional file 1 of Identification of a RAD51B enhancer variant for susceptibility and progression to glioma

Huang, L., Xu, W., Yan, D., Shi, X., Zhang, S., Chen, M., & Dai, L. (2023) · Figshare · doi:10.6084/m9.figshare.24406664

Additional file 1 of Ku70 affects the frequency of chromosome translocation in human lymphocytes after radiation and T-cell acute lymphoblastic leukemia

Cheng, Z., Wang, Y., Guo, L., Li, J., Zhang, W., Zhang, C., Liu, Y., Huang, Y., & Xu, K. (2022) · Figshare · doi:10.6084/m9.figshare.20521358

Additional file 3 of Identification of a RAD51B enhancer variant for susceptibility and progression to glioma

Huang, L., Xu, W., Yan, D., Shi, X., Zhang, S., Chen, M., & Dai, L. (2024) · Figshare · doi:10.6084/m9.figshare.26628829

Additional file 7 of Identification of a RAD51B enhancer variant for susceptibility and progression to glioma

Huang, L., Xu, W., Yan, D., Shi, X., Zhang, S., Chen, M., & Dai, L. (2024) · Figshare · doi:10.6084/m9.figshare.26628841

Additional file 1 of Ethical and practical considerations for cell and gene therapy toward an HIV cure: findings from a qualitative in-depth interview study in the United States

Dubé, K., Kanazawa, J. T., Patel, H., Louella, M., Sylla, L. N., Sheehy, J., Dee, L., Taylor, J., Adair, J., Anthony-Gonda, K., et al. (2022) · Figshare · doi:10.6084/m9.figshare.19571912

Additional file 8 of Identification of a RAD51B enhancer variant for susceptibility and progression to glioma

Huang, L., Xu, W., Yan, D., Shi, X., Zhang, S., Chen, M., & Dai, L. (2024) · Figshare · doi:10.6084/m9.figshare.26628844

Additional file 9 of Identification of a RAD51B enhancer variant for susceptibility and progression to glioma

Huang, L., Xu, W., Yan, D., Shi, X., Zhang, S., Chen, M., & Dai, L. (2024) · Figshare · doi:10.6084/m9.figshare.26628847

Additional file 5 of Identification of a RAD51B enhancer variant for susceptibility and progression to glioma

Huang, L., Xu, W., Yan, D., Shi, X., Zhang, S., Chen, M., & Dai, L. (2024) · Figshare · doi:10.6084/m9.figshare.26628835

GSK3β high /NFATc1 high subtype targeting overcomes therapy resistance in pancreatic cancer through transcriptional induction of homologous recombination repair

Latif, M. U., Liu, X., Bockelmann, A., Huhnold, L., Schmídt, G., Klein, L., Zhao, X., Conradi, L., Conrads, K., Weber, A. L., et al. (2025) · Gut · doi:10.1136/gutjnl-2025-336227

Novel RAD50 variants lead to Nijmegen Breakage Syndrome–like disorder and unplanned recombinant human growth hormone treatment response

Gong, Y., Jiang, M., Wu, S., Guo, S., & Lyu, Y. (2026) · Frontiers in Endocrinology · doi:10.3389/fendo.2026.1755251

Characterization of a novel DNA binding domain in the N-terminus of BRCA2 and evaluation of BRCA2 variants identified in breast cancer patients in the same region

Nicolai, C. V. (2016) · theses.fr (ABES) · doi:10.70675/8269fe86z1917z412bzbc67za5e61f3cb532

Degrees of H2AX phosphorylation correlate with unique features of the intratumoral immune microenvironment in colorectal carcinomas

Berrino, E., Bellomo, S. E., Aquilano, M. C., Falcinelli, M., Chesta, A., Valtorta, E., Zampieri, D., Mauri, G., Sala, G., Marsoni, S., et al. (2026) · The Oncologist · doi:10.1093/oncolo/oyag116

Comprendre et perturber le choix de la voie de réparation des cassures double brin de l'ADN pour augmenter l'efficacité et la sélectivité des agents anticancéreux génotoxiques

Chanut, P. (2017) · theses.fr (ABES) · doi:10.70675/8712c9e0za693z4ff3zac1cz5973c1d276f9

Crossover Pathways of Brassica napus Allopolyploid Meiosis

Gonzalo, A. (2017) · theses.fr (ABES) · doi:10.70675/2efd335dz7767z49fezb1f0z678daab8ce8b

Theoretical approach of complex DNA lesions : from formation to repair

Bignon, E. (2017) · theses.fr (ABES) · doi:10.70675/627be32az9b1dz4941za5fbz218b61cb1810

Etude structurale et fonctionnelle de complexes multi-protéiques impliqués dans la voie NHEJ humaine

Benferhat, K. (2018) · theses.fr (ABES) · doi:10.70675/574ef4f1z5d94z4d8czb4a1zccdbdb724e88

Développement de stratégies de criblage de mutations d'épissage dans des gènes de prédisposition au cancer.

Tubeuf, H. (2019) · theses.fr (ABES) · doi:10.70675/e62a0ca5z7722z4c72z9d57z726ae2bc0e42

Evaluation des mécanismes de cytotoxicité de molécules hautement énergétiques

Guyot, L. (2018) · theses.fr (ABES) · doi:10.70675/7e62e330z332az49d6zbf81z7256e3ee7c34

Functional studies of new protein-protein interactions potentially involved in homologous recombination in hyperthermophilic archaea : study of interactions between PCNA and Mre11-Rad50 complex & Primase and RadA

Lü, Y. (2018) · theses.fr (ABES) · doi:10.70675/16499280z0b60z48c3z9daez312cfec633a3

Mutations de la voie ATR-CHK1, réponse au stress réplicatif et cancer

Egger, T. (2018) · theses.fr (ABES) · doi:10.70675/eb51eb1ezc51dz4737zaf38z954d1a68dbea

Characterization of novel DNA double-stranded break repair factors in B lymphocytes

Wei, W. (2020) · theses.fr (ABES) · doi:10.70675/90f35f73z484fz4a69zbc98zb9b1adafb5a4

Development of an enzymatic assay on biochip measuring DNA double strand breaks repair capacity : biological validation and applications

Tatin, X. (2021) · theses.fr (ABES) · doi:10.70675/2e1efdc7ze73bz4150za65dzec3d74346874

Dynamics of Rad51 during homologous recombination in living yeast

Liu, S. (2022) · theses.fr (ABES) · doi:10.70675/80bdaa99zed42z4eb6zb888z9489e31eec93

Translational control in ovarian cancer : role of the glutaminyl-tRNA synthetase QARS in DNA damage response

Serafini, M. (2024) · theses.fr (ABES) · doi:10.70675/ab8b1f5az3c15z4b5fzba28z247b40b8c7e0

LINE-1 transposon derived DNA lesions reshape the chromatin landscape to promote genome instabilityPreprint

Kumar, A., Parida, A. S., Bhatoa, K., Raghav, S. K., & Tiwari, B. (2026) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2026.04.20.719662

SAGE1’s Sage Wisdom Stabilizes Genomes

Li, G. (2026) · Vita · doi:10.15302/vita.2026.05.0038

Synergistic perspectives—How single‐molecule biophysics complement biochemical understanding

de Bragança, S., Jansen, E. L., & Eeftens, J. M. (2026) · FEBS Letters · doi:10.1002/1873-3468.70444

From genomic instability to epigenetic regulation: the role of DNA repair gene variants and non-coding RNAs in colorectal carcinogenesis

Alsubeeh, K., Yaltir, A., Yalın, A. E., Ünal, N., & Yalın, S. (2026) · Nucleosides Nucleotides & Nucleic Acids · doi:10.1080/15257770.2026.2735915

Loss of PIMREG impairs double-strand break signaling and repair

Gasparini, M. V. D. R., do Carmo, L., de Almeida, G. G., Mamede, M. S. L., Cardoso, I. D., Sardinha, L. A., Dias, I. S., Black, J. A., Arfelli, V. C., Chang, Y.-C., et al. (2026) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2026.168486

Sulfonylurea receptor 1 deficiency alleviates acute lung injury by activating PARP1 in epithelial cells

Yin, X., Zhu, Q., Zhao, L., Ma, W., Wang, L., Li, H., Wang, C., Wang, Y., Xu, L., Zhang, H., et al. (2026) · iScience · doi:10.1016/j.isci.2026.117627

BindingDB Entry 50020461: Discovery of a 53BP1 Small Molecule Antagonist Using a Focused DNA-Encoded Library Screen.

BindingDB (2024) · UC San Diego · doi:10.7270/q2tf02t4

BindingDB Entry 50019692: Small Molecules Targeting DNA Polymerase Theta (POLθ) as Promising Synthetic Lethal Agents for Precision Cancer Therapy.

BindingDB (2024) · UC San Diego · doi:10.7270/q2z3242n

DNA Double-Strand Break Repair in Tumorigenesis and Anticancer Treatment

Her, C. (2014) · Chemotherapy Open access · doi:10.4172/2167-7700.1000124 · Cited by 2

Genomic Instability and Cancer Risk Associated with Erroneous DNA Repair

Yoshioka, K., Kusumoto‐Matsuo, R., Matsuno, Y., & Ishiai, M. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms222212254 · Cited by 63

Playing the End Game: DNA Double-Strand Break Repair Pathway Choice

Chapman, J. R., Taylor, M. R. G., & Boulton, S. J. (2012) · Molecular Cell · doi:10.1016/j.molcel.2012.07.029 · Cited by 1,728

Re: Choices have consequences: the nexus between DNA repair pathways and genomic instability in cancer

McKay, M. (2017) · Clinical and Translational Medicine · doi:10.1186/s40169-017-0137-6

The role of DNA breaks in genomic instability and tumorigenesis

Mills, K. D., Ferguson, D. O., & Alt, F. W. (2003) · Immunological Reviews · doi:10.1034/j.1600-065x.2003.00060.x · Cited by 368