DNA double-strand break repair pathway choice and cancer

A Programmable Dual-RNA–Guided DNA Endonuclease in Adaptive Bacterial Immunity

Jinek, M., Chylinski, K., Fonfara, I., Hauer, M., Doudna, J. A., & Charpentier, E. (2012) · Science · doi:10.1126/science.1225829 · Cited by 17,116

The mechanism of double-strand DNA break repair by the nonhomologous DNA end-joining pathway

Lieber, M. R. (2010) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.052308.093131 · Cited by 2,882

Massive genomic rearrangement acquired in a single catastrophic event during cancer development

Stephens, P. J., Greenman, C. D., Fu, B., Yang, F., Bignell, G. R., Mudie, L. J., Pleasance, E. D., Lau, K. W., Beare, D., Stebbings, L. A., et al. (2011) · Cell · doi:10.1016/j.cell.2010.11.055 · Cited by 2,414

DNA damage, aging, and Cancer

Hoeijmakers, J. H. J. (2009) · New England Journal of Medicine · doi:10.1056/nejmra0804615 · Cited by 2,239

A TALE nuclease architecture for efficient genome editing

Miller, J. C., Tan, S., Qiao, G., Barlow, K. A., Wang, J., Xia, D. F., Meng, X., Paschon, D. E., Leung, E., Hinkley, S. J., et al. (2011) · Nature Biotechnology · doi:10.1038/nbt.1755 · Cited by 2,098

53BP1 Inhibits Homologous Recombination in Brca1-Deficient Cells by Blocking Resection of DNA Breaks

Bunting, S. F., Callén, E., Wong, N., Chen, H.-T., Polato, F., Gunn, A., Bothmer, A., Feldhahn, N., Fernandez-Capetillo, O., Cao, L., et al. (2010) · Cell · doi:10.1016/j.cell.2010.03.012 · Cited by 1,671

Highly efficient endogenous human gene correction using designed zinc-finger nucleases

Urnov, F. D., Miller, J. C., Lee, Y.-L., Beausejour, C. M., Rock, J. M., Augustus, S., Jamieson, A. C., Porteus, M. H., Gregory, P. D., & Holmes, M. C. (2005) · Nature · doi:10.1038/nature03556 · Cited by 1,642

Double-Strand Break End Resection and Repair Pathway Choice

Symington, L. S., & Gautier, J. (2011) · Annual Review of Genetics · doi:10.1146/annurev-genet-110410-132435 · Cited by 1,556

Hairpin opening and overhang processing by an Artemis/DNA-dependent protein kinase complex in nonhomologous end joining and V(D)J recombination

Ma, Y., Pannicke, U., Schwarz, K., & Lieber, M. R. (2002) · Cell · doi:10.1016/s0092-8674(02)00671-2 · Cited by 1,166

DNA interstrand crosslink repair and cancer

Deans, A. J., & West, S. C. (2011) · Nature reviews. Cancer · doi:10.1038/nrc3088 · Cited by 1,063

Repair Pathway Choices and Consequences at the Double-Strand Break

Ceccaldi, R., Rondinelli, B., & D’Andrea, A. D. (2016) · Trends in Cell Biology · doi:10.1016/j.tcb.2015.07.009 · Cited by 1,499

Combination strategies with PD-1/PD-L1 blockade: current advances and future directions

Yi, M., Zheng, X., Niu, M., Zhu, S., Ge, H., & Wu, K. (2022) · Molecular Cancer · doi:10.1186/s12943-021-01489-2 · Cited by 1,445

DNA damage foci: Meaning and significance

Rothkamm, K., Barnard, S. G. R., Moquet, J., Ellender, M., Rana, Z., & Burdak‐Rothkamm, S. (2015) · Environmental and Molecular Mutagenesis · doi:10.1002/em.21944 · Cited by 345

Ionizing radiation-induced DNA injury and damage detection in patients with breast cancer

Borrego‐Soto, G., Ortı́z-López, R., & Rojas‐Martínez, A. (2015) · Genetics and Molecular Biology · doi:10.1590/s1415-475738420150019 · Cited by 336

Essential Roles for Polymerase θ-Mediated End Joining in the Repair of Chromosome Breaks

Wyatt, D. W., Feng, W., Conlin, M. P., Yousefzadeh, M. J., Roberts, S. A., Mieczkowski, P. A., Wood, R. D., Gupta, G. P., & Ramsden, D. A. (2016) · Molecular Cell · doi:10.1016/j.molcel.2016.06.020 · Cited by 316

Untangling the roles of TOP2A and TOP2B in transcription and cancer

Uusküla-Reimand, L., & Wilson, M. D. (2022) · Science Advances · doi:10.1126/sciadv.add4920 · Cited by 242

Do DNA Double-Strand Breaks Drive Aging?

White, R. R., & Vijg, J. (2016) · Molecular Cell · doi:10.1016/j.molcel.2016.08.004 · Cited by 232

A physicochemical model of reaction kinetics supports peroxyl radical recombination as the main determinant of the FLASH effect

Labarbe, R., Hotoiu, L., Barbier, J., & Favaudon, V. (2020) · Radiotherapy and Oncology · doi:10.1016/j.radonc.2020.06.001 · Cited by 222

Radiobiology of the FLASH effect

Friedl, A. A., Prise, K. M., Butterworth, K. T., Montay‐Gruel, P., & Favaudon, V. (2021) · Medical Physics · doi:10.1002/mp.15184 · Cited by 205

Mode of action-based risk assessment of genotoxic carcinogens

Hartwig, A., Arand, M., Epe, B., Guth, S., Jahnke, G., Lampen, A., Martus, H., Monien, B. H., Rietjens, I. M. C. M., Schmitz‐Spanke, S., et al. (2020) · Archives of Toxicology · doi:10.1007/s00204-020-02733-2 · Cited by 205

FANCD2 Maintains Fork Stability in BRCA1/2-Deficient Tumors and Promotes Alternative End-Joining DNA Repair

Kais, Z., Rondinelli, B., Holmes, A. L., O’Leary, C., Kozono, D., D’Andrea, A. D., & Ceccaldi, R. (2016) · Cell Reports · doi:10.1016/j.celrep.2016.05.031 · Cited by 208

Alternative end-joining repair pathways are the ultimate backup for abrogated classical non-homologous end-joining and homologous recombination repair: Implications for the formation of chromosome translocations

Iliakis, G. E., Murmann-Konda, T., & Soni, A. (2015) · Mutation Research/Genetic Toxicology and Environmental Mutagenesis · doi:10.1016/j.mrgentox.2015.07.001 · Cited by 199

Translocation and deletion breakpoints in cancer genomes are associated with potential non-B DNA-forming sequences

Bacolla, A., Tainer, J. A., Vásquez, K. M., & Cooper, D. N. (2016) · Nucleic Acids Research · doi:10.1093/nar/gkw261 · Cited by 164

Hypoxia-Driven Effects in Cancer: Characterization, Mechanisms, and Therapeutic Implications

Shi, R., Liao, C., & Zhang, Q. H. (2021) · Cells · doi:10.3390/cells10030678 · Cited by 151

HELB Is a Feedback Inhibitor of DNA End Resection

Tkáč, J., Xu, G., Adhikary, H., Young, J. T. F., Gallo, D., Escribano‐Diaz, C., Krietsch, J., Orthwein, A., Munro, M., Sol, W., et al. (2016) · Molecular Cell · doi:10.1016/j.molcel.2015.12.013 · Cited by 150

DNA-dependent protein kinase promotes DNA end processing by MRN and CtIP

Deshpande, R. A., Myler, L. R., Soniat, M. M., Makharashvili, N., Lee, L., Lees‐Miller, S. P., Finkelstein, I. J., & Paull, T. T. (2020) · Science Advances · doi:10.1126/sciadv.aay0922 · Cited by 141

The Abscopal Effect of Radiation Therapy

Craig, D. J., Nanavaty, N. S., Devanaboyina, M., Stanbery, L., Hamouda, D., Edelman, G. M., Dworkin, L. D., & Nemunaitis, J. J. (2021) · Future Oncology · doi:10.2217/fon-2020-0994 · Cited by 136

MRN, CtIP, and BRCA1 mediate repair of topoisomerase II–DNA adducts

Aparicio, T., Baer, R. J., Gottesman, M. E., & Gautier, J. (2016) · The Journal of Cell Biology · doi:10.1083/jcb.201504005 · Cited by 128

MCM8-9 complex promotes resection of double-strand break ends by MRE11-RAD50-NBS1 complex

Lee, K. Y., Im, J.-S., Shibata, E., Park, J.-H., Handa, N., Kowalczykowski, S. C., & Dutta, A. (2015) · Nature Communications · doi:10.1038/ncomms8744 · Cited by 116

RB localizes to DNA double-strand breaks and promotes DNA end resection and homologous recombination through the recruitment of BRG1Preprint

Vélez-Cruz, R., Manickavinayaham, S., Biswas, A., Clary, R. W., Premkumar, T., Cole, F., & Johnson, D. G. (2016) · Genes & Development · doi:10.1101/gad.288282.116 · Cited by 122

Advances and perspectives of PARP inhibitors

Yi, M., Dong, B., Qin, S., Chu, Q., Wu, K., & Luo, S. (2019) · Experimental Hematology & Oncology · doi:10.1186/s40164-019-0154-9 · Cited by 117

Contributions of DNA Damage to Alzheimer’s Disease

Lin, X., Kapoor, A., Gu, Y., Chow, M. J., Peng, J., Zhao, K., & Tang, D. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21051666 · Cited by 117

Patching Broken DNA: Nucleosome Dynamics and the Repair of DNA Breaks

Gürsoy-Yüzügüllü, Ö., House, N. C. M., & Price, B. D. (2015) · Journal of Molecular Biology · doi:10.1016/j.jmb.2015.11.021 · Cited by 118

Integrating the DNA damage and protein stress responses during cancer development and treatment

Gorgoulis, V. G., Pefani, D., Pateras, I. S., & Trougakos, I. P. (2018) · The Journal of Pathology · doi:10.1002/path.5097 · Cited by 108

A Mechanism to Minimize Errors during Non-homologous End Joining

Stinson, B. M., Moreno, A., Walter, J. C., & Loparo, J. J. (2019) · Molecular Cell · doi:10.1016/j.molcel.2019.11.018 · Cited by 108

Strategies to address key challenges of metallacycle/metallacage-based supramolecular coordination complexes in biomedical applications

Xu, D., Li, Y., Yin, S., & Huang, F. (2024) · Chemical Society Reviews · doi:10.1039/d3cs00926b · Cited by 109

DNA Damage and Pulmonary Hypertension

Ranchoux, B., Meloche, J., Paulin, R., Boucherat, O., Provencher, S., & Bonnet, S. (2016) · International Journal of Molecular Sciences · doi:10.3390/ijms17060990 · Cited by 111

Release of paused RNA polymerase II at specific loci favors DNA double-strand-break formation and promotes cancer translocations

Dellino, G. I., Palluzzi, F., Chiariello, A. M., Piccioni, R., Bianco, S., Furia, L., Conti, G. D., Bouwman, B. A. M., Melloni, G. E. M., Guido, D., et al. (2019) · Nature Genetics · doi:10.1038/s41588-019-0421-z · Cited by 104

H. pylori infection alters repair of DNA double-strand breaks via SNHG17

Han, T., Jing, X., Bao, J., Zhao, L., Zhang, A., Miao, R., Guo, H., Zhou, B., Zhang, S., Sun, J., et al. (2020) · Journal of Clinical Investigation · doi:10.1172/jci125581 · Cited by 100

RECQL4 Promotes DNA End Resection in Repair of DNA Double-Strand Breaks

Lu, H., Shamanna, R. A., Keijzers, G., Anand, R., Rasmussen, L. J., Ćejka, P., Croteau, D. L., & Bohr, V. A. (2016) · Cell Reports · doi:10.1016/j.celrep.2016.05.079 · Cited by 100

DNA Polymerase θ: A Unique Multifunctional End-Joining Machine

Black, S., Kashkina, E., Kent, T., & Pomerantz, R. T. (2016) · Genes · doi:10.3390/genes7090067 · Cited by 101

Genoprotective activities of plant natural substances in cancer and chemopreventive strategies in the context of 3P medicine

Koklesová, L., Líšková, A., Samec, M., Qaradakhi, T., Zulli, A., Šmejkal, K., Kajo, K., Jakubı́ková, J., Behzadi, P., Péč, M. J., et al. (2020) · The EPMA Journal · doi:10.1007/s13167-020-00210-5 · Cited by 96

Direct Involvement of Retinoblastoma Family Proteins in DNA Repair by Non-homologous End-Joining

Cook, R., Zoumpoulidou, G., Luczynski, M. T., Rieger, S., Moquet, J., Spanswick, V. J., Hartley, J. A., Rothkamm, K., Huang, P. H., & Mittnacht, S. (2015) · Cell Reports · doi:10.1016/j.celrep.2015.02.059 · Cited by 86

Regulation of DNA Double-Strand Break Repair by Non-Coding RNAs

Thapar, R. (2018) · Molecules · doi:10.3390/molecules23112789 · Cited by 86

BIBR1532, a Selective Telomerase Inhibitor, Enhances Radiosensitivity of Non-Small Cell Lung Cancer Through Increasing Telomere Dysfunction and ATM/CHK1 Inhibition

Ding, X., Cheng, J., Pang, Q., Wei, X., Zhang, X., Wang, P., Yuan, Z., & Qian, D. (2019) · International Journal of Radiation Oncology*Biology*Physics · doi:10.1016/j.ijrobp.2019.08.009 · Cited by 84

Homeostatic nuclear RAGE–ATM interaction is essential for efficient DNA repair

Kumar, V., Fleming, T. H., Terjung, S., Gorzelanny, C., Gebhardt, C., Agrawal, R., Mall, M. A., Ranzinger, J., Zeier, M. G., Madhusudhan, T., et al. (2017) · Nucleic Acids Research · doi:10.1093/nar/gkx705 · Cited by 82

Prophylactic mastectomy for the prevention of breast cancer: Review of the literature

Alaofi, R. K., Nassif, M. O., & Al‐Hajeili, M. (2018) · Avicenna Journal of Medicine · doi:10.4103/ajm.ajm_21_18 · Cited by 78

Role of Akt Activation in PARP Inhibitor Resistance in Cancer

Gallyas, F., Sümegi, B., & Szabó, C. (2020) · Cancers · doi:10.3390/cancers12030532 · Cited by 79

New Perspectives for Resistance to PARP Inhibitors in Triple-Negative Breast Cancer

Han, Y., Yu, X., Li, S., Tian, Y. E., & Liu, C. (2020) · Frontiers in Oncology · doi:10.3389/fonc.2020.578095 · Cited by 73

Sae2/CtIP prevents R-loop accumulation in eukaryotic cells

Makharashvili, N., Arora, S., Yin, Y., Fu, Q., Wen, X., Lee, J., Kao, C.-H., Leung, J. W. C., Miller, K. M., & Paull, T. T. (2018) · eLife · doi:10.7554/elife.42733 · Cited by 75

Effects of different doses of X‑ray irradiation on cell apoptosis, cell cycle, DNA damage repair and glycolysis in HeLa cells

Zhao, H. G., Zhuang, Y., Li, R., Liu, Y., Mei, Z., He, Z., Zhou, F., & Zhou, Y. (2018) · Oncology Letters · doi:10.3892/ol.2018.9566 · Cited by 71

Risky business: Microhomology-mediated end joining

Sinha, S., Villarreal, D. D., Shim, E. Y., & Lee, S. E. (2016) · Mutation research. Fundamental and molecular mechanisms of mutagenesis · doi:10.1016/j.mrfmmm.2015.12.005 · Cited by 66

Phosphorylation-mediated interactions with TOPBP1 couple 53BP1 and 9-1-1 to control the G1 DNA damage checkpoint

Bigot, N., Day, M., Baldock, R. A., Watts, F. Z., Oliver, A. W., & Pearl, L. H. (2019) · eLife · doi:10.7554/elife.44353 · Cited by 59

SUMO-Targeted Ubiquitin Ligases and Their Functions in Maintaining Genome Stability

Chang, Y., Oram, M. K., & Bielinsky, A. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22105391 · Cited by 64

The hidden risks of CRISPR/Cas: structural variations and genome integrity

Aussel, C., Cathomen, T., & Fuster‐García, C. (2025) · Nature Communications · doi:10.1038/s41467-025-62606-z · Cited by 72

Targeting Mcl-1 enhances DNA replication stress sensitivity to cancer therapy

Chen, G., Magis, A. T., Xu, K., Park, D., Yu, D. S., Owonikoko, T. K., Sica, G., Satola, S. W., Ramalingam, S. S., Curran, W. J., et al. (2017) · Journal of Clinical Investigation · doi:10.1172/jci92742 · Cited by 63

Therapeutic Editing of the TP53 Gene: Is CRISPR/Cas9 an Option?

Mirgayazova, R., Khadiullina, R., Chasov, V. V., Mingaleeva, R. N., Рифкатовна, М. Р., Rizvanov, A. A., & Bulatov, E. (2020) · Genes · doi:10.3390/genes11060704 · Cited by 68

Prognostic significance ofBRCAmutations in ovarian cancer: an updated systematic review with meta-analysis

Xu, K. L., Yang, S., & Zhao, Y. (2016) · Oncotarget · doi:10.18632/oncotarget.12306 · Cited by 62

The p97–Ataxin 3 complex regulates homeostasis of the DNA damage response E3 ubiquitin ligase RNF8

Singh, A. N., Oehler, J., Torrecilla, I., Kilgas, S., Li, S., Vaz, B., Guérillon, C., Fielden, J., Hernández-Carralero, E., Cabrera, E., et al. (2019) · The EMBO Journal · doi:10.15252/embj.2019102361 · Cited by 61

Suppressing the NHEJ pathway by DNA-PKcs inhibitor NU7026 prevents degradation of HBV cccDNA cleaved by CRISPR/Cas9

Kostyushev, D. S., Kostyusheva, A., Brezgin, S., Zarifyan, D., Utkina, A., Goptar, I. A., & Chulanov, V. (2019) · Scientific Reports · doi:10.1038/s41598-019-38526-6 · Cited by 62

REV7: Jack of many trades

de Krijger, I., Boersma, V., & Jacobs, J. (2021) · Trends in Cell Biology · doi:10.1016/j.tcb.2021.04.002 · Cited by 40

Multifaceted regulation and functions of 53BP1 in NHEJ‑mediated DSB repair (Review)

Lei, T., Du, S., Peng, Z., & Chen, L. (2022) · International Journal of Molecular Medicine · doi:10.3892/ijmm.2022.5145 · Cited by 66

Lamin A/C promotes DNA base excision repair

Maynard, S., Keijzers, G., Akbari, M., Ezra, M. B., Hall, A., Morevati, M., Scheibye‐Knudsen, M., Gonzalo, S., Bártek, J., & Bohr, V. A. (2019) · Nucleic Acids Research · doi:10.1093/nar/gkz912 · Cited by 60

Depletion of the RNA binding protein HNRNPD impairs homologous recombination by inhibiting DNA-end resection and inducing R-loop accumulation

Alfano, L., Caporaso, A., Altieri, A., Dell’Aquila, M., Landi, C., Bini, L., Pentimalli, F., & Giordano, A. (2019) · Nucleic Acids Research · doi:10.1093/nar/gkz076 · Cited by 57

DNA damage response and repair in ovarian cancer: Potential targets for therapeutic strategies

Mirza‐Aghazadeh‐Attari, M., Ostadian, C., Saei, A. A., Mihanfar, A., Darband, S. G., Sadighparvar, S., Kaviani, M., Kafil, H. S., Yousefi, B., & Majidinia, M. (2019) · DNA repair · doi:10.1016/j.dnarep.2019.06.005 · Cited by 56

Small Molecules Targeting DNA Polymerase Theta (POLθ) as Promising Synthetic Lethal Agents for Precision Cancer Therapy

Pismataro, M. C., Astolfi, A., Barreca, M. L., Pacetti, M., Schenone, S., Bandiera, T., Carbone, A., & Massari, S. (2023) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.2c02101 · Cited by 60

Ubiquitination Links DNA Damage and Repair Signaling to Cancer Metabolism

Koo, S.-Y., Park, E., Noh, H.-J., Jo, S.-M., Ko, B.-K., Shin, H.-J., & Lee, C. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24098441 · Cited by 60

The Complex Mechanisms by Which Neurons Die Following DNA Damage in Neurodegenerative Diseases

Shadfar, S., Brocardo, M. G., & Atkin, J. D. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23052484 · Cited by 60

Enrichment of Cdk1-cyclins at DNA double-strand breaks stimulates Fun30 phosphorylation and DNA end resection

Chen, X., Niu, H., Yu, Y., Wang, J., Zhu, S., Zhou, J.-J., Papusha, A., Cui, D., Pan, X., Kwon, Y., et al. (2016) · Nucleic Acids Research · doi:10.1093/nar/gkv1544 · Cited by 54

Induction of lipid metabolism dysfunction, oxidative stress and inflammation response by tris(1-chloro-2-propyl)phosphate in larval/adult zebrafish

Yan, J., Zhao, Z., Xia, M., Chen, S., Wan, X., He, A., Sheng, G. D., Wang, X., Qian, Q., & Wang, H. (2022) · Environment International · doi:10.1016/j.envint.2022.107081 · Cited by 52

The contribution of DNA repair pathways to genome editing and evolution in filamentous pathogens

Huang, J. T., & Cook, D. E. (2022) · FEMS Microbiology Reviews · doi:10.1093/femsre/fuac035 · Cited by 57

Super-resolution mapping of cellular double-strand break resection complexes during homologous recombination

Whelan, D. R., & Rothenberg, E. (2021) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2021963118 · Cited by 53

Suppressing Ku70/Ku80 expression elevates homology-directed repair efficiency in primary fibroblasts

Li, G., Liu, D., Zhang, X., Quan, R., Zhong, C., Mo, J., Huang, Y., Wang, H., Xiao-fang, R. U. A. N., Xu, Z., et al. (2018) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2018.04.011 · Cited by 50

CRISPR/Cas9-mediated Stearoyl-CoA Desaturase 1 (SCD1) Deficiency Affects Fatty Acid Metabolism in Goat Mammary Epithelial Cells

Tian, H., Luo, J., Zhang, Z., Wu, J., Zhang, T., Busato, S., Huang, L., Song, N., & Bionaz, M. (2018) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.8b03545 · Cited by 51

C-terminal region of bacterial Ku controls DNA bridging, DNA threading and recruitment of DNA ligase D for double strand breaks repair

McGovern, S., Baconnais, S., Roblin, P., Nicolas, P., Drevet, P., Simonson, H., Piétrement, O., Charbonnier, J., Cam, É. L., Noirot, P. H., et al. (2016) · Nucleic Acids Research · doi:10.1093/nar/gkw149 · Cited by 52

Interplay between Ubiquitin, SUMO, and Poly(ADP-Ribose) in the Cellular Response to Genotoxic Stress

Pellegrino, S., & Altmeyer, M. (2016) · Frontiers in Genetics · doi:10.3389/fgene.2016.00063 · Cited by 52

PLK1 targets CtIP to promote microhomology-mediated end joining

Wang, H., Qiu, Z., Liu, B., Wu, Y., Ren, J., Liu, Y., Zhao, Y., Wang, Y., Hao, S., Li, Z., et al. (2018) · Nucleic Acids Research · doi:10.1093/nar/gky810 · Cited by 50

Resveratrol sensitizes glioblastoma-initiating cells to temozolomide by inducing cell apoptosis and promoting differentiation

Li, H., LIU, Y., JIAO, Y., Guo, A., Xu, X., Qu, X., Wang, S., Zhao, J., Li, Y., & Cao, Y. B. (2015) · Oncology Reports · doi:10.3892/or.2015.4346 · Cited by 48

DNA double-strand break repair: a tale of pathway choices

Li, J., & Xu, X. (2016) · Acta Biochimica et Biophysica Sinica · doi:10.1093/abbs/gmw045 · Cited by 53

Regulatory control of Sgs1 and Dna2 during eukaryotic DNA end resection

Xue, C., Wang, W., Crickard, J. B., Moevus, C. J., Kwon, Y., Sung, P., & Greene, E. C. (2019) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1819276116 · Cited by 48

The COP9 signalosome is vital for timely repair of DNA double-strand breaks

Meir, M., Galanty, Y., Kashani, L., Blank, M., Khosravi, R., Fernández-Ávila, M. J., Cruz-García, A., Star, A., Shochot, L., Thomas, Y., et al. (2015) · Nucleic Acids Research · doi:10.1093/nar/gkv270 · Cited by 45

Role of RNF20 in cancer development and progression – a comprehensive review

Sethi, G., Shanmugam, M. K., Arfuso, F., & Kumar, A. P. (2018) · Bioscience Reports · doi:10.1042/bsr20171287 · Cited by 44

Recent advances in prostate cancer research: large-scale genomic analyses reveal novel driver mutations and DNA repair defects

Frank, S. B., Nelson, P. S., & Vasioukhin, V. I. (2018) · F1000Research · doi:10.12688/f1000research.14499.1 · Cited by 45

Mapping global and local coevolution across 600 species to identify novel homologous recombination repair genesPreprint

Sherill-Rofe, D., Rahat, D., Findlay, S., Mellul, A., Guberman, I., Braun, M., Bloch, I., Lalezari, A., Samiei, A., Sadreyev, R. I., et al. (2019) · Genome Research · doi:10.1101/gr.241414.118 · Cited by 39

Marked contribution of alternative end-joining to chromosome-translocation-formation by stochastically induced DNA double-strand-breaks in G2-phase human cells

Soni, A., Siemann, M., Pantelias, G. E., & Iliakis, G. E. (2015) · Mutation Research/Genetic Toxicology and Environmental Mutagenesis · doi:10.1016/j.mrgentox.2015.07.002 · Cited by 41

The Impact of Hedgehog Signaling Pathway on DNA Repair Mechanisms in Human Cancer

Meng, E., Hanna, A., Samant, R. S., & Shevde, L. A. (2015) · Cancers · doi:10.3390/cancers7030839 · Cited by 42

The Effect of Resveratrol on Cell Viability in the Burkitt’s Lymphoma Cell Line Ramos

Jara, P., Spies, J., Cárcamo, C., Arancibia, Y., Vargas, G. V., Martín, C., Salas, M., Carola Otth, L., & Zambrano, Á. (2017) · Molecules · doi:10.3390/molecules23010014 · Cited by 40

Hallmarks of Cancers: Primary Antibody Deficiency Versus Other Inborn Errors of Immunity

Abolhassani, H., Wang, Y., Hammarström, L. L. G., & Pan‐Hammarström, Q. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.720025 · Cited by 39

Phage Mu Gam protein promotes NHEJ in concert with Escherichia coli ligase

Bhattacharyya, S., Soniat, M. M., Walker, D. M., Jang, S., Finkelstein, I. J., & Harshey, R. M. (2018) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1816606115 · Cited by 39

Individual Radiosensitivity in Oncological Patients: Linking Adverse Normal Tissue Reactions and Genetic Features

Palumbo, E., Piotto, C., Calura, E., Fasanaro, E., Groff, E., Busato, F., Khouzai, B. E., Rigo, M., Baggio, L., Romualdi, C., et al. (2019) · Frontiers in Oncology · doi:10.3389/fonc.2019.00987 · Cited by 41

Mitochondrial dysfunction and DNA damage accompany enhanced levels of formaldehyde in cultured primary human fibroblasts

Nadalutti, C. A., Stefanick, D. F., Zhao, M., Horton, J. K., Prasad, R., Brooks, A. M., Griffith, J. D., & Wilson, S. H. (2020) · Scientific Reports · doi:10.1038/s41598-020-61477-2 · Cited by 41

Evolving insights: how DNA repair pathways impact cancer evolution

Zhou, J., Zhou, X. A., Zhang, N., & Wang, J. (2020) · Cancer Biology and Medicine · doi:10.20892/j.issn.2095-3941.2020.0177 · Cited by 40

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Helena, J., Joubert, A. M., Grobbelaar, S., Nolte, E., Nel, M., Pepper, M. S., Coetzee, M., & Mercier, A. E. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19041148 · Cited by 43

Six polymorphisms in genes involved in DNA double-strand break repair and chromosome synapsis: association with male infertility

Zhang, X., Ding, M., Ding, X., Li, T., & Chen, H. (2015) · Systems Biology in Reproductive Medicine · doi:10.3109/19396368.2015.1027014 · Cited by 40

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Bezine, E., Malaisé, Y., Loeuillet, A., Chevalier, M., Boutet-Robinet, E. A., Salles, B., Mirey, G., & Vignard, J. (2016) · Scientific Reports · doi:10.1038/srep36022 · Cited by 35

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Jin, H., Lee, B., Luo, Y., Choi, Y., Choi, E.-H., Jin, H. Y., Kim, K., Seo, S. B., Kim, Y., Lee, H. H., et al. (2020) · Nature Communications · doi:10.1038/s41467-020-15748-1 · Cited by 37

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Wesley, T., Berzins, S. P., Kannourakis, G., & Ahmed, N. (2021) · Cell Communication and Signaling · doi:10.1186/s12964-021-00726-x · Cited by 36

Detection of DNA damage response in nonalcoholic fatty liver disease via p53-binding protein 1 nuclear expression

Akazawa, Y., Nakashima, R., Matsuda, K., Okamaoto, K., Hirano, R., Kawasaki, H., Miuma, S., Miyaaki, H., Malhi, H., Abiru, S., et al. (2019) · Modern Pathology · doi:10.1038/s41379-019-0218-8 · Cited by 35

Human RAD50 deficiency: Confirmation of a distinctive phenotype

Ragamin, A., Yigit, G., Bousset, K., Beleggia, F., Verheijen, F. W., de Wit, M. Y., Strom, T. M., Dörk, T., Wollnik, B., & Mancini, G. M. S. (2020) · American Journal of Medical Genetics Part A · doi:10.1002/ajmg.a.61570 · Cited by 34

Ways of improving precise knock-in by genome-editing technologies

Smirnikhina, S., Anuchina, A. A., & Лавров, А. В. (2018) · Human Genetics · doi:10.1007/s00439-018-1953-5 · Cited by 32

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Iwasaki, D., Hayashihara, K., Shima, H., Higashide, M., Terasawa, M., Gasser, S. M., & Shinohara, M. (2016) · PLoS Genetics · doi:10.1371/journal.pgen.1005942 · Cited by 35

Strategies for Enhancing the Homology-Directed Repair Efficiency of CRISPR-Cas Systems

Sun, W., Liu, H., Yin, W., Qiao, J., Zhao, X., & Liu, Y. (2022) · The CRISPR Journal · doi:10.1089/crispr.2021.0039 · Cited by 33

Activation of homologous recombination DNA repair in human skin fibroblasts continuously exposed to X-ray radiation

Osipov, A. N., Grekhova, A., Pustovalova, M. V., Ozerov, I. V., Eremin, P. S., Vorobyeva, N. Y., Lazareva, N. L., Pulin, A. A., Zhavoronkov, A. A., Roumiantsev, S. A., et al. (2015) · Oncotarget · doi:10.18632/oncotarget.4946 · Cited by 32

Cell cycle-dependent resolution of DNA double-strand breaks

Ambrosio, S., Palo, G. D., Napolitano, G., Amente, S., Dellino, G. I., Faretta, M., Pelicci, P. G., Lania, L., & Majello, B. (2015) · Oncotarget · doi:10.18632/oncotarget.6644 · Cited by 32

BRCA1-A and BRISC: multifunctional molecular machines for ubiquitin signaling

Rabl, J. (2020) · Biomolecules · doi:10.3390/biom10111503 · Cited by 31

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Bartnik, K., Barth, A., Pilo‐Pais, M., Crevenna, Á. H., Liedl, T., & Lamb, D. C. (2019) · Journal of the American Chemical Society · doi:10.1021/jacs.9b09093 · Cited by 31

Accumulation of spontaneous γH2AX foci in long-term cultured mesenchymal stromal cells

Pustovalova, M. V., Grekhova, A., Astrelina, T. A., Nikitina, V. A., Dobrovolskaya, E. I., Suchkova, Y. B., Кобзева, И. В., Usupzhanova, D., Vorobyeva, N. Y., Samoylov, A., et al. (2016) · Aging · doi:10.18632/aging.101142 · Cited by 31

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Herzon, S. B. (2017) · Accounts of Chemical Research · doi:10.1021/acs.accounts.7b00347 · Cited by 32

How do telomeres and NHEJ coexist?

Marcand, S. (2014) · Molecular & Cellular Oncology · doi:10.4161/23723548.2014.963438 · Cited by 26

Competing interaction partners modulate the activity of Sgs1 helicase during DNA end resection

Kasaciunaite, K., Fettes, F., Levikova, M., Daldrop, P., Anand, R., Ćejka, P., & Seidel, R. (2019) · The EMBO Journal · doi:10.15252/embj.2019101516 · Cited by 28

DNA Double-Strand Break Repair in Tumorigenesis and Anticancer Treatment

Her, C. (2014) · Chemotherapy Open access · doi:10.4172/2167-7700.1000124 · Cited by 2

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Yoshioka, K., Kusumoto‐Matsuo, R., Matsuno, Y., & Ishiai, M. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms222212254 · Cited by 63

Playing the End Game: DNA Double-Strand Break Repair Pathway Choice

Chapman, J. R., Taylor, M. R. G., & Boulton, S. J. (2012) · Molecular Cell · doi:10.1016/j.molcel.2012.07.029 · Cited by 1,728

Re: Choices have consequences: the nexus between DNA repair pathways and genomic instability in cancer

McKay, M. (2017) · Clinical and Translational Medicine · doi:10.1186/s40169-017-0137-6

The role of DNA breaks in genomic instability and tumorigenesis

Mills, K. D., Ferguson, D. O., & Alt, F. W. (2003) · Immunological Reviews · doi:10.1034/j.1600-065x.2003.00060.x · Cited by 368