Cited by 139Characterization and Applications of Magnetic NanoparticlesNanoplatforms for cancer theranosticsNanoparticle-Based Drug Delivery

Next-generation superparamagnetic iron oxide nanoparticles for cancer theranostics

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Li, Kai, Nejadnik, Hossein, Daldrup-Link, Heike E.·2017·Drug Discovery Today

Abstract

Superparamagnetic iron oxide (SPIO) nanoparticles have been intensively studied for the development of contrast agents in MRI. First-generation SPIO nanoparticles had diagnostic capabilities only, whereas a new generation of SPIO nanoparticle has multifunctional characteristics for combined therapeutic and diagnostic applications. These theranostic nanoparticles hold great potential for image-guided cancer therapies. In particular, polymer-coated theranostic SPIO nanoparticles have enjoyed increasing attention as a result of good biocompatibility, biodegradability and versatile functionality endowed by polymeric matrices. This review provides an overview of recently developed polymer-coated multifunctional SPIO nanoparticles for cancer theranostics and discusses current challenges and future perspectives.

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Crossref · 10.1016/j.drudis.2017.04.008

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  • SPION have been loaded with many therapeutics, especially anticancer agents ranging from doxorubicin to siRNA.

    “SPION have been loaded with many different therapeutics drugs. Especially anticancer agents have been employed, ranging from standard low molecular weight chemotherapeutics, such as doxorubicin, to more advanced therapeutic compounds, such as siRNA [237, 238].”

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Authors
Li, K., Nejadnik, H., & Daldrup-Link, H. E.
Affiliations
Stanford Medicine (US)
Corresponding author
  • Li, Kai
  • Daldrup-Link, Heike E.
Venue
Drug Discovery Today
Publisher
Elsevier BV
Published
2017-09
Volume
22
Issue
9
Pages
1421-1429
ISSN
1359-6446 (ISSN-L)
OpenAlex
W2608879075
Cited by
139
References
62
Citations by year
2026: 3 · 2025: 8 · 2024: 12 · 2023: 16 · 2022: 21 · 2021: 24 · 2020: 18 · 2019: 17 · 2018: 17 · 2017: 2
FWCI
1.19
Type
journal article
Language
en
Open access
Locations
  • Drug Discovery Today (publishedVersion)
  • PubMed (publishedVersion)
  • Europe PMC (PubMed Central) (acceptedVersion)
  • PubMed Central (acceptedVersion)
Funders
  • National Cancer Institute (NCI) (R21CA190196)
  • National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) (R21AR066302, 2R01AR054458)
  • Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) (R01 HD081123-01A1)
  • Agency for Science, Technology and Research (A*STAR, Singapore)
Topics
  • Physical Sciences › Engineering › Biomedical Engineering › Characterization and Applications of Magnetic Nanoparticles
  • Physical Sciences › Engineering › Biomedical Engineering › Nanoplatforms for cancer theranostics
  • Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
Keywords
superparamagnetic iron oxide nanoparticles, theranostics, cancer theranostics, polymer-coated nanoparticles, multifunctional nanoparticles, MRI contrast agents, image-guided cancer therapy, biocompatibility, biodegradability
MeSH terms
Theranostic Nanomedicine, Animals, Ferric Compounds, Humans, Hyperthermia, Induced, Neoplasms, Phototherapy, Genetic Therapy, Metal Nanoparticles, Magnetic Phenomena

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