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Next-generation superparamagnetic iron oxide nanoparticles for cancer theranostics
Open accessAbstract
Superparamagnetic iron oxide (SPIO) nanoparticles have been intensively studied for the development of contrast agents in MRI. First-generation SPIO nanoparticles had diagnostic capabilities only, whereas a new generation of SPIO nanoparticle has multifunctional characteristics for combined therapeutic and diagnostic applications. These theranostic nanoparticles hold great potential for image-guided cancer therapies. In particular, polymer-coated theranostic SPIO nanoparticles have enjoyed increasing attention as a result of good biocompatibility, biodegradability and versatile functionality endowed by polymeric matrices. This review provides an overview of recently developed polymer-coated multifunctional SPIO nanoparticles for cancer theranostics and discusses current challenges and future perspectives.
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“SPION have been loaded with many different therapeutics drugs. Especially anticancer agents have been employed, ranging from standard low molecular weight chemotherapeutics, such as doxorubicin, to more advanced therapeutic compounds, such as siRNA [237, 238].”
From Iron oxide nanoparticles: Diagnostic, therapeutic and theranostic applications (2019) · cites this paper as [238]
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Metadata
- Authors
- Li, K., Nejadnik, H., & Daldrup-Link, H. E.
- Affiliations
- Stanford Medicine (US)
- Corresponding author
- Li, Kai
- Daldrup-Link, Heike E.
- Venue
- Drug Discovery Today
- Publisher
- Elsevier BV
- Published
- 2017-09
- Volume
- 22
- Issue
- 9
- Pages
- 1421-1429
- ISSN
- 1359-6446 (ISSN-L)
- PMC
- PMC5610947
- OpenAlex
- W2608879075
- Cited by
- 139
- References
- 62
- Citations by year
- 2026: 3 · 2025: 8 · 2024: 12 · 2023: 16 · 2022: 21 · 2021: 24 · 2020: 18 · 2019: 17 · 2018: 17 · 2017: 2
- FWCI
- 1.19
- Type
- journal article
- Language
- en
- Open access
- green
- europepmc.org
- Locations
- Drug Discovery Today (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Cancer Institute (NCI) (R21CA190196)
- National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) (R21AR066302, 2R01AR054458)
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) (R01 HD081123-01A1)
- Agency for Science, Technology and Research (A*STAR, Singapore)
- Topics
- Physical Sciences › Engineering › Biomedical Engineering › Characterization and Applications of Magnetic Nanoparticles
- Physical Sciences › Engineering › Biomedical Engineering › Nanoplatforms for cancer theranostics
- Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
- Keywords
- superparamagnetic iron oxide nanoparticles, theranostics, cancer theranostics, polymer-coated nanoparticles, multifunctional nanoparticles, MRI contrast agents, image-guided cancer therapy, biocompatibility, biodegradability
- MeSH terms
- Theranostic Nanomedicine, Animals, Ferric Compounds, Humans, Hyperthermia, Induced, Neoplasms, Phototherapy, Genetic Therapy, Metal Nanoparticles, Magnetic Phenomena
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