Cited by 61Opioid Use Disorder TreatmentSubstance Abuse Treatment and OutcomesMental Health Treatment and Access

Probability and predictors of treatment-seeking for prescription opioid use disorders: A National Study

Open access
Blanco, Carlos, Iza, Miren, Schwartz, Robert P., Rafful, Claudia, Wang, Shuai, Olfson, Mark·2013·Drug and Alcohol Dependence

Abstract

Background Prescription opioid use disorders are the second most common drug use disorder behind only cannabis use disorders. Despite this, very little is known about the help-seeking behavior among individuals with these disorders. Methods The sample included respondents of the Wave 2 of the National Epidemiologic Survey on Alcohol and Related Conditions (NESARC) with a lifetime diagnosis of prescription drug use disorders (N=623). Unadjusted and adjusted hazard ratios are presented for time to first treatment-seeking by sociodemographic characteristics and comorbid psychiatric disorders. Results The lifetime cumulative probability of treatment seeking was 42% and the median delay from prescription drug use disorder onset to first treatment was 3.83 years. Having an earlier onset of prescription opioid use disorder and a history of bipolar disorder, major depression disorder, specific phobia and cluster B personality disorders predicted shorter delays to treatment. Conclusions Although some comorbid psychiatric disorders increase the rate of treatment-seeking and decrease delays to first-treatment contact rates of treatment-seeking for prescription drug use disorder are low, even when compared with rates of treatment for other substance use disorders. Given the high prevalence and adverse consequences of prescription drug use disorder, there is a need to improve detection and treatment of prescription opioid use disorder.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Integrity signals

Registry

Crossref · 10.1016/j.drugalcdep.2012.12.013

Cites

11 of 11 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

  • Only a minority of persons with SUDs seek treatment.

    “Only a minority of persons with SUDs seek treatment 145 .”

    From Substance use disorders: a comprehensive update of classification, epidemiology, neurobiology, clinical aspects, treatment and prevention (2023) · cites this paper as [145]

    The Results (§3.1) report that 42.4% of people with prescription opioid use disorder ever sought treatment, supporting the claim for that subgroup. The claim extends this finding to substance use disorders generally; the Discussion (§4) also reports a separate estimate that 72% of respondents with lifetime substance use disorders had sought treatment at some point. (LLM, conf=0.87)

    Experimental — accuracy not yet measured

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Cites

Flagged first, then by citations

Research works printed but not linked: 46

  1. Adamson J Ben-Shlomo Y Chaturvedi N Donovan J Ethnicity, socioeconomic position and gender--do they affect reported health-care seeking behaviour? Soc. Sci. Med 2003 57 895 904 12850114
  2. Alegria M Canino G Rios R Vera M Calderon J Rusch D Ortega AN Inequalities in use of specialty mental health services among Latinos, African Americans, and non-Latino whites. Psychiatr. Serv 2002 53 1547 1555 12461214
  3. Ballantyne JC Opioid analgesia: perspectives on right use and utility. Pain Physician 2007 10 479 491 17525783
  4. Blanco C Alderson D Ogburn E Grant BF Nunes EV Hatzenbuehler ML Hasin DS Changes in the prevalence of non-medical prescription drug use and drug use disorders in the United States: 1991-1992 and 2001-2002. Drug Alcohol Depend 2007 90 252 260 17513069
  5. Blanco C Secades-Villa R Garcia-Rodriguez O Labrador-Mendez M Wang S Schwartz RP Probability and predictors of remission from life-time prescription drug use disorders: results from the National Epidemiologic Survey on Alcohol and Related Conditions. J. Psychiatr. Res 2012 epub ahead of print 22985744
  6. Chatterji S Saunders JB Vrasti R Grant BF Hasin D Mager D Reliability of the alcohol and drug modules of the Alcohol Use Disorder and Associated Disabilities Interview Schedule--Alcohol/Drug-Revised (AUDADIS-ADR): an international comparison. Drug Alcohol Depend 1997 47 171 185 9306043
  7. Chou R Fanciullo GJ Fine PG Adler JA Ballantyne JC Davies P Donovan MI Fishbain DA Foley KM Fudin J Gilson AM Kelter A Mauskop A O'Connor PG Passik SD Pasternak GW Portenoy RK Rich BA Roberts RG Todd KH Miaskowski C Clinical guidelines for the use of chronic opioid therapy in chronic noncancer pain. J. Pain 2009 10 113 130 19187889 PMC4043401
  8. Chu LF Angst MS Clark D Opioid-induced hyperalgesia in humans: molecular mechanisms and clinical considerations. Clin. J. Pain 2008 24 479 496 18574358
  9. Cicero TJ Inciardi JA Diversion and abuse of methadone prescribed for pain management. JAMA 2005 293 297 298 15657321
  10. Compton WM Volkow ND Major increases in opioid analgesic abuse in the United States: concerns and strategies. Drug Alcohol Depend 2006 81 103 107 16023304
  11. Cottler LB Grant BF Blaine J Mavreas V Pull C Hasin D Compton WM Rubio-Stipec M Mager D Concordance of DSM-IV alcohol and drug use disorder criteria and diagnoses as measured by AUDADIS-ADR, CIDI and SCAN. Drug Alcohol Depend 1997 47 195 205 9306045
  12. Fenton MC Keyes KM Martins SS Hasin DS The role of a prescription in anxiety medication use, abuse, and dependence. Am. J. Psychiatry 2010 167 1247 1253 20595413 PMC3756550
  13. Fossati A Barratt ES Borroni S Villa D Grazioli F Maffei C Impulsivity, aggressiveness, and DSM-IV personality disorders. Psychiatry Res 2007 149 157 167 17157921
  14. Gibbie TM Hides LM Cotton SM Lubman DI Aitken C Hellard M The relationship between personality disorders and mental health, substance use severity and quality of life among injecting drug users. Med. J. Aust 2011 195 S16 21 21806513
  15. Grant BF Dawson DA Stinson FS Chou PS Kay W Pickering R The Alcohol Use Disorder and Associated Disabilities Interview Schedule-IV (AUDADIS-IV): reliability of alcohol consumption, tobacco use, family history of depression and psychiatric diagnostic modules in a general population sample. Drug Alcohol Depend 2003 71 7 16 12821201
  16. Grant BF Goldstein RB Chou SP Huang B Stinson FS Dawson DA Saha TD Smith SM Pulay AJ Pickering RP Ruan WJ Compton WM Sociodemographic and psychopathologic predictors of first incidence of DSM-IV substance use, mood and anxiety disorders: results from the Wave 2 National Epidemiologic Survey on Alcohol and Related Conditions. Mol. Psychiatry 2009 14 1051 1066 18427559 PMC2766434
  17. Grant BF Harford TC Dawson DA Chou PS Pickering RP The Alcohol Use Disorder and Associated Disabilities Interview schedule (AUDADIS): reliability of alcohol and drug modules in a general population sample. Drug Alcohol Depend 1995 39 37 44 7587973
  18. Grant BF Hasin DS Stinson FS Dawson DA Chou SP Ruan WJ Pickering RP Prevalence, correlates, and disability of personality disorders in the United States: results from the national epidemiologic survey on alcohol and related conditions. J. Clin. Psychiatry 2004a 65 948 958 15291684
  19. Grant BF Stinson FS Dawson DA Chou SP Dufour MC Compton W Pickering RP Kaplan K Prevalence and co-occurrence of substance use disorders and independent mood and anxiety disorders: results from the National Epidemiologic Survey on Alcohol and Related Conditions. Arch. Gen. Psychiatry 2004c 61 807 816 15289279
  20. Grant BF Stinson FS Dawson DA Chou SP Ruan WJ Co-occurrence of DSM-IV personality disorders in the United States: results from the National Epidemiologic Survey on Alcohol and Related Conditions. Compr. Psychiatry 2005 46 1 5 15714187
  21. Howard MM Weiler RM Haddox JD Development and reliability of items measuring the nonmedical use of prescription drugs for the Youth Risk Behavior Survey: results from an initial pilot test. J. School Health 2009 79 554 560 19840233
  22. Huang B Dawson DA Stinson FS Hasin DS Ruan WJ Saha TD Smith SM Goldstein RB Grant BF Prevalence, correlates, and comorbidity of nonmedical prescription drug use and drug use disorders in the United States: Results of the National Epidemiologic Survey on Alcohol and Related Conditions. J. Clin. Psychiatry 2006 67 1062 1073 16889449
  23. Kessler RC Aguilar-Gaxiola S Berglund PA Caraveo-Anduaga JJ DeWit DJ Greenfield SF Kolody B Olfson M Vega WA Patterns and predictors of treatment seeking after onset of a substance use disorder. Arch. Gen. Psychiatry 2001 58 1065 1071 11695954
  24. Kessler RC Olfson M Berglund PA Patterns and predictors of treatment contact after first onset of psychiatric disorders. Am. J. Psychiatry 1998 155 62 69 9433340
  25. Kirana PS Rosen R Hatzichristou D Subjective well-being as a determinant of individuals’ responses to symptoms: a biopsychosocial perspective. Int. J. Clin. Pract 2009 63 1435 1445 19769700
  26. Kuehn BM Scientists, officials eye tools aimed at combating abuse of painkillers. JAMA 2012 307 19 21 22215154
  27. Lopez-Quintero C Hasin DS de Los Cobos JP Pines A Wang S Grant BF Blanco C Probability and predictors of remission from life-time nicotine, alcohol, cannabis or cocaine dependence: results from the National Epidemiologic Survey on Alcohol and Related Conditions. Addiction 2011a 106 657 669 21077975 PMC3227547
  28. Lopez-Quintero C Perez de los Cobos J Hasin DS Okuda M Wang S Grant BF Blanco C Probability and predictors of transition from first use to dependence on nicotine, alcohol, cannabis, and cocaine: results of the National Epidemiologic Survey on Alcohol and Related Conditions (NESARC). Drug Alcohol Depend 2011b 115 120 130 21145178 PMC3069146
  29. Manchikanti L Abdi S Atluri S Balog CC Benyamin RM Boswell MV Brown KR Bruel BM Bryce DA Burks PA Burton AW Calodney AK Caraway DL Cash KA Christo PJ Damron KS Datta S Deer TR Diwan S Eriator I Falco FJ Fellows B Geffert S Gharibo CG Glaser SE Grider JS Hameed H Hameed M Hansen H Harned ME Hayek SM Helm S 2nd Hirsch JA Janata JW Kaye AD Kaye AM Kloth DS Koyyalagunta D Lee M Malla Y Manchikanti KN McManus CD Pampati V Parr AT Pasupuleti R Patel VB Sehgal N Silverman SM Singh V Smith HS Snook LT Solanki DR Tracy DH Vallejo R Wargo BW American Society of Interventional Pain Physicians (ASIPP) guidelines for responsible opioid prescribing in chronic non-cancer pain: part 2--guidance. Pain Physician 2012 15 S67 116 22786449
  30. Martins SS Fenton MC Keyes KM Blanco C Zhu H Storr CL Mood and anxiety disorders and their association with non-medical prescription opioid use and prescription opioid-use disorder: longitudinal evidence from the National Epidemiologic Study on Alcohol and Related Conditions. Psychol. Med 2012 42 1261 1272 21999943 PMC3513363
  31. McCabe SE Correlates of nonmedical use of prescription benzodiazepine anxiolytics: results from a national survey of U.S. college students. Drug Alcohol Depend 2005 79 53 62 15943944 PMC1761924
  32. Meltzer EC Rybin D Saitz R Samet JH Schwartz SL Butler SF Liebschutz JM Identifying prescription opioid use disorder in primary care: diagnostic characteristics of the Current Opioid Misuse Measure (COMM). Pain 2011 152 397 402 21177035 PMC3027065
  33. Olfson M Kessler RC Berglund PA Lin E Psychiatric disorder onset and first treatment contact in the United States and Ontario. Am. J. Psychiatry 1998 155 1415 1422 9766774
  34. Olfson M Liu SM Grant BF Blanco C Influence of comorbid mental disorders on time to seeking treatment for major depressive disorder. Med. Care 2012 50 227 232 22186769 PMC3286829
  35. Perron BE Mowbray OP Glass JE Delva J Vaughn MG Howard MO Differences in service utilization and barriers among Blacks, Hispanics, and Whites with drug use disorders. Subst. Abuse Treat. Prev. Policy 2009 4 3 19284669 PMC2660316
  36. Pickles A Pickering K Simonoff E Silberg J Meyer J Maes H Genetic “clocks” and “soft” events: a twin model for pubertal development and other recalled sequences of developmental milestones, transitions, or ages at onset. Behav. Genet 1998 28 243 253 9803017
  37. Rigg KK Ibanez GE Motivations for non-medical prescription drug use: a mixed methods analysis. J. Subst. Abuse Treat 39 236 247 20667680 PMC2937068
  38. Rogler LH Cortes DE Help-seeking pathways: a unifying concept in mental health care. Am. J. Psychiatry 1993 150 554 561 8465869
  39. Subramaniam GA Stitzer MA Clinical characteristics of treatment-seeking prescription opioid versus heroin using adolescents with opioid use disorder. Drug Alcohol Depend 2009 101 13 19 19081205 PMC2746065
  40. Trescot AM Boswell MV Atluri SL Hansen HC Deer TR Abdi S Jasper JF Singh V Jordan AE Johnson BW Cicala RS Dunbar EE Helm S 2nd Varley KG Suchdev PK Swicegood JR Calodney AK Ogoke BA Minore WS Manchikanti L Opioid guidelines in the management of chronic non-cancer pain. Pain Physician 2006 9 1 39 16700278
  41. Trescot AM Helm S Hansen H Benyamin R Glaser SE Adlaka R Patel S Manchikanti L Opioids in the management of chronic non-cancer pain: an update of American Society of the Interventional Pain Physicians’ (ASIPP) Guidelines. Pain Physician 2008 11 S5 S62 18443640
  42. Tse SS Walsh AE How does work work for people with bipolar affective disorder? Occup. Ther. Int 2001 8 210 225 11823884
  43. Vaingankar JA Rekhi G Subramaniam M Abdin E Chong SA Age of onset of life-time mental disorders and treatment contact. Soc. Psychiatr Epidemiol 2012 in press 23076588
  44. Weiss RD Potter JS Provost SE Huang Z Jacobs P Hasson A Lindblad R Connery HS Prather K Ling W A multi-site, two-phase, Prescription Opioid Addiction Treatment Study (POATS): rationale, design, and methodology. Contemp. Clin. Trials 2010 31 189 199 20116457 PMC2831115
  45. White AG Birnbaum HG Mareva MN Daher M Vallow S Schein J Katz N Direct costs of opioid abuse in an insured population in the United States. J. Manag. Care Pharm 2005 11 469 479 15998164 PMC10437436
  46. Zacny J Bigelow G Compton P Foley K Iguchi M Sannerud C College on Problems of Drug Dependence taskforce on prescription opioid non-medical use and abuse: position statement. Drug Alcohol Depend 2003 69 215 232 12633908

Cited by

Sorted by citations

Authors
Blanco, C., Iza, M., Schwartz, R. P., Rafful, C., Wang, S., & Olfson, M.
Affiliations
  • New York State Psychiatric Institute (US)
  • Friends Research Institute (US)
Corresponding author
Blanco, Carlos
Venue
Drug and Alcohol Dependence
Publisher
Elsevier BV
Published
2013-07
Volume
131
Issue
1-2
Pages
143-148
ISSN
0376-8716 (ISSN-L)
OpenAlex
W2019482235
Cited by
61
References
11
Citations by year
2026: 4 · 2024: 5 · 2023: 6 · 2022: 4 · 2021: 8 · 2020: 5 · 2019: 6 · 2018: 5 · 2017: 8 · 2016: 3 · 2015: 4 · 2014: 1 · 2013: 1 · 2012: 1
FWCI
3.07
Type
journal article
Language
en
Open access
Locations
  • Drug and Alcohol Dependence (publishedVersion)
  • PubMed (publishedVersion)
  • Europe PMC (PubMed Central) (acceptedVersion)
  • PubMed Central (acceptedVersion)
Funders
  • National Institute of Mental Health (R01MH082773, MH076051, R01MH076051, MH082773)
  • National Institute on Drug Abuse (DA019606, R01DA023973, DA023200, R01DA019606, DA023973, K02DA023200)
  • National Cancer Institute (CA133050, R01CA133050)
Topics
  • Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Opioid Use Disorder Treatment
  • Health Sciences › Medicine › Epidemiology › Substance Abuse Treatment and Outcomes
  • Social Sciences › Psychology › Social Psychology › Mental Health Treatment and Access
Keywords
prescription opioid use disorder, treatment-seeking behavior, help-seeking delay, predictors of treatment, psychiatric comorbidity, bipolar disorder, major depressive disorder, specific phobia, cluster B personality disorders, age of onset, substance use disorders
MeSH terms
Adolescent, Adult, Analgesics, Opioid, Female, Humans, Male, Opioid-Related Disorders, Patient Acceptance of Health Care, Predictive Value of Tests, Probability, United States, Treatment Outcome, Prescription Drugs, Young Adult, Self Report

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review