Opioid-induced Hyperalgesia: A Qualitative Systematic Review

Acute Opioid Tolerance

Guignard, B., Bossard, A. E., Coste, C., Sessler, D. I., Lebrault, C., Alfonsi, P., Fletcher, D., & CHAUVIN, M. (2000) · Anesthesiology · doi:10.1097/00000542-200008000-00019 · Cited by 885 · see citing works

Evidence from rats that morphine tolerance is a learned response

Siegel, S. (1975) · Journal of Comparative and Physiological Psychology · doi:10.1037/h0077058 · Cited by 657 · see citing works

Long-lasting Hyperalgesia Induced by Fentanyl in Rats: Preventive Effect of Ketamine

Célèrier, E., Rivat, C., Jun, Y., Laulin, J.-P., Larcher, A., Reynier, P., & Simonnet, G. (2000) · Anesthesiology · doi:10.1097/00000542-200002000-00029 · Cited by 584 · see citing works

Opioid-induced abnormal pain sensitivity: implications in clinical opioid therapy

Mao, J. (2002) · Pain · doi:10.1016/s0304-3959(02)00422-0 · Cited by 463 · see citing works

Thermal hyperalgesia in association with the development of morphine tolerance in rats: roles of excitatory amino acid receptors and protein kinase C

Mao, J., Price, D. D., & Mayer, D. J. (1994) · Journal of Neuroscience · doi:10.1523/jneurosci.14-04-02301.1994 · Cited by 458 · see citing works

A Role for Proinflammatory Cytokines and Fractalkine in Analgesia, Tolerance, and Subsequent Pain Facilitation Induced by Chronic Intrathecal Morphine

Johnston, I. N., Milligan, E. D., Wieseler‐Frank, J., Frank, M. G., Zapata, V., Campisi, J., Langer, S. J., Martin, D., Green, P., Fleshner, M., et al. (2004) · Journal of Neuroscience · doi:10.1523/jneurosci.1850-04.2004 · Cited by 432 · see citing works

Short-term infusion of the μ-opioid agonist remifentanil in humans causes hyperalgesia during withdrawal

Angst, M. S., Koppert, W., Pahl, I., Clark, J. D., & Schmelz, M. (2003) · Pain · doi:10.1016/s0304-3959(03)00276-8 · Cited by 424 · see citing works

Chronic Morphine Induces Downregulation of Spinal Glutamate Transporters: Implications in Morphine Tolerance and Abnormal Pain Sensitivity

Mao, J., Sung, B., Ji, R., & Lim, G. (2002) · Journal of Neuroscience · doi:10.1523/jneurosci.22-18-08312.2002 · Cited by 409 · see citing works

Differential modulation of remifentanil-induced analgesia and postinfusion hyperalgesia by S-ketamine and clonidine in humans

Koppert, W., Sittl, R., Scheuber, K., Alsheimer, M., Schmelz, M., & Schüttler, J. (2003) · Anesthesiology · doi:10.1097/00000542-200307000-00025 · Cited by 352 · see citing works

Acute pain management in patients with prior opioid consumption: a case-controlled retrospective review

Rapp, S. E., Ready, B. L., & Nessly, M. L. (1995) · Pain · doi:10.1016/0304-3959(94)00168-e · Cited by 349 · see citing works

The role of ketamine in preventing fentanyl-induced hyperalgesia and subsequent acute morphine tolerance

Laulin, J.-P., Maurette, P., Corcuff, J.-B., Rivat, C., Chauvin, M., & Simonnet, G. (2002) · Anesthesia & Analgesia · doi:10.1097/00000539-200205000-00040 · Cited by 344 · see citing works

Dynorphin Promotes Abnormal Pain and Spinal Opioid Antinociceptive Tolerance

Vanderah, T. W., Gardell, L. R., Burgess, S. E., Ibrahim, M. M., Dogrul, A. B., Zhong, C.-M., Zhang, E.-T., Malan, T. P., Ossipov, M. H., Lai, J. Y., et al. (2000) · Journal of Neuroscience · doi:10.1523/jneurosci.20-18-07074.2000 · Cited by 344 · see citing works

Tonic Descending Facilitation from the Rostral Ventromedial Medulla Mediates Opioid-Induced Abnormal Pain and Antinociceptive Tolerance

Vanderah, T. W., Suenaga, N. M. H., Ossipov, M. H., Malan, T. P., Lai, J. Y., & Porreca, F. (2001) · Journal of Neuroscience · doi:10.1523/jneurosci.21-01-00279.2001 · Cited by 335 · see citing works

Progressive enhancement of delayed hyperalgesia induced by repeated heroin administration: a sensitization process

Célèrier, E., Laulin, J.-P., Corcuff, J.-B., Le Moal, M., & Simonnet, G. (2001) · The Journal of Neuroscience · doi:10.1523/jneurosci.21-11-04074.2001 · Cited by 315 · see citing works

Pain intolerance in opioid-maintained former opiate addicts: effect of long-acting maintenance agent

Compton, P., Charuvastra, V. C., & Ling, W. (2001) · Drug and Alcohol Dependence · doi:10.1016/s0376-8716(00)00200-3 · Cited by 311 · see citing works

Naloxone dose dependently produces analgesia and hyperalgesia in postoperative pain

Levine, J. D., Gordon, N. C., & Fields, H. L. (1979) · Nature · doi:10.1038/278740a0 · Cited by 309 · see citing works

Hyperalgesic responses in methadone maintenance patients

Doverty, M., White, J. M., Somogyi, A. A., Bochner, F., Ali, R., & Ling, W. (2001) · Pain · doi:10.1016/s0304-3959(00)00391-2 · Cited by 297 · see citing works

Intraoperative high dose fentanyl induces postoperative fentanyl tolerance

Chia, Y., Liu, K., Wang, J.-J., Kuo, M.-C., & Ho, S.-T. (1999) · Canadian Journal of Anesthesia/Journal canadien d anesthésie · doi:10.1007/bf03012978 · Cited by 296 · see citing works

Opioid-induced hyperalgesia: abnormal or normal pain?

Simonnet, G., & Rivat, C. (2003) · NeuroReport · doi:10.1097/00001756-200301200-00001 · Cited by 273 · see citing works

Attenuation of morphine tolerance, withdrawal-induced hyperalgesia, and associated spinal inflammatory immune responses by propentofylline in rats

Raghavendra, V., Tanga, F. Y., & DeLeo, J. A. (2004) · Neuropsychopharmacology · doi:10.1038/sj.npp.1300315 · Cited by 263 · see citing works

Opioid-sparing Effects of a Low-dose Infusion of Naloxone in Patient-administered Morphine Sulfate

Gan, T. J., Ginsberg, B., Glass, P. S. A., Fortney, J. T., Jhaveri, R., & Perno, R. (1997) · Anesthesiology · doi:10.1097/00000542-199711000-00011 · Cited by 262 · see citing works

Sustained Morphine Exposure Induces a Spinal Dynorphin-Dependent Enhancement of Excitatory Transmitter Release from Primary Afferent Fibers

Gardell, L. R., Wang, R., Burgess, S. E., Ossipov, M. H., Vanderah, T. W., Malan, T. P., Lai, J. Y., & Porreca, F. (2002) · Journal of Neuroscience · doi:10.1523/jneurosci.22-15-06747.2002 · Cited by 261 · see citing works

High Doses of Spinal Morphine Produce a Nonopiate Receptormediated Hyperesthesia

Yaksh, T. L., Harty, G. J., & Onofrio, B. M. (1986) · Anesthesiology · doi:10.1097/00000542-198605000-00008 · Cited by 254 · see citing works

Chronic Pain Prevalence and Analgesic Prescribing in a General Medical Population

Clark, J. D. (2002) · Journal of Pain and Symptom Management · doi:10.1016/s0885-3924(01)00396-7 · Cited by 240 · see citing works

Management of Perioperative Pain in Patients Chronically Consuming Opioids

Carroll, I. R., Angst, M. S., & Clark, J. D. (2004) · Regional Anesthesia & Pain Medicine · doi:10.1016/j.rapm.2004.06.009 · Cited by 222 · see citing works

The Effect of Ketamine on Opioid-Induced Acute Tolerance: Can It Explain Reduction of Opioid Consumption with Ketamine-Opioid Analgesic Combinations?

Kissin, I., Bright, C. A., & Bradley, E. L. (2000) · Anesthesia & Analgesia · doi:10.1097/00000539-200012000-00035 · Cited by 200 · see citing works

Pharmacology of the allodynia in rats evoked by high dose intrathecal morphine.

Yaksh, T. L., & Harty, G. J. (1988) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(25)24481-0 · Cited by 196 · see citing works

Clinical experience of long–term treatment with epidural and intrathecal opioids – a nationwide survey

Arnér, S., Rawal, N., & Gustafsson, L. L. (1988) · Acta Anaesthesiologica Scandinavica · doi:10.1111/j.1399-6576.1988.tb02725.x · Cited by 184 · see citing works

Acute tolerance associated with a single opiate administration: involvement of N-methyl-d-aspartate-dependent pain facilitatory systems

Larcher, A., Laulin, J., Célèrier, E., Moal, M. L., & Simonnet, G. (1998) · Neuroscience · doi:10.1016/s0306-4522(97)00556-3 · Cited by 183 · see citing works

Hyperalgesia during Naloxone-Precipitated Withdrawal from Morphine Is Associated with Increased On-Cell Activity in the Rostral Ventromedial Medulla

Bederson, J. B., Fields, H. L., & Barbaro, N. M. (1990) · Somatosensory & Motor Research · doi:10.3109/08990229009144706 · Cited by 182 · see citing works

Evidence for opiate-activated NMDA processes masking opiate analgesia in rats

Célèrier, E., Laulin, J.-P., Larcher, A., Le Moal, M., & Simonnet, G. (1999) · Brain Research · doi:10.1016/s0006-8993(99)01998-8 · Cited by 182 · see citing works

Pain Responses in Methadone-Maintained Opioid Abusers

Compton, P. A., Charuvastra, V. C., Kintaudi, K., & Ling, W. W. (2000) · Journal of Pain and Symptom Management · doi:10.1016/s0885-3924(00)00191-3 · Cited by 181 · see citing works

Disappearance of morphine-induced hyperalgesia after discontinuing or substituting morphine with other opioid agonists

Sjøgren, P., Jensen, N., & Jensen, T. S. (1994) · Pain · doi:10.1016/0304-3959(94)90084-1 · Cited by 181 · see citing works

Fentanyl Enhancement of Carrageenan-induced Long-lasting Hyperalgesia in Rats

Rivat, C., Laulin, J., Corcuff, J., Célèrier, E., Pain, L., & Simonnet, G. (2002) · Anesthesiology · doi:10.1097/00000542-200202000-00025 · Cited by 181 · see citing works

Intravenous Remifentanil Produces Withdrawal Hyperalgesia in Volunteers with Capsaicin-Induced Hyperalgesia

Hood, D. D., Curry, R. S., & Eisenach, J. C. (2003) · Anesthesia & Analgesia · doi:10.1213/01.ane.0000078811.80093.88 · Cited by 179 · see citing works

Opiate tolerance to daily heroin administration: an apparent phenomenon associated with enhanced pain sensitivity

Laulin, J. P., Célèrier, E., Larcher, A., Le Moal, M., & Simonnet, G. (1999) · Neuroscience · doi:10.1016/s0306-4522(98)00652-6 · Cited by 179 · see citing works

Hyperalgesia and myoclonus with intrathecal infusion of high-dose morphine

Conno, F. D., Caraceni, A. T., Martini, C., Spoldi, E., Salvetti, M., & Ventafridda, V. (1991) · Pain · doi:10.1016/0304-3959(91)90225-m · Cited by 175 · see citing works

Hyperalgesia during acute opioid abstinence: evidence for a nociceptive facilitating function of the rostral ventromedial medulla

Kaplan, H., & Fields, H. (1991) · Journal of Neuroscience · doi:10.1523/jneurosci.11-05-01433.1991 · Cited by 173 · see citing works

Multiple Receptors Involved in Peripheral α2, μ, and A1Antinociception, Tolerance, and Withdrawal

Aley, K. O., & Levine, J. D. (1997) · Journal of Neuroscience · doi:10.1523/jneurosci.17-02-00735.1997 · Cited by 170 · see citing works

Methadone maintenance patients are cross-tolerant to the antinociceptive effects of morphine

Doverty, M., Somogyi, A. A., White, J. M., Bochner, F., Beare, C. H., Menelaou, A., & Ling, W. W. (2001) · Pain · doi:10.1016/s0304-3959(01)00306-2 · Cited by 170 · see citing works

Intrathecal high dose morphine produces hyperalgesia in the rat

Woolf, C. J. (1981) · Brain Research · doi:10.1016/0006-8993(81)90176-1 · Cited by 169 · see citing works

No clinical evidence of acute opioid tolerance after remifentanil-based anaesthesia

Cortínez, L. I., Brandes, V., Muñoz, H. R., Guerrero, M., & Mur, M. (2001) · British Journal of Anaesthesia · doi:10.1093/bja/87.6.866 · Cited by 167 · see citing works

Cold-pressor pain tolerance in opiate and cocaine abusers: Correlates of drug type and use status

Compton, M. A. (1994) · Journal of Pain and Symptom Management · doi:10.1016/0885-3924(94)90203-8 · Cited by 164 · see citing works

Long-lasting increased pain sensitivity in rat following exposure to heroin for the first time

Laulin, J., Larcher, A., Célèrier, E., Moal, M. L., & Simonnet, G. (1998) · European Journal of Neuroscience · doi:10.1046/j.1460-9568.1998.00083.x · Cited by 156 · see citing works

A murine model of opioid-induced hyperalgesia

Li, X., Angst, M. S., & Clark, J. D. (2001) · Molecular Brain Research · doi:10.1016/s0169-328x(00)00260-6 · Cited by 155 · see citing works

Acute thermal hyperalgesia elicited by low-dose morphine in normal mice is blocked by ultra-low-dose naltrexone, unmasking potent opioid analgesia

Crain, S. M., & Shen, K.-F. (2001) · Brain Research · doi:10.1016/s0006-8993(00)03010-9 · Cited by 152 · see citing works

Dose-dependent analgesic and hyperalgesic effects of systemic naloxone in arthritic rats

Kayser, V., & Guilbaud, G. (1981) · Brain Research · doi:10.1016/0006-8993(81)91110-0 · Cited by 148 · see citing works

Steady-state pharmacokinetics and pharmacodynamics in methadone maintenance patients: Comparison of those who do and do not experience withdrawal and concentration-effect relationships

DYER, K., Foster, D. J. R., White, J. M., Somogyi, A. A., Menelaou, A., & Bochner, F. (1999) · Clinical Pharmacology & Therapeutics · doi:10.1016/s0009-9236(99)90090-5 · Cited by 148 · see citing works

Pain-related increases in spinal cord membrane-bound protein kinase C following peripheral nerve injury

Mao, J., Price, D. D., Mayer, D. J., & Hayes, R. L. (1992) · Brain Research · doi:10.1016/0006-8993(92)91354-h · Cited by 147 · see citing works

THE MORPHINE ABSTINENCE SYNDROME, ITS NATURE AND TREATMENT

Himmelsbach, C. K. (1941) · Annals of Internal Medicine · doi:10.7326/0003-4819-15-5-829 · Cited by 146 · see citing works

Addition of ultralow dose naloxone to postoperative morphine PCA: unchanged analgesia and opioid requirement but decreased incidence of opioid side effects

Cepeda, M. S., Álvarez, H., Morales, O., & Carr, D. B. (2003) · Pain · doi:10.1016/j.pain.2003.09.011 · Cited by 146 · see citing works

Modulation of Remifentanil-Induced Analgesia, Hyperalgesia, and Tolerance by Small-Dose Ketamine in Humans

hl, M. L., Gerber, A., Schnider, T. W., Petersen‐Felix, S., Arendt‐Nielsen, L., & Curatolo, M. (2003) · Anesthesia & Analgesia · doi:10.1213/01.ane.0000048086.58161.18 · Cited by 146 · see citing works

Hyperalgesia and myoclonus in terminal cancer patients treated with continuous intravenous morphine

Sjøgren, P., Jonsson, T., Jensen, N., Drenck, N.-E., & Jensen, T. S. (1993) · Pain · doi:10.1016/0304-3959(93)90188-u · Cited by 143 · see citing works

Continuous co-administration of dextromethorphan or MK-801 with morphine: attenuation of morphine dependence and naloxone-reversible attenuation of morphine tolerance

Manning, B. H., Mao, J., Frenk, H., Price, D. D., & Mayer, D. J. (1996) · Pain · doi:10.1016/0304-3959(96)81972-5 · Cited by 141 · see citing works

Role of corticotropin-releasing hormone in the amygdala and bed nucleus of the stria terminalis in the behavioral, pain modulatory, and endocrine consequences of opiate withdrawal

McNally, G. P., & Akil, H. (2002) · Neuroscience · doi:10.1016/s0306-4522(02)00105-7 · Cited by 141 · see citing works

Withdrawal hyperalgesia after acute opioid physical dependence in nonaddicted humans: a preliminary study

Compton, P., Athanasos, P., & Elashoff, D. (2003) · The Journal of Pain · doi:10.1016/j.jpain.2003.08.003 · Cited by 138 · see citing works

Large-amplitude 5-HT1A receptor activation: a new mechanism of profound, central analgesia

Colpaert, F. C., Tarayre, J. P., Koek, W., Pauwels, P. J., Bardin, L., Xu, X., Wiesenfeld‐Hallin, Z., Cosi, C., Carilla-Durand, E., Assié, M. B., et al. (2002) · Neuropharmacology · doi:10.1016/s0028-3908(02)00119-3 · Cited by 137 · see citing works

Characterization of nociceptin hyperalgesia and allodynia in conscious mice

Hara, N., Minami, T., Okuda‐Ashitaka, E., Sugimoto, T., Sakai, M., Onaka, M., Mori, H., Imanishi, T., Shingu, K., & Ito, S. (1997) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0701146 · Cited by 134 · see citing works

Hyperalgesia: An Emerging Iatrogenic Syndrome

Mercadante, S., Ferrera, P., Villari, P., & Arcuri, E. (2003) · Journal of Pain and Symptom Management · doi:10.1016/s0885-3924(03)00258-6 · Cited by 133 · see citing works

Opioid-Induced Hyperalgesia and Incisional Pain

Li, X., Angst, M. S., & Clark, J. D. (2001) · Anesthesia & Analgesia · doi:10.1097/00000539-200107000-00040 · Cited by 133 · see citing works

Effect of Remifentanil on Pain and Secondary Hyperalgesia Associated with the Heat–Capsaicin Sensitization Model in Healthy Volunteers

Petersen, K. L., Jones, B., Segredo, V., Dahl, J. B., & Rowbotham, M. C. (2001) · Anesthesiology · doi:10.1097/00000542-200101000-00008 · Cited by 132 · see citing works

Analgesia and hyperalgesia produced in the rat by intrathecal naloxone

Woolf, C. J. (1980) · Brain Research · doi:10.1016/0006-8993(80)90375-3 · Cited by 124 · see citing works

Reduced development of tolerance to the analgesic effects of morphine and clonidine in PKCγ mutant mice

Zeitz, K. P., Malmberg, A. B., Gilbert, H., & Basbaum, A. I. (2001) · Pain · doi:10.1016/s0304-3959(01)00353-0 · Cited by 116 · see citing works

The combination of low dose of naloxone and morphine in PCA does not decrease opioid requirements in the postoperative period

Cepeda, M. S., Africano, J. M., Manrique, A. M., Fragoso, W., & Carr, D. B. (2002) · Pain · doi:10.1016/s0304-3959(01)00425-0 · Cited by 108 · see citing works

Hyperalgesia during withdrawal as a means of measuring the degree of dependence in morphine dependent rats

Tilson, H. A., Rech, R. H., & Stolman, S. (1973) · Psychopharmacologia · doi:10.1007/bf00429309 · Cited by 107 · see citing works

Naloxone provokes similar pain facilitation as observed after short-term infusion of remifentanil in humans

Koppert, W., Angst, M. S., Alsheimer, M., Sittl, R., Albrecht, S., Schüttler, J., & Schmelz, M. (2003) · Pain · doi:10.1016/s0304-3959(03)00294-x · Cited by 106 · see citing works

Genetic variation in morphine analgesic tolerance

Kest, B., Hopkins, E., Palmese, C. A., Adler, M. A., & Mogil, J. S. (2002) · Pharmacology Biochemistry and Behavior · doi:10.1016/s0091-3057(02)00908-5 · Cited by 105 · see citing works

Spatial patterns of increased spinal cord membrane-bound protein kinase C and their relation to increases in 14C-2-deoxyglucose metabolic activity in rats with painful peripheral mononeuropathy

Mao, J., Mayer, D. J., Hayes, R. L., & Price, D. D. (1993) · Journal of Neurophysiology · doi:10.1152/jn.1993.70.2.470 · Cited by 105 · see citing works

Opiate alkaloids antagonize postsynaptic glycine and GABA responses: Correlation with convulsant action

Werz, M. A., & Macdonald, R. L. (1982) · Brain Research · doi:10.1016/0006-8993(82)90038-5 · Cited by 104 · see citing works

Effects of Prophylactic Nalmefene on the Incidence of Morphine-related Side Effects in Patients Receiving Intravenous Patient-controlled Analgesia

Joshi, G. P., Duffy, L. L., Chehade, J., Wesevich, J., Gajraj, N. M., & Johnson, E. R. (1999) · Anesthesiology · doi:10.1097/00000542-199904000-00013 · Cited by 102 · see citing works

Opioid and adenosine peripheral antinociception are subject to tolerance and withdrawal

Aley, K. O., Green, P., & Levine, J. (1995) · Journal of Neuroscience · doi:10.1523/jneurosci.15-12-08031.1995 · Cited by 101 · see citing works

Role of nitric oxide in the induction and expression of morphine tolerance and dependence in mice

Dambisya, Y. M., & Lee, T. (1996) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.1996.tb15280.x · Cited by 99 · see citing works

Increases in protein kinase C gamma immunoreactivity in the spinal cord dorsal horn of rats with painful mononeuropathy

Mao, J., Price, D. D., Phillips, L. L., Lü, J., & Mayer, D. J. (1995) · Neuroscience Letters · doi:10.1016/0304-3940(95)11975-3 · Cited by 96 · see citing works

Is development of hyperalgesia, allodynia and myoclonus related to morphine metabolism during long‐term administration?: Six case histories

Sjøgren, P., Thunedborg, L. P., Christrup, L. L., Hansen, S. H., & Franks, J. (1998) · Acta Anaesthesiologica Scandinavica · doi:10.1111/j.1399-6576.1998.tb05378.x · Cited by 94 · see citing works

Hyperalgesia Induced by High-Dose Intrathecal Sufentanil in Neuropathic Pain

Devulder, J. (1997) · Journal of Neurosurgical Anesthesiology · doi:10.1097/00008506-199704000-00007 · Cited by 85 · see citing works

Expression of calcitonin gene-related peptide, substance P and protein kinase C in cultured dorsal root ganglion neurons following chronic exposure to mu, delta and kappa opiates

Belanger, S., Ma, W., Chabot, J. ‐., & Quirion, R. (2002) · Neuroscience · doi:10.1016/s0306-4522(02)00452-9 · Cited by 83 · see citing works

Conditional hyperalgesia is elicited by environmental signals of morphine

Krank, M. D., Hinson, R. E., & Siegel, S. (1981) · Behavioral and Neural Biology · doi:10.1016/s0163-1047(81)90411-8 · Cited by 76 · see citing works

Morphine analgesia and acute physical dependence: rapid onset of two opposing, dose-related processes

Kim, D., Fields, H. L., & Barbaro, N. M. (1990) · Brain Research · doi:10.1016/0006-8993(90)90894-h · Cited by 75 · see citing works

Drug-onset cues as signals: Intraadministration associations and tolerance.

Kim, J. A., Siegel, S., & Patenall, V. R. A. (1999) · Journal of Experimental Psychology Animal Behavior Processes · doi:10.1037/0097-7403.25.4.491 · Cited by 73 · see citing works

Antagonists at excitatory opioid receptors on sensory neurons in culture increase potency and specificity of opiate analgesics and attenuate development of tolerance/dependence

Shen, K.-F., & Crain, S. M. (1994) · Brain Research · doi:10.1016/0006-8993(94)91028-6 · Cited by 73 · see citing works

Repetitive Opioid Abstinence Causes Progressive Hyperalgesia Sensitive to N-Methyl-d-aspartate Receptor Blockade in the Rat

Dunbar, S. A., & Pulai, I. (1998) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(24)37250-7 · Cited by 72 · see citing works

MORPHINE-INDUCED HYPERALGESIA IN RATS TESTED ON THE HOT PLATE

Kayan, S., Woods, L. A., & Mitchell, C. L. (1971) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(25)28909-1 · Cited by 69 · see citing works

Effect of transient naloxone antagonism on tolerance development in rats receiving continuous spinal morphine infusion

Ibuki, T., Dunbar, S. A., & Yaksh, T. L. (1997) · Pain · doi:10.1016/s0304-3959(96)03283-6 · Cited by 69 · see citing works

Modeling of tolerance development and rebound effect during different intravenous administrations of morphine to rats.

Ekblom, M., Hammarlund‐Udenaes, M., & Paalzow, L. (1993) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(25)38315-1 · Cited by 66 · see citing works

Severe opioid toxicity and somatizationof psychosocial distress in a cancer patient with a background of chemical dependence

Lawlor, P. G., Walker, P. J., Bruera, E. D., & Mitchell, S. (1997) · Journal of Pain and Symptom Management · doi:10.1016/s0885-3924(97)00081-x · Cited by 66 · see citing works

Paradoxical hyperalgesic effect of exceedingly low doses of systemic morphine in an animal model of persistent pain (Freund's adjuvant-induced arthritic rats)

Kayser, V., Besson, J., & Guilbaud, G. (1987) · Brain Research · doi:10.1016/0006-8993(87)91338-2 · Cited by 66 · see citing works

Roles of α1- and α2-Adrenoceptors in the Nucleus Raphe Magnus in Opioid Analgesia and Opioid Abstinence-Induced Hyperalgesia

Bie, B., Fields, H. L., Williams, J. T., & Pan, Z. Z. (2003) · Journal of Neuroscience · doi:10.1523/jneurosci.23-21-07950.2003 · Cited by 63 · see citing works

Intraadministration associations: Conditional hyperalgesia elicited by morphine onset cues.

Sokolowska, M., Siegel, S., & Kim, J. A. (2002) · Journal of Experimental Psychology Animal Behavior Processes · doi:10.1037/0097-7403.28.3.309 · Cited by 61 · see citing works

Presynaptic Mechanism for Anti-Analgesic and Anti-Hyperalgesic Actions of κ-Opioid Receptors

Bie, B., & Pan, Z. Z. (2003) · Journal of Neuroscience · doi:10.1523/jneurosci.23-19-07262.2003 · Cited by 59 · see citing works

Mu-opioid agonist enhancement of prostaglandin-induced hyperalgesia in the rat: A G-protein βγ subunit-mediated effect?

Khasar, S. G., Wang, J., Taiwo, Y. O., Heller, P. H., Green, P. G., & Levine, J. D. (1995) · Neuroscience · doi:10.1016/0306-4522(94)00632-f · Cited by 59 · see citing works

Different Mechanisms Mediate Development and Expression of Tolerance and Dependence for Peripheral μ-Opioid Antinociception in Rat

Aley, K. O., & Levine, J. D. (1997) · Journal of Neuroscience · doi:10.1523/jneurosci.17-20-08018.1997 · Cited by 59 · see citing works

Neuraminidase inhibitor, oseltamivir blocks GM1 ganglioside-regulated excitatory opioid receptor-mediated hyperalgesia, enhances opioid analgesia and attenuates tolerance in mice

Crain, S. M., & Shen, K.-F. (2003) · Brain Research · doi:10.1016/j.brainres.2003.09.068 · Cited by 58 · see citing works

Genetic differences in morphine sensitivity, tolerance and withdrawal in rats

Hoffmann, O. I., Plesan, A., & Wiesenfeld‐Hallin, Z. (1998) · Brain Research · doi:10.1016/s0006-8993(98)00768-9 · Cited by 57 · see citing works

Morphine tolerance increases [ 3 H]MK-801 binding affinity and constitutive neuronal nitric oxide synthase expression in rat spinal cord

Wong, C., Hsu, M., Chou, Y., Tao, P., & Tung, C. (2000) · British Journal of Anaesthesia · doi:10.1093/bja/85.4.587 · Cited by 57 · see citing works

Pharmacodynamics of morphine-induced neuronal nitric oxide production and antinociceptive tolerance development

Heinzen, E. L., & Pollack, G. M. (2004) · Brain Research · doi:10.1016/j.brainres.2004.07.015 · Cited by 53 · see citing works

Exaggerated nociceptive responses on morphine withdrawal: roles of protein kinase C ε and γ

Sweitzer, S. M., Wong, S. M. E., Tjølsen, A., Allen, C. P., Mochly‐Rosen, D., & Kendig, J. J. (2004) · Pain · doi:10.1016/j.pain.2004.04.004 · Cited by 53 · see citing works

Lesson of the week: Morphine induced allodynia in a child with brain tumour What is allodynia?

Heger, S., Maier, C., Otter, K., Helwig, U., Suttorp, M., & Berger, A. (1999) · BMJ · doi:10.1136/bmj.319.7210.627 · Cited by 51 · see citing works

Hyperalgesia During Opioid Abstinence: Mediation by Glutamate and Substance P

Li, X., & Clark, J. D. (2002) · Anesthesia & Analgesia · doi:10.1097/00000539-200210000-00035 · Cited by 51 · see citing works

Opioid hyperalgesia and tolerance versus 5-HT1A receptor-mediated inverse tolerance

Xu, X., Colpaert, F. C., & Wiesenfeld‐Hallin, Z. (2003) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2003.10.005 · Cited by 51 · see citing works

Cholera toxin-B subunit blocks excitatory opioid receptor-mediated hyperalgesic effects in mice, thereby unmasking potent opioid analgesia and attenuating opioid tolerance/dependence

Shen, K.-F., & Crain, S. M. (2001) · Brain Research · doi:10.1016/s0006-8993(01)02990-0 · Cited by 50 · see citing works

Hyperalgesic effects of divalent cations and antinociceptive effects of a calcium chelator in naive and morphine-dependent mice.

Schmidt, W. K., & Way, E. L. (1980) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(25)31909-9 · Cited by 49 · see citing works

THE EFFECT OF OPIATES ON THE PAIN THRESHOLD IN POST-ADDICTS

Andrews, H. L. (1943) · Journal of Clinical Investigation · doi:10.1172/jci101420 · Cited by 49 · see citing works

Heme oxygenase type 2 modulates behavioral and molecular changes during chronic exposure to morphine

Liang, D., Li, X., Lighthall, G. K., & Clark, J. D. (2003) · Neuroscience · doi:10.1016/s0306-4522(03)00483-4 · Cited by 49 · see citing works

The effects of p-chlorophenylalanine on morphine analgesia, tolerance and dependence development in two strains of rats

Tilson, H. A., & Rech, R. H. (1974) · Psychopharmacology · doi:10.1007/bf00421565 · Cited by 49 · see citing works

Intrathecal Clonidine

Milne, B., Cervenko, F. W., Jhamandas, K. H., & Sutak, M. (1985) · Anesthesiology · doi:10.1097/00000542-198501000-00007 · Cited by 48 · see citing works

Dissociation of Tolerance and Dependence for Opioid Peripheral Antinociception in Rats

Aley, K. O., & Levine, J. D. (1997) · Journal of Neuroscience · doi:10.1523/jneurosci.17-10-03907.1997 · Cited by 47 · see citing works

Potentiated startle and hyperalgesia during withdrawal from acute morphine: effects of multiple opiate exposures

Harris, A. C., Hanes, S. L., & Gewirtz, J. C. (2004) · Psychopharmacology · doi:10.1007/s00213-004-1889-4 · Cited by 46 · see citing works

Conditioned hyperalgesia depends on the pain sensitivity measure.

Krank, M. D. (1987) · Behavioral Neuroscience · doi:10.1037//0735-7044.101.6.854 · Cited by 45 · see citing works

Morphine hyperalgesia: A case report

Wilson, G. R., & Reisfield, G. M. (2003) · American Journal of Hospice and Palliative Medicine® · doi:10.1177/104990910302000608 · Cited by 44 · see citing works

The development of morphine tolerance and dependence in rats with chronic pain

Yu, W., Hao, J., Xu, X., & Wiesenfeld‐Hallin, Z. (1997) · Brain Research · doi:10.1016/s0006-8993(97)00132-7 · Cited by 41 · see citing works

The development of pain-related behaviour and opioid tolerance after neuropathy-inducing surgery and sham surgery

Christensen, D., & Kayser, V. (2000) · Pain · doi:10.1016/s0304-3959(00)00334-1 · Cited by 40 · see citing works

Acute neuropsychiatric findings in a patient receiving fentanyl for cancer pain

Bruera, E. D., & Pereira, J. (1997) · Pain · doi:10.1016/s0304-3959(96)03238-1 · Cited by 39 · see citing works

Spinal cord mechanisms of opioid tolerance and dependence: Fos-like immunoreactivity expression increases in subpopulations of spinal cord neurons during withdrawal

Rohde, D. S., Detweiler, D. J., & Basbaum, A. I. (1996) · Neuroscience · doi:10.1016/0306-4522(95)00529-3 · Cited by 38 · see citing works

Possible medullary κ hyperalgesic mechanism I. A new potential role for endogenous opioid peptides in pain perception

Wu, K. M., Martin, W. R., Kamerling, S. G., & Wettstein, J. G. (1983) · Life Sciences · doi:10.1016/0024-3205(83)90691-4 · Cited by 38 · see citing works

Morphine hyperalgesic effects on the formalin test in domestic fowl (Gallus gallus)

Hughes, R. A., & Sufka, K. J. (1991) · Pharmacology Biochemistry and Behavior · doi:10.1016/0091-3057(91)90273-5 · Cited by 38 · see citing works

Morphine-3β-d-glucuronide Suppresses Inhibitory Synaptic Transmission in Rat Substantia Gelatinosa

Moran, T. D., & Smith, P. A. (2002) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.102.035626 · Cited by 38 · see citing works

Behavioral and electrophysiological evidence for tolerance to continuous morphine administration into the ventrolateral periaqueductal gray

Lane, D., Tortorici, V., & Morgan, M. M. (2004) · Neuroscience · doi:10.1016/j.neuroscience.2004.01.023 · Cited by 36 · see citing works

Precipitated opioid withdrawal across acute physical dependence induction methods

Compton, P. A. (2003) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2003.10.017 · Cited by 36 · see citing works

Prevention of fentanyl-induced delayed pronociceptive effects in mice lacking the protein kinase Cγ gene

Célérier, E., Simonnet, G., & Maldonado, R. (2004) · Neuropharmacology · doi:10.1016/j.neuropharm.2003.08.008 · Cited by 36 · see citing works

Opioid and nicotinic analgesic and hyperalgesic loci in the rat brain stem.

Hamann, S. R., & Martin, W. R. (1992) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(25)11095-1 · Cited by 35 · see citing works

Procedures that produce context-specific tolerance to morphine in rats also produce context-specific withdrawal.

Falls, W. A., & Kelsey, J. E. (1989) · Behavioral Neuroscience · doi:10.1037//0735-7044.103.4.842 · Cited by 34 · see citing works

Codeine analgesic and morphine hyperalgesic effects on thermal nociception in domestic fowl

Hughes, R. A. (1990) · Pharmacology Biochemistry and Behavior · doi:10.1016/0091-3057(90)90291-o · Cited by 34 · see citing works

Chronic opioid treatment of neuroblastoma X dorsal root ganglion neuron hybrid F11 cells results in elevated GM1 ganglioside and cyclic adenosine monophosphate levels and onset of naloxone‐evoked decreases in membrane K+ currents

Wu, G., Fan, S., Lu, Z., Ledeen, R. W., & Crain, S. M. (1995) · Journal of Neuroscience Research · doi:10.1002/jnr.490420408 · Cited by 34 · see citing works

Comparison of subjective and objective analgesic effects of intravenous and intrathecal morphine in chronic pain patients by heat beam dolorimetry

Lipman, J. J., & Blumenkopf, B. (1989) · Pain · doi:10.1016/0304-3959(89)90037-7 · Cited by 33 · see citing works

Effects of systemic, intracerebral, or intrathecal administration on an N-methyl-D-aspartate receptor antagonist on associative morphine analgesic tolerance and hyperalgesia in rats.

McNally, G. P., & Westbrook, R. F. (1998) · Behavioral Neuroscience · doi:10.1037//0735-7044.112.4.966 · Cited by 33 · see citing works

Single dose oral dihydrocodeine for acute postoperative pain

Moore, R. A., Edwards, J. E., Derry, S., & McQuay, H. J. (2000) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd002760 · Cited by 31 · see citing works

Mechanical allodynia and thermal hyperalgesia upon acute opioid withdrawal in the neonatal rat

Sweitzer, S. M., Allen, C. P., Zissen, M. H., & Kendig, J. J. (2004) · Pain · doi:10.1016/j.pain.2004.04.003 · Cited by 31 · see citing works

Route of morphine administration modulates conditioned analgesic tolerance and hyperalgesia

Grisel, J. E., Wiertelak, E. P., Watkins, L. R., & Maier, S. F. (1994) · Pharmacology Biochemistry and Behavior · doi:10.1016/0091-3057(94)90260-7 · Cited by 31 · see citing works

Pain Perception of Intravenous Heroin Users on Maintenance Therapy with Levomethadone

Schall, U., KATTA, T., PRIES, E., Klöppel, A., & Gastpar, M. (1996) · Pharmacopsychiatry · doi:10.1055/s-2007-979567 · Cited by 31 · see citing works

Treatment of chronic allodynia in spinally injured rats: effects of intrathecal selective opioid receptor agonists

Hao, J., Yu, W., Wiesenfeld‐Hallin, Z., & Xu, X. (1998) · Pain · doi:10.1016/s0304-3959(97)00221-2 · Cited by 31 · see citing works

Intracerebroventricular treatment of mice with pertussis toxin induces hyperalgesia and enhances 3H-nitrendipine binding to synaptic membranes: Similarity with morphine tolerance

Ohnishi, T., Saito, K., Maeda, S., Matsumoto, K., SAKUDA, M., & Inoki, R. (1990) · Naunyn-Schmiedeberg s Archives of Pharmacology · doi:10.1007/bf00195068 · Cited by 31 · see citing works

The Effect of Spinal Ibuprofen on Opioid Withdrawal in the Rat

Dunbar, S. A., Karamov, I. G., & Buerkle, H. (2000) · Anesthesia & Analgesia · doi:10.1097/00000539-200008000-00035 · Cited by 31 · see citing works

Interaction between alcohol deprivation and morphine withdrawal in mice

Салимов, Р. М., Salimova, N. B., Клодт, П. Д., & Maisky, A. (1993) · Drug and Alcohol Dependence · doi:10.1016/0376-8716(93)90046-s · Cited by 31 · see citing works

Opiate dependence and withdrawal--a new synthesis?

Hendrie, C. (1985) · Pharmacology, Biochemistry and Behavior · doi:10.1016/0091-3057(85)90084-x · Cited by 30 · see citing works

Intrathecal high-dose morphine induces spinally-mediated behavioral responses through NMDA receptors

Sakurada, T., Watanabe, C., Okuda, K., Sugiyama, A., Moriyama, T., Sakurada, C., Tan–No, K., & Sakurada, S. (2002) · Molecular Brain Research · doi:10.1016/s0169-328x(01)00332-1 · Cited by 30 · see citing works

DIHYDROCODEINE-INDUCED HYPERALGESIA IN POSTOPERATIVE DENTAL PAIN

Seymour, R. A., Rawlins, M. D., & Rowell, F. J. (1982) · The Lancet · doi:10.1016/s0140-6736(82)92448-5 · Cited by 30 · see citing works

Hyperalgesic and analgesic actions of morphine, U50-488, naltrexone, and (−)-lobeline in the rat brainstem

Hamann, S. R., & Martin, W. R. (1994) · Pharmacology Biochemistry and Behavior · doi:10.1016/0091-3057(94)90131-7 · Cited by 30 · see citing works

Opioid mediation of the antiaversive and hyperalgesic actions of bradykinin injected into the dorsal periaqueductal gray of the rat

Burdin, T. A., Graeff, F. G., & Pelá, I. R. (1992) · Physiology & Behavior · doi:10.1016/0031-9384(92)90325-v · Cited by 29 · see citing works

Genetic differences in the antinociceptive effect of morphine and its potentiation by dextromethorphan in rats

Plesan, A., Hoffmann, O. I., Xu, X.-J., & Wiesenfeld‐Hallin, Z. (1999) · Neuroscience Letters · doi:10.1016/s0304-3940(99)00109-3 · Cited by 29 · see citing works

Hyperalgesia mediated by peripheral opiate receptors in the rat

van der Kooy, D., & Nagy, J. I. (1985) · Behavioural Brain Research · doi:10.1016/0166-4328(85)90044-0 · Cited by 29 · see citing works

Differential contribution of descending serotonergic and noradrenergic systems to central Tyr-D-Ala2-Gly-NMePhe4-Gly-ol5 (DAMGO) and morphine-induced antinociception in mice.

Arts, K. S., Holmes, B. B., & Fujimoto, J. M. (1990) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(25)23194-9 · Cited by 29 · see citing works

Dexmedetomidine Fails to Cause Hyperalgesia After Cessation of Chronic Administration

Davies, M. F., Haimor, F., Lighthall, G. K., & Clark, J. D. (2003) · Anesthesia & Analgesia · doi:10.1097/00000539-200301000-00041 · Cited by 28 · see citing works

Allodynia After Acute Intrathecal Morphine Administration in a Patient with Neuropathic Pain After Spinal Cord Injury

Parisod, E., Siddall, P. J., Viney, M., McClelland, J. M., & Cousins, M. J. (2003) · Anesthesia & Analgesia · doi:10.1213/01.ane.0000068482.67289.1a · Cited by 26 · see citing works

A case of uncommon withdrawal symptoms after a short period of spinal morphine administration

Devulder, J., Bohyn, P., Castille, F., Laat, M. D., & Rolly, G. (1996) · Pain · doi:10.1016/0304-3959(95)00187-5 · Cited by 25 · see citing works

INDOMETHACIN, CAFFEINE AND PROCHLORPERAZINE ALONE AND COMBINED REVERT HYPERALGESIA IN IN VIVO MODELS OF MIGRAINE

Galeotti, N., Ghelardini, C., Grazioli, I., & Uslenghi, C. (2002) · Pharmacological Research · doi:10.1016/s1043-6618(02)00126-3 · Cited by 25 · see citing works

Naloxone-sensitive hyperalgesia follows analgesia induced by morphine and environmental stimulation

Hendrie, C. A. (1989) · Pharmacology Biochemistry and Behavior · doi:10.1016/0091-3057(89)90066-x · Cited by 24 · see citing works

A withdrawal hyperalgesia test for physical dependence: Evaluation of μ and mixed-partial opioid agonists

VonVoigtlander, P. F., & Lewis, R. A. (1983) · Journal of Pharmacological Methods · doi:10.1016/0160-5402(83)90022-0 · Cited by 24 · see citing works

Spinal amino acid release and repeated withdrawal in spinal morphine tolerant rats

Ibuki, T., Maršala, M., Masuyama, T., & Yaksh, T. L. (2003) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0705102 · Cited by 23 · see citing works

Formalin-evoked Fos expression in spinal cord is enhanced in morphine-tolerant rats

Rohde, D. S., Detweiler, D. J., & Basbaum, A. I. (1997) · Brain Research · doi:10.1016/s0006-8993(97)00582-9 · Cited by 23 · see citing works

Ueber die Gewöhnung an Gifte

Rossbach, M. J. (1880) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/bf01637005 · Cited by 23 · see citing works

Contribution of sacral spinal cord neurons to the autonomic and somatic consequences of withdrawal from morphine in the rat

Rohde, D. S., McKay, W. R., Abbadie, C., & Basbaum, A. I. (1997) · Brain Research · doi:10.1016/s0006-8993(96)01132-8 · Cited by 20 · see citing works

Periaqueductal gray naloxone microinjections in morphine-dependent rats: Hyperalgesia without “classical” withdrawal

WILCOX, R., Mikuła, J., & LEVLTT, R. (1979) · Neuropharmacology · doi:10.1016/0028-3908(79)90118-7 · Cited by 20 · see citing works

Effects of pethidine, acetylsalicylic acid, and indomethacin on pain and behavior in the mole-rat

Towett, P. K., & Kanui, T. I. (1993) · Pharmacology Biochemistry and Behavior · doi:10.1016/0091-3057(93)90099-f · Cited by 18 · see citing works

Opioid Insights

Fine, P. G. (2004) · Journal of Pain & Palliative Care Pharmacotherapy · doi:10.1080/j354v18n03_08 · Cited by 18 · see citing works

Pharmacologic characteristics of a medullary hyperalgesic center.

Parvini, S., Hamann, S. R., & Martin, W. R. (1993) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(25)38102-4 · Cited by 17 · see citing works

Acute morphine dependence: Effects observed in shock and light discrimination tasks

Grilly, D. M., & Gowans, G. C. (1986) · Psychopharmacology · doi:10.1007/bf00178515 · Cited by 17 · see citing works

Context-specific morphine tolerance on the paw-pressure and tail-shock vocalization tests: evidence of associative tolerance without conditioned compensatory responding

Antonio Cepeda-benito, A., Tiffany, S. T., & Cox, L. S. (1999) · Psychopharmacology · doi:10.1007/s002130051077 · Cited by 17 · see citing works

Opioid and nicotinic medullary hyperalgesic influences in the decerebrated rat

Martin, W. R., Kumar, S. S., & Sloan, J. W. (1988) · Pharmacology Biochemistry and Behavior · doi:10.1016/0091-3057(88)90194-3 · Cited by 16 · see citing works

Kappa opioid receptors participate in nerve growth factor-induced hyperalgesia

Apfel, S. C., Newel, M., Dormia, C., & Kessler, J. A. (1995) · Neuroscience · doi:10.1016/0306-4522(95)00209-2 · Cited by 15 · see citing works

Associative morphine tolerance in the rat: Examinations of compensatory responding and cross-tolerance with stress-induced analgesia

Maude‐Griffin, P. M., & Tiffany, S. T. (1989) · Behavioral and Neural Biology · doi:10.1016/s0163-1047(89)90621-3 · Cited by 15 · see citing works

The role of cholecystokinin in conditional compensatory responding and morphine tolerance in rats.

Kim, J. A., & Siegel, S. (2001) · Behavioral Neuroscience · doi:10.1037//0735-7044.115.3.704 · Cited by 15 · see citing works

Conditioned tolerance to morphine hypoalgesia: compensatory hyperalgesia in the experimental group or conditioned hypoalgesia in the control group?

Westbrook, R. F., & Greeley, J. D. (1992) · PubMed · Cited by 14 · see citing works

Cross-tolerance between analgesic low doses of morphine and naloxone in arthritic rats

Kayser, V., & Guilbaud, G. (1987) · Brain Research · doi:10.1016/0006-8993(87)90996-6 · Cited by 14 · see citing works

Amniotic-Fluid Ingestion Enhances \nMorphine Analgesia During Morphine \nTolerance and Withdrawal in RatsPreprint

Doerr, J. C., & Kristal, M. B. (1991) · CogPrints (University of Southampton) · Cited by 14 · see citing works

Intrathecal injection of a ϰ opioid agonist produces hyperalgesia in the guinea pig

Leighton, G. E., Hill, R. G., & Hughes, J. W. (1988) · European Journal of Pharmacology · doi:10.1016/0014-2999(88)90390-1 · Cited by 13 · see citing works

Periodic abstinence enhances nociception without significantly altering the antinociceptive efficacy of spinal morphine in the rat

Dunbar, S. A., & Karamian, I. (2003) · Neuroscience Letters · doi:10.1016/s0304-3940(03)00227-1 · Cited by 13 · see citing works

Intrathecal Ketorolac Reverses Hypersensitivity following Acute Fentanyl Exposure

Kang, Y.-J., Vincler, M. A., Li, X., Conklin, D. R., & Eisenach, J. C. (2002) · Anesthesiology · doi:10.1097/00000542-200212000-00046 · Cited by 12 · see citing works

Questioning the cardiocirculatory excitatory effects of opioids under volatile anaesthesia

Docquier, M.-A., Lavand'homme, P. M., Boulanger, V., Collet, V., & Kock, M. D. (2004) · British Journal of Anaesthesia · doi:10.1093/bja/aeh216 · Cited by 11 · see citing works

Analgesic actions of dynorphin A(1–13) antiserum in the rat brain stem

Hamann, S. R., & Martin, W. R. (1992) · Brain Research Bulletin · doi:10.1016/0361-9230(92)90129-l · Cited by 10 · see citing works

Cholecystokinin receptor binding in morphine analgesia: Tolerance, withdrawal and abstinence

Welin, M., Harro, J., Yukhananov, R. Y., Nyberg, F., & Oreland, L. (1994) · Neuropeptides · doi:10.1016/0143-4179(94)90022-1 · Cited by 9 · see citing works

The Effects of Chronic Morphine Administration on Tooth Pulp Thresholds in Dogs and Cats

Kayan, S., & Mitchell, C. L. (1968) · Experimental Biology and Medicine · doi:10.3181/00379727-128-33117 · Cited by 9 · see citing works

The role of contextual cues on counterirritation in the development process of analgesic tolerance to morphine

Nakama-Kitamura, M. (2002) · Life Sciences · doi:10.1016/s0024-3205(02)02248-8 · Cited by 6 · see citing works

An analysis of the effects of contextual cues on the development of morphine tolerance in rats.

Nakama-Kitamura, M., Kawai, N., Hayashi, T., & Imada, H. (2002) · PubMed · Cited by 5 · see citing works

Morphine dependence in rats assessed in a shock discrimination task

Grilly, D. M., Nowak, M. J., Walsh, P. A., & Dugovics, J. P. (1981) · Psychopharmacology · doi:10.1007/bf00427104 · Cited by 5 · see citing works

Hyperalgesia following administration of morphine and pethidine in the root rat (Tachyoryctes splendens)

Towett, P. K., & Kanui, T. I. (1995) · Journal of Veterinary Pharmacology and Therapeutics · doi:10.1111/j.1365-2885.1995.tb00553.x · Cited by 3 · see citing works

Associative factors in tolerance to analgesia produced by electrical stimulation in the brainstem.

Paúl, D., & Phillips, A. G. (1990) · Behavioral Neuroscience · doi:10.1037/h0092462 · Cited by 3 · see citing works

Clinical Guidelines for the Use of Chronic Opioid Therapy in Chronic Noncancer Pain

Chou, R., Fanciullo, G. J., Fine, P. G., Adler, J. A., Ballantyne, J. C., Davies, P., Donovan, M. I., Fishbain, D. A., Foley, K. M., Fudin, J., et al. (2009) · The Journal of Pain · doi:10.1016/j.jpain.2008.10.008 · Cited by 2,192 · see citing works

Pharmacologic management of neuropathic pain: Evidence-based recommendations

Dworkin, R. H., O’Connor, A. B., Backonja, M., Farrar, J. T., Finnerup, N. B., Jensen, T. S., Kalso, E. A., Loeser, J. D., Miaskowski, C., Nurmikko, T. J., et al. (2007) · Pain · doi:10.1016/j.pain.2007.08.033 · Cited by 2,126 · see citing works

The Prescription Opioid and Heroin Crisis: A Public Health Approach to an Epidemic of Addiction

Kolodny, A., Courtwright, D. T., Hwang, C. S., Kreiner, P., Eadie, J. L., Clark, T. W., & Alexander, G. C. (2015) · Annual Review of Public Health · doi:10.1146/annurev-publhealth-031914-122957 · Cited by 1,388 · see citing works

Opioid Epidemic in the United States

Manchikanti, L. (2012) · Pain Physician · doi:10.36076/ppj.2012/15/es9 · Cited by 1,180 · see citing works

A Comprehensive Review of Opioid-Induced Hyperalgesia

Lee, M. O. (2011) · Pain Physician · doi:10.36076/ppj.2011/14/145 · Cited by 1,122 · see citing works

Opioid-induced hyperalgesia in patients after surgery: a systematic review and a meta-analysis

Fletcher, D., & Martinez, V. (2014) · British Journal of Anaesthesia · doi:10.1093/bja/aeu137 · Cited by 635 · see citing works

Opioids and the treatment of chronic pain: Controversies, current status, and future directions.

Rosenblum, A., Marsch, L. A., Joseph, H., & Portenoy, R. K. (2008) · Experimental and Clinical Psychopharmacology · doi:10.1037/a0013628 · Cited by 648 · see citing works

Treatment of acute postoperative pain

Wu, C. L., & Raja, S. N. (2011) · The Lancet · doi:10.1016/s0140-6736(11)60245-6 · Cited by 628 · see citing works

The Appropriate Use of Neurostimulation of the Spinal Cord and Peripheral Nervous System for the Treatment of Chronic Pain and Ischemic Diseases: The Neuromodulation Appropriateness Consensus Committee

Deer, T. R., Mekhail, N. A., Provenzano, D. A., Pope, J. E., Krames, E. S., Leong, M. S., Levy, R. M., Abejón, D., Buchser, E., Burton, A., et al. (2014) · Neuromodulation Technology at the Neural Interface · doi:10.1111/ner.12208 · Cited by 606 · see citing works

Opioid-induced Hyperalgesia in Humans

Chu, L. F., Angst, M. S., & Clark, J. D. (2008) · Clinical Journal of Pain · doi:10.1097/ajp.0b013e31816b2f43 · Cited by 572 · see citing works

Therapeutic Use, Abuse, and Nonmedical Use of Opioids: A Ten-Year Perspective

Manchikanti, L. (2010) · Pain Physician · doi:10.36076/ppj.2010/13/401 · Cited by 535 · see citing works

Complex Regional Pain Syndrome: Practical Diagnostic and Treatment Guidelines, 4th Edition

Harden, R. N., Oaklander, A. L., Burton, A. W., Perez, R. S. G. M., Richardson, K., Swan, M., Barthel, J., Costa, B., Graciosa, J. R., & Bruehl, S. (2013) · Pain Medicine · doi:10.1111/pme.12033 · Cited by 534 · see citing works

Critical role of nociceptor plasticity in chronic pain

Reichling, D. B., & Levine, J. D. (2009) · Trends in Neurosciences · doi:10.1016/j.tins.2009.07.007 · Cited by 495 · see citing works

Neurobiology of opioid addiction: Opponent process, hyperkatifeia, and negative reinforcement

Koob, G. F. (2020) · Biological Psychiatry · doi:10.1016/j.biopsych.2019.05.023 · Cited by 477 · see citing works

Total Pancreatectomy and Islet Autotransplantation for Chronic Pancreatitis

Sutherland, D. E. R., Radosevich, D. M., Bellin, M. D., Hering, B. J., Beilman, G. J., Dunn, T. B., Chinnakotla, S., Vickers, S. M., Bland, B. J., Balamurugan, A. N., et al. (2012) · Journal of the American College of Surgeons · doi:10.1016/j.jamcollsurg.2011.12.040 · Cited by 461 · see citing works

The dark side of emotion: the addiction perspective

Koob, G. F. (2015) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2014.11.044 · Cited by 433 · see citing works

Definitions of the phenotypic manifestations of sickle cell disease

Ballas, S. K., Lieff, S., Benjamin, L. J., Dampier, C., Heeney, M. M., Hoppe, C. C., Johnson, C. S., Rogers, Z. R., Smith‐Whitley, K., Wang, W. C., et al. (2009) · American Journal of Hematology · doi:10.1002/ajh.21550 · Cited by 454 · see citing works

Opioid dependence and addiction during opioid treatment of chronic pain

Ballantyne, J. C., & LaForge, S. K. (2007) · Pain · doi:10.1016/j.pain.2007.03.028 · Cited by 445 · see citing works

Persistent Postsurgical Pain

Richebé, P., Capdevila, X., & Rivat, C. (2018) · Anesthesiology · doi:10.1097/aln.0000000000002238 · Cited by 439 · see citing works

Preoperative predictors of poor acute postoperative pain control: a systematic review and meta-analysis

Yang, M. M. H., Hartley, R. L., Leung, A. A., Ronksley, P. E., Jetté, N., Casha, S., & Riva-Cambrin, J. (2019) · BMJ Open · doi:10.1136/bmjopen-2018-025091 · Cited by 414 · see citing works

Inappropriate opioid prescription after surgery

Neuman, M. D., Bateman, B. T., & Wunsch, H. (2019) · The Lancet · doi:10.1016/s0140-6736(19)30428-3 · Cited by 416 · see citing works

Exploring the Neuroimmunopharmacology of Opioids: An Integrative Review of Mechanisms of Central Immune Signaling and Their Implications for Opioid Analgesia

Hutchinson, M. R., Shavit, Y., Grace, P. M., Rice, K. C., Maier, S. F., & Watkins, L. R. (2011) · Pharmacological Reviews · doi:10.1124/pr.110.004135 · Cited by 397 · see citing works

Opioid-induced hyperalgesia: Cellular and molecular mechanisms

Roeckel, L.-A., Coz, G.-M. L., Gavériaux‐Ruff, C., & Simonin, F. (2016) · Neuroscience · doi:10.1016/j.neuroscience.2016.06.029 · Cited by 389 · see citing works

Research Gaps on Use of Opioids for Chronic Noncancer Pain: Findings From a Review of the Evidence for an American Pain Society and American Academy of Pain Medicine Clinical Practice Guideline

Chou, R., Ballantyne, J. C., Fanciullo, G. J., Fine, P. G., & Miaskowski, C. A. (2009) · Journal of Pain · doi:10.1016/j.jpain.2008.10.007 · Cited by 384 · see citing works

Perioperative intravenous ketamine for acute postoperative pain in adults

Brinck, E. C. V., Tiippana, E., Heesen, M. A., Bell, R. F., Straube, S., Moore, A., & Kontinen, V. (2018) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd012033.pub4 · Cited by 385 · see citing works

Predicting Opioid Misuse by Chronic Pain Patients: A Systematic Review and Literature Synthesis

Turk, D., Swanson, K., & Gatchel, R. (2008) · The Clinical Journal of Pain · doi:10.1097/ajp.0b013e31816b1070 · Cited by 416 · see citing works

Fast Synaptic Inhibition in Spinal Sensory Processing and Pain Control

Zeilhofer, H., Wildner, H., & Yévenes, G. E. (2012) · Physiological Reviews · doi:10.1152/physrev.00043.2010 · Cited by 364 · see citing works

Efficacy of Opioids for Chronic Pain: A Review of the Evidence

Ballantyne, J., & Shin, N. S. (2008) · The Clinical Journal of Pain · doi:10.1097/ajp.0b013e31816b2f26 · Cited by 361 · see citing works

Analgesic impact of intra‐operative opioids vs. opioid‐free anaesthesia: a systematic review and meta‐analysis

Frauenknecht, J., Kirkham, K. R., Jacot-Guillarmod, A., & Albrecht, É. (2019) · Anaesthesia · doi:10.1111/anae.14582 · Cited by 382 · see citing works

Alcohol dependence as a chronic pain disorder

Egli, M., Koob, G. F., & Edwards, S. (2012) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2012.07.010 · Cited by 347 · see citing works

Loss of μ opioid receptor signaling in nociceptors, but not microglia, abrogates morphine tolerance without disrupting analgesia

Corder, G. F., Tawfik, V. L., Wang, D., Sypek, E. I., Low, S. A., Dickinson, J. R., Sotoudeh, C., Clark, J. D., Barres, B. A., Bohlen, C. J., et al. (2017) · Nature Medicine · doi:10.1038/nm.4262 · Cited by 347 · see citing works

Drug Addiction: Hyperkatifeia/Negative Reinforcement as a Framework for Medications Development

Koob, G. F. (2021) · Pharmacological Reviews · doi:10.1124/pharmrev.120.000083 · Cited by 337 · see citing works

Postoperative analgesia for shoulder surgery: a critical appraisal and review of current techniques

Fredrickson, M. J., Krishnan, S., & Chen, C. Y. (2010) · Anaesthesia · doi:10.1111/j.1365-2044.2009.06231.x · Cited by 338 · see citing works

Clarifying the roles of homeostasis and allostasis in physiological regulation.

Ramsay, D. S., & Woods, S. C. (2014) · Psychological Review · doi:10.1037/a0035942 · Cited by 339 · see citing works

Polyanalgesic Consensus Conference 2012: Recommendations for the Management of Pain by Intrathecal (Intraspinal) Drug Delivery: Report of an Interdisciplinary Expert Panel

Deer, T. R., Prager, J. P., Levy, R. M., Rathmell, J. P., Buchser, E., Burton, A., Caraway, D. L., Cousins, M. J., Andrés, J. A. D., Diwan, S. A., et al. (2012) · Neuromodulation Technology at the Neural Interface · doi:10.1111/j.1525-1403.2012.00476.x · Cited by 326 · see citing works

Pharmacotherapy of chronic pain: a synthesis of recommendations from systematic reviews

Kroenke, K., Krebs, E. E., & Bair, M. J. (2009) · General Hospital Psychiatry · doi:10.1016/j.genhosppsych.2008.12.006 · Cited by 308 · see citing works

Challenges in Using Opioids to Treat Pain in Persons With Substance Use Disorders

Savage, S. R., Kirsh, K. L., & Passik, S. D. (2008) · Addiction Science & Clinical Practice · doi:10.1151/ascp08424 · Cited by 291 · see citing works

Persistent opioid use following cesarean delivery: patterns and predictors among opioid-naïve women

Bateman, B. T., Franklin, J. M., Bykov, K., Avorn, J., Shrank, W. H., Brennan, T. A., Landon, J. E., Rathmell, J. P., Huybrechts, K. F., Fischer, M. A., et al. (2016) · American Journal of Obstetrics and Gynecology · doi:10.1016/j.ajog.2016.03.016 · Cited by 287 · see citing works

Preoperative Reduction of Opioid Use Before Total Joint Arthroplasty

Nguyen, L.-C. L., Sing, D. C., & Bozic, K. J. (2016) · The Journal of Arthroplasty · doi:10.1016/j.arth.2016.01.068 · Cited by 272 · see citing works

Peripheral mechanisms of pain and analgesia

Stein, C., Clark, J. D., Oh, U., Vasko, M. R., Wilcox, G. L., Overland, A. C., Vanderah, T. W., & Spencer, R. H. (2009) · Brain Research Reviews · doi:10.1016/j.brainresrev.2008.12.017 · Cited by 268 · see citing works

Acute and Perioperative Care of the Burn-injured Patient

Bittner, E. A., Shank, E. S., Woodson, L. C., & Martyn, J. A. J. (2014) · Anesthesiology · doi:10.1097/aln.0000000000000559 · Cited by 268 · see citing works

Trends in use of opioids for chronic non-cancer pain among individuals with mental health and substance use disorders: the TROUP study

Edlund, M., Martin, B., DeVries, A., Fan, M.-Y., Braden, J., & Sullivan, M. (2010) · The Clinical Journal of Pain · doi:10.1097/ajp.0b013e3181b99f35 · Cited by 267 · see citing works

Prediction of Postoperative Pain

Werner, M. U., Mjöbo, H. N., Nielsen, P. R., Rudin, A. Y., & Warner, D. S. (2010) · Anesthesiology · doi:10.1097/aln.0b013e3181dcd5a0 · Cited by 260 · see citing works

Benzodiazepines I: Upping the Care on Downers: The Evidence of Risks, Benefits and Alternatives

Guina, J., & Merrill, B. (2018) · Journal of Clinical Medicine · doi:10.3390/jcm7020017 · Cited by 253 · see citing works

The evolution of pain management in the critically ill trauma patient: Emerging concepts from the global war on terrorism

Malchow, R. J., & Black, I. H. (2008) · Critical Care Medicine · doi:10.1097/ccm.0b013e31817e2fc9 · Cited by 248 · see citing works

Preoperative Opioid Use and Its Association With Perioperative Opioid Demand and Postoperative Opioid Independence in Patients Undergoing Spine Surgery

Armaghani, S. J., Lee, D. S., Bible, J. E., Archer, K. R., Shau, D. N., Kay, H. F., Zhang, C., McGirt, M. J., & Devin, C. J. (2014) · Spine · doi:10.1097/brs.0000000000000622 · Cited by 248 · see citing works

Opioid Induced Hyperalgesia: Clinical Implications for the Pain Practitioner

Silverman, S. M. (2009) · Pain Physician · doi:10.36076/ppj.2009/12/679 · Cited by 238 · see citing works

Constitutive μ-Opioid Receptor Activity Leads to Long-Term Endogenous Analgesia and Dependence

Corder, G., Doolen, S., Donahue, R. R., Winter, M. K., Jutras, B. L., He, Y., Hu, X., Wieskopf, J. S., Mogil, J. S., Storm, D. R., et al. (2013) · Science · doi:10.1126/science.1239403 · Cited by 240 · see citing works

Long-Term Potentiation in Spinal Nociceptive Pathways as a Novel Target for Pain Therapy

Ruscheweyh, R., Wilder‐Smith, O. H. G., Drdla-Schutting, R., Liu, X., & Sandkühler, J. (2011) · Molecular Pain · doi:10.1186/1744-8069-7-20 · Cited by 236 · see citing works

Acute Pain Management in Opioid-Tolerant Patients: A Growing Challenge

Huxtable, C. A., Roberts, L. J., Somogyi, A. A., & Macintyre, P. E. (2011) · Anaesthesia and Intensive Care · doi:10.1177/0310057x1103900505 · Cited by 230 · see citing works

Reward deficiency and anti-reward in pain chronification

Borsook, D., Linnman, C., Faria, V., Strassman, A. M., Becerra, L. R., & Elman, I. (2016) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2016.05.033 · Cited by 227 · see citing works

Management of cancer pain: ESMO Clinical Practice Guidelines

Jost, L., & Roila, F. (2010) · Annals of Oncology · doi:10.1093/annonc/mdq224 · Cited by 227 · see citing works

Patient-Controlled Analgesia in the Management of Postoperative Pain

Momeni, M., Crucitti, M., & Kock, M. D. (2006) · Drugs · doi:10.2165/00003495-200666180-00005 · Cited by 226 · see citing works

Remifentanil tolerance and hyperalgesia: short‐term gain, long‐term pain?

Yu, H., Tran, D. H. D., Lam, S. W., & Irwin, M. G. (2016) · Anaesthesia · doi:10.1111/anae.13602 · Cited by 225 · see citing works

A systematic review of therapeutic interventions to reduce acute and chronic post‐surgical pain after amputation, thoracotomy or mastectomy

Humble, S. R., Dalton, A. J., & Li, L. (2015) · European Journal of Pain · doi:10.1002/ejp.567 · Cited by 220 · see citing works

Opioids, pain, the brain, and hyperkatifeia: a framework for the rational use of opioids for pain

Shurman, J., Koob, G. F., & Gutstein, H. B. (2010) · Pain Medicine · doi:10.1111/j.1526-4637.2010.00881.x · Cited by 215 · see citing works

Cytokines in Pain: Harnessing Endogenous Anti-Inflammatory Signaling for Improved Pain Management

Vanderwall, A. G., & Milligan, E. D. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.03009 · Cited by 219 · see citing works

Induction of Synaptic Long-Term Potentiation After Opioid Withdrawal

Drdla-Schutting, R., Gassner, M., Gingl, E., & Sandkühler, J. (2009) · Science · doi:10.1126/science.1171759 · Cited by 216 · see citing works

Tapering Long-term Opioid Therapy in Chronic Noncancer Pain

Berna, C., Kulich, R. J., & Rathmell, J. P. (2015) · Mayo Clinic Proceedings · doi:10.1016/j.mayocp.2015.04.003 · Cited by 217 · see citing works

Prescription opioid analgesics rapidly change the human brain

Younger, J., Chu, L. F., D’Arcy, N. T., Trott, K. E., Jastrzab, L. E., & Mackey, S. (2011) · Pain · doi:10.1016/j.pain.2011.03.028 · Cited by 210 · see citing works

Acute and Persistent Postoperative Pain after Breast Surgery

Fecho, K., Miller, N. R., Merritt, S. A., Klauber‐DeMore, N., Hultman, C. S., & Blau, W. S. (2009) · Pain Medicine · doi:10.1111/j.1526-4637.2009.00611.x · Cited by 209 · see citing works

Higher Opioid Doses Predict Poorer Functional Outcome in Patients with Chronic Disabling Occupational Musculoskeletal Disorders

Kidner, C. L., Mayer, T. G., & Gatchel, R. J. (2009) · Journal of Bone and Joint Surgery · doi:10.2106/jbjs.h.00286 · Cited by 208 · see citing works

The Appropriate Use of Neurostimulation: Avoidance and Treatment of Complications of Neurostimulation Therapies for the Treatment of Chronic Pain

Deer, T. R., Mekhail, N. A., Provenzano, D. A., Pope, J. E., Krames, E. S., Thomson, S., Raso, L. J., Burton, A., DeAndres, J., Buchser, E., et al. (2014) · Neuromodulation Technology at the Neural Interface · doi:10.1111/ner.12206 · Cited by 205 · see citing works

Opioid-free total intravenous anesthesia with propofol, dexmedetomidine and lidocaine infusions for laparoscopic cholecystectomy: a prospective, randomized, double-blinded study

Bakan, M., Umutoğlu, T., Topuz, U., Uysal, H., Bayram, M., Kadioğlu, H., & Salihoğlu, Z. (2014) · Brazilian Journal of Anesthesiology (English Edition) · doi:10.1016/j.bjane.2014.05.001 · Cited by 205 · see citing works

Total pancreatectomy and islet autotransplantation in chronic pancreatitis: Recommendations from PancreasFest

Bellin, M. D., Freeman, M. L., Gelrud, A., Slivka, A. A., Clavel, A. L., Humar, A., Schwarzenberg, S. J., Lowe, M. E., Rickels, M. R., Whitcomb, D. C., et al. (2013) · Pancreatology · doi:10.1016/j.pan.2013.10.009 · Cited by 196 · see citing works

Opioid Induced Hyperalgesia

Yi, P., & Pryzbylkowski, P. (2015) · Pain Medicine · doi:10.1111/pme.12914 · Cited by 191 · see citing works

Adverse effects of chronic opioid therapy for chronic musculoskeletal pain

Crofford, L. J. (2010) · Nature Reviews Rheumatology · doi:10.1038/nrrheum.2010.24 · Cited by 180 · see citing works

Pharmacology of Sedative-Analgesic Agents: Dexmedetomidine, Remifentanil, Ketamine, Volatile Anesthetics, and the Role of Peripheral Mu Antagonists

Panzer, O. P. F., Moitra, V. K., & Sladen, R. N. (2009) · Critical Care Clinics · doi:10.1016/j.ccc.2009.04.004 · Cited by 180 · see citing works

Clinical characteristics of veterans prescribed high doses of opioid medications for chronic non-cancer pain

Morasco, B. J., Duckart, J. P., Carr, T. P., Deyo, R. A., & Dobscha, S. K. (2010) · Pain · doi:10.1016/j.pain.2010.08.002 · Cited by 176 · see citing works

The Role of Total Pancreatectomy and Islet Autotransplantation for Chronic Pancreatitis

Blondet, J. J., Carlson, A. M., Kobayashi, T., Jie, T., Bellin, M. D., Hering, B. J., Freeman, M. L., Beilman, G. J., & Sutherland, D. E. R. (2007) · Surgical Clinics of North America · doi:10.1016/j.suc.2007.08.014 · Cited by 174 · see citing works

Opioid Pharmacotherapy for Chronic Non-Cancer Pain in the United States: A Research Guideline for Developing an Evidence-Base

Chapman, C. R., Lipschitz, D. L., Angst, M. S., Chou, R., Denisco, R. C., Donaldson, G. W., Fine, P. G., Foley, K. M., Gallagher, R. M., Gilson, A. M., et al. (2010) · Journal of Pain · doi:10.1016/j.jpain.2010.02.019 · Cited by 172 · see citing works

Predictors for moderate to severe acute postoperative pain after total hip and knee replacement

Liu, S. S., Buvanendran, A., Rathmell, J. P., Sawhney, M., Bae, J. J., Moric, M., Perros, S., Pope, A. J., Poultsides, L., Valle, C. J. D., et al. (2012) · International Orthopaedics · doi:10.1007/s00264-012-1623-5 · Cited by 167 · see citing works

Do Opioids Induce Hyperalgesia in Humans? An Evidence-Based Structured Review

Fishbain, D. A., Cole, B., Lewis, J. E., Gao, J., & Rosomoff, R. S. (2009) · Pain Medicine · doi:10.1111/j.1526-4637.2009.00653.x · Cited by 167 · see citing works

The dark side of opioids in pain management: basic science explains clinical observation

Rivat, C., & Ballantyne, J. (2016) · PAIN Reports · doi:10.1097/pr9.0000000000000570 · Cited by 160 · see citing works

Mechanisms of Opioid-Induced Tolerance and Hyperalgesia

DuPen, A., Shen, D. D., & Ersek, M. T. (2007) · Pain Management Nursing · doi:10.1016/j.pmn.2007.02.004 · Cited by 165 · see citing works

Keeping Up with Clinical Advances: Opioid Use Disorder

Patel, B., & Kosten, T. R. (2019) · CNS Spectrums · doi:10.1017/s109285291900110x · Cited by 164 · see citing works

Endogenous opioidergic dysregulation of pain in fibromyalgia: a PET and fMRI study

Schrepf, A., Harper, D., Harte, S. E., Wang, H., Ichesco, E., Hampson, J. P., Zubieta, J., Clauw, D. J., & Harris, R. E. (2016) · Pain · doi:10.1097/j.pain.0000000000000633 · Cited by 163 · see citing works

Preoperative Chronic Opioid Therapy

Jain, N. K., Phillips, F. M., Weaver, T. E., & Khan, S. N. (2018) · Spine · doi:10.1097/brs.0000000000002609 · Cited by 163 · see citing works

Opioid Receptors in Immune and Glial Cells—Implications for Pain Control

Machelska, H., & Celik, M. Ö. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.00300 · Cited by 160 · see citing works

Development of mechanical hypersensitivity in rats during heroin and ethanol dependence: Alleviation by CRF1 receptor antagonism

Edwards, S., Vendruscolo, L. F., Schlosburg, J. E., Misra, K., Wee, S., Park, P. E., Schulteis, G., & Koob, G. F. (2011) · Neuropharmacology · doi:10.1016/j.neuropharm.2011.11.006 · Cited by 158 · see citing works

Hyperalgesia in Opioid-Managed Chronic Pain and Opioid-Dependent Patients

Hay, J. L., White, J. M., Bochner, F., Somogyi, A. A., Semple, T. J., & Rounsefell, B. (2008) · Journal of Pain · doi:10.1016/j.jpain.2008.10.003 · Cited by 154 · see citing works

The impact of opioid-induced hyperalgesia for postoperative pain

Koppert, W., & Schmelz, M. (2007) · Best Practice & Research Clinical Anaesthesiology · doi:10.1016/j.bpa.2006.12.004 · Cited by 154 · see citing works

The effects of ibudilast, a glial activation inhibitor, on opioid withdrawal symptoms in opioid-dependent volunteers

Cooper, Z. D., Johnson, K. W., Pavlicová, M., Glass, A., Vosburg, S. K., Sullivan, M. A., Manubay, J. M., Martínez, D., Jones, J. D., Saccone, P. A., et al. (2015) · Addiction Biology · doi:10.1111/adb.12261 · Cited by 153 · see citing works

Impact of Perioperative Pain Intensity, Pain Qualities, and Opioid Use on Chronic Pain After Surgery: A Prospective Cohort Study

VanDenKerkhof, E. G., Hopman, W. M., Goldstein, D. H., Wilson, R. A., Towheed, T. E., Lam, M., Harrison, M. B., Reitsma, M. L., Johnston, S. L., Medd, J. D., et al. (2012) · Regional Anesthesia and Pain Medicine · doi:10.1097/aap.0b013e318237516e · Cited by 149 · see citing works

Quality of Life Improves for Pediatric Patients After Total Pancreatectomy and Islet Autotransplant for Chronic Pancreatitis

Bellin, M. D., Freeman, M. L., Schwarzenberg, S. J., Dunn, T. B., Beilman, G. J., Vickers, S. M., Chinnakotla, S., Balamurugan, A. N., Hering, B. J., Radosevich, D. M., et al. (2011) · Clinical Gastroenterology and Hepatology · doi:10.1016/j.cgh.2011.04.024 · Cited by 148 · see citing works

Intraoperative use of remifentanil and opioid induced hyperalgesia/acute opioid tolerance: systematic review

Kim, S. H., Stoicea, N., Soghomonyan, S., & Bergese, S. D. (2014) · Frontiers in Pharmacology · doi:10.3389/fphar.2014.00108 · Cited by 147 · see citing works

Non-Nociceptive Environmental Stress Induces Hyperalgesia, Not Analgesia, in Pain and Opioid-Experienced Rats

Rivat, C., Laboureyras, E., Laulin, J., Roy, C. L., Richebé, P., & Simonnet, G. (2007) · Neuropsychopharmacology · doi:10.1038/sj.npp.1301340 · Cited by 145 · see citing works

A Comparison of Long- and Short-Acting Opioids for the Treatment of Chronic Noncancer Pain: Tailoring Therapy to Meet Patient Needs

Argoff, C. E., & Silvershein, D. I. (2009) · Mayo Clinic Proceedings · doi:10.1016/s0025-6196(11)60749-0 · Cited by 141 · see citing works

An epidemic of the use, misuse and overdose of opioids and deaths due to overdose, in the United States and Canada

Helmerhorst, G. T. T., Teunis, T., Janssen, S. J., & Ring, D. (2017) · The Bone & Joint Journal · doi:10.1302/0301-620x.99b7.bjj-2016-1350.r1 · Cited by 141 · see citing works

2009 Clinical Guidelines from the American Pain Society and the American Academy of Pain Medicine on the use of chronic opioid therapy in chronic noncancer pain: what are the key messages for clinical practice?

Chou, R. (2009) · Polskie Archiwum Medycyny Wewnętrznej · doi:10.20452/pamw.741 · Cited by 140 · see citing works

Opioid and chemokine receptor crosstalk: a promising target for pain therapy?

Parsadaniantz, S. M., Rivat, C., Rostène, W. H., & Goazigo, A. R.-L. (2015) · Nature reviews. Neuroscience · doi:10.1038/nrn3858 · Cited by 138 · see citing works

Whither syndemics?: Trends in syndemics research, a review 2015–2019

Singer, M., Bulled, N., & Ostrach, B. (2020) · Global Public Health · doi:10.1080/17441692.2020.1724317 · Cited by 133 · see citing works

Drug-Related Side Effects of Long-term Intrathecal Morphine Therapy

Ruan, X. (2007) · Pain Physician · doi:10.36076/ppj.2007/10/357 · Cited by 135 · see citing works

Perioperative Opioids and Public Health

Kharasch, E. D., & Brunt, L. M. (2016) · Anesthesiology · doi:10.1097/aln.0000000000001012 · Cited by 132 · see citing works

Altered quantitative sensory testing outcome in subjects with opioid therapy

Chen, L. L., Malarick, C., Seefeld, L., Wang, S., Houghton, M., & Mao, J. (2009) · Pain · doi:10.1016/j.pain.2009.01.022 · Cited by 131 · see citing works

American Society of Interventional Pain Physicians (ASIPP) guidelines for responsible opioid prescribing in chronic non-cancer pain: Part I--evidence assessment.

Manchikanti, L., Abdi, S., Atluri, S. L., Balog, C. C., Benyamin, R. M., Boswell, M. V., Brown, K. R., Bruel, B. M., Bryce, D. A., Burks, P. A., et al. (2012) · PubMed · Cited by 129 · see citing works

Remifentanil-induced postoperative hyperalgesia: current perspectives on mechanisms and therapeutic strategies

Santonocito, C., Noto, A., Crimi, C., & Sanfilippo, F. (2018) · Local and Regional Anesthesia · doi:10.2147/lra.s143618 · Cited by 127 · see citing works

Anestesia venosa total livre de opioides, com infusões de propofol, dexmedetomidina e lidocaína para colecistectomia laparoscópica: estudo prospectivo, randomizado e duplo‐cego

Bakan, M., Umutoğlu, T., Topuz, U., Uysal, H., Bayram, M., Kadioğlu, H., & Salihoğlu, Z. (2014) · Brazilian Journal of Anesthesiology · doi:10.1016/j.bjan.2014.05.006 · Cited by 126 · see citing works

Cancer Pain: Part 1: Pathophysiology; Oncological, Pharmacological, and Psychological Treatments: A Perspective from the British Pain Society Endorsed by the UK Association of Palliative Medicine and the Royal College of General Practitioners

Raphael, J. H., Ahmedzai, S. H., Hester, J., Urch, C., Barrie, J., Williams, J. E., Farquhar-Smith, P. W., Fallon, M., Hoskin, P., Robb, K. A., et al. (2010) · Pain Medicine · doi:10.1111/j.1526-4637.2010.00840.x · Cited by 125 · see citing works

Modulation of Remifentanil-induced Analgesia and Postinfusion Hyperalgesia by Parecoxib in Humans

Tröster, A., Sittl, R., Singler, B., Schmelz, M., Schüttler, J., & Koppert, W. (2006) · Anesthesiology · doi:10.1097/00000542-200611000-00024 · Cited by 124 · see citing works

Opioid Tolerance, Dependence and Hyperalgesia

Ballantyne, J. C. (2009) · CRC Press eBooks · doi:10.3109/9781420089004-6 · Cited by 2 · see citing works

Opioid-Induced Hyperalgesia: Clinically Relevant or Extraneous Research Phenomenon?

Tompkins, D. A., & Campbell, C. M. (2011) · Current Pain and Headache Reports · doi:10.1007/s11916-010-0171-1 · Cited by 117 · see citing works

Opioid-Induced Hyperalgesia Syndrome in the Rehabilitation Patient

Scarfo, K. A. (2017) · Springer eBooks · doi:10.1007/978-3-319-16784-8_31

Complications of Long-Term Opioid Therapy for Management of Chronic Pain: the Paradox of Opioid-Induced Hyperalgesia

Brush, D. E. (2012) · Journal of Medical Toxicology · doi:10.1007/s13181-012-0260-0 · Cited by 101 · see citing works

Opioid-Induced Hyperalgesia: Is It Clinically Relevant for the Treatment of Pain Patients?

Raffa, R. B., & Pergolizzi, J. V. (2011) · Pain Management Nursing · doi:10.1016/j.pmn.2011.04.002 · Cited by 40 · see citing works