Reagents and models for detecting endogenous GLP1R and GIPR

THE GREEN FLUORESCENT PROTEIN

Tsien, R. Y. (1998) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.67.1.509 · Cited by 6,178 · see citing works

Once-Weekly Semaglutide in Adults with Overweight or Obesity

Wilding, J. P. H., Batterham, R. L., Calanna, S., Davies, M., Van Gaal, L. F., Lingvay, I., McGowan, B. M., Rosenstock, J., Tran, M. T. D., Wadden, T. A., et al. (2021) · New England Journal of Medicine · doi:10.1056/nejmoa2032183 · Cited by 5,205 · see citing works

Regulation of Renal Organic Anion Transporter 3 (SLC22A8) Expression and Function by the Integrity of Lipid Raft Domains and their Associated Cytoskeleton

Srimaroeng, C., Cecile, J. P., Walden, R., & Pritchard, J. B. (2013) · Cellular Physiology and Biochemistry · doi:10.1159/000350077 · Cited by 2,989 · see citing works

HaloTag: A Novel Protein Labeling Technology for Cell Imaging and Protein Analysis

Los, G. V., Encell, L. P., McDougall, M. G., Hartzell, D., Karassina, N., Zimprich, C., Wood, M. G., Learish, R., Ohana, R. F., Urh, M., et al. (2008) · ACS Chemical Biology · doi:10.1021/cb800025k · Cited by 2,527 · see citing works

Liraglutide safety and efficacy in patients with non-alcoholic steatohepatitis (LEAN): a multicentre, double-blind, randomised, placebo-controlled phase 2 study

Armstrong, M. J., Gaunt, P., Aithal, G. P., Barton, D., Hull, D., Parker, R., Hazlehurst, J. M., Guo, K., Abouda, G., Aldersley, M. A., et al. (2016) · The Lancet · doi:10.1016/s0140-6736(15)00803-x · Cited by 2,203 · see citing works

Mechanisms of Action and Therapeutic Application of Glucagon-like Peptide-1

Drucker, D. J. (2018) · Cell Metabolism · doi:10.1016/j.cmet.2018.03.001 · Cited by 2,170 · see citing works

Tirzepatide versus Semaglutide Once Weekly in Patients with Type 2 Diabetes

Frías, J. P., Davies, M. J., Rosenstock, J., Pérez Manghi, F. C., Fernández Landó, L., Bergman, B. K., Liu, B., Cui, X., & Brown, K. (2021) · New England Journal of Medicine · doi:10.1056/nejmoa2107519 · Cited by 2,096 · see citing works

A Placebo-controlled trial of subcutaneous semaglutide in nonalcoholic steatohepatitis

Newsome, P. N., Buchholtz, K., Cusi, K., Linder, M., Okanoue, T., Ratziu, V., Sanyal, A. J., Sejling, A.-S., & Harrison, S. A. (2021) · New England Journal of Medicine · doi:10.1056/nejmoa2028395 · Cited by 2,039 · see citing works

Single-Cell Transcriptome Profiling of Human Pancreatic Islets in Health and Type 2 Diabetes

Segerstolpe, Å., Palasantza, A., Eliasson, P., Andersson, E.-M., Andréasson, A.-C., Sun, X., Picelli, S., Sabirsh, A., Clausen, M., Bjursell, M. K., et al. (2016) · Cell Metabolism · doi:10.1016/j.cmet.2016.08.020 · Cited by 1,550 · see citing works

An Engineered Protein Tag for Multiprotein Labeling in Living Cells

Gautier, A., Juillerat, A., Heinis, C., et al. (2008) · Chemistry & Biology · doi:10.1016/j.chembiol.2008.01.007 · Cited by 1,096 · see citing works

Massively parallel single-nucleus RNA-seq with DroNc-seq

Habib, N., Avraham-Davidi, I., Basu, A., Burks, T., Shekhar, K., Hofree, M., Choudhury, S. R., Aguet, F., Gelfand, E., Ardlie, K., et al. (2017) · Nature Methods · doi:10.1038/nmeth.4407 · Cited by 1,069 · see citing works

The arcuate nucleus mediates GLP-1 receptor agonist liraglutide-dependent weight loss

Secher, A., Jelsing, J., Baquero, A. F., Hecksher-Sørensen, J., Cowley, M. A., Dalbøge, L. S., Hansen, G., Grove, K. L., Pyke, C., Raun, K., et al. (2014) · Journal of Clinical Investigation · doi:10.1172/jci75276 · Cited by 961 · see citing works

Expression cloning of the pancreatic beta cell receptor for the gluco-incretin hormone glucagon-like peptide 1.

Thorens, B. (1992) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.89.18.8641 · Cited by 906 · see citing works

GLP-1 Receptor Localization in Monkey and Human Tissue: Novel Distribution Revealed With Extensively Validated Monoclonal Antibody

Pyke, C., Heller, R. S., Kirk, R. K., Ørskov, C., Reedtz-Runge, S., Kaastrup, P., Hvelplund, A., Bardram, L., Calatayud, D., & Knudsen, L. B. (2014) · Endocrinology · doi:10.1210/en.2013-1934 · Cited by 876 · see citing works

Incretin effects of increasing glucose loads in man calculated from venous insulin and C-peptide responses

NAUCK, M. A., HOMBERGER, E., SIEGEL, E. G., ALLEN, R. C., EATON, R. P., EBERT, R., & CREUTZFELDT, W. (1986) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-63-2-492 · Cited by 874 · see citing works

Glucose intolerance but normal satiety in mice with a null mutation in the glucagon–like peptide 1 receptor gene

Scrocchi, L. A., Brown, T. J., Maclusky, N., Brubaker, P. L., Auerbach, A. B., Joyner, A. L., & Drucker, D. J. (1996) · Nature Medicine · doi:10.1038/nm1196-1254 · Cited by 793 · see citing works

Semaglutide lowers body weight in rodents via distributed neural pathways.

Gabery, S., Salinas, C. G., Paulsen, S. J., Ahnfelt-Rønne, J., Alanentalo, T., Baquero, A. F., Buckley, S. T., Farkas, E., Fekete, C., Frederiksen, K. S., et al. (2020) · JCI Insight · doi:10.1172/jci.insight.133429 · Cited by 717 · see citing works

Unimolecular Dual Incretins Maximize Metabolic Benefits in Rodents, Monkeys, and Humans

Finan, B., Ma, T., Ottaway, N., Müller, T. D., Habegger, K. M., Heppner, K. M., Kirchner, H., Holland, J., Hembree, J., Raver, C., et al. (2013) · Science Translational Medicine · doi:10.1126/scitranslmed.3007218 · Cited by 696 · see citing works

Function and mechanisms of enteroendocrine cells and gut hormones in metabolism

Gribble, F. M., & Reimann, F. (2019) · Nature Reviews Endocrinology · doi:10.1038/s41574-019-0168-8 · Cited by 670 · see citing works

Sensory neurons that detect stretch and nutrients in the digestive system

Williams, E. K., Chang, R. B., Strochlic, D. E., Umans, B. D., Lowell, B. B., & Liberles, S. D. (2016) · Cell · doi:10.1016/j.cell.2016.05.011 · Cited by 645 · see citing works

Gastric inhibitory polypeptide receptor, a member of the secretin-vasoactive intestinal peptide receptor family, is widely distributed in peripheral organs and the brain.

Usdin, T. B., Mezey, E., Button, D. C., Brownstein, M. J., & Bonner, T. I. (1993) · Endocrinology · doi:10.1210/endo.133.6.8243312 · Cited by 534 · see citing works

A genetically engineered human pancreatic β cell line exhibiting glucose-inducible insulin secretion.

Ravassard, P., Hazhouz, Y., Pechberty, S., Bricout-Neveu, E., Armanet, M., Czernichow, P., & Scharfmann, R. (2011) · Journal of Clinical Investigation · doi:10.1172/jci58447 · Cited by 504 · see citing works

The incretin effect in healthy individuals and those with type 2 diabetes: Physiology, pathophysiology, and response to therapeutic interventions

Nauck, M. A., & Meier, J. J. (2016) · The Lancet Diabetes & Endocrinology · doi:10.1016/s2213-8587(15)00482-9 · Cited by 503 · see citing works

Identification and characterization of GLP-1 receptor–expressing cells using a new transgenic mouse model

Richards, P., Parker, H. E., Adriaenssens, A. E., Hodgson, J. M., Cork, S. C., Trapp, S., Gribble, F. M., & Reimann, F. (2014) · Diabetes · doi:10.2337/db13-1440 · Cited by 472 · see citing works

Glucose intolerance caused by a defect in the entero-insular axis: A study in gastric inhibitory polypeptide receptor knockout mice

Miyawaki, K., Yamada, Y., Yano, H., Niwa, H., Ban, N., Ihara, Y., Kubota, A., Fujimoto, S., Kajikawa, M., Kuroe, A., et al. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.26.14843 · Cited by 454 · see citing works

Comprehensive alpha, beta and delta cell transcriptomes reveal that ghrelin selectively activates delta cells and promotes somatostatin release from pancreatic islets

DiGruccio, M. R., Mawla, A. M., Donaldson, C. J., Noguchi, G. M., Vaughan, J., Cowing-Zitron, C., van der Meulen, T., & Huising, M. O. (2016) · Molecular Metabolism · doi:10.1016/j.molmet.2016.04.007 · Cited by 353 · see citing works

Novel Observations From Next-Generation RNA Sequencing of Highly Purified Human Adult and Fetal Islet Cell Subsets

Blodgett, D. M., Nowosielska, A., Afik, S., Pechhold, S., Cura, A. J., Kennedy, N. J., Kim, S., Kucukural, A., Davis, R. J., Kent, S. C., et al. (2015) · Diabetes · doi:10.2337/db15-0039 · Cited by 330 · see citing works

Glucose-Dependent Insulinotropic Polypeptide Receptor-Expressing Cells in the Hypothalamus Regulate Food Intake

Adriaenssens, A. E., Biggs, E. K., Darwish, T., Tadross, J., Sukthankar, T., Girish, M., Polex-Wolf, J., Lam, B. Y., Zvetkova, I., Pan, W., et al. (2019) · Cell Metabolism · doi:10.1016/j.cmet.2019.07.013 · Cited by 324 · see citing works

GLP-1 Receptor Expression Within the Human Heart

Baggio, L. L., Yusta, B., Mulvihill, E. E., Cao, X., Streutker, C. J., Butany, J., Cappola, T. P., Margulies, K. B., & Drucker, D. J. (2018) · Endocrinology · doi:10.1210/en.2018-00004 · Cited by 312 · see citing works

Double Incretin Receptor Knockout (DIRKO) Mice Reveal an Essential Role for the Enteroinsular Axis in Transducing the Glucoregulatory Actions of DPP-IV Inhibitors

Hansotia, T., Baggio, L. L., Delmeire, D., Hinke, S. A., Yamada, Y., Tsukiyama, K., Seino, Y., Holst, J. J., Schuit, F., & Drucker, D. J. (2004) · Diabetes · doi:10.2337/diabetes.53.5.1326 · Cited by 309 · see citing works

Revisiting the Complexity of GLP-1 Action from Sites of Synthesis to Receptor Activation

McLean, B. A., Wong, C. K., Campbell, J. E., Hodson, D. J., Trapp, S., & Drucker, D. J. (2021) · Endocrine Reviews · doi:10.1210/endrev/bnaa032 · Cited by 289 · see citing works

Vertical Sleeve Gastrectomy Is Effective in Two Genetic Mouse Models of Glucagon-Like Peptide 1 Receptor Deficiency

Wilson, H., Chambers, A. P., Ryan, K. K., Li, B., Sandoval, D. A., Stoffers, D. A., Drucker, D. J., Pérez–Tilve, D., & Seeley, R. J. (2013) · Diabetes · doi:10.2337/db12-1498 · Cited by 286 · see citing works

Targeting GLP-1 receptor trafficking to improve agonist efficacy

Jones, B. J., Buenaventura, T., Kanda, N., CHABOSSEAU, P. L., Owen, B. M., Scott, R., Goldin, R. D., Angkathunyakul, N., Junior, I. R. C., Bosco, D., et al. (2018) · Nature Communications · doi:10.1038/s41467-018-03941-2 · Cited by 274 · see citing works

Anti-obesity effects of GIPR antagonists alone and in combination with GLP-1R agonists in preclinical models

Killion, E. A., Wang, J., Yie, J., Shi, S. D.-H., Bates, D., Min, X., Komorowski, R., Hager, T., Deng, L., Atangan, L., et al. (2018) · Science Translational Medicine · doi:10.1126/scitranslmed.aat3392 · Cited by 237 · see citing works

Crystal structure of the incretin-bound extracellular domain of a G protein-coupled receptor

Parthier, C., Kleinschmidt, M., Neumann, P., Rudolph, R., Manhart, S., Schlenzig, D., Fanghänel, J., Rahfeld, J., Demuth, H., & Stubbs, M. T. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0706404104 · Cited by 232 · see citing works

Transcriptomic profiling of pancreatic alpha, beta and delta cell populations identifies delta cells as a principal target for ghrelin in mouse islets

Adriaenssens, A. E., Svendsen, B., Lam, B. Y. H., Yeo, G. S. H., Holst, J. J., Reimann, F., & Gribble, F. M. (2016) · Diabetologia · doi:10.1007/s00125-016-4033-1 · Cited by 223 · see citing works

Lipotoxicity disrupts incretin-regulated human β cell connectivity

Hodson, D. J., Mitchell, R. K., Bellomo, E. A., Sun, G., Vinet, L., Meda, P., Li, D., Li, W.-H., Bugliani, M., Marchetti, P., et al. (2013) · Journal of Clinical Investigation · doi:10.1172/jci68459 · Cited by 210 · see citing works

GIP as a Therapeutic Target in Diabetes and Obesity: Insight From Incretin Co-agonists

Holst, J. J., & Rosenkilde, M. M. (2020) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/clinem/dgaa327 · Cited by 207 · see citing works

Labeling of fusion proteins of O6-alkylguanine-DNA alkyltransferase with small molecules in vivo and in vitro

Keppler, A., Kindermann, M., Gendreizig, S., et al. (2004) · Methods · doi:10.1016/j.ymeth.2003.10.007 · Cited by 202 · see citing works

GIP receptor agonism attenuates GLP-1 receptor agonist induced nausea and emesis in preclinical models

Borner, T., Geisler, C. E., Fortin, S. M., Cosgrove, R., Alsina-Fernandez, J., Dogra, M., Doebley, S., Sanchez-Navarro, M. J., Leon, R. M., Gaisinsky, J., et al. (2021) · Diabetes · doi:10.2337/db21-0459 · Cited by 202 · see citing works

Cryo FIB-SEM: Volume imaging of cellular ultrastructure in native frozen specimens

Schertel, A., Snaidero, N., Han, H., et al. (2013) · Journal of Structural Biology · doi:10.1016/j.jsb.2013.09.024 · Cited by 192 · see citing works

Electron microscopy using the genetically encoded APEX2 tag in cultured mammalian cells

Martell, J. D., Deerinck, T. J., Lam, S. S., Ellisman, M. H., & Ting, A. Y. (2017) · Nature Protocols · doi:10.1038/nprot.2017.065 · Cited by 190 · see citing works

A genetic map of the mouse dorsal vagal complex and its role in obesity

Ludwig, M. Q., Cheng, W., Gordian, D., Lee, J., Paulsen, S. J., Hansen, S. N., Egerod, K. L., Barkholt, P., Rhodes, C. J., Secher, A., et al. (2021) · Nature Metabolism · doi:10.1038/s42255-021-00363-1 · Cited by 186 · see citing works

Reappraisal of GIP Pharmacology for Metabolic Diseases

Finan, B., Müller, T. D., Clemmensen, C., Perez-Tilve, D., DiMarchi, R. D., & Tschöp, M. H. (2016) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2016.03.005 · Cited by 180 · see citing works

The Glucagon-Like Peptide-1 Receptor—or Not?

Pyke, C., & Knudsen, L. B. (2013) · Endocrinology · doi:10.1210/en.2012-2124 · Cited by 154 · see citing works

Chronic glucose-dependent insulinotropic polypeptide receptor (GIPR) agonism desensitizes adipocyte GIPR activity mimicking functional GIPR antagonism

Killion, E. A., Chen, M., Falsey, J. R., Sivits, G., Hager, T., Atangan, L., Helmering, J., Lee, J., Li, H., Wu, B., et al. (2020) · Nature Communications · doi:10.1038/s41467-020-18751-8 · Cited by 151 · see citing works

Characterization of the Glucagonlike Peptide-1 Receptor in Male Mouse Brain Using a Novel Antibody and In Situ Hybridization

Jensen, C. B., Pyke, C., Rasch, M. G., Dahl, A. B., Knudsen, L. B., & Secher, A. (2018) · Endocrinology · doi:10.1210/en.2017-00812 · Cited by 145 · see citing works

TCF1 links GIPR signaling to the control of beta cell function and survival

Campbell, J. E., Ussher, J. R., Mulvihill, E. E., Kolic, J., Baggio, L. L., Cao, X., Liu, Y., Lamont, B. J., Morii, T., Streutker, C. J., et al. (2016) · Nature Medicine · doi:10.1038/nm.3997 · Cited by 142 · see citing works

Activation of GLP-1 receptors on vascular smooth muscle cells reduces the autoregulatory response in afferent arterioles and increases renal blood flow

Jensen, E. P., Poulsen, S. S., Kissow, H., Holstein-Rathlou, N.-H., Deacon, C. F., Jensen, B. L., Holst, J. J., & Sorensen, C. M. (2015) · American Journal of Physiology-Renal Physiology · doi:10.1152/ajprenal.00527.2014 · Cited by 141 · see citing works

Full-length human GLP-1 receptor structure without orthosteric ligands

Wu, F., Yang, L., Hang, K., Laursen, M., Wu, L., Han, G. W., Ren, Q., Roed, N. K., Lin, G., Hanson, M. A., et al. (2020) · Nature Communications · doi:10.1038/s41467-020-14934-5 · Cited by 141 · see citing works

Caveolin-1 Regulates Cellular Trafficking and Function of the Glucagon-Like Peptide 1 Receptor

Syme, C. A., Zhang, L., & Bisello, A. (2006) · Molecular Endocrinology · doi:10.1210/me.2006-0178 · Cited by 138 · see citing works

Super-resolution microscopy compatible fluorescent probes reveal endogenous glucagon-like peptide-1 receptor distribution and dynamics

Ast, J., Arvaniti, A., Fine, N. H. F., Nasteska, D., Ashford, F. B., Stamataki, Z., Kőszegi, Z., Bacon, A., Jones, B. J., Lucey, M., et al. (2020) · Nature Communications · doi:10.1038/s41467-020-14309-w · Cited by 135 · see citing works

The EndoC-βH1 cell line is a valid model of human beta cells and applicable for screenings to identify novel drug target candidates

Tsonkova, V. G., Sand, F. W., Wolf, X. A., Grunnet, L. G., Ringgaard, A. K., Ingvorsen, C., Winkel, L., Kalisz, M., Dalgaard, K., Bruun, C., et al. (2017) · Molecular Metabolism · doi:10.1016/j.molmet.2017.12.007 · Cited by 127 · see citing works

Fluorescent proteins such as eGFP lead to catalytic oxidative stress in cells

Ganini, D., Leinisch, F., Kumar, A., Jiang, J., Tokar, E. J., Malone, C. C., Petrovich, R. M., & Mason, R. P. (2017) · Redox Biology · doi:10.1016/j.redox.2017.03.002 · Cited by 124 · see citing works

Accurate measurement of pancreatic islet β-cell mass using a second-generation fluorescent exendin-4 analog

Reiner, T., Thurber, G., Gaglia, J., Vinegoni, C., Liew, C. W., Upadhyay, R., Kohler, R. H., Li, L., Kulkarni, R. N., Benoist, C., et al. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1109859108 · Cited by 120 · see citing works

A Naturally Occurring GIP Receptor Variant Undergoes Enhanced Agonist-Induced Desensitization, Which Impairs GIP Control of Adipose Insulin Sensitivity

Mohammad, S., Patel, R. T., Bruno, J., Panhwar, M. S., Wen, J., & McGraw, T. E. (2014) · Molecular and Cellular Biology · doi:10.1128/mcb.00256-14 · Cited by 104 · see citing works

Inactivation of the Glucose-Dependent Insulinotropic Polypeptide Receptor Improves Outcomes following Experimental Myocardial Infarction

Ussher, J. R., Campbell, J. E., Mulvihill, E. E., Baggio, L. L., Bates, H. E., McLean, B. A., Gopal, K., Capozzi, M. E., Yusta, B., Cao, X., et al. (2017) · Cell Metabolism · doi:10.1016/j.cmet.2017.11.003 · Cited by 103 · see citing works

3D FIB-SEM reconstruction of microtubule–organelle interaction in whole primary mouse β cells

Müller, A., Schmidt, D., Xu, C. S., Pang, S., D’Costa, J. V., Kretschmar, S., Münster, C., Kurth, T., Jug, F., WEIGERT, M. G., et al. (2020) · The Journal of Cell Biology · doi:10.1083/jcb.202010039 · Cited by 103 · see citing works

The Mammalian Crumbs Complex Defines a Distinct Polarity Domain Apical of Epithelial Tight Junctions

Tan, B., Yatim, S. M. J. M., Peng, S., Gunaratne, J., Hunziker, W., & Ludwig, A. (2020) · Current Biology · doi:10.1016/j.cub.2020.05.032 · Cited by 98 · see citing works

Spatiotemporal GLP-1 and GIP receptor signaling and trafficking/recycling dynamics induced by selected receptor mono- and dual-agonists

Novikoff, A., O’Brien, S. L., Bernecker, M., Grandl, G., Kleinert, M., Knerr, P. J., Stemmer, K., Klingenspor, M., Zeigerer, A., DiMarchi, R. D., et al. (2021) · Molecular Metabolism · doi:10.1016/j.molmet.2021.101181 · Cited by 95 · see citing works

Agonist-induced membrane nanodomain clustering drives GLP-1 receptor responses in pancreatic beta cells

Buenaventura, T., Bitsi, S., Laughlin, W. E., Burgoyne, T., Lyu, Z., Oqua, A. I., Norman, H., McGlone, E. R., Klymchenko, A. S., Junior, I. R. C., et al. (2019) · PLoS Biology · doi:10.1371/journal.pbio.3000097 · Cited by 94 · see citing works

GIPR antagonist antibodies conjugated to GLP-1 peptide are bispecific molecules that decrease weight in obese mice and monkeys

Lu, S.-C., Chen, M., Atangan, L., Killion, E. A., Komorowski, R., Cheng, Y., Netirojjanakul, C., Falsey, J. R., Stolina, M., Dwyer, D., et al. (2021) · Cell Reports Medicine · doi:10.1016/j.xcrm.2021.100263 · Cited by 91 · see citing works

A human beta cell line with drug inducible excision of immortalizing transgenes

Benazra, M., Lecomte, M., Colace, C., Müller, A., Machado, C., Pechberty, S., Bricout-Neveu, E., Grenier-Godard, M., Solimena, M., Scharfmann, R., et al. (2015) · Molecular Metabolism · doi:10.1016/j.molmet.2015.09.008 · Cited by 87 · see citing works

Dual optical control and mechanistic insights into photoswitchable group II and III metabotropic glutamate receptors

Levitz, J., Broichhagen, J., Leippe, P., et al. (2017) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1619652114 · Cited by 86 · see citing works

Differential importance of endothelial and hematopoietic cell GLP-1Rs for cardiometabolic versus hepatic actions of semaglutide

McLean, B. A., Wong, C. K., Kaur, K. D., Seeley, R. J., & Drucker, D. J. (2021) · JCI Insight · doi:10.1172/jci.insight.153732 · Cited by 84 · see citing works

Functional Consequences of Glucagon-like Peptide-1 Receptor Cross-talk and Trafficking

Roed, S. N., Nøhr, A. C., Wismann, P., Iversen, H. K., Bräuner‐Osborne, H., Knudsen, S. M., & Waldhoer, M. (2014) · Journal of Biological Chemistry · doi:10.1074/jbc.m114.592436 · Cited by 78 · see citing works

Distribution and ultrastructural localization of the glucagon-like peptide-1 receptor (GLP-1R) in the rat brain

Farkas, E., Szilvásy‐Szabó, A., Ruska, Y., Sinkó, R., Rasch, M. G., Egebjerg, T., Pyke, C., Gereben, B., Knudsen, L. B., & Fekete, C. (2020) · Brain Structure and Function · doi:10.1007/s00429-020-02189-1 · Cited by 77 · see citing works

Genetic targeting of chemical indicators in vivo

Yang, G., Reis, F. D. C., Sundukova, M., et al. (2014) · Nature Methods · doi:10.1038/nmeth.3207 · Cited by 66 · see citing works

Visualizing subcellular rearrangements in intact β cells using soft x-ray tomography

White, K. L., Singla, J., Loconte, V., et al. (2020) · Science Advances · doi:10.1126/sciadv.abc8262 · Cited by 62 · see citing works

Use of CRISPR/Cas9-engineered INS-1 pancreatic β cells to define the pharmacology of dual GIPR/GLP-1R agonists

Naylor, J., Suckow, A. T., Seth, A., Baker, D. J., Sermadiras, I., Ravn, P., Howes, R., Li, J., Snaith, M. R., Coghlan, M. P., et al. (2016) · Biochemical Journal · doi:10.1042/bcj20160476 · Cited by 60 · see citing works

Inventing Liraglutide, a Glucagon-Like Peptide-1 Analogue, for the Treatment of Diabetes and Obesity

Knudsen, L. B. (2019) · ACS Pharmacology & Translational Science · doi:10.1021/acsptsci.9b00048 · Cited by 56 · see citing works

Using a Reporter Mouse to Map Known and Novel Sites of GLP-1 Receptor Expression in Peripheral Tissues of Male Mice

Andersen, D. B., Grunddal, K. V., Pedersen, J., Kuhre, R. E., Lund, M. L., Holst, J. J., & Ørskov, C. (2021) · Endocrinology · doi:10.1210/endocr/bqaa246 · Cited by 54 · see citing works

Downregulation of a GPCR by β-Arrestin2-Mediated Switch from an Endosomal to a TGN Recycling Pathway

Abdullah, N., Beg, M., Soares, D., Dittman, J. S., & McGraw, T. E. (2016) · Cell Reports · doi:10.1016/j.celrep.2016.11.050 · Cited by 53 · see citing works

CRISPR-based genome editing in primary human pancreatic islet cells

Bevacqua, R. J., Dai, X.-Q., Lam, J. Y., Gu, X., Friedlander, M. S. H., Tellez, K., Miguel-Escalada, I., Bonàs‐Guarch, S., Atla, G., Zhao, W., et al. (2021) · Nature Communications · doi:10.1038/s41467-021-22651-w · Cited by 53 · see citing works

Signalling, trafficking and glucoregulatory properties of glucagon‐like peptide‐1 receptor agonists exendin‐4 and lixisenatide

Pickford, P., Lucey, M., Fang, Z., Bitsi, S., de la Serna, J. B., Broichhagen, J., Hodson, D. J., MINNION, J. S., Rutter, G. A., Bloom, S. R., et al. (2020) · British Journal of Pharmacology · doi:10.1111/bph.15134 · Cited by 49 · see citing works

Role of the signal peptide in the synthesis and processing of the glucagon‐like peptide‐1 receptor

Huang, Y., Wilkinson, G. H., & Willars, G. B. (2009) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.2009.00517.x · Cited by 48 · see citing works

Near-Infrared Fluorescent Probe for Imaging of Pancreatic β Cells

Reiner, T., Köhler, R. H., Liew, C. W., Hill, J. A., Gaglia, J. L., Kulkarni, R., & Weissleder, R. (2010) · Bioconjugate Chemistry · doi:10.1021/bc100184w · Cited by 48 · see citing works

Interrogating surface versus intracellular transmembrane receptor populations using cell-impermeable SNAP-tag substrates

Poc, P., Gutzeit, V. A., Ast, J., Lee, J., Jones, B. J., D’Este, E., Mathes, B., Lehmann, M., Hodson, D. J., Levitz, J., et al. (2020) · Chemical Science · doi:10.1039/d0sc02794d · Cited by 47 · see citing works

A Global Approach for Quantitative Super Resolution and Electron Microscopy on Cryo and Epoxy Sections Using Self-labeling Protein Tags

Müller, A., Neukam, M., Ivanova, A., Sönmez, A., Münster, C., Kretschmar, S., Kalaidzidis, Y. L., Kurth, T., Verbavatz, J., & Solimena, M. (2017) · Scientific Reports · doi:10.1038/s41598-017-00033-x · Cited by 45 · see citing works

Genetically encoded tags for direct synthesis of EM-visible gold nanoparticles in cells

Jiang, Z., Jin, X., Li, Y., et al. (2020) · Nature Methods · doi:10.1038/s41592-020-0911-z · Cited by 45 · see citing works

A Targeted RNAi Screen Identifies Endocytic Trafficking Factors That Control GLP-1 Receptor Signaling in Pancreatic β-Cells

Buenaventura, T., Kanda, N., Douzenis, P. C., Jones, B. J., Bloom, S. R., CHABOSSEAU, P. L., Junior, I. R. C., Bosco, D., Piemonti, L., Marchetti, P., et al. (2017) · Diabetes · doi:10.2337/db17-0639 · Cited by 44 · see citing works

Ligand-Specific Factors Influencing GLP-1 Receptor Post-Endocytic Trafficking and Degradation in Pancreatic Beta Cells

Fang, Z., Chen, S., Manchanda, Y., Bitsi, S., Pickford, P., David, A., Shchepinova, M. M., Junior, I. R. C., Hodson, D. J., Broichhagen, J., et al. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21218404 · Cited by 43 · see citing works

Fluorescent exendin-4 derivatives for pancreatic β-cell analysis

Clardy, S. M., Keliher, E. J., Mohan, J. F., Sebas, M., Benoist, C., Mathis, D., & Weissleder, R. (2014) · Bioconjugate Chemistry · doi:10.1021/bc4005014 · Cited by 41 · see citing works

Structural and compositional diversity in the kainate receptor family

Selvakumar, P., Lee, J., Khanra, N., He, C., Munguba, H., Kiese, L., Broichhagen, J., Reiner, A., Levitz, J., & Meyerson, J. R. (2021) · Cell Reports · doi:10.1016/j.celrep.2021.109891 · Cited by 41 · see citing works

Discordance between GLP-1R gene and protein expression in mouse pancreatic islet cells

Gray, S. M., Xin, Y., Ross, E. C., Chazotte, B. M., Capozzi, M. E., EL, K. M., Svendsen, B., Ravn, P., Sloop, K. W., Tong, J., et al. (2020) · Journal of Biological Chemistry · doi:10.1074/jbc.ra120.014368 · Cited by 40 · see citing works

Development and characterisation of a novel glucagon like peptide-1 receptor antibody

Biggs, E. K., Liang, L., Naylor, J., Madalli, S., Collier, R., Coghlan, M. P., Baker, D. J., Hornigold, D. C., Ravn, P., Reimann, F. M., et al. (2017) · Diabetologia · doi:10.1007/s00125-017-4491-0 · Cited by 37 · see citing works

Acylation of the Incretin Peptide Exendin-4 Directly Impacts Glucagon-Like Peptide-1 Receptor Signaling and Trafficking

Lucey, M., Ashik, T., Marzook, A., Wang, Y., Goulding, J., Oishi, A., Broichhagen, J., Hodson, D. J., MINNION, J. S., Elani, Y., et al. (2021) · Molecular Pharmacology · doi:10.1124/molpharm.121.000270 · Cited by 37 · see citing works

AutoCLEM: An Automated Workflow for Correlative Live-Cell Fluorescence Microscopy and Cryo-Electron Tomography

Fu, X., Ning, J., Zhong, Z., Ambrose, Z., Watkins, S. C., & Zhang, P. (2019) · Scientific Reports · doi:10.1038/s41598-019-55766-8 · Cited by 32 · see citing works

Conditional and Reversible Activation of Class A and B G Protein-Coupled Receptors Using Tethered Pharmacology

Podewin, T., Ast, J., Broichhagen, J., Fine, N. H. F., Nasteska, D., Leippe, P., Gailer, M., Buenaventura, T., Kanda, N., Jones, B. J., et al. (2018) · ACS Central Science · doi:10.1021/acscentsci.7b00237 · Cited by 29 · see citing works

Expanded LUXendin Color Palette for GLP1R Detection and Visualization In Vitro and In Vivo

Ast, J., Novak, A. N., Podewin, T., Fine, N. H. F., Jones, B. J., Tomás, A., Birke, R., Roßmann, K., Mathes, B., Eichhorst, J., et al. (2022) · JACS Au · doi:10.1021/jacsau.2c00130 · Cited by 24 · see citing works

Rapid, high efficiency isolation of pancreatic ß-cells

Clardy, S. M., Mohan, J. F., Vinegoni, C., Keliher, E. J., Iwamoto, Y., Benoist, C. O., Mathis, D. J., & Weissleder, R. (2015) · Scientific Reports · doi:10.1038/srep13681 · Cited by 18 · see citing works

Beta cell specific probing with fluorescent exendin-4 is progressively reduced in type 2 diabetic mouse models

Lehtonen, J., Schäffer, L., Rasch, M. G., Hecksher‐Sørensen, J., & Ahnfelt‐Rønne, J. (2015) · Islets · doi:10.1080/19382014.2015.1137415 · Cited by 17 · see citing works

Repurposing GLP-1 Receptor Agonists for Parkinson’s Disease: Current Evidence and Future Opportunities

Victorino, D. B., Nejm, M. B., Guimarães‐Marques, M., Scorza, F. A., & Scorza, C. A. (2021) · Pharmaceutical Medicine · doi:10.1007/s40290-020-00374-5 · Cited by 15 · see citing works

Decreased expression of the GLP-1 receptor after segmental artery injury in mice

Bjørnholm, K. D., Povlsen, G. K., Ougaard, M. E., Pyke, C., Rakipovski, G., Tveden-Nyborg, P., Lykkesfeldt, J., & Skovsted, G. F. (2021) · Journal of Endocrinology · doi:10.1530/joe-20-0608 · Cited by 10 · see citing works

Optoacoustic Imaging of Glucagon-like Peptide-1 Receptor with a Near-Infrared Exendin-4 Analog

Roberts, S. S., Khera, E., Choi, C., Navaratna, T. A., Grimm, J., Thurber, G. M., & Reiner, T. (2020) · Journal of Nuclear Medicine · doi:10.2967/jnumed.120.252262 · Cited by 9 · see citing works

Sulfonated rhodamines as impermeable labelling substrates for cell surface protein visualizationPreprint

Birke, R., Ast, J., Roosen, D. A., et al. (2021) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2021.03.16.435698 · Cited by 3 · see citing works

An expanded LUXendin color palette for GLP1R detection and visualization in vitro and in vivoPreprint

Ast, J., Novak, A. N., Podewin, T., et al. (2021) · doi:10.33774/chemrxiv-2021-7rngq · Cited by 1 · see citing works

The expanding incretin universe: from basic biology to clinical translation

Drucker, D. J., & Holst, J. J. (2023) · Diabetologia · doi:10.1007/s00125-023-05906-7 · Cited by 243 · see citing works

GLP1R and GIPR expression and signaling in pancreatic alpha cells, beta cells and delta cells

Shilleh, A. H., Viloria, K., Broichhagen, J., Campbell, J. E., & Hodson, D. J. (2024) · Peptides · doi:10.1016/j.peptides.2024.171179 · Cited by 39 · see citing works

Randomised trial comparing weight loss through lifestyle and GLP-1 receptor agonist therapy in people with MASLD

Moolla, A., Poolman, T., Othonos, N., Dong, J., Smith, K., Cornfield, T., White, S., Ray, D. W., Mouchti, S., Mózes, F. E., et al. (2025) · JHEP Reports · doi:10.1016/j.jhepr.2025.101363 · Cited by 33 · see citing works

Glucose-dependent insulinotropic polypeptide receptor signaling alleviates gut inflammation in mice

Hammoud, R., Kaur, K. D., Koehler, J. A., Baggio, L. L., Wong, C. K., Advani, K. E., Yusta, B., Efimova, I., Gribble, F. M., Reimann, F., et al. (2025) · JCI Insight · doi:10.1172/jci.insight.174825 · Cited by 24 · see citing works

Reassessment of antibody-based detection of the murine T cell GLP-1 receptor

Wong, C. K., Yusta, B., Tong, J. C. L., Broichhagen, J., Hodson, D. J., & Drucker, D. J. (2025) · Cell Metabolism · doi:10.1016/j.cmet.2025.06.012 · Cited by 14 · see citing works

ИСПОЛЬЗОВAНИЕ ПОТЕНЦИAЛA СОЦИAЛЬНЫХ ПAРТНЕРОВ В ПОДГОТОВКЕ БУДУЩИХ ПЕДAГОГОВ

Атабекова, Б. Б. (2024) · Habaršy. Pedagogika ġylymdary seriâsy · doi:10.51889/2959-5762.2023.80.4.019

Exogenous Glucocorticoids and a High-Fat Diet Cause Severe Hyperglycemia and Hyperinsulinemia and Limit Islet Glucose Responsiveness in Young Male Sprague-Dawley Rats

Beaudry, J. L., D'souza, A. M., Teich, T., Tsushima, R. G., & Riddell, M. C. (2013) · Endocrinology · doi:10.1210/en.2012-2114 · Cited by 44 · see citing works

The Effect of Fasting on Tissue Cyclic cAMP and Plasma Glucagon in the Obese Hyperglycemic Mouse

VINE, R. L. L., Voyles, N. R., Perrino, P. V., & Recant, L. (1975) · Endocrinology · doi:10.1210/endo-97-3-615 · Cited by 38 · see citing works

Modulation of Adipoinsular Axis in Prediabetic Zucker Diabetic Fatty Rats by Diazoxide

Alemzadeh, R., & Tushaus, K. (2004) · Endocrinology · doi:10.1210/en.2003-1523 · Cited by 38 · see citing works

Growth hormone binding protein in the rat: effects of gonadal steroids

Carmignac, D. F., Gabrielsson, B. G., & Robinson, I. C. A. F. (1993) · Endocrinology · doi:10.1210/endo.133.6.8243263 · Cited by 68 · see citing works