Testosterone administration in older men
Abstract
The only indication for testosterone administration in older men is testosterone replacement therapy for male hypogonadism. Compared with young hypogonadal men, the diagnosis and management of male hypogonadism in older men is more challenging. Both the clinical manifestations of androgen deficiency and low testosterone levels may be caused or modified by comorbid illnesses that occur and medications taken more frequently by older men, resulting in a greater likelihood for overdiagnosis of hypogonadism and subsequent inappropriate use of and inadequate response to testosterone treatment. It is important to use a systematic, holistic approach to the diagnosis and management of older men with hypogonadism.
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Functional hypogonadism is due to functional HPT axis suppression.
“functional hypogonadism is due to functional HPT axis suppression.”
From A Perspective on Middle-Aged and Older Men With Functional Hypogonadism: Focus on Holistic Management (2017) · cites this paper as [12]
Functional hypogonadism is potentially reversible.
“is potentially reversible”
From A Perspective on Middle-Aged and Older Men With Functional Hypogonadism: Focus on Holistic Management (2017) · cites this paper as [12]
In middle-aged and older men, functional hypogonadism is usually associated with low or normal gonadotropin levels.
“In middle-aged and older men, functional (late-onset, age-related onset, or adult onset) hypogonadism is usually associated with low or normal gonadotropin levels.”
From A Perspective on Middle-Aged and Older Men With Functional Hypogonadism: Focus on Holistic Management (2017) · cites this paper as [12]
Organic hypogonadism is not usually reversible.
“and is not usually reversible”
From A Perspective on Middle-Aged and Older Men With Functional Hypogonadism: Focus on Holistic Management (2017) · cites this paper as [12]
Functional hypogonadism often presents with less severe androgen deficiency.
“functional hypogonadism often presents with less severe androgen deficiency”
From A Perspective on Middle-Aged and Older Men With Functional Hypogonadism: Focus on Holistic Management (2017) · cites this paper as [12]
Organic hypogonadism typically presents with clinically and biochemically severe androgen deficiency.
“Whereas organic hypogonadism typically presents with clinically and biochemically severe androgen deficiency”
From A Perspective on Middle-Aged and Older Men With Functional Hypogonadism: Focus on Holistic Management (2017) · cites this paper as [12]
Functional hypogonadism is more common than organic hypogonadism.
“and is more common than organic hypogonadism.”
From A Perspective on Middle-Aged and Older Men With Functional Hypogonadism: Focus on Holistic Management (2017) · cites this paper as [12]
Cites
Screening and Prostate-Cancer Mortality in a Randomized European Study
Schröder, F. H., Hugosson, J., Roobol, M. J., Tammela, T. L. J., Ciatto, S., Nelen, V., KWIATKOWSKI, M. K., Lujan, M., Lilja, H. G., Zappa, M., et al. (2009) · New England Journal of Medicine · doi:10.1056/nejmoa0810084 · Cited by 4,016 · see citing works
Mortality Results from a Randomized Prostate-Cancer Screening Trial
Andriole, G. L., Crawford, E. D., Grubb, R. L., Buys, S. S., Chia, D., Church, T. R., Fouad, M. N., Gelmann, E. P., Kvale, P. A., Reding, D. J., et al. (2009) · New England Journal of Medicine · doi:10.1056/nejmoa0810696 · Cited by 2,879 · see citing works
Longitudinal Effects of Aging on Serum Total and Free Testosterone Levels in Healthy Men
Harman, S. M., Metter, E. J., Tobin, J. D., Pearson, J., & Blackman, M. R. (2001) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.86.2.7219 · Cited by 2,760 · see citing works
Bhasin, S., Cunningham, G. R., Hayes, F. J., Matsumoto, A. M., Snyder, P. J., Swerdloff, R. S., & Montori, V. M. (2010) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2009-2354 · Cited by 1,954 · see citing works
Self-citationIdentification of late-onset hypogonadism in middle-aged and elderly men
Wu, F. C. W., Tajar, A., Beynon, J. M., Pye, S. R., Silman, A. J., Finn, J. D., O'Neill, T. W., Bartfai, G., Casanueva, F. F., Forti, G., et al. (2010) · New England Journal of Medicine · doi:10.1056/nejmoa0911101 · Cited by 1,544 · see citing works
Adverse Events Associated with Testosterone Administration
Basaria, S., Coviello, A. D., Travison, T. G., Storer, T. W., Farwell, W. R., Jette, A. M., Eder, R., Tennstedt, S., Ulloor, J., Zhang, A., et al. (2010) · New England Journal of Medicine · doi:10.1056/nejmoa1000485 · Cited by 1,494 · see citing works
Gray, A., Feldman, H. A., McKinlay, J. B., & Longcope, C. (1991) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-73-5-1016 · Cited by 1,104 · see citing works
Loss of Circadian Rhythmicity in Blood Testosterone Levels with Aging in Normal Men*
Bremner, W. J., Vitiello, M. V., & Prinz, P. N. (1983) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-56-6-1278 · Cited by 785 · see citing works
Prevalence of Symptomatic Androgen Deficiency in Men
Araujo, A. B., Esche, G. R., Kupelian, V., O’Donnell, A. B., Travison, T. G., Williams, R. E., Clark, R. V., & McKinlay, J. B. (2007) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2007-1245 · Cited by 720 · see citing works
Adverse Effects of Testosterone Therapy in Adult Men: A Systematic Review and Meta-Analysis
Fernández-Balsells, M. M., Murad, M. H., Lane, M., Lampropulos, J. F., Albuquerque, F., Mullan, R. J., Agrwal, N., Elamin, M. B., Gallegos-Orozco, J. F., Wang, A. T., et al. (2010) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2009-2575 · Cited by 713 · see citing works
Srinivas-Shankar, U., Roberts, S. A., Connolly, M. J., O'Connell, M. D. L., Adams, J. E., Oldham, J. A., & Wu, F. C. W. (2010) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2009-1251 · Cited by 629 · see citing works
Osteoporosis in Men: An Endocrine Society Clinical Practice Guideline
Watts, N. B., Adler, R. A., Bilezikian, J. P., Drake, M. T., Eastell, R., Orwoll, E. S., & Finkelstein, J. S. (2012) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2011-3045 · Cited by 611 · see citing works
Tajar, A., Forti, G., O'Neill, T. W., Lee, D. M., Silman, A. J., Finn, J. D., Bartfai, G., Boonen, S., Casanueva, F. F., Giwercman, A., et al. (2010) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2009-1796 · Cited by 604 · see citing works
Araujo, A. B., O’Donnell, A. B., Brambilla, D. J., Simpson, W. B., Longcope, C., Matsumoto, A. M., & McKinlay, J. B. (2004) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2003-031719 · Cited by 591 · see citing works
Self-citationWang, C., Catlin, D. H., Demers, L. M., Starcevic, B., & Swerdloff, R. S. (2004) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2003-031287 · Cited by 580 · see citing works
Brambilla, D. J., Matsumoto, A. M., Araujo, A. B., & McKinlay, J. B. (2009) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2008-1902 · Cited by 448 · see citing works
Self-citationTravison, T. G., Araujo, A. B., Kupelian, V., O’Donnell, A. B., & McKinlay, J. B. (2007) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2006-1859 · Cited by 410 · see citing works
Effects of graded doses of testosterone on erythropoiesis in healthy young and older men
Coviello, A. D., Kaplan, B., Lakshman, K. M., Chen, T., Singh, A. B., & Bhasin, S. (2008) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2007-1692 · Cited by 404 · see citing works
Dobs, A. S. (1999) · Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.84.10.3469 · Cited by 381 · see citing works
Long-Term Pharmacokinetics of Transdermal Testosterone Gel in Hypogonadal Men 1
Swerdloff, R. S., Wang, C., Cunningham, G. R., Dobs, A. S., Iranmanesh, A., Matsumoto, A. M., Snyder, P. J., Weber, T. J., Longstreth, J. A., & Berman, N. (2000) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.85.12.7045 · Cited by 343 · see citing works
Self-citationThe Short-Term Effects of High-Dose Testosterone on Sleep, Breathing, and Function in Older Men
Liu, P. Y., Yee, B., Wishart, S. M., Jimenez, M., Jung, D. G., Grunstein, R. R., & Handelsman, D. J. (2003) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2003-030236 · Cited by 275 · see citing works
Long-Term Pharmacokinetics of Transdermal Testosterone Gel in Hypogonadal Men
Swerdloff, R. S. (2000) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.85.12.4500 · Cited by 262 · see citing works
The Response of Metastatic Adenocarcinoma of the Prostate to Exogenous Testosterone
Fowler, J. E., & Whitmore, W. F. (1981) · The Journal of Urology · doi:10.1016/s0022-5347(17)54531-0 · Cited by 259 · see citing works
PLYMATE, S. R., TENOVER, J. S., & BREMNER, W. J. (1989) · Journal of Andrology · doi:10.1002/j.1939-4640.1989.tb00120.x · Cited by 239 · see citing works
Brambilla, D. J., O'Donnell, A. B., Matsumoto, A. M., & McKinlay, J. B. (2007) · Clinical Endocrinology · doi:10.1111/j.1365-2265.2007.02976.x · Cited by 207 · see citing works
Self-citationObstructive Sleep Apnea Syndrome Induced by Testosterone Administration
Sandblom, R. E., Matsumoto, A. M., Schoene, R. B., Lee, K. A., Giblin, E. C., Bremner, W. J., & Pierson, D. J. (1983) · New England Journal of Medicine · doi:10.1056/nejm198303033080908 · Cited by 205 · see citing works
Self-citationBoloña, E. R., Uraga, M. V., Haddad, R. M., Tracz, M. J., Sideras, K., Kennedy, C. C., Caples, S. M., Erwin, P. J., & Montori, V. M. (2007) · Mayo Clinic Proceedings · doi:10.1016/s0025-6196(11)60963-4 · Cited by 184 · see citing works
Influence of testosterone on breathing during sleep
Schneider, B. K., Pickett, C. K., Zwillich, C. W., Weil, J. V., McDermott, M. T., Santen, R. J., Varano, L. A., & White, D. P. (1986) · Journal of Applied Physiology · doi:10.1152/jappl.1986.61.2.618 · Cited by 179 · see citing works
Thompson, I. M., Zeidman, E. J., & Rodriguez, F. R. (1990) · The Journal of Urology · doi:10.1016/s0022-5347(17)39774-4 · Cited by 114 · see citing works
Chrisp, P., & Sorkin, E. M. (1991) · Drugs & Aging · doi:10.2165/00002512-199101060-00008 · Cited by 60 · see citing works
Basaria, S. S., Davda, M. N., Travison, T. G., Ulloor, J., Singh, R., & Bhasin, S. (2012) · The Journals of Gerontology Series A · doi:10.1093/gerona/gls138 · Cited by 56 · see citing works
Anawalt, B. D., Hotaling, J. M., Walsh, T. J., & Matsumoto, A. M. (2012) · Journal of Urology · doi:10.1016/j.juro.2011.11.095 · Cited by 55 · see citing works
Self-citationCoviello, A. D., Lakshman, K. M., Mazer, N. A., & Bhasin, S. (2006) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2006-0822 · Cited by 44 · see citing works
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1 of the 34 references couldn’t be matched to a known paper.
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Grossmann, M., & Matsumoto, A. M. (2017) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2016-3580 · Cited by 246 · see citing works
Self-citationSierra, F. (2016) · Cold Spring Harbor Perspectives in Medicine · doi:10.1101/cshperspect.a025163 · Cited by 213 · see citing works
Physiology of the Hypothalamic Pituitary Gonadal Axis in the Male
Corradi, P. F., Corradi, R. B., & Greene, L. W. (2016) · Urologic Clinics of North America · doi:10.1016/j.ucl.2016.01.001 · Cited by 152 · see citing works
Hackett, G. I., Kirby, M. G., Edwards, D., Jones, T. H., Wylie, K. R., Ossei‐Gerning, N., David, J., & Muneer, A. (2017) · The Journal of Sexual Medicine · doi:10.1016/j.jsxm.2017.10.067 · Cited by 145 · see citing works
Genomic and non-genomic effects of androgens in the cardiovascular system: clinical implications
Lucas-Herald, A. K., Alves-Lopes, R., Montezano, A. C. I., Ahmed, S. F., & Touyz, R. M. (2017) · Clinical Science · doi:10.1042/cs20170090 · Cited by 132 · see citing works
Testosterone and glucose metabolism in men: current concepts and controversies.
Grossmann, M. (2014) · Journal of Endocrinology · doi:10.1530/joe-13-0393 · Cited by 96 · see citing works
Hackett, G. I., Kirby, M. G., Rees, R. W., Jones, T. H., Muneer, A., Livingston, M. A., Ossei‐Gerning, N., David, J., Foster, J., Kalra, P. A., et al. (2023) · The World Journal of Men s Health · doi:10.5534/wjmh.221027 · Cited by 99 · see citing works
Amory, J. K. (2016) · Fertility and Sterility · doi:10.1016/j.fertnstert.2016.08.036 · Cited by 72 · see citing works
Development of Novel Male Contraceptives
Amory, J. K. (2019) · Clinical and Translational Science · doi:10.1111/cts.12708 · Cited by 70 · see citing works
Testosterone, aging and survival
Shores, M. M., & Matsumoto, A. M. (2014) · Current Opinion in Endocrinology Diabetes and Obesity · doi:10.1097/med.0000000000000057 · Cited by 52 · see citing works
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Stancampiano, M. R., Lucas-Herald, A. K., Russo, G., Rogol, A. D., & Ahmed, S. F. (2019) · Hormone Research in Paediatrics · doi:10.1159/000504670 · Cited by 48 · see citing works
Cardiovascular and metabolic actions of the androgens: Is testosterone a Janus-faced molecule?
Stallone, J. N., & Oloyo, A. K. (2022) · Biochemical Pharmacology · doi:10.1016/j.bcp.2022.115347 · Cited by 21 · see citing works
Sexual Dimorphism in Cardiometabolic Diseases: The Role of AMPK
Kvandová, M., Púzserová, A., & Bališ, P. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms241511986 · Cited by 19 · see citing works
Chapter 19 – Testicular Disorders
Matsumoto, A., & Bremner, W. (2011) · Elsevier eBooks · doi:10.1016/b978-0-323-29738-7.00019-8 · Cited by 15 · see citing works
Self-citationAndrogens and Non-Genomic vascular responses in hypertension
Perusquı́a, M. (2022) · Biochemical Pharmacology · doi:10.1016/j.bcp.2022.115200 · Cited by 16 · see citing works
Matsumoto, A. M. (2019) · Current Opinion in Endocrine and Metabolic Research · doi:10.1016/j.coemr.2019.04.004 · Cited by 15 · see citing works
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Matsumoto, A. M. (2022) · Endocrinology and Metabolism Clinics of North America · doi:10.1016/j.ecl.2021.11.001 · Cited by 9 · see citing works
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Jácome, A. (2019) · Revista Colombiana de Endocrinología Diabetes & Metabolismo · doi:10.53853/encr.6.3.538 · Cited by 6 · see citing works
The Implications of Low Testosterone on Mortality in Men
Shores, M. M. (2014) · Current Sexual Health Reports · doi:10.1007/s11930-014-0030-x · Cited by 5 · see citing works
Iglesias, P., Prado, F., & Díez, J. J. (2017) · Springer eBooks · doi:10.1007/978-3-319-46086-4_8 · Cited by 3 · see citing works
Valencia, W. M., & Florez, H. J. (2016) · Springer eBooks · doi:10.1007/978-3-319-31831-8_22 · Cited by 3 · see citing works
Ottinger, M. A., Duffy, K., Schlappal, A., Sitzmann, B. D., Wu, J., & Zimmer, D. (2014) · Elsevier eBooks · doi:10.1016/b978-0-12-801238-3.00156-2 · Cited by 2 · see citing works
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Matsumoto, A. M. (2016) · The Endocrine Society eBooks · doi:10.1210/mtp5.9781943550043.ch59 · Cited by 1 · see citing works
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Corradi, P. F., Corradi, R. B., & Greene, L. W. (2016)
Evaluation of Men With Hypogonadotropic Hypogonadism: Clinical, Laboratory, and Imaging
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Amory, J. K. (2021) · Trends in andrology and sexual medicine · doi:10.1007/978-3-030-70932-7_24
Valencia, W. M., & Florez, H. J. (2021) · Springer eBooks · doi:10.1007/978-3-030-76271-1_20
Şahin, S., & Taşkıran, E. (2022) · Pathy's Principles and Practice of Geriatric Medicine · doi:10.1002/9781119484288.ch2
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Iglesias, P., Núñez, A., & Díez, J. J. (2023) · Springer eBooks · doi:10.1007/978-3-031-31501-5_9
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Iglesias, P., Núñez, A., & Díez, J. J. (2024) · Springer eBooks · doi:10.1007/978-3-031-65245-5_9
- Authors
- Matsumoto, A. M.
- Affiliations
- University of Washington (US)
- Corresponding author
- Matsumoto, Alvin M.
- ORCID
- Matsumoto, Alvin M.
- Venue
- Endocrinology and Metabolism Clinics of North America
- Publisher
- Elsevier BV
- Published
- 2013-06
- Volume
- 42
- Issue
- 2
- Pages
- 271-286
- ISSN
- 0889-8529 (ISSN-L)
- OpenAlex
- W2101118336
- Cited by
- 32
- References
- 34
- Citations by year
- 2024: 1 · 2023: 3 · 2022: 4 · 2021: 2 · 2019: 4 · 2017: 5 · 2016: 7 · 2015: 1 · 2014: 4 · 2013: 1
- FWCI
- 0.63
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Endocrinology and Metabolism Clinics of North America (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Hormonal and reproductive studies
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adrenal Hormones and Disorders
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Menopause: Health Impacts and Treatments
- Keywords
- testosterone replacement therapy, male hypogonadism, older men, androgen deficiency, comorbidities, overdiagnosis, inappropriate treatment
- MeSH terms
- Aging, Androgens, Humans, Hypogonadism, Male, Quality of Life, Testosterone, Drug Monitoring, Hormone Replacement Therapy, Precision Medicine
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