Cited by 373Pain Mechanisms and TreatmentsPeripheral Neuropathies and DisordersAldose Reductase and Taurine

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Diabetic Neuropathy

Vinik, Aaron I., Nevoret, Marie-Laure, Casellini, Carolina, Parson, Henri·2013·Endocrinology and Metabolism Clinics of North America

DOI 10.1016/j.ecl.2013.06.001

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Abstract

Diabetic neuropathy (DN) is the most common and troublesome complication of diabetes mellitus, leading to the greatest morbidity and mortality and resulting in a huge economic burden for diabetes care. The clinical assessment of diabetic peripheral neuropathy and its treatment options are multifactorial. Patients with DN should be screened for autonomic neuropathy, as there is a high degree of coexistence of the two complications. A review of the clinical assessment and treatment algorithms for diabetic neuropathy, painful neuropathy, and autonomic dysfunction is provided.

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The definition of orthostatic hypotension, pure autonomic failure, and multiple system atrophy
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Health Care Costs in Patients with Painful Diabetic Peripheral Neuropathy Prescribed Pregabalin or Duloxetine
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Untitled work
de Valk (1998) · doi:10.1002/(sici)1096-9136(199806)15:6

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Barada, 1999, Proximal diabetic neuropathy—response to immunotherapy, Diabetes, 48, A148
Vinik, 1999, Treatment of diabetic polyneuropathy (DPN) with recombinant human nerve growth factor (rhNGF), Diabetes, 48, A54
Bastyr, 2002, Neuropathy Total symptom Score-6 Questionnaire (NTSS-6) is a valid instrument for assessing the positive symptoms of diabetic peripheral neuropathy (DPN), Diabetes, 51, A199
Ziegler, 2011, Antioxidant treatment with alpha-lipoic acid in diabetic polyneuropathy: a 4-year randomized double-blind trial (NATHAN 1), Diabetologia, 50, S63

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Authors: Vinik, A. I., Nevoret, M.-L., Casellini, C., & Parson, H.
Affiliations: Eastern Virginia Medical School (US)
Corresponding author: Vinik, Aaron I.
ORCID: Vinik, Aaron I.
Casellini, Carolina
Parson, Henri
Venue: Endocrinology and Metabolism Clinics of North America
Publisher: Elsevier BV
Published: 2013-12
Volume: 42
Issue: 4
Pages: 747-787
ISSN: 0889-8529 (ISSN-L)
DOI: 10.1016/j.ecl.2013.06.001
OpenAlex: W4210977503
Cited by: 366
References: 181
Citations by year: 2026: 30 · 2025: 36 · 2024: 42 · 2023: 38 · 2022: 40 · 2021: 36 · 2020: 41 · 2019: 27 · 2018: 12 · 2017: 16 · 2016: 17 · 2015: 15 · 2014: 16
FWCI: 1.76
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
Locations: Endocrinology and Metabolism Clinics of North America (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Physiology (medical) › Pain Mechanisms and Treatments
Health Sciences › Medicine › Clinical Neurology › Peripheral Neuropathies and Disorders
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Aldose Reductase and Taurine
Keywords: diabetic neuropathy, diabetic peripheral neuropathy, autonomic neuropathy, diabetic neuropathic pain, autonomic dysfunction, diabetes complications, neuropathy screening, clinical evaluation
MeSH terms: Autonomic Nervous System Diseases, Cardiovascular Diseases, Diabetic Neuropathies, Humans, Hyperglycemia, Neuralgia, Guidelines as Topic

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