Cited by 293Atrial Fibrillation Management and OutcomesCardiac Arrhythmias and TreatmentsCardiac electrophysiology and arrhythmias

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Use of enalapril to facilitate sinus rhythm maintenance after external cardioversion of long-standing persistent atrial fibrillation. Results of a prospective and controlled study

Ueng, K·2003·European Heart Journal

DOI 10.1016/j.ehj.2003.08.014

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Abstract

AIMS: This study aimed to assess whether enalapril could improve cardioversion outcome and facilitate sinus rhythm maintenance after conversion of chronic atrial fibrillation (AF). METHODS AND RESULTS: Patients with chronic AF for more than 3 months were assigned to receive either amiodarone (200mg orally 3 times a day; group I: n=75) or the same dosage of amiodarone plus enalapril (10mg twice a day; group II: n=70) 4 weeks before scheduled external cardioversion. The end-point was the time to first recurrence of AF. In 125 patients (86.2%), AF was converted to sinus rhythm. Group II had a trend to a trend to a lower rate of immediate recurrence of AF than group I did (4.3% vs 14.7%, P=0.067). Kaplan-Meier analysis demonstrated a higher probability of group II remaining in sinus rhythm at 4 weeks (84.3% vs 61.3%, P=0.002) and at the median follow-up period of 270 days (74.3% vs 57.3%, P=0.021) than in group II. CONCLUSIONS: The addition of enalapril to amiodarone decreased the rate of immediate and subacute arrhythmia recurrences and facilitated subsequent long-term maintenance of sinus rhythm after cardioversion of persistent AF.

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Authors: Ueng, K.
Affiliations: Chung Shan Medical University Hospital (TW)
Corresponding author: Ueng, K
ORCID: Ueng, K
Venue: European Heart Journal
Publisher: Oxford University Press (OUP)
Published: 2003-12
Volume: 24
Issue: 23
Pages: 2090-2098
ISSN: 0195-668X (ISSN-L)
DOI: 10.1016/j.ehj.2003.08.014
OpenAlex: W1946485105
Cited by: 293
References: 45
Citations by year: 2026: 2 · 2025: 1 · 2024: 1 · 2023: 3 · 2022: 5 · 2021: 3 · 2020: 3 · 2019: 2 · 2018: 3 · 2017: 1 · 2016: 6 · 2015: 7 · 2014: 6 · 2013: 13 · 2012: 9
FWCI: 13.45
Type: journal article
Language: en
Open access: closed
Locations: European Heart Journal (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Atrial Fibrillation Management and Outcomes
Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac Arrhythmias and Treatments
Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac electrophysiology and arrhythmias
Keywords: enalapril, amiodarone, atrial fibrillation, external cardioversion, sinus rhythm maintenance, atrial fibrillation recurrence, long-standing persistent atrial fibrillation, combination anticoagulant therapy, ACE inhibitors
MeSH terms: Adolescent, Adult, Aged, Amiodarone, Angiotensin-Converting Enzyme Inhibitors, Anti-Arrhythmia Agents, Antihypertensive Agents, Atrial Fibrillation, Combined Modality Therapy, Drug Therapy, Combination, Electric Countershock, Enalapril, Humans, Long-Term Care, Middle Aged, Prospective Studies, Treatment Outcome, Disease-Free Survival, Secondary Prevention

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Use of enalapril to facilitate sinus rhythm maintenance after external cardioversion of long-standing persistent atrial fibrillation. Results of a prospective and controlled study

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