ETS transcription factors and their emerging roles in human cancer

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Molecular biology of the Ets family of transcription factors

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Childhood Leukemias

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Ets target genes: past, present and future

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SUMO Promotes HDAC-Mediated Transcriptional Repression

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Contributions of Stromal Metalloproteinase-9 to Angiogenesis and Growth of Human Ovarian Carcinoma in Mice

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Biology of EWS/ETS fusions in Ewing's family tumors

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Frequent overexpression of ETS-related gene-1 (ERG1) in prostate cancer transcriptome

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Ets ternary complex transcription factors

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Signal transduction and the Ets family of transcription factors

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MafB Is an Interaction Partner and Repressor of Ets-1 That Inhibits Erythroid Differentiation

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Ets proteins in biological control and cancer

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Ets-1 regulates angiogenesis by inducing the expression of urokinase-type plasminogen activator and matrix metalloproteinase-1 and the migration of vascular endothelial cells

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EWS-Fli1 antisense oligodeoxynucleotide inhibits proliferation of human Ewing's sarcoma and primitive neuroectodermal tumor cells.

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Transcriptional regulation of osteopontin gene in vivo by PEBP2αA/CBFA1 and ETS1 in the skeletal tissues

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PDEF, a Novel Prostate Epithelium-specific Ets Transcription Factor, Interacts with the Androgen Receptor and Activates Prostate-specific Antigen Gene Expression

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An RNA-binding protein gene, TLS/FUS, is fused to ERG in human myeloid leukemia with t(16;21) chromosomal translocation.

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Heterozygous PU.1 mutations are associated with acute myeloid leukemia

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c-ets1 proto-oncogene is a transcription factor expressed in endothelial cells during tumor vascularization and other forms of angiogenesis in humans.

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Regulation of Ets function by protein–protein interactions

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Translocation (12;22) (p13;q11) in myeloproliferative disorders results in fusion of the ETS-like TEL gene on 12p13 to the MN1 gene on 22q11.

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The Ets-1 and Ets-2 transcription factors activate the promoters for invasion-associated urokinase and collagenase genes in response to epidermal growth factor

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Expression profiles frame the promoter specificity dilemma of the ETS family of transcription factors

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ETS-1 converts endothelial cells to the angiogenic phenotype by inducing the expression of matrix metalloproteinases and integrin ?3

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Cell–cell interaction in prostate gene regulation and cytodifferentiation

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EAP1/Daxx interacts with ETS1 and represses transcriptional activation of ETS1 target genes

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A tumor profile in Down syndrome

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ESX: a structurally unique Ets overexpressed early during human breast tumorigenesis

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Acute myeloid leukemia with complex karyotypes and abnormal chromosome 21: Amplification discloses overexpression of APP , ETS2 , and ERG genes

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Prediction of Gene Function by Genome-Scale Expression Analysis: Prostate Cancer-Associated Genes

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Oncogenic TLS/ERG and EWS/Fli-1 fusion proteins inhibit RNA splicing mediated by YB-1 protein.

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Identification of Target Genes for the Ewing's Sarcoma EWS/FLI Fusion Protein by Representational Difference Analysis

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HER2/Neu and the Ets transcription activator PEA3 are coordinately upregulated in human breast cancer

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Matrix metalloproteinase-1 promoter polymorphism 1G/2G is correlated with colorectal cancer invasiveness.

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Proteins of the ETS family with transcriptional repressor activity

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A cAMP Response Element and an Ets Motif Are Involved in the Transcriptional Regulation of flt-1 Tyrosine Kinase (Vascular Endothelial Growth Factor Receptor 1) Gene

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Mitogenic Signaling By Colony-Stimulating Factor 1 and ras Is Suppressed by the ets-2 DNA-Binding Domain and Restored by myc Overexpression

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A novel epithelial-expressed ETS gene, ELF3: human and murine cDNA sequences, murine genomic organization, human mapping to 1q32.2 and expression in tissues and cancer

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Expression analyses identify MLL as a prominent target of 11q23 amplification and support an etiologic role for MLL gain of function in myeloid malignancies

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Expression of the transcription factor Ets-1 is an independent prognostic marker for relapse-free survival in breast cancer

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When Ets transcription factors meet their partners

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The Splicing Factor U1C Represses EWS/FLI-mediated Transactivation

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The pea3 subfamily ets genes are required for HER2/Neu-mediated mammary oncogenesis

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Changes in the Expression of Many Ets Family Transcription Factors and of Potential Target Genes in Normal Mammary Tissue and Tumors

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The Ets-1 transcription factor is up-regulated together with MMP 1 and MMP 9 in the stroma of pre-invasive breast cancer

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TLS-ERG Leukemia Fusion Protein Inhibits RNA Splicing Mediated by Serine-Arginine Proteins

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The c-ets-1 proto-oncogene has oncogenic activity and is positively autoregulated.

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Associations and Interactions between Ets-1 and Ets-2 and Coregulatory Proteins, SRC-1, AIB1, and NCoR in Breast Cancer

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Small ubiquitin-like modifier conjugation regulates nuclear export of TEL, a putative tumor suppressor

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Pdef expression in human breast cancer is correlated with invasive potential and altered gene expression.

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Ets factors and regulation of the extracellular matrix

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Ets1 Is an Effector of the Transforming Growth Factor β (TGF-β) Signaling Pathway and an Antagonist of the Profibrotic Effects of TGF-β

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Angiogenic Property of Hepatocyte Growth Factor Is Dependent on Upregulation of Essential Transcription Factor for Angiogenesis, ets-1

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The paired box domain gene PAX5 is fused to ETV6/TEL in an acute lymphoblastic leukemia case.

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Fatal myeloproliferation, induced in mice by TEL/PDGFβR expression, depends on PDGFβR tyrosines 579/581

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EWS/FLI Alters 5′-Splice Site Selection

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Acetylation-Mediated Transcriptional Activation of the ETS Protein ER81 by p300, P/CAF, and HER2/Neu

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HER2/Neu-mediated activation of the ETS transcription factor ER81 and its target gene MMP-1

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Hepatocyte growth factor upregulates E1AF that induces oral squamous cell carcinoma cell invasion by activating matrix metalloproteinase genes

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TEL-AML1, expressed from t(12;21) in human acute lymphocytic leukemia, induces acute leukemia in mice.

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Triplex DNA-mediated downregulation of Ets2 expression results in growth inhibition and apoptosis in human prostate cancer cells

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Role of the Ets Transcription Factors in the Regulation of the Vascular-Specific Tie2 Gene

Dube, A., Akbarali, Y., Sato, T. N., Libermann, T. A., & Oettgen, P. (1999) · Circulation Research · doi:10.1161/01.res.84.10.1177 · Cited by 97

Amplification and Rearrangement of Hu- ets -1 in Leukemia and Lymphoma with Involvement of 11q23

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Stromelysin 3, Ets-1, and Vascular Endothelial Growth Factor Expression in Oral Precancerous and Cancerous Lesions: Correlation with Microvessel Density, Progression, and Prognosis

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Role of Ets factors in the activity and endothelial cell specificity of the mouse Tie gene promoter

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The MN1-TEL Fusion Protein, Encoded by the Translocation (12;22)(p13;q11) in Myeloid Leukemia, Is a Transcription Factor with Transforming Activity

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Inhibition of vascular endothelial growth factor-induced endothelial cell migration by ETS1 antisense oligonucleotides.

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Expression of the Ets-1 transcription factor in human astrocytomas is associated with Fms-like tyrosine kinase-1 (Flt-1)/vascular endothelial growth factor receptor-1 synthesis and neoangiogenesis.

Valter, M. M., Hügel, A., Huang, H. J., Cavenee, W. K., Wiestler, O. D., Pietsch, T., & Wernert, N. (1999) · PubMed · Cited by 94

Molecular profiling of mouse lung tumors: association with tumor progression, lung development, and human lung adenocarcinomas

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Association of ets‐related transcriptional factor E1AF expression with tumour progression and overexpression of MMP‐1 and matrilysin in human colorectal cancer

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The Epithelium-specific ETS Protein EHF/ESE-3 Is a Context-dependent Transcriptional Repressor Downstream of MAPK Signaling Cascades

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Structural Analysis of the Autoinhibition of Ets-1 and Its Role in Protein Partnerships

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The t(1;12)(q21;p13) translocation of human acute myeloblastic leukemia results in a TEL-ARNT fusion

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Ets transcription factors cooperate with Sp1 to activate the human Tenascin-C promoter

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ETS-1 Transcription Factor Binds Cooperatively to the Palindromic Head to Head ETS-binding Sites of the Stromelysin-1 Promoter by Counteracting Autoinhibition

Baillat, D., Bègue, A., Stéhelin, D., & Aumercier, M. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m200088200 · Cited by 84

A novel transcription factor, ELF5, belongs to the ELF subfamily of ETS genes and maps to human chromosome 11p13–15, a region subject to LOH and rearrangement in human carcinoma cell lines

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The MN1 oncoprotein synergizes with coactivators RAC3 and p300 in RAR-RXR-mediated transcription

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Secondary Structure of the ETS Domain Places Murine Ets-1 in the Superfamily of Winged Helix-Turn-Helix DNA-Binding Proteins

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Modulation of TEL transcription activity by interaction with the ubiquitin-conjugating enzyme UBC9

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c-ets-2 protooncogene has mitogenic and oncogenic activity.

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