The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
Worldwide human papillomavirus genotype attribution in over 2000 cases of intraepithelial and invasive lesions of the vulva
Open accessAbstract
BACKGROUND Human papillomavirus (HPV) contribution in vulvar intraepithelial lesions (VIN) and invasive vulvar cancer (IVC) is not clearly established. This study provides novel data on HPV markers in a large series of VIN and IVC lesions. METHODS Histologically confirmed VIN and IVC from 39 countries were assembled at the Catalan Institute of Oncology (ICO). HPV-DNA detection was done by polymerase chain reaction using SPF-10 broad-spectrum primers and genotyping by reverse hybridisation line probe assay (LiPA25) (version 1). IVC cases were tested for p16(INK4a) by immunohistochemistry (CINtec histology kit, ROCHE). An IVC was considered HPV driven if both HPV-DNA and p16(INK4a) overexpression were observed simultaneously. Data analyses included algorithms allocating multiple infections to calculate type-specific contribution and logistic regression models to estimate adjusted prevalence (AP) and its 95% confidence intervals (CI). RESULTS Of 2296 cases, 587 were VIN and 1709 IVC. HPV-DNA was detected in 86.7% and 28.6% of the cases respectively. Amongst IVC cases, 25.1% were both HPV-DNA and p16(INK4a) positive. IVC cases were largely keratinising squamous cell carcinoma (KSCC) (N=1234). Overall prevalence of HPV related IVC cases was highest in younger women for any histological subtype. SCC with warty or basaloid features (SCC_WB) (N=326) were more likely to be HPV and p16(INK4a) positive (AP=69.5%, CI=63.6-74.8) versus KSCC (AP=11.5%, CI=9.7-13.5). HPV 16 was the commonest type (72.5%) followed by HPV 33 (6.5%) and HPV 18 (4.6%). Enrichment from VIN to IVC was significantly high for HPV 45 (8.5-fold). CONCLUSION Combined data from HPV-DNA and p16(INK4a) testing are likely to represent a closer estimate of the real fraction of IVC induced by HPV. Our results indicate that HPV contribution in invasive vulvar cancer has probably been overestimated. HPV 16 remains the major player worldwide.
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A review of human carcinogens—Part B: biological agents
Bouvard, V., Baan, R., Straif, K., Grosse, Y., Secretan, B., Ghissassi, F. E., Benbrahim-Tallaa, L., Guha, N., Freeman, C., Galichet, L., et al. (2009) · The Lancet Oncology · doi:10.1016/s1470-2045(09)70096-8 · Cited by 2,935
de Sanjose, S., Quint, W. G., Alemany, L., Geraets, D. T., Klaustermeier, J. E., Lloveras, B., Tous, S., Felix, A., Bravo, L. E., Shin, H.-R., et al. (2010) · The Lancet Oncology · doi:10.1016/s1470-2045(10)70230-8 · Cited by 2,728
Self-citationGuan, P., Howell‐Jones, R., Li, N., Bruni, L., de Sanjosé, S., Franceschi, S., & Clifford, G. M. (2012) · International Journal of Cancer · doi:10.1002/ijc.27485 · Cited by 927
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Parkin, D. M., Hämmerl, L., Ferlay, J., & Kantelhardt, E. J. (2020) · International Journal of Cancer · doi:10.1002/ijc.32538 · Cited by 130
Maternal HPV Infection and the Estimated Risks for Adverse Pregnancy Outcomes—A Systematic Review
Popescu, S. D., Boiangiu, A. G., Sima, R.-M., Bilteanu, L., Vladareanu, S., & Vladareanu, R. (2022) · Diagnostics · doi:10.3390/diagnostics12061471 · Cited by 17
Metadata
- Authors
- de Sanjosé, S., Alemany, L., Ordi, J., Tous, S., Alejo, M., Bigby, S. M., Joura, E. A., Maldonado, P., Laco, J., Bravo, I. G., Vidal, A., Guimerà, N., Cross, P., Wain, G. V., Petry, K. U., Mariani, L., Bergeron, C., Mandys, V., Sica, A. R., Félix, A., Usubutun, A., Seoud, M., Hernández-Suárez, G., Nowakowski, A. M., Wilson, G., Dalstein, V., Hampl, M., Kasamatsu, E. S., Lombardi, L. E., Tinoco, L., Alvarado-Cabrero, I., Perrotta, M., Bhatla, N., Agorastos, T., Lynch, C. F., Goodman, M. T., Shin, H.-R., Viarheichyk, H., Jach, R., Cruz, M. O. L. E., Velasco, J., Molina, C., Bornstein, J., Ferrera, A., Domingo, E. J., Chou, C.-Y., Banjo, A. F., Castellsagué, X., Pawlita, M., Lloveras, B., Quint, W. G. V., Muñoz, N., & Bosch, F. X.
- Venue
- European Journal of Cancer
- Publisher
- Elsevier BV
- Published
- 2013-11
- Volume
- 49
- Issue
- 16
- Pages
- 3450-3461
- ISSN
- 0959-8049 (ISSN-L)
- OpenAlex
- W2049108277
- Cited by
- 394
- References
- 3
- FWCI
- 21.84
- Type
- journal article
- Language
- en
- Open access
- green
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- The paper
- de Sanjosé, S., Alemany, L., Ordi, J., Tous, S., Alejo, M., Bigby, S. M., Joura, E. A., Maldonado, P., Laco, J., Bravo, I. G., Vidal, A., Guimerà, N., Cross, P., Wain, G. V., Petry, K. U., Mariani, L., Bergeron, C., Mandys, V., Sica, A. R., . . . Bosch, F. X. (2013). Worldwide human papillomavirus genotype attribution in over 2000 cases of intraepithelial and invasive lesions of the vulva. European Journal of Cancer. https://doi.org/10.1016/j.ejca.2013.06.033
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