Tea catechins improve left ventricular dysfunction, suppress myocardial inflammation and fibrosis, and alter cytokine expression in rat autoimmune myocarditis

Recommendations regarding quantitation in M-mode echocardiography: results of a survey of echocardiographic measurements.

Sahn, D. J., DeMaria, A. N., KISSLO, J. A., & Weyman, A. E. (1978) · Circulation · doi:10.1161/01.cir.58.6.1072 · Cited by 7,430 · see citing works

Dietary Intake and Bioavailability of Polyphenols

Scalbert, A., & Williamson, G. (2000) · The Journal of Nutrition · doi:10.1093/jn/130.8.2073s · Cited by 3,658 · see citing works

I<scp>NHIBITION OF</scp> C<scp>ARCINOGENESIS BY</scp> D<scp>IETARY</scp> P<scp>OLYPHENOLIC</scp> C<scp>OMPOUNDS</scp>

Yang, C. S., Landau, J. M., Huang, M.-T., & Newmark, H. L. (2001) · Annual Review of Nutrition · doi:10.1146/annurev.nutr.21.1.381 · Cited by 1,260 · see citing works

Why drinking green tea could prevent cancer

Jankun, J., Selman, S. H., Swiercz, R., & Skrzypczak‐Jankun, E. (1997) · Nature · doi:10.1038/42381 · Cited by 720 · see citing works

Antiviral effect of catechins in green tea on influenza virus

Song, J. M., Lee, K. H., & Seong, B. L. (2005) · Antiviral Research · doi:10.1016/j.antiviral.2005.06.010 · Cited by 655 · see citing works

(-)-Epigallocatechin-3-gallate blocks the induction of nitric oxide synthase by down-regulating lipopolysaccharide-induced activity of transcription factor nuclear factor-kappaB.

Lin, Y., & Lin, J. (1997) · PubMed · Cited by 539 · see citing works

Endothelial nuclear factor-kappa B and the initiation of the atherosclerotic lesion.

Collins, T. (1993) · PubMed · Cited by 526 · see citing works

Interferon-β Treatment Eliminates Cardiotropic Viruses and Improves Left Ventricular Function in Patients With Myocardial Persistence of Viral Genomes and Left Ventricular Dysfunction

Kühl, U., Pauschinger, M., Schwimmbeck, P. L., Seeberg, B., Lober, C., Noutsias, M., Poller, W. C., & Schultheiß, H. (2003) · Circulation · doi:10.1161/01.cir.0000072766.67150.51 · Cited by 499 · see citing works

Advances in the Understanding of Myocarditis

Liu, P. P., & Mason, J. W. (2001) · Circulation · doi:10.1161/hc3401.095198 · Cited by 496 · see citing works

(−)-Epigallocatechin-3-gallate Blocks the Induction of Nitric Oxide Synthase by Down-Regulating Lipopolysaccharide-Induced Activity of Transcription Factor Nuclear Factor-κB

Lin, Y., & Lin, J. (1997) · Molecular Pharmacology · doi:10.1124/mol.52.3.465 · Cited by 463 · see citing works

Immunosuppressive Therapy for Active Lymphocytic Myocarditis: Virological and Immunologic Profile of Responders Versus Nonresponders

Frustaci, A., Chimenti, C., Calabrese, F., Pieroni, M., Thiene, G., & Maseri, A. (2003) · Circulation · doi:10.1161/01.cir.0000048147.15962.31 · Cited by 462 · see citing works

Randomized, Placebo-Controlled Study for Immunosuppressive Treatment of Inflammatory Dilated Cardiomyopathy

Wojnicz, R., Nowalany-Kozielska, E., Wojciechowska, C., Glanowska, G., Wilczewski, P., Niklewski, T., Zembala, M., Poloński, L., Rozek, M. M., & Wodniecki, J. (2001) · Circulation · doi:10.1161/01.cir.104.1.39 · Cited by 455 · see citing works

Serial echocardiographic assessment of left ventricular geometry and function after large myocardial infarction in the rat.

Litwin, S. E., Katz, S. E., Morgan, J. P., & Douglas, P. S. (1994) · Circulation · doi:10.1161/01.cir.89.1.345 · Cited by 420 · see citing works

Cancer chemopreventive activity and bioavailability of tea and tea polyphenols

Lambert, J. D., & Yang, C. S. (2003) · Mutation research. Fundamental and molecular mechanisms of mutagenesis · doi:10.1016/s0027-5107(02)00336-6 · Cited by 342 · see citing works

Neutrophil Restraint by Green Tea: Inhibition of Inflammation, Associated Angiogenesis, and Pulmonary Fibrosis

Donà, M., Dell’Aica, I., Calabrese, F., Benelli, R., Morini, M., Albini, A., & Garbisa, S. (2003) · The Journal of Immunology · doi:10.4049/jimmunol.170.8.4335 · Cited by 334 · see citing works

A novel experimental model of giant cell myocarditis induced in rats by immunization with cardiac myosin fraction

Kodama, M., Matsumoto, Y., Fujiwara, M., Masani, F., Izumi, T., & Shibata, A. (1990) · Clinical Immunology and Immunopathology · doi:10.1016/0090-1229(90)90039-s · Cited by 330 · see citing works

Cancer chemoprevention by tea polyphenols through mitotic signal transduction blockade

Lin, J.-K., Liang, Y., & Lin‐Shiau, S. (1999) · Biochemical Pharmacology · doi:10.1016/s0006-2952(99)00112-4 · Cited by 324 · see citing works

Effect of tea flavonoid supplementation on the susceptibility of low-density lipoprotein to oxidative modification

Ishikawa, T., Suzukawa, M., Ito, T., Yoshida, H., Ayaori, M., Nishiwaki, M., Yonemura, A., Hara, Y., & Nakamura, H. (1997) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/66.2.261 · Cited by 296 · see citing works

Pomegranate juice flavonoids inhibit low-density lipoprotein oxidation and cardiovascular diseases: studies in atherosclerotic mice and in humans.

Aviram, M., Dornfeld, L., Kaplan, M., Coleman, R., Gaitini, D. E., Nitecki, S. S., Hofman, A., Rosenblat, M., Volkova, N., Presser, D., et al. (2002) · PubMed · Cited by 268 · see citing works

Parvovirus B19 Infection Mimicking Acute Myocardial Infarction

Kühl, U., Pauschinger, M., Bock, C. –., Klingel, K., Schwimmbeck, C. P. L., Seeberg, B., Krautwurm, L., Poller, W. C., Schultheiß, H., & Kandolf, R. (2003) · Circulation · doi:10.1161/01.cir.0000085168.02782.2c · Cited by 256 · see citing works

Inhibition of adenovirus infection and adenain by green tea catechins

WEBER, J. M., Ruzindana-Umunyana, A., Imbeault, L., & Sircar, S. (2003) · Antiviral Research · doi:10.1016/s0166-3542(02)00212-7 · Cited by 225 · see citing works

High incidence of myocarditis by endomyocardial biopsy in patients with idiopathic congestive cardiomyopathy

Zee-Cheng, C.-S., Tsai, C. C., Palmer, D. C., Codd, J. E., Pennington, D. G., & Williams, G. A. (1984) · Journal of the American College of Cardiology · doi:10.1016/s0735-1097(84)80431-3 · Cited by 205 · see citing works

The results of transvenous endomyocardial biopsy can frequently be used to diagnose myocardial diseases in patients with idiopathic heart failure. Endomyocardial biopsies in 100 consecutive patients revealed a substantial incidence of myocarditis.

Parrillo, J. E., Aretz, H. T., Palacios, I. F., Fallon, J. T., & Block, P. C. (1984) · Circulation · doi:10.1161/01.cir.69.1.93 · Cited by 156 · see citing works

Anti-Invasive Effects of Green Tea Polyphenol EpiGalloCatechin-3-Gallate (EGCG), a Natural Inhibitor of Metallo and Serine Proteases

Benelli, R., Venè, R., Bisacchi, D., Garbisa, S., & Albini, A. (2002) · Biological Chemistry · doi:10.1515/bc.2002.010 · Cited by 112 · see citing works

Lifestyle, health and disease prevention: the underlying mechanisms.

Jh, W. (2002) · PubMed · Cited by 86 · see citing works

Analysis of Tea Polyphenols

Beecher, G. R., Warden, B. A., & Merken, H. M. (1999) · Proceedings of The Society for Experimental Biology and Medicine · doi:10.1046/j.1525-1373.1999.d01-47.x · Cited by 76 · see citing works

cis Element Decoy Against Nuclear Factor-κB Attenuates Development of Experimental Autoimmune Myocarditis in Rats

Yokoseki, O., Suzuki, J., Kitabayashi, H., Watanabe, N., Wada, Y., Aoki, M., Morishita, R., Kaneda, Y., Ogihara, T., Futamatsu, H., et al. (2001) · Circulation Research · doi:10.1161/hh2201.099373 · Cited by 75 · see citing works

Viral myocarditis: balance between viral infection and immune response.

Liu, P., Martino, T. A., Opavsky, M. A., & Penninger, J. M. (1996) · PubMed · Cited by 72 · see citing works

Myocarditis, pericarditis and other pericardial diseases

Oakley, C. M. (2000) · Heart · doi:10.1136/heart.84.4.449 · Cited by 71 · see citing works

FTY720 Prevents Development of Experimental Autoimmune Myocarditis Through Reduction of Circulating Lymphocytes

Kitabayashi, H., Isobe, M., Watanabe, N., Suzuki, J., Yazaki, Y., & Sekiguchi, M. (2000) · Journal of Cardiovascular Pharmacology · doi:10.1097/00005344-200003000-00010 · Cited by 66 · see citing works

Successful TCR-Based Immunotherapy for Autoimmune Myocarditis with DNA Vaccines After Rapid Identification of Pathogenic TCR

Matsumoto, Y., Jee, Y., & Sugisaki, M. (2000) · The Journal of Immunology · doi:10.4049/jimmunol.164.4.2248 · Cited by 62 · see citing works

Attenuation of experimental autoimmune myocarditis by blocking activated T cells through inducible costimulatory molecule pathway

Futamatsu, H. (2003) · Cardiovascular Research · doi:10.1016/s0008-6363(03)00334-1 · Cited by 54 · see citing works

Acute myocarditis

Batra, A. S., & Lewis, A. B. (2001) · Current Opinion in Pediatrics · doi:10.1097/00008480-200106000-00004 · Cited by 53 · see citing works

Green tea polyphenols inhibit human vascular smooth muscle cell proliferation stimulated by native low-density lipoprotein

Locher, R., Emmanuele, L., Suter, P. M., Vetter, W., & Barton, M. (2002) · European Journal of Pharmacology · doi:10.1016/s0014-2999(01)01535-7 · Cited by 50 · see citing works

Vegetables, fruits, fibre and colorectal cancer

Hill, M. J. (2002) · European Journal of Cancer Prevention · doi:10.1097/00008469-200202000-00001 · Cited by 47 · see citing works

Tumor Necrosis Factor Receptor ‐1 and ‐2 Double Deficiency Reduces Graft Arterial Disease in Murine Cardiac Allografts

Suzuki, J., Cole, S., Batırel, S., Kosuge, H., Shimizu, K., Isobe, M., Libby, P., & Mitchell, R. N. (2003) · American Journal of Transplantation · doi:10.1034/j.1600-6143.2003.00164.x · Cited by 46 · see citing works

Effects of In Vivo Administration of Anti–B7-1/B7-2 Monoclonal Antibodies on Murine Acute Myocarditis Caused by Coxsackievirus B3

Seko, Y., Takahashi, N., Azuma, M., Yagita∥, H., Okumura, K., & Yazaki, Y. (1998) · Circulation Research · doi:10.1161/01.res.82.5.613 · Cited by 38 · see citing works

Etiology, Evaluation, and Management of Acute Myocarditis

Haas, G. J. (2001) · Cardiology in Review · doi:10.1097/00045415-200103000-00007 · Cited by 37 · see citing works

Tea catechins attenuate ventricular remodeling and graft arterial diseases in murine cardiac allografts

SUZUKI, J., OGAWA, M., Sagesaka, Y. M., & ISOBE, M. (2005) · Cardiovascular Research · doi:10.1016/j.cardiores.2005.07.009 · Cited by 35 · see citing works

Effects of Green Tea Catechins (Polyphenon 100) on Cerulein-Induced Acute Pancreatitis in Rats

Takabayashi, F., & Harada, N. (1997) · Pancreas · doi:10.1097/00006676-199704000-00009 · Cited by 32 · see citing works

Experimental Autoimmune Myocarditis

Kodama, M., & Izumi, T. (1991) · Institutional Repositories DataBase (IRDB) · Cited by 18 · see citing works

Carvedilol Inhibits Platelet-Derived Growth Factor-Induced Signal Transduction in Human Cardiac Fibroblasts

Lotze, U., Heinke, S., Fritzenwanger, M., Krack, A., Müller, S., & Figulla, H. R. (2002) · Journal of Cardiovascular Pharmacology · doi:10.1097/00005344-200204000-00014 · Cited by 12 · see citing works

The Role of Catechins in Cellular Responses to Oxidative Stress

Bernatonienė, J., & Kopustinskienė, D. M. (2018) · Molecules · doi:10.3390/molecules23040965 · Cited by 704 · see citing works

Modifications of dietary flavonoids towards improved bioactivity: An update on structure–activity relationship

Chen, L., Teng, H., Xie, Z., Cao, H., Cheang, W. S., Skalicka‐Woźniak, K., Georgiev, M. I., & Xiao, J. (2016) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2016.1196334 · Cited by 291 · see citing works

Mediterranean Diet as an Antioxidant: The Impact on Metabolic Health and Overall Wellbeing

Gantenbein, K. V., & Kanaka-Gantenbein, C. (2021) · Nutrients · doi:10.3390/nu13061951 · Cited by 288 · see citing works

Phytochemicals and their impact on adipose tissue inflammation and diabetes

Leiherer, A., Muendlein, A., & Drexel, H. (2012) · Vascular Pharmacology · doi:10.1016/j.vph.2012.09.002 · Cited by 169 · see citing works

Chlorpyrifos induced hepatotoxic and hematologic changes in rats: The role of quercetin and catechin

Uzun, F. G., & Kalender, Y. (2013) · Food and Chemical Toxicology · doi:10.1016/j.fct.2013.01.056 · Cited by 155 · see citing works

Catechin protects against oxidative stress and inflammatory-mediated cardiotoxicity in adriamycin-treated rats

El-Aziz, T. A. A., Mohamed, R. H., Pasha, H. F., & Abdel-Aziz, H. R. (2011) · Clinical and Experimental Medicine · doi:10.1007/s10238-011-0165-2 · Cited by 132 · see citing works

Green tea catechins: defensive role in cardiovascular disorders

Bhardwaj, P., & Khanna, D. (2013) · Chinese Journal of Natural Medicines · doi:10.1016/s1875-5364(13)60051-5 · Cited by 118 · see citing works

Modulation of Hypercholesterolemia‐Induced Oxidative/Nitrative Stress in the Heart

Csonka, C., Sárközy, M., Pipicz, M., László, A., & Csont, T. (2015) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2016/3863726 · Cited by 121 · see citing works

Green Tea Polyphenols and Metabolites in Prostatectomy Tissue: Implications for Cancer Prevention

Wang, P., Aronson, W. J., Huang, M., Zhang, Y., Lee, R., Heber, D., & Henning, S. M. (2010) · Cancer Prevention Research · doi:10.1158/1940-6207.capr-09-0210 · Cited by 101 · see citing works

Flavonoids: Potential therapeutic agents for cardiovascular disease

Liu, Y., Luo, J., Peng, L., Zhang, Q., Rong, X., Luo, Y., & Li, J. (2024) · Heliyon · doi:10.1016/j.heliyon.2024.e32563 · Cited by 82 · see citing works

Novel IκB kinase inhibitors for treatment of nuclear factor-κB-related diseases

Suzuki, J., Ogawa, M., Muto, S., Itai, A., Isobe, M., Hirata, Y., & Nagai, R. (2011) · Expert Opinion on Investigational Drugs · doi:10.1517/13543784.2011.559162 · Cited by 69 · see citing works

Anti-inflammatory and anti-arthritic activity of a methanol extract from Vitellaria paradoxa stem bark

Foyet, H. S., Tsala, D. E., Bodo, J. Z. E., Carine, A., Heroyne, L., & Oben, E. (2015) · Pharmacognosy Research · doi:10.4103/0974-8490.159569 · Cited by 65 · see citing works

Green tea and cardiovascular disease: from molecular targets towards human health

Jochmann, N., Baumann, G., & Stangl, V. (2008) · Current Opinion in Clinical Nutrition & Metabolic Care · doi:10.1097/mco.0b013e328314b68b · Cited by 60 · see citing works

Suppression of Inflammation in Rat Autoimmune Myocarditis by S100A8/A9 Through Modulation of the Proinflammatory Cytokine Network

Otsuka, K., Terasaki, F., Ikemoto, M., Fujita, S., Tsukada, B., Katashima, T., Kanzaki, Y., Sohmiya, K., Kono, T., Toko, H., et al. (2009) · European Journal of Heart Failure · doi:10.1093/eurjhf/hfn049 · Cited by 56 · see citing works

Chinese medicinal herb Radix Astragali suppresses cardiac contractile dysfunction and inflammation in a rat model of autoimmune myocarditis

Zhao, P., SU, G., Xiao, X., HAO, E., Zhu, X., & Ren, J. T. (2008) · Toxicology Letters · doi:10.1016/j.toxlet.2008.08.002 · Cited by 55 · see citing works

Natural products with anti-inflammatory and immunomodulatory activities against autoimmune myocarditis

Javadi, B., & Sahebkar, A. (2017) · Pharmacological Research · doi:10.1016/j.phrs.2017.07.022 · Cited by 54 · see citing works

P2X7 Receptor–Mediated Inflammation in Cardiovascular Disease

Zhou, J., Zhou, Z., Liu, X., Yin, H., Tang, Y., & Cao, X. (2021) · Frontiers in Pharmacology · doi:10.3389/fphar.2021.654425 · Cited by 53 · see citing works

Therapeutic Potential of Polyphenols in Cardiac Fibrosis

Zhang, N., Wei, W., Li, L., Hu, C., & Tang, Q. (2018) · Frontiers in Pharmacology · doi:10.3389/fphar.2018.00122 · Cited by 52 · see citing works

Anti-allergic activity of standardized extract ofAlbizia lebbeckwith reference to catechin as a phytomarker

Venkatesh, P., Mukherjee, P. K., Satheeshkumar, N., Bandyopadhyay, A., Fukui, H., Mizuguchi, H., & Islam, N. (2010) · Immunopharmacology and Immunotoxicology · doi:10.3109/08923970903305481 · Cited by 51 · see citing works

The P2X7 purinergic receptor: An emerging therapeutic target in cardiovascular diseases

Chen, Z., He, L., Li, L., & Chen, L. (2018) · Clinica Chimica Acta · doi:10.1016/j.cca.2018.01.032 · Cited by 50 · see citing works

Oxidative stress and myocarditis

Tada, Y., & Suzuki, J. (2016) · Current Pharmaceutical Design · doi:10.2174/1381612822666151222160559 · Cited by 52 · see citing works

Flavonoids for gastrointestinal tract local and associated systemic effects: A review of clinical trials and future perspectives

Li, X., Xie, E., Sun, S., Shen, J., Ding, Y., Wang, J., Peng, X., Zheng, R., Farag, M. A. F., & Xiao, J. (2025) · Journal of Advanced Research · doi:10.1016/j.jare.2025.01.014 · Cited by 46 · see citing works

Myeloid differentiation factor-88 contributes to TLR9-mediated modulation of acute coxsackievirus B3-induced myocarditis in vivo

Riad, A., Westermann, D., Escher, F., Becher, P. M., Savvatis, K., Lettau, O., Heimesaat, M. M., Bereswill, S., Volk, H., Schultheiß, H., et al. (2010) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.01188.2009 · Cited by 44 · see citing works

Determination of phenolic profile by HPLC-ESI-MS/MS and anti-inflammatory activity of crude hydroalcoholic extract and ethyl acetate fraction from leaves of Eugenia brasiliensis

Siebert, D. A., Bastos, J., Spudeit, D. A., Micke, G. A., & Alberton, M. D. (2017) · Revista Brasileira de Farmacognosia · doi:10.1016/j.bjp.2017.01.008 · Cited by 40 · see citing works

Tea Polyphenols Regulate Key Mediators on Inflammatory Cardiovascular Diseases

Suzuki, J., Isobe, M., Morishita, R., & Nagai, R. (2009) · Mediators of Inflammation · doi:10.1155/2009/494928 · Cited by 38 · see citing works

Tea catechins attenuate chronic ventricular remodeling after myocardial ischemia in rats

Suzuki, J.-I., Ogawa, M., Maejima, Y., Isobe, K., Tanaka, H., Sagesaka, Y. M., & Isobe, M. (2007) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2006.10.006 · Cited by 37 · see citing works

Catechin Attenuates Coronary Heart Disease in a Rat Model by Inhibiting Inflammation

Tu, S., Xiao, F., Min, X., Chen, H., Fan, X., & Cao, K. (2018) · Cardiovascular Toxicology · doi:10.1007/s12012-018-9449-z · Cited by 32 · see citing works

Chinese herbal medicine for the treatment of cardiovascular diseases ─ targeting cardiac ion channels.

Yan, Z., Zhong, L., Zhu, W.-D., Chung, S., & Hou, P.-P. (2023) · Pharmacological Research · doi:10.1016/j.phrs.2023.106765 · Cited by 23 · see citing works

Effects of Isorhamnetin in Human Amniotic Epithelial Stem Cells in vitro and Its Cardioprotective Effects in vivo

Aonuma, K., Ferdousi, F., Xu, D., Tominaga, K., & Isoda, H. (2020) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2020.578197 · Cited by 27 · see citing works

Effects of catechins on litter size, reproductive performance and antioxidative status in gestating sows

Fan, Z., Xiao, Y., Chen, Y., Wu, X., Zhang, G., Wang, Q., & Xie, C. (2015) · Animal nutrition · doi:10.1016/j.aninu.2015.11.002 · Cited by 27 · see citing works

Oleuropein prevents the development of experimental autoimmune myocarditis in rats

Zhang, J., Yang, Z., Fang, K., Shi, Z.-L., Ren, D., & Sun, J. (2017) · International Immunopharmacology · doi:10.1016/j.intimp.2017.05.013 · Cited by 27 · see citing works

Green tea extract protects rats against myocardial infarction associated with left anterior descending coronary artery ligation

Hsieh, S., Tsai, D.-C., Chen, J., Tsai, S., & Liou, Y. (2009) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/s00424-009-0655-1 · Cited by 25 · see citing works

Angiotensin II receptor blocker irbesartan attenuates cardiac dysfunction induced by myocardial infarction in the presence of renal failure

Watanabe, R., Suzuki, J.-I., Wakayama, K., Kumagai, H., Ikeda, Y., Akazawa, H., Komuro, I., & Isobe, M. (2015) · Hypertension Research · doi:10.1038/hr.2015.141 · Cited by 25 · see citing works

Green tea polyphenols in cardiometabolic health: A critical appraisal on phytogenomics towards personalized green tea

Logesh, R., Radhakrishnan, A., Alagarsamy, K. N., Srivastava, A., Dhingra, S., Booker, A., Rolfe, V., Palaniswamy, D. S., & Mohankumar, S. K. (2022) · PharmaNutrition · doi:10.1016/j.phanu.2022.100296 · Cited by 24 · see citing works

A P2X7 receptor antagonist attenuates experimental autoimmune myocarditis via suppressed myocardial CD4+ T and macrophage infiltration and NADPH oxidase 2/4 expression in mice

Zempo, H., Sugita, Y., Ogawa, M., Watanabe, R., Suzuki, J., & Isobe, M. (2014) · Heart and Vessels · doi:10.1007/s00380-014-0527-2 · Cited by 24 · see citing works

Epigallocatechin-Gallate (EGCG): An Essential Molecule for Human Health and Well-Being

Rovaldi, E., Donato, V. D., Paolino, G., Bruno, M., Medei, A., Nisticò, S. P., Pellacani, G., Kiss, N., Azzella, G., Bánvölgyi, A., et al. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26189253 · Cited by 27 · see citing works

Autoimmune giant cell myocarditis – clinical characteristics, experimental models and future treatments

Suzuki, J., Ogawa, M., Watanabe, R., Morishita, R., Hirata, Y., Nagai, R., & Isobe, M. (2011) · Expert Opinion on Therapeutic Targets · doi:10.1517/14728222.2011.601294 · Cited by 22 · see citing works

Inhibition of NF-κB activation by a novel IKK inhibitor reduces the severity of experimental autoimmune myocarditis via suppression of T-cell activation

Watanabe, R., Azuma, R. W., Suzuki, J., Ogawa, M., Itai, A., Hirata, Y., Komuro, I., & Isobe, M. (2013) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00159.2013 · Cited by 22 · see citing works

Oligomeric proanthocyanidins protect myocardium by mitigating left ventricular remodeling in isoproterenol‐induced postmyocardial infarction

Ashokkumar, R., Jamuna, S., Sadullah, S. S. M., & Devaraj, S. N. (2017) · Fundamental and Clinical Pharmacology · doi:10.1111/fcp.12325 · Cited by 22 · see citing works

Positive Inotropic Effects of Epigallocatechin-3-Gallate (EGCG) Involve Activation of Na+/H+ and Na+/Ca2+ Exchangers

Lorenz, M., Hellige, N., Rieder, P., Kinkel, H.-T., Trimpert, C., Staudt, A., Felix, S. B., Baumann, G., Stangl, K., & Stangl, V. (2008) · European Journal of Heart Failure · doi:10.1016/j.ejheart.2008.03.004 · Cited by 22 · see citing works

Melissa officinalis L. Supplementation Provides Cardioprotection in a Rat Model of Experimental Autoimmune Myocarditis

Draginic, N. D., Jakovljevic, V. L., Jeremic, J. N., Srejovic, I. M., Andjic, M. M., Rankovic, M. R., Sretenovic, J. Z., Zivkovic, V. I., Ljujić, B., Mitrović, S., et al. (2022) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2022/1344946 · Cited by 21 · see citing works

The Anti-Inflammatory Mechanism of Prostaglandin E2 Receptor 4 Activation in Rat Experimental Autoimmune Myocarditis

Ngoc, P. B., Suzuki, J., Ogawa, M., Hishikari, K., Takayama, K., Hirata, Y., Nagai, R., & Isobe, M. (2011) · Journal of Cardiovascular Pharmacology · doi:10.1097/fjc.0b013e31820b7be1 · Cited by 21 · see citing works

Early treatment with clarithromycin attenuates rat autoimmune myocarditis via inhibition of matrix metalloproteinase activity

Hishikari, K., Watanabe, R., Ogawa, M., Suzuki, J.-I., Masumura, M., Shimizu, T., Takayama, K., Hirata, Y., Nagai, R., & Isobe, M. (2010) · Heart · doi:10.1136/hrt.2009.188094 · Cited by 21 · see citing works

Advances in the Anti-Atherosclerotic Mechanisms of Epigallocatechin Gallate

Liu, Y., Long, Y., Fang, J. Q., & Liu, G. (2024) · Nutrients · doi:10.3390/nu16132074 · Cited by 20 · see citing works

Epigallocatechin-3-gallate modulates arrhythmogenic activity and calcium homeostasis of left atrium

Chang, J.-H., Chang, S., Hong, P., Chen, P.-N., Hsu, C.-H., Lu, Y., & Chen, Y. (2017) · International Journal of Cardiology · doi:10.1016/j.ijcard.2017.01.090 · Cited by 20 · see citing works

Cyclodextrin-Based Delivery Systems for Flavonoids: Mechanisms, Advances, Formulation, and Application Opportunities

Fenyvesi, F., Klusóczki, Á., Rusznyák, Á., Zsebik, B., Bácskay, I., & Váradi, J. (2025) · Antioxidants · doi:10.3390/antiox14080998 · Cited by 18 · see citing works

Structure – Activity Relationship and Therapeutic Benefits of Flavonoids in the Management of Diabetes and Associated Disorders

Lodhi, S., & Kori, M. L. (2021) · Pharmaceutical Chemistry Journal · doi:10.1007/s11094-021-02329-9 · Cited by 20 · see citing works

A specific inhibitor of plasminogen activator inhibitor-1 suppresses rat autoimmune myocarditis

Suzuki, J., Ogawa, M., Muto, S., Itai, A., & Isobe, M. (2008) · Expert Opinion on Therapeutic Targets · doi:10.1517/14728222.12.11.1313 · Cited by 14 · see citing works

Fragmented QRS Is Predictive of Myocardial Dysfunction, Pulmonary Hypertension and Severity in Mitral Stenosis

Yüce, M., Davutoğlu, V., Ozbala, B., Ercan, S., Kızılkan, N., Akçay, M., Sarı, İ., Akkoyun, Ç., Doğan, A., Alıcı, M. H., et al. (2010) · The Tohoku Journal of Experimental Medicine · doi:10.1620/tjem.220.279 · Cited by 14 · see citing works

Effect of interleukin-15 on the course of myocarditis in Coxsackievirus B3-infected BALB/c mice

Bigalke, B., Schwimmbeck, P. L., Haas, C. S., & Lindemann, S. (2009) · Canadian Journal of Cardiology · doi:10.1016/s0828-282x(09)70511-2 · Cited by 13 · see citing works

A critical role of sympathetic nerve regulation for the treatment of impaired daily rhythm in hypertensive Dahl rats

Suzuki, J., Ogawa, M., Tamura, N., Maejima, Y., Takayama, K., Maemura, K., Honda, K., Hirata, Y., Nagai, R., & Isobe, M. (2010) · Hypertension Research · doi:10.1038/hr.2010.125 · Cited by 12 · see citing works

Cardioprotective effects of omega 3 fatty acids from fish oil and it enhances autoimmunity in porcine cardiac myosin-induced myocarditis in the rat model

Li, L., Wang, X., Zhang, T.-C., Liu, Z., & Gao, J. (2021) · Zeitschrift für Naturforschung C · doi:10.1515/znc-2021-0057 · Cited by 11 · see citing works

Epigallocatechin-3-Gallate Inhibits Atrial Fibrosis and Reduces the Occurrence and Maintenance of Atrial Fibrillation and its Possible Mechanisms

Li, T., Tong, Q., Wang, Z., Yang, Z., Sun, Y., Cai, J., Xu, Q., Lu, Y., Liu, X., Lin, K., et al. (2023) · Cardiovascular Drugs and Therapy · doi:10.1007/s10557-023-07447-y · Cited by 10 · see citing works

Novel Effects of Macrolide Antibiotics on Cardiovascular Diseases

Suzuki, J., Ogawa, M., Hishikari, K., Watanabe, R., Takayama, K., Hirata, Y., Nagai, R., & Isobe, M. (2011) · Cardiovascular Therapeutics · doi:10.1111/j.1755-5922.2011.00303.x · Cited by 10 · see citing works

Cacao polyphenols ameliorate autoimmune myocarditis in mice

Zempo, H., Suzuki, J.-I., Watanabe, R., Wakayama, K., Kumagai, H., Ikeda, Y., Akazawa, H., Komuro, I., & Isobe, M. (2015) · Hypertension Research · doi:10.1038/hr.2015.136 · Cited by 10 · see citing works

Antihypertensive effects of the combined extract of Sorghum bicolor, Vigna angularis, and Eleusine coracana in spontaneously hypertensive rats

Jeong, E., Yun, D., Baek, Y., Kim, H., & Lee, H. G. (2024) · Scientific Reports · doi:10.1038/s41598-024-51364-5 · Cited by 7 · see citing works

Influence of periostin-positive cell-specific Klf5 deletion on aortic thickening in DOCA-salt hypertensive mice

Zempo, H., Suzuki, J.-I., Ogawa, M., Watanabe, R., Fujiu, K., Manabe, I., Conway, S. J., Taniyama, Y., Morishita, R., Hirata, Y., et al. (2016) · Hypertension Research · doi:10.1038/hr.2016.65 · Cited by 7 · see citing works

Potential Therapeutic Effects of Flavonoids in Cardiovascular Disorders: Review

Singh, S. K., Ahuja, A., & Varshney, M. (2025) · Current Hypertension Reviews · doi:10.2174/0115734021373759250730062326 · Cited by 7 · see citing works

INHIBITION OF LEFT VENTRICULAR REMODELLING IN SPONTANEOUSLY HYPERTENSIVE RATS by Gαq‐PROTEIN CARBOXYL TERMINUS IMITATION POLYPEPTIDE GCIP‐27 IS NOT ENTIRELY DEPENDENT ON BLOOD PRESSURE

Wang, X., Zhang, H., Cheng, Y., & Li, X. (2008) · Clinical and Experimental Pharmacology and Physiology · doi:10.1111/j.1440-1681.2008.04981.x · Cited by 6 · see citing works

Antioxidant properties and bioactive compounds in rooibos (Aspalathus linearis) and tea (Camellia sinensis) infusions

Płatkiewicz, J., Łapawa, A., Frankowski, R., Grześkowiak, T., Jeszka‐Skowron, M., Werner, J., & Zgoła‐Grześkowiak, A. (2025) · European Food Research and Technology · doi:10.1007/s00217-025-04661-w · Cited by 5 · see citing works

Remodeling of white adipose tissue microenvironment against obesity by phytochemicals

Ke, S., Hu, Q., Zhu, G., Li, L., Sun, X., Cheng, H., Li, L., Yao, Y., & Li, H. (2023) · Phytotherapy Research · doi:10.1002/ptr.7758 · Cited by 5 · see citing works

Natural products with antiinflammatory activities against autoimmune myocarditis

Nair, A., & Gopi, S. (2021) · Elsevier eBooks · doi:10.1016/b978-0-12-819218-4.00002-x · Cited by 4 · see citing works

Attenuation of Some Metabolic Deterioration Induced by Diabetes Mellitus Using Different Jatropha curcas Extracts

Ali, F. F., El‐Baz, F., El-Rahman, A. I. A., Aly, H. F., Mohamed, A. A., & Saad, S. A. (2015) · Cited by 4 · see citing works

Tea catechins as potent antioxidant and anti-inflammatory agents: possibilities of drug development to promote healthy aging

Dubey, P. (2022) · Elsevier eBooks · doi:10.1016/b978-0-323-90581-7.00017-7 · Cited by 4 · see citing works

The effects of catechins on the cardiac mitochondria

Kopustinskienė, D. M., Bernatonienė, J., Jakštas, V., & Morkūnienė, R. (2021) · Elsevier eBooks · doi:10.1016/b978-0-12-821562-3.00012-5 · Cited by 3 · see citing works

Integrated metabolomics and transcriptomics analysis reveals the mechanism of Tangbi capsule for diabetic lower extremities arterial disease

Luo, Y.-H., Wang, D., Yao, J., Hu, Y., Zhao, L., Wen, J., Zhang, J., Wu, L., Fan, G., & Song, W. (2024) · Frontiers in Microbiology · doi:10.3389/fmicb.2024.1423428 · Cited by 3 · see citing works

Biophysical Characterization of Epigallocatechin-3-Gallate Effect on the Cardiac Sodium Channel Nav1.5

Amarouch, M., Kurt, H., Delemotte, L., & Abriel, H. (2020) · Molecules · doi:10.3390/molecules25040902 · Cited by 3 · see citing works

Hydrogen protects against autoimmune myocarditis by inhibiting necroptosis via the TNF/TNFR1 signalling pathway

Pan, S., Yu, M., Fan, B., Wang, B., Yang, X., Zhang, J., Liu, X., Hong, X., & Yang, W. P. (2025) · Clinical Immunology · doi:10.1016/j.clim.2025.110577 · Cited by 2 · see citing works

Antioxidation in Prevention of Cardiovascular Diseases – An Effect of Polyphenols

Suzuki, J., Isobe, M., Morishita, R., & Nagai, R. (2010) · Humana Press eBooks · doi:10.1007/978-1-60761-602-3_14 · Cited by 2 · see citing works

Unravelling Potential Health-Beneficial Properties of Corema album Phenolic Compounds: A Systematic Review

Cerquido, A. S., Vojtek, M., Ribeiro-Oliveira, R., Viegas, O., Sousa, J. B., Ferreira, I. M. P. L. V. O., & Diniz, C. (2022) · Pharmaceuticals · doi:10.3390/ph15101231 · Cited by 2 · see citing works

Prospects and Challenges of Catechins in Cardiovascular Disease

Chen, Y., Ren, Y., Zhou, K., Lei, W., Yang, Y., & Wang, X. (2025) · The AAPS Journal · doi:10.1208/s12248-025-01105-x · Cited by 1 · see citing works

Effect of Tea and Tea Constituents on Inflammation

Ho, C.-T., Lin, J.-K., & Shahidi, F. (2008) · CRC Press eBooks · doi:10.1201/9781420008036-14 · Cited by 1 · see citing works

Mechanisms of Protection of the Brain from Ischemic Injury by Components of Tea

Vlasov, T. D. (2014) · Neuroscience and Behavioral Physiology · doi:10.1007/s11055-014-9922-5 · Cited by 1 · see citing works

Effect of Epigallocatechin Gallate on Markers of Inflammation

Geraldine, P., Elango, R., Theodore, J., Sheu, J., & Thomas, P. A. (2012) · Tea in Health and Disease Prevention · doi:10.1016/b978-0-12-384937-3.00103-8

Effects of Tea Catechins on Cardiac Allografts

Suzuki, J., Ogawa, M., Hirata, Y., Nagai, R., & Isobe, M. (2012) · Tea in Health and Disease Prevention · doi:10.1016/b978-0-12-384937-3.00106-3

Effect of Tea and Tea Constituents on Inflammation

Shahidi, F., Ramji, D., Ho, C., & Huang, M. (2008) · Nutraceutical science and technology · doi:10.1201/9781420008036.ch10

Natural Compounds Targeting Coronary Microvascular Dysfunction: Mechanisms and Beyond

Chen, M., Xiang, X., Yang, X., Fu, Y., Wan, Z., Yang, S., Liu, Q., Luo, G., & Liu, M. (2026) · Drug Design Development and Therapy · doi:10.2147/dddt.s591542 · Cited by 1 · see citing works

Tea catechins suppress ventricular remodeling in inflamed hearts

Suzuki, J., Ogawa, M., & Isobe, M. (2008) · Journal of Cardiac Failure · doi:10.1016/j.cardfail.2008.07.099

Tea catechins attenuate chronic ventricular remodeling after myocardial ischemia in rats

Suzuki, J.-I., Ogawa, M., Maejima, Y., Isobe, K., Tanaka, H., Sagesaka, Y. M., & Isobe, M. (2007) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2006.10.006 · Cited by 37 · see citing works

Regulation of Inflammation and Myocardial Fibrosis in Experimental Autoimmune Myocarditis

Watanabe, K., Sukumaran, V., Veeraveedu, P. T., Thandavarayan, R. A., Gurusamy, N., Ma, M., Arozal, W., Sari, F. R., Lakshmanan, A. P., Arumugam, S., et al. (2011) · Inflammation & Allergy - Drug Targets · doi:10.2174/187152811795564091 · Cited by 37 · see citing works

Empirical study about left ventricular remodeling in postmyocarditis rats

Zhang, Z. (2011) · Journal of Clinical Medicine in Practice

Mast Cell Inhibition Attenuates Myocardial Damage, Adverse Remodeling, and Dysfunction During Fulminant Myocarditis in the Rat

Mina, Y., Rinkevich-Shop, S., Konen, E., Goitein, O., Kushnir, T., Epstein, F. H., Feinberg, M. S., Leor, J., & Landa‐Rouben, N. (2012) · Journal of Cardiovascular Pharmacology and Therapeutics · doi:10.1177/1074248412458975 · Cited by 28 · see citing works