Cited by 37Cardiac Fibrosis and RemodelingTea Polyphenols and EffectsCardiac Ischemia and Reperfusion

Tea catechins attenuate chronic ventricular remodeling after myocardial ischemia in rats

Suzuki, Jun-ichi, Ogawa, Masahito, Maejima, Yasuhiro, Isobe, Kazuya, Tanaka, Hiroyuki, Sagesaka, Yuko M., Isobe, Mitsuaki·2007·Journal of Molecular and Cellular Cardiology

Abstract

Tea catechins have many biological functions; these effects are induced by the suppression of several inflammatory factors. However, the effects of catechins on ventricular remodeling after myocardial ischemia have not been well investigated. To test the hypothesis that catechins can attenuate chronic ventricular remodeling after myocardial ischemia, we performed oral administration of catechins into rat myocardial ischemia models. We analyzed the mechanisms using physiological, pathological and molecular examinations. Although severe myocardial fibrosis with enhancement of inflammatory factors were observed in the non-treated ischemia group on day 28, catechins attenuated these changes with suppressed NF-kappaB and matrix metalloproteinases without systemic adverse effects. Catechins are potent for the suppression of chronic ventricular remodeling after myocardial ischemia because they are critically involved in the suppression of several inflammatory genes.

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Crossref · 10.1016/j.yjmcc.2006.10.006

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Authors
Suzuki, J.-I., Ogawa, M., Maejima, Y., Isobe, K., Tanaka, H., Sagesaka, Y. M., & Isobe, M.
Affiliations
  • Tokyo Medical and Dental University (JP)
  • ITO EN, Ltd. (Japan) (JP)
Corresponding author
Suzuki, Jun-ichi
Venue
Journal of Molecular and Cellular Cardiology
Publisher
Elsevier BV
Published
2007-02
Volume
42
Issue
2
Pages
432-440
ISSN
0022-2828 (ISSN-L)
OpenAlex
W2012051348
Cited by
37
References
52
Citations by year
2025: 1 · 2021: 1 · 2020: 1 · 2018: 2 · 2017: 1 · 2015: 3 · 2013: 4 · 2012: 6
FWCI
2.14
Type
journal article
Language
en
Open access
closed
Locations
  • Journal of Molecular and Cellular Cardiology (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • Japan Cardiovascular Research Foundation
  • Ministry of Education, Culture, Sports, Science and Technology
Topics
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac Fibrosis and Remodeling
  • Health Sciences › Medicine › Pathology and Forensic Medicine › Tea Polyphenols and Effects
  • Health Sciences › Medicine › Pathology and Forensic Medicine › Cardiac Ischemia and Reperfusion
Keywords
tea catechins, ventricular remodeling, myocardial ischemia, myocardial fibrosis, inflammation, NF-κB, matrix metalloproteinases, cardioprotection
MeSH terms
Animals, Catechin, Gene Expression Regulation, Inflammation, Male, Tea, Myocardial Ischemia, Rats, Sprague-Dawley, Inflammation Mediators, Ventricular Remodeling, Rats

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