Tea catechins attenuate chronic ventricular remodeling after myocardial ischemia in rats
Abstract
Tea catechins have many biological functions; these effects are induced by the suppression of several inflammatory factors. However, the effects of catechins on ventricular remodeling after myocardial ischemia have not been well investigated. To test the hypothesis that catechins can attenuate chronic ventricular remodeling after myocardial ischemia, we performed oral administration of catechins into rat myocardial ischemia models. We analyzed the mechanisms using physiological, pathological and molecular examinations. Although severe myocardial fibrosis with enhancement of inflammatory factors were observed in the non-treated ischemia group on day 28, catechins attenuated these changes with suppressed NF-kappaB and matrix metalloproteinases without systemic adverse effects. Catechins are potent for the suppression of chronic ventricular remodeling after myocardial ischemia because they are critically involved in the suppression of several inflammatory genes.
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Catechins protect against remodeling after myocardial infarction by suppressing proinflammatory cytokine secretion.
“According to Suzuki et al., catechins, the phenol component of tea, protect against remodeling after myocardial infarction by suppressing proinflammatory cytokine secretion [65].”
From Mediterranean Diet as an Antioxidant: The Impact on Metabolic Health and Overall Wellbeing (2021) · cites this paper as [65]
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- Authors
- Suzuki, J.-I., Ogawa, M., Maejima, Y., Isobe, K., Tanaka, H., Sagesaka, Y. M., & Isobe, M.
- Affiliations
- Tokyo Medical and Dental University (JP)
- ITO EN, Ltd. (Japan) (JP)
- Corresponding author
- Suzuki, Jun-ichi
- Venue
- Journal of Molecular and Cellular Cardiology
- Publisher
- Elsevier BV
- Published
- 2007-02
- Volume
- 42
- Issue
- 2
- Pages
- 432-440
- ISSN
- 0022-2828 (ISSN-L)
- OpenAlex
- W2012051348
- Cited by
- 37
- References
- 52
- Citations by year
- 2025: 1 · 2021: 1 · 2020: 1 · 2018: 2 · 2017: 1 · 2015: 3 · 2013: 4 · 2012: 6
- FWCI
- 2.14
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- Locations
- Journal of Molecular and Cellular Cardiology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Japan Cardiovascular Research Foundation
- Ministry of Education, Culture, Sports, Science and Technology
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac Fibrosis and Remodeling
- Health Sciences › Medicine › Pathology and Forensic Medicine › Tea Polyphenols and Effects
- Health Sciences › Medicine › Pathology and Forensic Medicine › Cardiac Ischemia and Reperfusion
- Keywords
- tea catechins, ventricular remodeling, myocardial ischemia, myocardial fibrosis, inflammation, NF-κB, matrix metalloproteinases, cardioprotection
- MeSH terms
- Animals, Catechin, Gene Expression Regulation, Inflammation, Male, Tea, Myocardial Ischemia, Rats, Sprague-Dawley, Inflammation Mediators, Ventricular Remodeling, Rats
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