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Red emissive fluorescent carbon dots based on ternary carbon source for imaging α-synuclein fibrils.

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Conjugation of tacrine with genipin derivative not only enhances effects on AChE but also leads to autophagy against Alzheimer’s disease

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Enhanced Recognition Memory through Dual Modulation of Brain Carbonic Anhydrases and Cholinesterases

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Functionalized aromatic esters of the Amaryllidaceae alkaloid haemanthamine and their in vitro and in silico biological activity connected to Alzheimer’s disease

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Extraction, isolation, synthesis, and biological evaluation of novel piperic acid derivatives for the treatment of Alzheimer’s disease

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The Cholinesterase Inhibitory Properties of Stephaniae Tetrandrae Radix

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Huprine Y – Tryptophan heterodimers with potential implication to Alzheimer’s disease treatment

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Novel drug-like fluorenyl derivatives as selective butyrylcholinesterase and β-amyloid inhibitors for the treatment of Alzheimer’s disease

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Recent Advances in Transition Metal Free Synthetic Protocols for Quinoline Derivatives

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Molecular and Computational Analysis Identify Statins as Selective Inhibitors of Human Butyrylcholinesterase

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Azole antifungal compounds could have dual cholinesterase inhibitory potential according to virtual screening, enzyme kinetics, and toxicity studies of an inhouse library

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Novel conjugates of 4-amino-2,3-polymethylenequinolines and vanillin as potential multitarget agents for AD treatment

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Discovery of novel substituted (Z)-N′-hydroxy-3-(3-phenylureido)benzimidamide derivatives as multifunctional molecules targeting pathological hallmarks of Alzheimer's disease

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Discovery of novel thiosemicarbazone-acridine targeting butyrylcholinesterase with antioxidant, metal complexing and neuroprotector abilities as potential treatment of Alzheimer's disease: In vitro, in vivo, and in silico studies

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Fused 1,4‐Dihydropyridines and Their Corresponding Pyridines: Synthesis, Molecular Modeling and Cholinesterase Inhibition

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Recent developments in the synthesis of pyridine analogues as a potent anti-Alzheimer's therapeutic leads

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Potential of nafimidone derivatives against co‐morbidities of epilepsy: In vitro, in vivo, and in silico investigations

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Anticholinesterase and Serotoninergic Evaluation of Benzimidazole–Carboxamides as Potential Multifunctional Agents for the Treatment of Alzheimer’s Disease

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LC-qTOF-MS/MS phytochemical profiling of Tabebuia impetiginosa (Mart. Ex DC.) Standl. leaf and assessment of its neuroprotective potential in rats

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Evaluation of Anticholinesterase Activity of the Fungicides Mefentrifluconazole and Pyraclostrobin

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TMF Attenuates Cognitive Impairment and Neuroinflammation by Inhibiting the MAPK/NF-κB Pathway in Alzheimer’s Disease: A Multi-Omics Analysis

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Synthetic strategies of functionalized pyridines and their therapeutic potential as multifunctional anti-Alzheimer's agents

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New Heterostilbene and Triazole Oximes as Potential CNS-Active and Cholinesterase-Targeted Therapeutics

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Design, synthesis, and biological evaluation of caffeic acid-based novel multifunctional molecules for the management of Alzheimer's disease

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Antifungal Azole Derivatives Featuring Naphthalene Prove Potent and Competitive Cholinesterase Inhibitors with Potential CNS Penetration According to the in Vitro and in Silico Studies

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Discovery of 6,7-dimethoxyquinazoline-hydrazide hybrids as dual inhibitors of acetylcholinesterase and β-secretase

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The role of unsaturated fatty acids in modulating human butyrylcholinesterase activity: insights from kinetics and molecular docking

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New tetracyclic systems integrated thienopyridine scaffold as an anti-dementia lead: in silico study and biological screening

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Development of an efficient, one‐pot, multicomponent protocol for synthesis of 8‐hydroxy‐4‐phenyl‐1,2‐dihydroquinoline derivatives

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Design, Synthesis, and Biological Evaluation of Some Benzothiazolone Derivatives as Cholinesterase Inhibitors

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Role of quinoline and indole-based heterocycles in revolutionizing Alzheimer’s drug discovery: Promising futuristic structural designs

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Novel benzothiazole-based cholinesterase inhibitors with amyloid beta disaggregation and antioxidant activity against Alzheimer's disease

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Tryptophan methyl ester: a proposal of the thermal decomposition mechanism

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Synthesis and In Vitro Screening of Novel Heterocyclic β-d-Gluco- and β-d-Galactoconjugates as Butyrylcholinesterase Inhibitors

Baumann, K., Kordić, L., Močibob, M., Šinko, G., & Tomić, S. (2019) · Molecules · doi:10.3390/molecules24152833 · Cited by 5 · see citing works

Inhibition of cholinesterases by safranin O: Integration of inhibition kinetics with molecular docking simulations

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Novel 2‐Alkoxy‐3‐Cyanopyridine Derivatives as Cholinesterase Inhibitors: Synthesis, Biological Evaluation, and In Silico Investigations

Kadi, I., Seyhan, G., Zebbiche, Z., Sarı, S., Barut, B., Boumoud, T., Mermer, A., & Boulebd, H. (2025) · Chemistry & Biodiversity · doi:10.1002/cbdv.202402915 · Cited by 4 · see citing works

Azole derivatives inhibit wildtype butyrylcholinesterase and its common mutants

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Why is binding of a divalent metal cation to a structural motif containing four carboxylate residues not accompanied by a conformational change?

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Non-targeted metabolomic profiling of Cistus species and association with anticholinesterase efficacy for Alzheimer’s disease: In vitro and in silico evaluation

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Indole amide derivatives in Alzheimer’s disease: advancing from synthesis to drug discovery

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UHPLC-HRMS study of anti-Alzheimer’s drug candidates: metabolism of 7-MEOTA-tryptophan hybrids hampers their passage into brain

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The Effect of Tacrine on Functional Response of the Lower Oesophageal Sphincter Assessed by Endoscopic Luminal Impedance Planimetry in Experimental Pigs

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Novel multipotent conjugate bearing tacrine and donepezil motifs with dual cholinergic inhibition and neuroprotective properties targeting Alzheimer's disease

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Unveiling a New Cholinesterase Inhibitor Iridoid From Verbascum uschakense (Murb.) Hub.‐Mor.: In Vitro and In Silico Evaluation

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Rational Design and Greener Synthesis of Selenylated Indolamides as Potential Anti-Alzheimer’s Agents

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Chlorogenic acid reduces Lipopolysaccharide-Induced intestinal inflammation through Inhibition of acetylcholinesterase and activation of muscarinic receptors

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Innovative Approaches to Alzheimer's Treatment: Utilizing Tacrine Hybrids to Inhibit Amyloid Beta Aggregation as a Strategic Focus

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Indole Metabolites as Modulators of Human Cholinesterases: A Kinetic and Molecular Docking Study with Comparison to Alzheimer’s Drugs

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Evolution of Multitarget Strategies for Alzheimer’s Disease: From Cholinergic Inhibition to Network-Oriented Therapeutic Design (2006–2025)

Mella, J., Vega-Muñoz, A., Soto, M., Moraga, D., Campanini-Salinas, J., Sandoval-Obando, E., Contreras-Barraza, N., Salazar-Sepúlveda, G., Salas, N., Carabantes-Silva, R., et al. (2026) · Pharmaceuticals · doi:10.3390/ph19071024 · Cited by 1 · see citing works

Alzheimer's disease therapeutics

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Tryptophan-derived Alkaloids from Hedera rhombea Fruits and Their Butyrylcholinesterase Inhibitory Activity

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New tacrine–acridine hybrids as promising multifunctional drugs for potential treatment of Alzheimer's disease

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Phenothiazine-Tacrine Heterodimers: Pursuing Multitarget Directed Approach in Alzheimer’s Disease

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Design and Synthesis of Novel Tacrine–Indole Hybrids As Potential Multitarget-Directed Ligands for the Treatment of Alzheimer's Disease

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Tacrine, Trolox and Tryptoline as Lead Compounds for the Design and Synthesis of Multi-target Agents for Alzheimer’s Disease Therapy

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Design, synthesis, and biological evaluation of novel capsaicin-tacrine hybrids as multi-target agents for the treatment of Alzheimer's disease

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