Multifunctional and stimuli-sensitive pharmaceutical nanocarriers

Synthesis and surface engineering of iron oxide nanoparticles for biomedical applications

Gupta, A. K., & Gupta, M. S. (2004) · Biomaterials · doi:10.1016/j.biomaterials.2004.10.012 · Cited by 6,906

Tumor vascular permeability and the EPR effect in macromolecular therapeutics: a review

Maeda, H., Wu, J., Sawa, T., Matsumura, Y., & Hori, K. (2000) · Journal of Controlled Release · doi:10.1016/s0168-3659(99)00248-5 · Cited by 6,565

A versatile vector for gene and oligonucleotide transfer into cells in culture and in vivo: polyethylenimine.

Boussif, O., Lezoualc’h, F., Zanta, M. A., Djavaheri‐Mergny, M., Scherman, D., DEMENEIX, B. A., & Behr, J. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.16.7297 · Cited by 6,256

Poly(N-isopropylacrylamide): experiment, theory and application

Schild, H. G. (1992) · Progress in Polymer Science · doi:10.1016/0079-6700(92)90023-r · Cited by 5,162

Monodisperse MFe2O4 (M = Fe, Co, Mn) Nanoparticles

Sun, S., Zeng, H., Robinson, D., Raoux, S., Rice, P. M., Wang, S. X., & Li, G. (2003) · Journal of the American Chemical Society · doi:10.1021/ja0380852 · Cited by 3,484

Untitled work

(1989) · PubMed · Cited by 3,343

Biodegradable Long-Circulating Polymeric Nanospheres

Gref, R., Minamitake, Y., Peracchia, M. T., Trubetskoy, V. S., Torchilin, V. P., & Langer, R. (1994) · Science · doi:10.1126/science.8128245 · Cited by 2,951

Size-Controlled Synthesis of Magnetite Nanoparticles

Sun, S., & Zeng, H. (2002) · Journal of the American Chemical Society · doi:10.1021/ja026501x · Cited by 2,876

Cellular uptake of the tat protein from human immunodeficiency virus

Frankel, A. D., & Pabo, C. O. (1988) · Cell · doi:10.1016/0092-8674(88)90263-2 · Cited by 2,782

The enhanced permeability and retention (EPR) effect in tumor vasculature: the key role of tumor-selective macromolecular drug targeting

Maeda, H. (2001) · Advances in Enzyme Regulation · doi:10.1016/s0065-2571(00)00013-3 · Cited by 2,495

Nanoparticle and targeted systems for cancer therapy

Brannon‐Peppas, L., & Blanchette, J. O. (2004) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2004.02.014 · Cited by 2,335

Synthesis of Highly Crystalline and Monodisperse Maghemite Nanocrystallites without a Size-Selection Process

Hyeon, T., Lee, S. S., Park, J., Chung, Y., & Na, H. B. (2001) · Journal of the American Chemical Society · doi:10.1021/ja016812s · Cited by 2,040

The third helix of the Antennapedia homeodomain translocates through biological membranes.

Derossi, D., Joliot, A., Chassaing, G., & Prochiantz, A. (1994) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)34080-2 · Cited by 2,034

Amphipathic polyethyleneglycols effectively prolong the circulation time of liposomes

Klibanov, A. L., Maruyama, K., Torchilin, V. P., & Huang, L. (1990) · FEBS Letters · doi:10.1016/0014-5793(90)81016-h · Cited by 2,030

Micellar Nanocarriers: Pharmaceutical Perspectives

Torchilin, V. P. (2006) · Pharmaceutical Research · doi:10.1007/s11095-006-9132-0 · Cited by 1,910

Transducible TAT-HA fusogenic peptide enhances escape of TAT-fusion proteins after lipid raft macropinocytosis

Wadia, J. S., Stan, R. V., & Dowdy, S. F. (2004) · Nature Medicine · doi:10.1038/nm996 · Cited by 1,647

Sterically stabilized liposomes: improvements in pharmacokinetics and antitumor therapeutic efficacy.

Papahadjopoulos, D., Allen, T. M., Gabizón, A., Mayhew, E. G., Matthay, K. K., Huang, S. K., Lee, K. D., Woodle, M. C., Lasiç, D. D., & Redemann, C. T. (1991) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.88.24.11460 · Cited by 1,621

Medical application of functionalized magnetic nanoparticles

Itô, A., Shinkai, M., Honda, H., & Kobayashi, T. (2005) · Journal of Bioscience and Bioengineering · doi:10.1263/jbb.100.1 · Cited by 1,469

Drug delivery strategy utilizing conjugation via reversible disulfide linkages: Role and site of cellular reducing activities

Saito, G., Swanson, J. A., & Lee, K.-D. (2003) · Advanced Drug Delivery Reviews · doi:10.1016/s0169-409x(02)00179-5 · Cited by 1,407

Liposomes containing synthetic lipid derivatives of poly(ethylene glycol) show prolonged circulation half-lives in vivo

Allen, T. M., Hansen, C., Martin, F., Redemann, C. T., & Yau‐Young, A. O. (1991) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/0005-2736(91)90246-5 · Cited by 1,392

Prolonged circulation time and enhanced accumulation in malignant exudates of doxorubicin encapsulated in polyethylene-glycol coated liposomes.

Gabizón, A., Catane, R., Uziely, B., Kaufman, B., Safra, T., Cohen, R., Martin, F., Huang, A., & Barenholz, Y. (1994) · PubMed · Cited by 1,382

Multifunctional nanocarriers☆

Torchilin, V. P. (2006) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2006.09.009 · Cited by 1,274

Comb-type grafted hydrogels with rapid deswelling response to temperature changes

Yoshida, R., Uchida, K., Kaneko, Y., Sakai, K., Kikuchi, A., Sakurai, Y., & Okano, T. (1995) · Nature · doi:10.1038/374240a0 · Cited by 1,257

Stealth liposomes and long circulating nanoparticles: critical issues in pharmacokinetics, opsonization and protein-binding properties

Moghimi, S. M., & Szebeni, J. (2003) · Progress in Lipid Research · doi:10.1016/s0163-7827(03)00033-x · Cited by 1,228

Untitled work

(1996) · PubMed · Cited by 1,141

Mechanism of DNA Release from Cationic Liposome/DNA Complexes Used in Cell Transfection,

Xu, Y., & Szoka, F. C. (1996) · Biochemistry · doi:10.1021/bi9602019 · Cited by 1,136

Liposome formulations with prolonged circulation time in blood and enhanced uptake by tumors.

Gabizón, A., & Papahadjopoulos, D. (1988) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.85.18.6949 · Cited by 1,134

Peptide and protein PEGylation

Veronese, F. M. (2001) · Biomaterials · doi:10.1016/s0142-9612(00)00193-9 · Cited by 1,068

Design of Liposomes for Enhanced Local Release of Drugs by Hyperthermia

Yatvin, M. B., Weinstein, J. N., Dennis, W. H., & Blumenthal, R. P. (1978) · Science · doi:10.1126/science.364652 · Cited by 959

Folate-mediated delivery of macromolecular anticancer therapeutic agents

Lu, Y. J., & Low, P. S. (2002) · Advanced Drug Delivery Reviews · doi:10.1016/s0169-409x(02)00042-x · Cited by 942

The relevance of tumour pH to the treatment of malignant disease

Wike-Hooley, J. L., HAVEMAN, J., & Reinhold, H. S. (1984) · Radiotherapy and Oncology · doi:10.1016/s0167-8140(84)80077-8 · Cited by 908

High-Efficiency Intracellular Magnetic Labeling with Novel Superparamagnetic-Tat Peptide Conjugates

Josephson, L., Tung, C., Moore, A. V., & Weissleder, R. (1999) · Bioconjugate Chemistry · doi:10.1021/bc980125h · Cited by 882

Locoregional cancer treatment with magnetic drug targeting.

Alexiou, C., Arnold, W. J., Klein, R. J., Parak, F., Hulin, P., Bergemann, C., Erhardt, W. D., Wagenpfeil, S., & Lübbe, A. S. (2000) · PubMed · Cited by 863

Receptor-mediated in vitro gene transformation by a soluble DNA carrier system.

Wu, G. Y., & Wu, C. H. (1987) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)61209-8 · Cited by 855

The controlled intravenous delivery of drugs using PEG-coated sterically stabilized nanospheres

Gref, R., Domb, A. J., Quellec, P., Blunk, T., Müller, R. H., Verbavatz, J., & Langer, R. (1995) · Advanced Drug Delivery Reviews · doi:10.1016/0169-409x(95)00026-4 · Cited by 820

Low-molecular-weight polyethylenimine as a non-viral vector for DNA delivery: comparison of physicochemical properties, transfection efficiency and in vivo distribution with high-molecular-weight polyethylenimine

Kunath, K. (2003) · Journal of Controlled Release · doi:10.1016/s0168-3659(03)00076-2 · Cited by 809

Clinical hyperthermia of prostate cancer using magnetic nanoparticles: Presentation of a new interstitial technique

Johannsen, M., Gneveckow, U., Eckelt, L., Feussner, A., Waldöfner, N., Scholz, R., Değer, S., Wust, P., Loening, S. A., & Jordan, A. (2005) · International Journal of Hyperthermia · doi:10.1080/02656730500158360 · Cited by 802

The role of dioleoyl phosphatidylethanolamine in cationic liposome mediated gene transfer

Farhood, H., Serbina, N. V., & Huang, L. (1995) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/0005-2736(95)80016-9 · Cited by 799

Preparation and biological characterization of polymeric micelle drug carriers with intracellular pH-triggered drug release property: tumor permeability, controlled subcellular drug distribution, and enhanced in vivo antitumor efficacy

Bae, Y., Nishiyama, N., Fukushima, S., Koyama, H., Yasuhiro, M., & Kataoka, K. (2005) · Bioconjugate Chemistry · doi:10.1021/bc0498166 · Cited by 742

Multifunctional nanorods for gene delivery

Salem, A. K., Searson, P. C., & Leong, K. W. (2003) · Nature Materials · doi:10.1038/nmat974 · Cited by 732

Polyethylenimine but Not Cationic Lipids Promotes Transgene Delivery to the Nucleus in Mammalian Cells

Pollard, H., Rémy, J.-S., Loussouarn, G., Demolombe, S., Behr, J., & Escande, D. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.13.7507 · Cited by 711

Recent advances on surface engineering of magnetic iron oxide nanoparticles and their biomedical applications

Gupta, A. K., Naregalkar, R. R., Vaidya, V. D., & Gupta, M. (2007) · Nanomedicine · doi:10.2217/17435889.2.1.23 · Cited by 708

Delivery of liposomes into cultured KB cells via folate receptor-mediated endocytosis.

Lee, R., & Low, P. S. (1994) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)41848-5 · Cited by 694

Cell penetration by transportan

Pooga, M., Hällbrink, M., Zorko, M., & Langel, U. (1998) · The FASEB Journal · doi:10.1096/fasebj.12.1.67 · Cited by 680

Intracellular delivery of large molecules and small particles by cell-penetrating proteins and peptides

GUPTA, B., Levchenko, T. S., & Torchilin, V. P. (2004) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2004.10.007 · Cited by 643

Role of Membrane Potential and Hydrogen Bonding in the Mechanism of Translocation of Guanidinium-Rich Peptides into Cells

Rothbard, J. B., Jessop, T. C., Lewis, R. S., Murray, B. A., & Wender, P. A. (2004) · Journal of the American Chemical Society · doi:10.1021/ja0482536 · Cited by 642

Polymeric micelle for tumor pH and folate-mediated targeting

Lee, E. (2003) · Journal of Controlled Release · doi:10.1016/s0168-3659(03)00239-6 · Cited by 620

Super pH-Sensitive Multifunctional Polymeric Micelle

Lee, E. S., Na, K., & Bae, Y. H. (2005) · Nano Letters · doi:10.1021/nl0479987 · Cited by 611

Fate and behavior of liposomes in vivo: a review of controlling factors.

Senior, J. H. (1987) · PubMed · Cited by 592

Therapeutic applications of lipid-coated microbubbles

Unger, E. C., Porter, T. R., Culp, W. C., LaBell, R., Matsunaga, T. O., & Zutshi, R. (2004) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2003.12.006 · Cited by 591

Chemistry of polyethylene glycol conjugates with biologically active molecules

Zalipsky, S. (1995) · Advanced Drug Delivery Reviews · doi:10.1016/0169-409x(95)00023-z · Cited by 568

Multifunctional Nanoparticles for Combining Ultrasonic Tumor Imaging and Targeted Chemotherapy

Rapoport, N. Y., Gao, Z., & Kennedy, A. (2007) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/djm043 · Cited by 560

Delivery of macromolecules into living cells: a method that exploits folate receptor endocytosis.

Leamon, C. P., & Low, P. S. (1991) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.88.13.5572 · Cited by 558

Protein transduction: unrestricted delivery into all cells?

Schwarze, S. R., Hruska, K. A., & Dowdy, S. F. (2000) · Trends in Cell Biology · doi:10.1016/s0962-8924(00)01771-2 · Cited by 551

Stimuli-Responsive Supramolecular Assemblies of Linear-Dendritic Copolymers

Gillies, E. R., Jonsson, T. B., & Fréchet, J. M. J. (2004) · Journal of the American Chemical Society · doi:10.1021/ja0463738 · Cited by 549

Targeted polymeric micelles for delivery of poorly soluble drugs

Torchilin, V. P. (2004) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-004-4153-5 · Cited by 549

RECENT APPROACHES TO INTRACELLULAR DELIVERY OF DRUGS AND DNA AND ORGANELLE TARGETING

Torchilin, V. P. (2006) · Annual Review of Biomedical Engineering · doi:10.1146/annurev.bioeng.8.061505.095735 · Cited by 548

Sterically stabilized liposomes: a hypothesis on the molecular origin of the extended circulation times

Lasiç, D. D., Martin, F. J., Gabizón, A., Huang, S. K., & Papahadjopoulos, D. (1991) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/0005-2736(91)90162-2 · Cited by 545

“SMART” Drug Delivery Systems: Double-Targeted pH-Responsive Pharmaceutical Nanocarriers

Sawant, R. M., Hurley, J. P., Salmaso, S., Kale, A., Tolcheva, E., Levchenko, T. S., & Torchilin, V. P. (2006) · Bioconjugate Chemistry · doi:10.1021/bc060080h · Cited by 540

Immunomicelles: Targeted pharmaceutical carriers for poorly soluble drugs

Torchilin, V. P., Lukyanov, A. N., Gao, Z., & Papahadjopoulos‐Sternberg, B. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0931428100 · Cited by 538

Influence of surface hydrophilicity of liposomes on their interaction with plasma protein and clearance from the circulation: Studies with poly(ethylene glycol)-coated vesicles

Senior, J. H., Delgado, C., Fisher, D., Tilcock, C., & Gregoriadis, G. (1991) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/0005-2736(91)90337-8 · Cited by 521

Monocrystalline iron oxide nanocompounds (MION): Physicochemical properties

Shen, T. T., Weissleder, R., Papisov, M. I., Bogdanov, A. A., Jr., & Brady, T. J. (1993) · Magnetic Resonance in Medicine · doi:10.1002/mrm.1910290504 · Cited by 496

Recent advances in tumor-targeting anticancer drug conjugates

Jaracz, S., Chen, J., Kuznetsova, L. V., & Ojima, I. (2005) · Bioorganic & Medicinal Chemistry · doi:10.1016/j.bmc.2005.04.084 · Cited by 491

On the formulation of pH-sensitive liposomes with long circulation times

Simões, S. (2004) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2003.10.038 · Cited by 485

Targeting Folate Receptor with Folate Linked to Extremities of Poly(ethylene glycol)-Grafted Liposomes: In Vitro Studies

Gabizón, A., Horowitz, A. T., Goren, D., Tzemach, D., Mandelbaum-Shavit, F., Qazen, M. M., & Zalipsky, S. (1999) · Bioconjugate Chemistry · doi:10.1021/bc9801124 · Cited by 467

Poly(ethylene glycol) on the liposome surface: on the mechanism of polymer-coated liposome longevity

Torchilin, V. P., Omelyanenko, V. G., Papisov, M. I., Bogdanov, A. A., Jr., Trubetskoy, V. S., Herron, J. N., & Gentry, C. A. (1994) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/0005-2736(94)90003-5 · Cited by 466

Tumor cell targeting of liposome-entrapped drugs with phospholipid-anchored folic acid–PEG conjugates

Gabizon, A. (2004) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2004.01.011 · Cited by 464

Formation and Intracellular Trafficking of Lipoplexes and Polyplexes

Elouahabi, A., & Ruysschaert, J. (2005) · Molecular Therapy · doi:10.1016/j.ymthe.2004.12.006 · Cited by 464

Association of blood proteins with large unilamellar liposomes in vivo. Relation to circulation lifetimes.

Chonn, A., Semple, S. C., & Cullis, P. R. (1992) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)37026-7 · Cited by 461

Magnetic Microspheres: A Model System for Site Specific Drug Delivery in Vivo

Widder, K. J., Senyei, A. E., & Scarpelli, D. G. (1978) · Experimental Biology and Medicine · doi:10.3181/00379727-158-40158 · Cited by 455

Poly(l-histidine)–PEG block copolymer micelles and pH-induced destabilization

Lee, E. S., Shin, H. J., Na, K., & Bae, Y. H. (2003) · Journal of Controlled Release · doi:10.1016/s0168-3659(03)00205-0 · Cited by 452

Cellular uptake of an α-helical amphipathic model peptide with the potential to deliver polar compounds into the cell interior non-endocytically

Oehlke, J., Scheller, A., Wiesner, B., Krause, E., Beyermann, M., Klauschenz, E., Melzig, M., & Bienert, M. (1998) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/s0005-2736(98)00161-8 · Cited by 448

Toxicity and immunomodulatory activity of liposomal vectors formulated with cationic lipids toward immune effector cells

Filion, M. C., & Phillips, N. C. (1997) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/s0005-2736(97)00126-0 · Cited by 428

Cell transfection in vitro and in vivo with nontoxic TAT peptide-liposome–DNA complexes

Torchilin, V. P., Levchenko, T. S., Rammohan, R., Volodina, N., Papahadjopoulos‐Sternberg, B., & D’Souza, G. G. M. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0435906100 · Cited by 419

Drug targeting using thermally responsive polymers and local hyperthermia

Meyer, D. E., Shin, B. C., Kong, G. A., Dewhirst, M. W., & Chilkoti, A. (2001) · Journal of Controlled Release · doi:10.1016/s0168-3659(01)00319-4 · Cited by 416

A peptide nucleic acid–nuclear localization signal fusion that mediates nuclear transport of DNA

Brandén, L. J., Mohamed, A. J., & Smith, C. I. E. (1999) · Nature Biotechnology · doi:10.1038/11726 · Cited by 376

Phosphatodylethanolamine liposomes: drug delivery, gene transfer and immunodiagnostic applications

Litzinger, D. C., & Huang, L. (1992) · Biochimica et Biophysica Acta (BBA) - Reviews on Biomembranes · doi:10.1016/0304-4157(92)90039-d · Cited by 368

Inner core segment design for drug delivery control of thermo-responsive polymeric micelles

Chung, J. E., Yokoyama, M., & Okano, T. (2000) · Journal of Controlled Release · doi:10.1016/s0168-3659(99)00242-4 · Cited by 364

New Amphipatic Polymer-Lipid Conjugates Forming Long-Circulating Reticuloendothelial System-Evading Liposomes

Woodle, M. C., Engbers, C. M., & Zalipsky, S. (1994) · Bioconjugate Chemistry · doi:10.1021/bc00030a001 · Cited by 361

Multi-functional polymeric nanoparticles for tumour-targeted drug delivery

van Vlerken, L. E., & Amiji, M. M. (2006) · Expert Opinion on Drug Delivery · doi:10.1517/17425247.3.2.205 · Cited by 358

Tumor targeting using anti-her2 immunoliposomes

Park, J. W., Kirpotin, D. B., Hong, K., Shalaby, R., Shao, Y., Nielsen, U. B., Marks, J. D., Papahadjopoulos, D., & Benz, C. C. (2001) · Journal of Controlled Release · doi:10.1016/s0168-3659(01)00315-7 · Cited by 341

Specific Targeting of Tumor Angiogenesis by RGD-Conjugated Ultrasmall Superparamagnetic Iron Oxide Particles Using a Clinical 1.5-T Magnetic Resonance Scanner

Zhang, C., Jugold, M., Woenne, E. C., Lammers, T., Morgenstern, B., Mueller, M. M., Zentgraf, H., Bock, M., Eisenhut, M., Semmler, W., et al. (2007) · Cancer Research · doi:10.1158/0008-5472.can-06-1668 · Cited by 335

Poly(ethylene oxide)-modified poly(ɛ-caprolactone) nanoparticles for targeted delivery of tamoxifen in breast cancer

Shenoy, D. B., & Amiji, M. M. (2005) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2004.12.010 · Cited by 331

Functional Magnetic Particles for Medical Application.

Shinkai, M. (2002) · Journal of Bioscience and Bioengineering · doi:10.1263/jbb.94.606 · Cited by 331

Polyester Dendritic Systems for Drug Delivery Applications: Design, Synthesis, and Characterization

Ihre, H. R., Jesús, O. L. P. D., Szoka, F. C., & Fréchet, J. M. J. (2002) · Bioconjugate Chemistry · doi:10.1021/bc010102u · Cited by 329

The use of glycolipids and hydrophilic polymers in avoiding rapid uptake of liposomes by the mononuclear phagocyte system

Allen, T. M. (1994) · Advanced Drug Delivery Reviews · doi:10.1016/0169-409x(94)90016-7 · Cited by 325

Doxorubicin-conjugated biodegradable polymeric micelles having acid-cleavable linkages

Yoo, H. S., Lee, E. A., & Park, T. G. (2002) · Journal of Controlled Release · doi:10.1016/s0168-3659(02)00088-3 · Cited by 324

Differential Conjugation of Tat Peptide to Superparamagnetic Nanoparticles and Its Effect on Cellular Uptake

Zhao, M., Kircher, M. F., Josephson, L., & Weissleder, R. (2002) · Bioconjugate Chemistry · doi:10.1021/bc0255236 · Cited by 319

Encapsulated ultrasound microbubbles: Therapeutic application in drug/gene delivery

Liu, Y., Miyoshi, H., & Nakamura, M. (2006) · Journal of Controlled Release · doi:10.1016/j.jconrel.2006.05.018 · Cited by 318

Cargo delivery kinetics of cell-penetrating peptides

Hällbrink, M., Florén, A., Elmquist, A., Pooga, M., Bartfai, T., & Langel, Ü. (2001) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/s0005-2736(01)00398-4 · Cited by 312

Anti-tumor efficacy of tumor vasculature-targeted liposomal doxorubicin

Schiffelers, R. M. (2003) · Journal of Controlled Release · doi:10.1016/s0168-3659(03)00240-2 · Cited by 307

Thermosensitive polymer-modified liposomes

Kono, K. (2001) · Advanced Drug Delivery Reviews · doi:10.1016/s0169-409x(01)00204-6 · Cited by 303

Magnetic nanoparticles for interstitial thermotherapy – feasibility, tolerance and achieved temperatures

Wust, P., Gneveckow, U., Wust, P., Gneveckow, U., Johannsen, M., Böhmer, D., Henkel, T. O., Kahmann, F., Sehouli, J., FELIX, R., et al. (2006) · International Journal of Hyperthermia · doi:10.1080/02656730601106037 · Cited by 295

Tumor-targeted liposomes: doxorubicin-loaded long-circulating liposomes modified with anti-cancer antibody

Lukyanov, A. N., ElBayoumi, T. A., Chakilam, A. R., & Torchilin, V. P. (2004) · Journal of Controlled Release · doi:10.1016/j.jconrel.2004.08.007 · Cited by 294

Magnetic Drug Targeting--Biodistribution of the Magnetic Carrier and the Chemotherapeutic agent Mitoxantrone after Locoregional Cancer Treatment

Huenges, E., Parak, F., Alexiou, C., Jurgons, R., Schmid, R. J., Bergemann, C., Henke, J., & Erhardt, W. D. (2003) · Journal of drug targeting · doi:10.1080/1061186031000150791 · Cited by 293

Specific targeting with poly(ethylene glycol)-modified liposomes: coupling of homing devices to the ends of the polymeric chains combines effective target binding with long circulation times

Blume, G., Cevc, G., Crommelin, M. D. J. A., Bakker‐Woudenberg, I. A. J. M., Kluft, C., & Storm, G. (1993) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/0005-2736(93)90039-3 · Cited by 282

Hyperthermia mediated liposomal drug delivery

Ponce, A. M., Vujašković, Ž., Yuan, F., Needham, D., & Dewhirst, M. W. (2006) · International Journal of Hyperthermia · doi:10.1080/02656730600582956 · Cited by 280

p-Nitrophenylcarbonyl-PEG-PE-liposomes: fast and simple attachment of specific ligands, including monoclonal antibodies, to distal ends of PEG chains via p-nitrophenylcarbonyl groups

Torchilin, V. P., Levchenko, T. S., Lukyanov, A. N., Khaw, B., Klibanov, A. L., Rammohan, R., Samokhin, G. P., & Whiteman, K. R. (2001) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/s0005-2728(01)00165-7 · Cited by 271

Transferrin-Modified Liposomes Equipped with a pH-Sensitive Fusogenic Peptide: An Artificial Viral-like Delivery System

Kakudo, T., Chaki, S., Futaki, S., Nakase, I., Akaji, K., Kawakami, T., Maruyama, K., Kamiya, H., & Harashima, H. (2004) · Biochemistry · doi:10.1021/bi035802w · Cited by 269

Acoustically active liposomes for drug encapsulation and ultrasound-triggered release

Huang, S.-L., & MacDonald, R. C. (2004) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/j.bbamem.2004.07.003 · Cited by 268

Acoustically Active Lipospheres Containing Paclitaxel

Unger, E. C., McCreery, T. P., Sweitzer, R. H., Caldwell, V. E., & WU, Y. (1998) · Investigative Radiology · doi:10.1097/00004424-199812000-00007 · Cited by 267

Preparation and characterization of methoxy poly(ethylene glycol)/poly(ε-caprolactone) amphiphilic block copolymeric nanospheres for tumor-specific folate-mediated targeting of anticancer drugs

Park, E. K., Lee, S. B., & Lee, Y. M. (2004) · Biomaterials · doi:10.1016/j.biomaterials.2004.04.008 · Cited by 265

The role of surface charge and hydrophilic groups on liposome clearance in vivo

Gabizon, A., & Papahadjopoulos, D. (1992) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/0005-2736(92)90061-p · Cited by 264

Liposomes Bearing Polyethyleneglycol-Coupled Transferrin with Intracellular Targeting Property to the Solid Tumors In Vivo

Ishida, O., Maruyama, K., Tanahashi, H., Iwatsuru, M., Sasaki, K., Eriguchi, M., & Yanagië, H. (2001) · Pharmaceutical Research · doi:10.1023/a:1010960900254 · Cited by 258

A Branched Monomethoxypoly(ethylene glycol) for Protein Modification

Monfardini, C., Schiavon, O., Caliceti, P., Morpurgo, M., Harris, J. M., & Veronese, F. M. (1995) · Bioconjugate Chemistry · doi:10.1021/bc00031a006 · Cited by 256

Direct Measurement of a Tethered Ligand-Receptor Interaction Potential

Wong, J. Y., Kuhl, T. L., Israelachvili, J. N., Mullah, N. N., & Zalipsky, S. (1997) · Science · doi:10.1126/science.275.5301.820 · Cited by 255

Liposome circulation time and tumor targeting: implications for cancer chemotherapy

Gabizón, A. (1995) · Advanced Drug Delivery Reviews · doi:10.1016/0169-409x(95)00030-b · Cited by 255

Basis of Pulmonary Toxicity Associated with Cationic Lipid-Mediated Gene Transfer to the Mammalian Lung

Scheule, R. K., George, J. A. S., Bagley, R. G., Marshall, J., Kaplan, J. M., Akita, G. Y., Wang, K. X., Lee, E. R., Harris, D. J., Jiang, C., et al. (1997) · Human Gene Therapy · doi:10.1089/hum.1997.8.6-689 · Cited by 251

Poly(Ethylene Oxide)-Modified Poly(β-Amino Ester) Nanoparticles as a pH-Sensitive System for Tumor-Targeted Delivery of Hydrophobic Drugs: Part 2. In Vivo Distribution and Tumor Localization Studies

Shenoy, D. B., Little, S. R., Langer, R., & Amiji, M. M. (2005) · Pharmaceutical Research · doi:10.1007/s11095-005-8343-0 · Cited by 246

Systemic tumor-targeted gene delivery by anti-transferrin receptor scFv-immunoliposomes.

Xu, L., Huang, C., Huang, W., Tang, W., Rait, A. S., Yin, Y. Z., Cruz, I., Xiang, L., Pirollo, K. F., & Chang, E. H. (2002) · PubMed · Cited by 243

Translocation of Liposomes into Cancer Cells by Cell-Penetrating Peptides Penetratin and Tat: A Kinetic and Efficacy Study

Tseng, Y., Liu, J., & Hong, R. (2002) · Molecular Pharmacology · doi:10.1124/mol.62.4.864 · Cited by 241

pH‐sensitive liposomes mediate cytoplasmic delivery of encapsulated macromolecules

Straubinger, R. M., Düzgüneş, N., & Papahadjopoulos, D. (1985) · FEBS Letters · doi:10.1016/0014-5793(85)80210-6 · Cited by 240

Controlling liposomal drug release with low frequency ultrasound: mechanism and feasibility.

Schroeder, A., Avnir, Y., Weisman, S., Najajreh, Y., Gabizon, A., Talmon, Y., Kost, J., & Barenholz, Y. (2007) · Langmuir · doi:10.1021/la0631668 · Cited by 239

Polymer-coated long-circulating microparticulate pharmaceuticals

Torchilin, V. P. (1998) · Journal of Microencapsulation · doi:10.3109/02652049809006831 · Cited by 236

Steric Stabilization of Fusogenic Liposomes by a Low-pH Sensitive PEG−Diortho Ester−Lipid Conjugate

Guo, X. D., & Szoka, F. C. (2001) · Bioconjugate Chemistry · doi:10.1021/bc000110v · Cited by 233

Magnetic Drug Targeting—Biodistribution of the Magnetic Carrier and the Chemotherapeutic agent Mitoxantrone after Locoregional Cancer Treatment

Alexiou, C., Jurgons, R., Schmid, R. J., et al. (2003) · Journal of drug targeting · doi:10.3109/1061186031000150791 · Cited by 232

Loading mitomycin C inside long circulating hyaluronan targeted nano‐liposomes increases its antitumor activity in three mice tumor models

Peer, D., & Margalit, R. (2003) · International Journal of Cancer · doi:10.1002/ijc.11615 · Cited by 229

Design, Synthesis, and Characterization of pH-Sensitive PEG−PE Conjugates for Stimuli-Sensitive Pharmaceutical Nanocarriers: The Effect of Substitutes at the Hydrazone Linkage on the pH Stability of PEG−PE Conjugates

Kale, A. A., & Torchilin, V. P. (2007) · Bioconjugate Chemistry · doi:10.1021/bc060228x · Cited by 228

Multifunctionalized Polymer Microcapsules: Novel Tools for Biological and Pharmacological Applications

Sukhorukov, G. B., Rogach, A. L., Garstka, M. A., Springer, S., Parak, W. J., Muñoz‐Javier, A., Kreft, O., Skirtach, A. G., Susha, A. S., Ramaye, Y., et al. (2007) · Small · doi:10.1002/smll.200600622 · Cited by 227

Thermal Ablation of Tumors Using Magnetic Nanoparticles

Hilger, I., Hiergeist, R., Hergt, R., Winnefeld, K., Schubert, H., & Kaiser, W. A. (2002) · Investigative Radiology · doi:10.1097/00004424-200210000-00008 · Cited by 224

Synthesis of Pegylated Immunonanoparticles

Olivier, J., Huertas, R. E., Lee, H. J., Calon, F., & Pardridge, W. M. (2002) · Pharmaceutical Research · doi:10.1023/a:1019842024814 · Cited by 221

Preparation and Evaluation of Thiol-Modified Gelatin Nanoparticles for Intracellular DNA Delivery in Response to Glutathione

Kommareddy, S., & Amiji, M. M. (2005) · Bioconjugate Chemistry · doi:10.1021/bc050146t · Cited by 220

pH-Sensitive Unimolecular Polymeric Micelles: Synthesis of a Novel Drug Carrier

Jones, M., Ranger, M., & Leroux, J. (2003) · Bioconjugate Chemistry · doi:10.1021/bc020041f · Cited by 217

“Smart” delivery of antisense oligonucleotides by anionic pH-sensitive liposomes

Fattal, E. (2004) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2003.10.037 · Cited by 216

Membrane-destabilizing polyanions: interaction with lipid bilayers and endosomal escape of biomacromolecules

Yessine, M. (2004) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2003.10.039 · Cited by 213

siRNA-containing liposomes modified with polyarginine effectively silence the targeted gene

Zhang, C., Tang, N., Liu, X., Liang, W. P., Xu, W., & Torchilin, V. P. (2006) · Journal of Controlled Release · doi:10.1016/j.jconrel.2006.01.022 · Cited by 213

DNA/polyethylenimine transfection particles: Influence of ligands, polymer size, and PEGylation on internalization and gene expression

Ogris, M., Steinlein, P., Carotta, S., Brunner, S., & Wagner, E. (2001) · AAPS PharmSci · doi:10.1208/ps030321 · Cited by 210

Liposomes with detachable polymer coating: destabilization and fusion of dioleoylphosphatidylethanolamine vesicles triggered by cleavage of surface‐grafted poly(ethylene glycol)

Kirpotin, D. B., Hong, K., Mullah, N. N., Papahadjopoulos, D., & Zalipsky, S. (1996) · FEBS Letters · doi:10.1016/0014-5793(96)00521-2 · Cited by 210

Immunogenicity and pharmacokinetic attributes of poly(ethylene glycol)-grafted immunoliposomes

Harding, J. A., Engbers, C. M., Newman, M. S., Goldstein, N. I., & Zalipsky, S. (1997) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/s0005-2736(97)00056-4 · Cited by 202

Poly(ethylene oxide)-modified poly(β-amino ester) nanoparticles as a pH-sensitive biodegradable system for paclitaxel delivery

Potineni, A., Lynn, D. M., Langer, R., & Amiji, M. M. (2003) · Journal of Controlled Release · doi:10.1016/s0168-3659(02)00374-7 · Cited by 201

Microparticulate Systems for the Delivery of Proteins and Vaccines

(2020) · CRC Press eBooks · doi:10.1201/9781003067542 · Cited by 199

N-isopropylacrylamide copolymers for the preparation of pH-sensitive liposomes and polymeric micelles

Leroux, J., Roux, E., Garrec, D. L., Hong, K., & Drummond, D. C. (2001) · Journal of Controlled Release · doi:10.1016/s0168-3659(01)00263-2 · Cited by 199

New Detachable Poly(ethylene glycol) Conjugates: Cysteine-Cleavable Lipopolymers Regenerating Natural Phospholipid, Diacyl Phosphatidylethanolamine

Zalipsky, S., Qazen, M. M., Walker, J. A., Mullah, N. N., Quinn, Y. P., & Huang, S. K. (1999) · Bioconjugate Chemistry · doi:10.1021/bc990031n · Cited by 198

Poly(ethylene oxide)-Modified Poly(β-amino ester) Nanoparticles as a pH-Sensitive System for Tumor-Targeted Delivery of Hydrophobic Drugs. 1. In Vitro Evaluations

Shenoy, D. B., Little, S. R., Langer, R., & Amiji, M. M. (2005) · Molecular Pharmaceutics · doi:10.1021/mp0500420 · Cited by 193

Efficient intracellular drug and gene delivery using folate receptor-targeted pH-sensitive liposomes composed of cationic/anionic lipid combinations

Shi, G., Guo, W., Stephenson, S. M., & Lee, R. J. (2002) · Journal of Controlled Release · doi:10.1016/s0168-3659(02)00017-2 · Cited by 192

Liposomes and hyperthermia in mice: increased tumor uptake and therapeutic efficacy of doxorubicin in sterically stabilized liposomes.

Huang, S. K., Stauffer, P. R., Hong, K., Guo, J., Phillips, T. L., Huang, A., & Papahadjopoulos, D. (1994) · PubMed · Cited by 183

Polymeric micelles for delivery of poorly soluble drugs: Preparation and anticancer activityin vitroof paclitaxel incorporated into mixed micelles based on poly(ethylene glycol)-lipid conjugate and positively charged lipids

Wang, J., Mongayt, D., & Torchilin, V. P. (2005) · Journal of drug targeting · doi:10.1080/10611860400011935 · Cited by 183

Drug-Polymer Conjugates Containing Acid-Cleavable Bonds

Kratz, F., Beyer, U., & Schütte, M. T. (1999) · Critical Reviews in Therapeutic Drug Carrier Systems · doi:10.1615/critrevtherdrugcarriersyst.v16.i3.10 · Cited by 182

Increased accumulation of PEG–PE micelles in the area of experimental myocardial infarction in rabbits

Lukyanov, A. N., Hartner, W. C., & Torchilin, V. P. (2003) · Journal of Controlled Release · doi:10.1016/j.jconrel.2003.10.008 · Cited by 175

The polyoxyethylene/polyoxypropylene block co‐polymer Poloxamer‐407 selectively redirects intravenously injected microspheres to sinusoidal endothelial cells of rabbit bone marrow

Porter, C. J. H., Moghimi, S. M., Illum, L., & Davis, S. S. (1992) · FEBS Letters · doi:10.1016/0014-5793(92)80655-z · Cited by 173

Functional Characterization of an Endosome-disruptive Peptide and Its Application in Cytosolic Delivery of Immunoliposome-entrapped Proteins

Mastrobattista, E., Koning, G. A., van Bloois, L., Filipe, A. C. S., Jiskoot, W., & Storm, G. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m200429200 · Cited by 173

Mechanisms of TfR-mediated transcytosis and sorting in epithelial cells and applications toward drug delivery

Widera, A., Norouziyan, F., & Shen, W. (2003) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2003.07.004 · Cited by 173

Nanoparticulate Drug Delivery Systems

Thassu, D. (2007) · CRC Press eBooks · doi:10.1201/9781420008449 · Cited by 171

Gene Delivery Using Ultrasound Contrast Agents

Unger, E. C., Hersh, E., Vannan, M. A., & McCreery, T. P. (2001) · Echocardiography · doi:10.1046/j.1540-8175.2001.00355.x · Cited by 170

Effect of DNA/liposome mixing ratio on the physicochemical characteristics, cellular uptake and intracellular trafficking of plasmid DNA/cationic liposome complexes and subsequent gene expression

Sakurai, F., Inoue, R., Nishino, Y., Okuda, A., Matsumoto, O., Taga, T., Yamashita, F., Takakura, Y., & Hashida, M. (2000) · Journal of Controlled Release · doi:10.1016/s0168-3659(99)00280-1 · Cited by 169

Reversible Covalent Chemistry in Drug Delivery

West, K. R., & Otto, S. (2005) · Current Drug Discovery Technologies · doi:10.2174/1570163054866882 · Cited by 166

A pH-Sensitive Polymer That Enhances Cationic Lipid-Mediated Gene Transfer

Cheung, C., Murthy, N., Stayton, P. S., & Hoffman, A. S. (2001) · Bioconjugate Chemistry · doi:10.1021/bc0100408 · Cited by 164

Silica- and Alkoxysilane-Coated Ultrasmall Superparamagnetic Iron Oxide Particles: A Promising Tool To Label Cells for Magnetic Resonance Imaging

Zhang, C., Wängler, B., Morgenstern, B., Zentgraf, H., Eisenhut, M., Untenecker, H., Krüger, R., Huss, R., Seliger, C., Semmler, W., et al. (2006) · Langmuir · doi:10.1021/la061879k · Cited by 162

Cardiac safety of liposomal anthracyclines

Ewer, M. S., Martin, F. J., Henderson, I. C., Shapiro, C. L., Benjamin, R. S., & Gabizón, A. (2004) · Seminars in Oncology · doi:10.1053/j.seminoncol.2004.08.006 · Cited by 162

Novel Intracellular Delivery System of Antisense Oligonucleotide by Self-Assembled Hybrid Micelles Composed of DNA/PEG Conjugate and Cationic Fusogenic Peptide

Jeong, J. H., Kim, S. W., & Park, T. G. (2003) · Bioconjugate Chemistry · doi:10.1021/bc025632k · Cited by 162

Stealth liposomes: an improved sustained release system for 1-beta-D-arabinofuranosylcytosine.

Allen, T. M., Mehra, T., Hansen, C., & Chin, Y. C. (1992) · PubMed · Cited by 159

Enhanced transfection of tumor cellsin vivousing “Smart” pH-sensitive TAT-modified pegylated liposomes

Kale, A. A., & Torchilin, V. P. (2007) · Journal of drug targeting · doi:10.1080/10611860701498203 · Cited by 159

Poly(ethylene oxide)-modified poly(beta-amino ester) nanoparticles as a pH-sensitive system for tumor-targeted delivery of hydrophobic drugs: part 3. Therapeutic efficacy and safety studies in ovarian cancer xenograft model

Devalapally, H., Shenoy, D. B., Little, S. R., Langer, R., & Amiji, M. M. (2006) · Cancer Chemotherapy and Pharmacology · doi:10.1007/s00280-006-0287-5 · Cited by 155

Pegylated Liposomal Doxorubicin: Optimizing the Dosing Schedule in Ovarian Cancer

Rose, P. G. (2005) · The Oncologist · doi:10.1634/theoncologist.10-3-205 · Cited by 155

pH-sensitive immunoliposomes as an efficient and target-specific carrier for antitumor drugs.

Connor, J., & Huang, L. (1986) · PubMed · Cited by 148

Therapeutic effects of paclitaxel-containing ultrasound contrast agents

Tartis, M., McCallan, J. L., Lum, A. F. H., LaBell, R., Stieger‐Vanegas, S. M., Matsunaga, T. O., & Ferrara, K. W. (2006) · Ultrasound in Medicine & Biology · doi:10.1016/j.ultrasmedbio.2006.03.017 · Cited by 148

Use of polyoxyethylene-lipid conjugates as long-circulating carriers for delivery of therapeutic and diagnostic agents

Trubetskoy, V. S., & Torchilin, V. P. (1995) · Advanced Drug Delivery Reviews · doi:10.1016/0169-409x(95)00032-3 · Cited by 148

Ca2+-sensitive cytosolic nucleases prevent efficient delivery to the nucleus of injected plasmids

Pollard, H., Toumaniantz, G., Amos, J.-L., Avet‐Loiseau, H., Guihard, G., Behr, J., & Escande, D. (2001) · The Journal of Gene Medicine · doi:10.1002/jgm.160 · Cited by 148

Factors governing the in vivo tissue uptake of transferrin-coupled polyethylene glycol liposomes in vivo

Hatakeyama, H., Akita, H., Maruyama, K., Suhara, T., & Harashima, H. (2004) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2004.05.025 · Cited by 147

Monomer-Coated Very Small Superparamagnetic Iron Oxide Particles as Contrast Medium for Magnetic Resonance Imaging

Wagner, S., Schnorr, J., Pilgrimm, H., Hamm, B., & Taupitz, M. (2002) · Investigative Radiology · doi:10.1097/00004424-200204000-00002 · Cited by 145

Poly(ethylene glycol)–modified thiolated gelatin nanoparticles for glutathione-responsive intracellular DNA delivery

Kommareddy, S., & Amiji, M. M. (2007) · Nanomedicine Nanotechnology Biology and Medicine · doi:10.1016/j.nano.2006.11.005 · Cited by 144

Synthesis and Aqueous Solution Behavior of a pH-Responsive Schizophrenic Diblock Copolymer

Liu, S., & Armes, S. P. (2003) · Langmuir · doi:10.1021/la020951l · Cited by 143

A novel pH-sensitive liposome formulation containing oleyl alcohol

Sudimack, J. J., Guo, W., Tjarks, W., & Lee, R. J. (2002) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/s0005-2736(02)00399-1 · Cited by 143

Highly efficient DNA delivery mediated by pH-sensitive immunoliposomes

Wang, C. Y., & Huang, L. (1989) · Biochemistry · doi:10.1021/bi00450a039 · Cited by 141

Surface-modified liposomes: assessment and characterization for increased stability and prolonged blood circulation

Woodle, M. C. (1993) · Chemistry and Physics of Lipids · doi:10.1016/0009-3084(93)90069-f · Cited by 140

Long Circulating Liposomes: Old Drugs, New Therapeutics

Woodle, M. C., & Storm, G. (1998) · Springer eBooks · doi:10.1007/978-3-662-22115-0 · Cited by 137

Liposomal Gd-DTPA: preparation and characterization of relaxivity.

Tilcock, C., Unger, E. C., Cullis, P. R., & MacDougall, P. (1989) · Radiology · doi:10.1148/radiology.171.1.2928549 · Cited by 137

pH-Sensitive Liposomes

Torchilin, V. P., Zhou, F., & Huang, L. (1993) · Journal of Liposome Research · doi:10.3109/08982109309148213 · Cited by 134

Thermosensitive polymer-modified liposomes that release contents around physiological temperature

Kono, K., Nakai, R., Morimoto, K., & Takagishi, T. (1999) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/s0005-2736(98)00226-0 · Cited by 133

Rapid Protein Anchoring into the Membranes of Mammalian Cells Using Oleyl Chain and Poly(ethylene glycol) Derivatives

Kato, K., Itoh, C., Yasukouchi, T., & Nagamune, T. (2004) · Biotechnology Progress · doi:10.1021/bp0342093 · Cited by 127

Liposomal vincristine which exhibits increased drug retention and increased circulation longevity cures mice bearing P388 tumors.

Boman, N. L., Masin, D., Mayer, L. D., Cullis, P. R., & Bally, M. B. (1994) · PubMed · Cited by 126

Diacyllipid Micelle-Based Nanocarrier for Magnetically Guided Delivery of Drugs in Photodynamic Therapy

Cinteză, L. O., Ohulchanskyy, T. Y., Sahoo, Y., Bergey, E. J., Pandey, R. K., & Prasad, P. N. (2006) · Molecular Pharmaceutics · doi:10.1021/mp060015p · Cited by 125

Specific E-selectin targeting with a superparamagnetic MRI contrast agent

Boutry, S., Laurent, S., Elst, L. V., & Müller, R. N. (2006) · Contrast Media & Molecular Imaging · doi:10.1002/cmmi.87 · Cited by 125

Polymeric Contrast Agents for Medical Imaging

Torchilin, V. P. (2000) · Current Pharmaceutical Biotechnology · doi:10.2174/1389201003378960 · Cited by 125

Separation of large unilamellar liposomes from blood components by a spin column procedure: towards identifying plasma proteins which mediate liposome clearance in vivo

Chonn, A., Semple, S. C., & Cullis, P. R. (1991) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/0005-2736(91)90167-7 · Cited by 124

Characterization of a novel pH-sensitive peptide that enhances drug release from folate-targeted liposomes at endosomal pHs

Turk, M. J., Reddy, J. A., Chmielewski, J. A., & Low, P. S. (2002) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/s0005-2736(01)00441-2 · Cited by 123

Enhanced heparan sulfate proteoglycan-mediated uptake of cell-penetrating peptide-modified liposomes

Marty, C., Meylan, C., Schott, H. N., Ballmer‐Hofer, K., & Schwendener, R. A. (2004) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-004-4166-0 · Cited by 121

Characterization of the membrane-destabilizing properties of different pH-sensitive methacrylic acid copolymers

Yessine, M., Lafleur, M., Meier, C. B., Petereit, H.-U., & Leroux, J. (2003) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/s0005-2736(03)00137-8 · Cited by 119

VIP grafted sterically stabilized liposomes for targeted imaging of breast cancer: in vivo studies

Dagar, S. (2003) · Journal of Controlled Release · doi:10.1016/s0168-3659(03)00242-6 · Cited by 118

The drug loading, cytotoxicty and tumor vascular targeting characteristics of magnetite in magnetic drug targeting

Dandamudi, S., & Campbell, R. B. (2007) · Biomaterials · doi:10.1016/j.biomaterials.2007.07.024 · Cited by 118

Sialyl Lewis x Liposomes as a Multivalent Ligand and Inhibitor of E-Selectin Mediated Cellular Adhesion

DeFrees, S. A., Phillips, L., Guo, L., & Zalipsky, S. (1996) · Journal of the American Chemical Society · doi:10.1021/ja954122g · Cited by 115

Polymer‐coated polyethylenimine/DNA complexes designed for triggered activation by intracellular reduction

Carlisle, R. C., Etrych, T., Briggs, S. S., Preece, J. A., Ulbrich, K., & Seymour, L. W. (2004) · The Journal of Gene Medicine · doi:10.1002/jgm.525 · Cited by 114

Effect of molecular weight in amphipathic polyethyleneglycol on prolonging the circulation time of large unilamellar liposomes.

Maruyama, K., Tsutomu, Y. U. D. A., Okamoto, A., Ishikura, C., Kojima, S., & Iwatsuru, M. (1991) · Chemical and Pharmaceutical Bulletin · doi:10.1248/cpb.39.1620 · Cited by 114

Gadolinium‐labeled liposomes containing various amphiphilic Gd‐DTPA derivatives: Targeted MRI contrast enhancement agents for the liver

Kabalka, G. W., Davis, M. A. F., Moss, T. H., Buonocore, E., Hübner, K. F., Holmberg, E. G., Maruyama, K., & Huang, L. (1991) · Magnetic Resonance in Medicine · doi:10.1002/mrm.1910190231 · Cited by 111

Acid- and Salt-Triggered Multifunctional Poly(propylene imine) Dendrimer as a Prospective Drug Delivery System

Paleos, C. M., Tsiourvas, D., Sideratou, Z., & Tziveleka, L. (2004) · Biomacromolecules · doi:10.1021/bm030068h · Cited by 111

OVCAR-3 cells internalize TAT-peptide modified liposomes by endocytosis

Fretz, M. M., Koning, G. A., Mastrobattista, E., Jiskoot, W., & Storm, G. (2004) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/j.bbamem.2004.06.022 · Cited by 110

Iron oxide‐enhanced MR lymphography: The evaluation of cervical lymph node metastases in head and neck cancer

Anzai, Y., & Prince, M. R. (1997) · Journal of Magnetic Resonance Imaging · doi:10.1002/jmri.1880070111 · Cited by 104

Enhanced accumulation of long-circulating liposomes modified with the nucleosome-specific monoclonal antibody 2C5 in various tumours in mice: gamma-imaging studies

ElBayoumi, T. A., & Torchilin, V. P. (2006) · European Journal of Nuclear Medicine and Molecular Imaging · doi:10.1007/s00259-006-0139-x · Cited by 104

A liposomal MRI contrast agent: Phosphatid ylethanolamine‐DTPA

Grant, C. W. M., Karlik, S. J., & Florio, E. (1989) · Magnetic Resonance in Medicine · doi:10.1002/mrm.1910110211 · Cited by 103

Drug delivery of oligonucleotides by peptides

Lochmann, D., Jauk, E., & Zimmer, A. (2004) · European Journal of Pharmaceutics and Biopharmaceutics · doi:10.1016/j.ejpb.2004.03.031 · Cited by 102

Liposomes as carriers of amphiphilic gadolinium chelates: the effect of membrane composition on incorporation efficacy and in vitro relaxivity

Gløgård, C., Stensrud, G., Hovland, R., Fossheim, S. L., & Klaveness, J. (2002) · International Journal of Pharmaceutics · doi:10.1016/s0378-5173(01)00935-8 · Cited by 101

Controlled delivery of Gd-containing liposomes to lymph nodes: surface modification may enhance MRI contrast properties

Trubetskoy, V. S., Cannillo, J. A., Milshtein, A., Wolf, G. L., & Torchilin, V. P. (1995) · Magnetic Resonance Imaging · doi:10.1016/0730-725x(94)00083-f · Cited by 98

Functional Magnetic Particles for Medical Application

Shinkai, M., & Itô, A. (2004) · Advances in biochemical engineering, biotechnology · doi:10.1007/b94212 · Cited by 97

Surface modification of haemoglobin-containing liposomes with polyethylene glycol prevents liposome aggregation in blood plasma

Yoshioka, H. (1991) · Biomaterials · doi:10.1016/0142-9612(91)90075-l · Cited by 97

Polylactic acid nanoparticles, a colloidal drug delivery system for lipophilic drugs

Krause, H.-J., Schwarz, A., & Rohdewald, P. J. (1985) · International Journal of Pharmaceutics · doi:10.1016/0378-5173(85)90064-x · Cited by 97

Pharmaco attributes of dioleoylphosphatidylethanolamine/cholesterylhemisuccinate liposomes containing different types of cleavable lipopolymers

Zhang, J. X. (2003) · Pharmacological Research · doi:10.1016/j.phrs.2003.09.003 · Cited by 95

The mechanism of liposome accumulation in infarction

Palmer, T. N., Caride, V. J., Caldecourt, M. A., Twickler, J., & Abdullah, V. S. (1984) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/0304-4165(84)90258-7 · Cited by 95

Use of Dithiodiglycolic Acid as a Tether for Cationic Lipids Decreases the Cytotoxicity and Increases Transgene Expression of Plasmid DNA in Vitro

Tang, F., & Hughes, J. A. (1999) · Bioconjugate Chemistry · doi:10.1021/bc990016i · Cited by 94

Hepatic metastases: liposomal Gd-DTPA-enhanced MR imaging.

Unger, E. C., Winokur, T. S., MacDougall, P., Rosenblum, J., Clair, M. R., Gatenby, R. A., & Tilcock, C. (1989) · Radiology · doi:10.1148/radiology.171.1.2928550 · Cited by 92

Phosphatidyl polyglycerols prolong liposome circulation in vivo

Maruyama, K., Okuizumi, S., Ishida, O., YAMAUCHI, H., KIKUCHI, H., & Iwatsuru, M. (1994) · International Journal of Pharmaceutics · doi:10.1016/0378-5173(94)90407-3 · Cited by 92

To exploit the tumor microenvironment: Passive and active tumor targeting of nanocarriers for anti-cancer drug delivery

Danhier, F., Féron, O., & Véronique Préat, A. (2010) · Journal of Controlled Release · doi:10.1016/j.jconrel.2010.08.027 · Cited by 2,891

Liposomes as nanomedical devices

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