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Multifunctional and stimuli-sensitive pharmaceutical nanocarriers
Open accessAbstract
Currently used pharmaceutical nanocarriers, such as liposomes, micelles, and polymeric nanoparticles, demonstrate a broad variety of useful properties, such as longevity in the body; specific targeting to certain disease sites; enhanced intracellular penetration; contrast properties allowing for direct carrier visualization in vivo; stimuli-sensitivity, and others. Some of those pharmaceutical carriers have already made their way into clinic, while others are still under preclinical development. In certain cases, the pharmaceutical nanocarriers combine several of the listed properties. Long-circulating immunoliposomes capable of prolonged residence in the blood and specific target recognition represent one of the examples of this kind. The engineering of multifunctional pharmaceutical nanocarriers combining several useful properties in one particle can significantly enhance the efficacy of many therapeutic and diagnostic protocols. This paper considers the current status and possible future directions in the emerging area of multifunctional nanocarriers with primary attention on the combination of such properties as longevity, targetability, intracellular penetration, contrast loading, and stimuli-sensitivity.
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“Selective delivery is achieved via novel design of various stimuli-responsive nanomicelles that release drugs based on endogenous or exogenous stimulations such as pH, temperature, ultrasound, light, redox potential, and others.”
From Recent Advances in Nanomicelles Delivery Systems. (2020) · cites this paper as [19]
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Metadata
- Authors
- Torchilin, V.
- Affiliations
- Northeastern University (US)
- Corresponding author
- Torchilin, Vladimir
- ORCID
- Torchilin, Vladimir
- Venue
- European Journal of Pharmaceutics and Biopharmaceutics
- Publisher
- Elsevier BV
- Published
- 2009-03
- Volume
- 71
- Issue
- 3
- Pages
- 431-444
- ISSN
- 0939-6411 (ISSN-L)
- PMC
- PMC3197821
- OpenAlex
- W2046772999
- Cited by
- 583
- References
- 269
- Citations by year
- 2026: 21 · 2025: 11 · 2024: 12 · 2023: 19 · 2022: 25 · 2021: 17 · 2020: 28 · 2019: 27 · 2018: 29 · 2017: 41 · 2016: 50 · 2015: 53 · 2014: 52 · 2013: 43 · 2012: 57
- FWCI
- 1.52
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- European Journal of Pharmaceutics and Biopharmaceutics (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Cancer Institute (R01CA121838)
- Topics
- Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Advanced Drug Delivery Systems
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA Interference and Gene Delivery
- Keywords
- multifunctional nanocarriers, stimuli-responsive drug delivery, long-circulating liposomes, immunoliposomes, targeted drug delivery, intracellular penetration, contrast media, polymeric nanoparticles, micelles
- MeSH terms
- Animals, Biological Transport, Chemistry, Pharmaceutical, Delayed-Action Preparations, Drug Carriers, Humans, Liposomes, Micelles, Polymers, Drug Delivery Systems, Nanoparticles
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