Co-encapsulation of resveratrol and curcumin in lipid-core nanocapsules improves their in vitro antioxidant effects
Abstract
Resveratrol and curcumin are natural antioxidants found in the human diet that have been used in the prevention and treatment of different diseases associated with oxidative stress. Aiming to improve the antioxidant effects of resveratrol and curcumin, lipid-core nanocapsules containing the combination of both polyphenols were developed. Physicochemical characteristics were evaluated and compared to the formulations containing each polyphenol individually. Co-encapsulation did not influence nanotechnological characteristics, and all formulations presented mean diameter around 200 nm, low polydispersity index, and encapsulation efficiency close to 100%. Nanoencapsulation increases the photostability of resveratrol and curcumin, and co-encapsulation improves resveratrol photostability. The in vitro antioxidant activity of polyphenols against HO radicals was enhanced by nanoencapsulation, and a better effect was observed after their co-nanoencapsulation. Also, nanocapsules exhibited controlled release profile, for both polyphenols. The results showed that the strategy to co-encapsulate resveratrol and curcumin is a promising approach to improve the performance of medicines used to prevent and treat diseases associated with oxidative stress.
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In cell culture, nanostructured lipid carrier-mediated controlled delivery of resveratrol and curcumin showed synergistic effects against oxidative stress-induced neurodegeneration.
“In cell culture, the nanostructured lipid carrier-mediated controlled delivery of resveratrol and curcumin showed synergistic effects against oxidative stress-induced neurodegeneration.113”
From Targeted therapy in chronic diseases using nanomaterial-based drug delivery vehicles (2019) · cites this paper as [113]
Cites
Oxidative stress, inflammation, and cancer: How are they linked?
Reuter, S., Gupta, S. C., Chaturvedi, M. M., & Aggarwal, B. B. (2010) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2010.09.006 · Cited by 5,441 · see citing works
Filipe, V., Hawe, A., & Jiskoot, W. (2010) · Pharmaceutical Research · doi:10.1007/s11095-010-0073-2 · Cited by 1,885 · see citing works
Sharma, R. A., Gescher, A. J., & Steward, W. P. (2005) · European Journal of Cancer · doi:10.1016/j.ejca.2005.05.009 · Cited by 1,701 · see citing works
Combinatorial drug therapy for cancer in the post-genomic era
Al-Lazikani, B., Banerji, U., & Workman, P. (2012) · Nature Biotechnology · doi:10.1038/nbt.2284 · Cited by 1,070 · see citing works
Physical and chemical stability of drug nanoparticles
Wu, L., Zhang, J., & Watanabe, W. (2011) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2011.02.001 · Cited by 998 · see citing works
Shaikh, J., Ankola, D. D., Beniwal, V., Singh, D., & Kumar, M. N. V. R. (2009) · European Journal of Pharmaceutical Sciences · doi:10.1016/j.ejps.2009.02.019 · Cited by 970 · see citing works
Curcumin nanoformulations: a future nanomedicine for cancer
Yallapu, M. M., Jaggi, M., & Chauhan, S. C. (2011) · Drug Discovery Today · doi:10.1016/j.drudis.2011.09.009 · Cited by 780 · see citing works
Resveratrol scavenges reactive oxygen species and effects radical-induced cellular responses
Leonard, S. S., Xia, C., Jiang, B.-H., Stinefelt, B. M., KLANDORF, H., Harris, G. K., & Shi, X. (2003) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2003.08.105 · Cited by 683 · see citing works
Administration of resveratrol: What formulation solutions to bioavailability limitations?
Amri, A., Chaumeil, J. C., Sfar, S., & Charrueau, C. (2011) · Journal of Controlled Release · doi:10.1016/j.jconrel.2011.09.083 · Cited by 622 · see citing works
Mohanty, C., & Sahoo, S. K. (2010) · Biomaterials · doi:10.1016/j.biomaterials.2010.04.062 · Cited by 533 · see citing works
The evidence for solid lipid nanoparticles mediated cell uptake of resveratrol
Teskač, K., & Kristl, J. (2009) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2009.10.011 · Cited by 288 · see citing works
Bioavailability of encapsulated resveratrol into nanoemulsion-based delivery systems
Sessa, M., Balestrieri, M. L., Ferrari, G., Servillo, L., Castaldo, D., D’Onofrio, N., Donsı̀, F., & Tsao, R. (2013) · Food Chemistry · doi:10.1016/j.foodchem.2013.09.088 · Cited by 285 · see citing works
Jain, A., Thanki, K., & Jain, S. (2013) · Molecular Pharmaceutics · doi:10.1021/mp400311j · Cited by 235 · see citing works
Misra, R., & Sahoo, S. K. (2011) · Molecular Pharmaceutics · doi:10.1021/mp100455h · Cited by 232 · see citing works
Ishrat, T., Hoda, M. N., Khan, M. B., Yousuf, S., Ahmad, M., Khan, M. M., Ahmad, A., & Islam, F. (2009) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2009.02.002 · Cited by 230 · see citing works
Poly(ϵ-caprolactone) microcapsules and nanocapsules in drug delivery
Pohlmann, A. R., da Fonseca, F. N., Paese, K., Detoni, C. B., Coradini, K., Beck, R. C. R., & Guterres, S. S. (2013) · Expert Opinion on Drug Delivery · doi:10.1517/17425247.2013.769956 · Cited by 229 · see citing works
Self-citationBisht, K., Wagner, K., & Bulmer, A. C. (2009) · Toxicology · doi:10.1016/j.tox.2009.11.008 · Cited by 220 · see citing works
Effect of resveratrol incorporated in liposomes on proliferation and UV-B protection of cells
Caddeo, C., Teskač, K., Sinico, C., & Kristl, J. (2008) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2008.07.024 · Cited by 219 · see citing works
Kakkar, V., & Kaur, I. P. (2011) · Food and Chemical Toxicology · doi:10.1016/j.fct.2011.08.006 · Cited by 212 · see citing works
Resveratrol-loaded polymeric micelles protect cells from Aβ-induced oxidative stress
Lu, X., Ji, C., Xu, H., Li, X., Ding, H., Ye, M., Zhu, Z., Ding, D., Jiang, X., Ding, X., et al. (2009) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2009.03.021 · Cited by 193 · see citing works
Frozza, R. L., Bernardi, A., Paese, K., Hoppe, J. B., da Silva, T., Battastini, A. M. O., Pohlmann, A. R., Guterres, S. S., & Salbego, C. G. (2010) · Journal of Biomedical Nanotechnology · doi:10.1166/jbn.2010.1161 · Cited by 172 · see citing works
Araújo, J., Nikolic, S., Egea, M. A., Souto, E. B., & García, M. L. (2011) · Colloids and Surfaces B Biointerfaces · doi:10.1016/j.colsurfb.2011.06.025 · Cited by 171 · see citing works
Formulation of lipid core nanocapsules
Venturini, C. G., Jäger, E., de Oliveira, C. P., et al. (2010) · Colloids and Surfaces A Physicochemical and Engineering Aspects · doi:10.1016/j.colsurfa.2010.12.011 · Cited by 171 · see citing works
Self-citationFrozza, R. L., Bernardi, A., Hoppe, J. B., Meneghetti, A. B., Matté, A., Battastini, A. M. O., Pohlmann, A. R., Guterres, S. S., & Salbego, C. (2013) · Molecular Neurobiology · doi:10.1007/s12035-013-8401-2 · Cited by 165 · see citing works
Indomethacin-loaded nanocapsules treatment reduces in vivo glioblastoma growth in a rat glioma model
Bernardi, A., Braganhol, E., Jäger, E., Figueiró, F., Edelweiss, M. I. A., Pohlmann, A. R., Guterres, S. S., & Battastini, A. M. O. (2009) · Cancer Letters · doi:10.1016/j.canlet.2009.02.018 · Cited by 161 · see citing works
Zanotto‐Filho, A., Coradini, K., Braganhol, E., Schröder, R., de Oliveira, C. M., Pires, A. S., Battastini, A. M. O., Pohlmann, A. R., Guterres, S. S., Forcelini, C. M., et al. (2012) · European Journal of Pharmaceutics and Biopharmaceutics · doi:10.1016/j.ejpb.2012.10.019 · Cited by 161 · see citing works
Self-citationSechi, M., Vanna, S., Roggio, A. M., Siliani, Piccinini, M., Marceddu, S., & Mariani, A. (2012) · International Journal of Nanomedicine · doi:10.2147/ijn.s36684 · Cited by 157 · see citing works
Jäger, E., Venturini, C. G., Poletto, F. S., Colomé, L. M., Pohlmann, J. P. U., Bernardi, A., Battastini, A. M. O., Guterres, S. S., & Pohlmann, A. R. (2009) · Journal of Biomedical Nanotechnology · doi:10.1166/jbn.2009.1004 · Cited by 152 · see citing works
Lazar, A. N., Mourtas, S., Youssef, I., Parizot, C., Dauphin, A., Delatour, B., Antimisiaris, S. G., & Duyckaerts, C. (2013) · Nanomedicine Nanotechnology Biology and Medicine · doi:10.1016/j.nano.2012.11.004 · Cited by 149 · see citing works
Effects of indomethacin‐loaded nanocapsules in experimental models of inflammation in rats
Bernardi, A., Zilberstein, A., Jäger, E., Campos, M. M., Morrone, F. B., Calixto, J. Β., Pohlmann, A. R., Guterres, S. S., & Battastini, A. (2009) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.2009.00244.x · Cited by 135 · see citing works
Transferrin modified PEG-PLA-resveratrol conjugates: In vitro and in vivo studies for glioma
Guo, W., Li, A., Jia, Z., Yuan, Y., Dai, H., & Hong-xiu, L. (2013) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2013.09.034 · Cited by 122 · see citing works
Antioxidant activities of curcumin and combinations of this curcuminoid with other phytochemicals
Aftab, N. F., & Vieira, A. V. (2009) · Phytotherapy Research · doi:10.1002/ptr.2960 · Cited by 116 · see citing works
Resveratrol-Loaded Lipid-Core Nanocapsules Treatment Reduces In Vitro and In Vivo Glioma Growth
Figueiró, F., Bernardi, A., Frozza, R. L., Terroso, T. F., Zanotto‐Filho, A., Jandrey, E. H. F., Moreira, J. C. F., Salbego, C. G., Edelweiss, M. I. A., Pohlmann, A. R., et al. (2013) · Journal of Biomedical Nanotechnology · doi:10.1166/jbn.2013.1547 · Cited by 109 · see citing works
Nanostructured Systems Containing Rutin: In Vitro Antioxidant Activity and Photostability Studies
Almeida, J., Lima, F. O., Ros, S. D., Bulhões, L. O. S., de Carvalho, L. M., & Beck, R. C. R. (2010) · Nanoscale Research Letters · doi:10.1007/s11671-010-9683-1 · Cited by 92 · see citing works
Self-citationBernardi, A., Frozza, R. L., Meneghetti, Hoppe, Battastini, A. M. O., Pohlmann, Guterres, S. S., & Salbego (2012) · International Journal of Nanomedicine · doi:10.2147/ijn.s35333 · Cited by 90 · see citing works
Fontana, M. C., Rezer, J. F. P., Coradini, K., Leal, D. B. R., & Beck, R. C. R. (2011) · European Journal of Pharmaceutics and Biopharmaceutics · doi:10.1016/j.ejpb.2011.05.002 · Cited by 88 · see citing works
Self-citationPhotostability and Skin Penetration of Different E‐Resveratrol‐Loaded Supramolecular Structures
Detoni, C. B., Souto, G. D., da Silva, A. L. M., Pohlmann, A. R., & Guterres, S. S. (2012) · Photochemistry and Photobiology · doi:10.1111/j.1751-1097.2012.01147.x · Cited by 87 · see citing works
Fontana, M. C., Coradini, K., Guterres, S. S., Pohlmann, A. R., & Beck, R. C. R. (2009) · Journal of Biomedical Nanotechnology · doi:10.1166/jbn.2009.1030 · Cited by 80 · see citing works
Self-citationAn algorithm to determine the mechanism of drug distribution in lipid-core nanocapsule formulations
de Oliveira, C. P., Venturini, C. G., Donida, B., et al. (2012) · Soft Matter · doi:10.1039/c2sm26959g · Cited by 79 · see citing works
Self-citationImproving the anti-colon cancer activity of curcumin with biodegradable nano-micelles
Gao, X., Zheng, F., Guo, G. F., Liu, X., Fan, R., Qian, Z., Huang, N., & Wei, Y.-Q. (2013) · Journal of Materials Chemistry B · doi:10.1039/c3tb21091j · Cited by 59 · see citing works
Nanoencapsulation Improves the In Vitro Antioxidant Activity of Lipoic Acid
Külkamp‐Guerreiro, I. C., Rabelo, B. D., Berlitz, S. J., et al. (2011) · Journal of Biomedical Nanotechnology · doi:10.1166/jbn.2011.1318 · Cited by 45 · see citing works
Iwuchukwu, O. F., Tallarida, R. J., & Nagar, S. (2011) · Life Sciences · doi:10.1016/j.lfs.2011.03.016 · Cited by 42 · see citing works
Ourique, A. F., Azoubel, S., Ferreira, C. V., Silva, C. B., Marchiori, M. C. L., Pohlmann, A. R., Guterres, S. S., & Beck, R. C. R. (2010) · Journal of Biomedical Nanotechnology · doi:10.1166/jbn.2010.1120 · Cited by 40 · see citing works
Self-citationYen, K., Mandal, T. K., & Woo, E. M. (2007) · Journal of Biomedical Materials Research Part A · doi:10.1002/jbm.a.31461 · Cited by 35 · see citing works
Modulatory effects of curcumin and resveratrol on lung carcinogenesis in mice
Malhotra, A., Nair, P., & Dhawan, D. K. (2009) · Phytotherapy Research · doi:10.1002/ptr.3087 · Cited by 31 · see citing works
He, Y. Q., Li, J., Uyama, H., et al. (2001) · Journal of Polymer Science Part B Polymer Physics · doi:10.1002/polb.10044 · Cited by 23 · see citing works
Use of nanoparticles to increase the systemic bioavailability of trans-resveratrol
Oganesyan, E. A., Мирошниченко, И. И., Вихриева, Н. С., et al. (2010) · Pharmaceutical Chemistry Journal · doi:10.1007/s11094-010-0401-1 · Cited by 20 · see citing works
de Carvalho, L. M., Monserrat, J. M., Scholz, F., et al. (2013) · Separation Science and Technology · doi:10.1080/01496395.2012.724139 · Cited by 7 · see citing works
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Targeted therapy in chronic diseases using nanomaterial-based drug delivery vehicles
Singh, A. P., Biswas, A., Shukla, A., & Maiti, P. (2019) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-019-0068-3 · Cited by 645 · see citing works
Nasr, M. (2016) · Drug Delivery · doi:10.3109/10717544.2015.1092619 · Cited by 208 · see citing works
- Authors
- Coradini, K., Lima, F. O., Oliveira, C. M., Chaves, P. S., Athayde, M. L., Carvalho, L. M., & Beck, R. C. R.
- Affiliations
- Universidade Federal do Rio Grande do Sul (BR)
- Universidade Federal de Santa Maria (BR)
- Corresponding author
- Beck, R.C.R.
- Venue
- European Journal of Pharmaceutics and Biopharmaceutics
- Publisher
- Elsevier BV
- Published
- 2014-09
- Volume
- 88
- Issue
- 1
- Pages
- 178-185
- ISSN
- 0939-6411 (ISSN-L)
- OpenAlex
- W2014415285
- Cited by
- 200
- References
- 48
- Citations by year
- 2026: 10 · 2025: 12 · 2024: 13 · 2023: 10 · 2022: 17 · 2021: 17 · 2020: 30 · 2019: 18 · 2018: 23 · 2017: 16 · 2016: 14 · 2015: 20
- FWCI
- 23.89
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- European Journal of Pharmaceutics and Biopharmaceutics (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Agricultural and Biological Sciences › Food Science › Microencapsulation and Drying Processes
- Life Sciences › Agricultural and Biological Sciences › Food Science › Proteins in Food Systems
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Drug Solubulity and Delivery Systems
- Keywords
- resveratrol, curcumin, lipid-core nanocapsules, co-encapsulation, polyphenols, antioxidant activity, hydroxyl radical scavenging, photostability, controlled release, oxidative stress, encapsulation efficiency
- MeSH terms
- Resveratrol, Antioxidants, Chromatography, High Pressure Liquid, Curcumin, Free Radicals, Humans, Hydrogen-Ion Concentration, Inflammation, Lipids, Particle Size, Stilbenes, Drug Delivery Systems, Oxidative Stress, Nanotechnology, Microscopy, Electron, Transmission, Nanoparticles, Nanocapsules, Polyphenols
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