Cited by 200Microencapsulation and Drying ProcessesProteins in Food SystemsDrug Solubulity and Delivery Systems

Co-encapsulation of resveratrol and curcumin in lipid-core nanocapsules improves their in vitro antioxidant effects

Coradini, K., Lima, F.O., Oliveira, C.M., Chaves, P.S., Athayde, M.L., Carvalho, L.M., Beck, R.C.R.·2014·European Journal of Pharmaceutics and Biopharmaceutics

Abstract

Resveratrol and curcumin are natural antioxidants found in the human diet that have been used in the prevention and treatment of different diseases associated with oxidative stress. Aiming to improve the antioxidant effects of resveratrol and curcumin, lipid-core nanocapsules containing the combination of both polyphenols were developed. Physicochemical characteristics were evaluated and compared to the formulations containing each polyphenol individually. Co-encapsulation did not influence nanotechnological characteristics, and all formulations presented mean diameter around 200 nm, low polydispersity index, and encapsulation efficiency close to 100%. Nanoencapsulation increases the photostability of resveratrol and curcumin, and co-encapsulation improves resveratrol photostability. The in vitro antioxidant activity of polyphenols against HO radicals was enhanced by nanoencapsulation, and a better effect was observed after their co-nanoencapsulation. Also, nanocapsules exhibited controlled release profile, for both polyphenols. The results showed that the strategy to co-encapsulate resveratrol and curcumin is a promising approach to improve the performance of medicines used to prevent and treat diseases associated with oxidative stress.

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Crossref · 10.1016/j.ejpb.2014.04.009

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  • In cell culture, nanostructured lipid carrier-mediated controlled delivery of resveratrol and curcumin showed synergistic effects against oxidative stress-induced neurodegeneration.

    “In cell culture, the nanostructured lipid carrier-mediated controlled delivery of resveratrol and curcumin showed synergistic effects against oxidative stress-induced neurodegeneration.113”

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Authors
Coradini, K., Lima, F. O., Oliveira, C. M., Chaves, P. S., Athayde, M. L., Carvalho, L. M., & Beck, R. C. R.
Affiliations
  • Universidade Federal do Rio Grande do Sul (BR)
  • Universidade Federal de Santa Maria (BR)
Corresponding author
Beck, R.C.R.
Venue
European Journal of Pharmaceutics and Biopharmaceutics
Publisher
Elsevier BV
Published
2014-09
Volume
88
Issue
1
Pages
178-185
ISSN
0939-6411 (ISSN-L)
OpenAlex
W2014415285
Cited by
200
References
48
Citations by year
2026: 10 · 2025: 12 · 2024: 13 · 2023: 10 · 2022: 17 · 2021: 17 · 2020: 30 · 2019: 18 · 2018: 23 · 2017: 16 · 2016: 14 · 2015: 20
FWCI
23.89
Type
journal article
Language
en
Open access
closed
Locations
  • European Journal of Pharmaceutics and Biopharmaceutics (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Agricultural and Biological Sciences › Food Science › Microencapsulation and Drying Processes
  • Life Sciences › Agricultural and Biological Sciences › Food Science › Proteins in Food Systems
  • Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Drug Solubulity and Delivery Systems
Keywords
resveratrol, curcumin, lipid-core nanocapsules, co-encapsulation, polyphenols, antioxidant activity, hydroxyl radical scavenging, photostability, controlled release, oxidative stress, encapsulation efficiency
MeSH terms
Resveratrol, Antioxidants, Chromatography, High Pressure Liquid, Curcumin, Free Radicals, Humans, Hydrogen-Ion Concentration, Inflammation, Lipids, Particle Size, Stilbenes, Drug Delivery Systems, Oxidative Stress, Nanotechnology, Microscopy, Electron, Transmission, Nanoparticles, Nanocapsules, Polyphenols

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