Neuroprotective Effects of Resveratrol Against Aβ Administration in Rats are Improved by Lipid-Core Nanocapsules
Open accessAbstract
Alzheimer's disease (AD), a neurodegenerative disorder exhibiting a gradual decline in cognitive function, is characterized by the presence of neuritic plaques composed of neurofibrillary tangles and amyloid-β (Aβ) peptide. Available drugs for AD therapy have small effect sizes and do not alter disease progression. Several studies have been shown that resveratrol is associated with anti-amyloidogenic properties, but therapeutic application of its beneficial effects is limited. Here we compared the neuroprotective effects of free resveratrol treatment with those of resveratrol-loaded lipid-core nanocapsule treatment against intracerebroventricular injection of Aβ1-42 in rats. Animals received a single intracerebroventricular injection of Aβ1-42 (2 nmol), and 1 day after Aβ infusion, they were administered either free resveratrol (RSV) or resveratrol-loaded lipid-core nanocapsules (5 mg/kg, each 12 h, intraperitoneally), for 14 days. Aβ1-42-infused animals showed a significant impairment on learning memory ability, which was paralleled by a significant decrease in hippocampal synaptophysin levels. Furthermore, animals exhibited activated astrocytes and microglial cells, as well as disturbance in c-Jun N-terminal kinase (JNK) and glycogen synthase kinase-3β (GSK-3β) activation, beyond destabilization of β-catenin levels. Our results clearly show that by using lipid-core nanocapsules, resveratrol was able to rescue the deleterious effects of Aβ1-42 while treatment with RSV presented only partial beneficial effects. These findings might be explained by the robust increase of resveratrol concentration in the brain tissue achieved by lipid-core nanocapsules. Our data not only confirm the potential of resveratrol in treating AD but also offer an effective way to improve the efficiency of resveratrol through the use of nanodrug delivery systems.
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Resveratrol-encapsulated lipid core nanocapsules are highly effective against Aβ-induced neurotoxicity in an in vivo study.
“An in vivo study suggested that resveratrol-encapsulated lipid core nanocapsules are highly effective against Aβ-induced neurotoxicity.”
From Targeted therapy in chronic diseases using nanomaterial-based drug delivery vehicles (2019) · cites this paper as [111]
Improvement in short-term and long-term memory after resveratrol-encapsulated lipid core nanocapsules was attributed to higher bioavailability of resveratrol in brain.
“The promising improvement in short-term and long-term memory was attributed to the higher bioavailability of resveratrol in the brain.111”
From Targeted therapy in chronic diseases using nanomaterial-based drug delivery vehicles (2019) · cites this paper as [111]
Cites
The rat brain in stereotaxic coordinates
Palkovits, M. (1983) · Neuropeptides · doi:10.1016/0143-4179(83)90049-5 · Cited by 28,959 · see citing works
The Rat Brain in Stereotaxic Coordinates
Paxinos, G., & Watson, C. (1983) · Elsevier eBooks · doi:10.1016/c2009-0-63235-9 · Cited by 28,585 · see citing works
Resveratrol improves health and survival of mice on a high-calorie diet
Baur, J. A., Pearson, K. J., Price, N. L., Jamieson, H. A., Lerin, C., Kalra, A., Prabhu, V. V., Allard, J. S., Lopez-Lluch, G., Lewis, K., et al. (2006) · Nature · doi:10.1038/nature05354 · Cited by 4,290 · see citing works
Therapeutic potential of resveratrol: the in vivo evidence
Baur, J. A., & Sinclair, D. A. (2006) · Nature Reviews Drug Discovery · doi:10.1038/nrd2060 · Cited by 3,958 · see citing works
Biodegradable polymeric nanoparticles as drug delivery devices
Soppimath, K. S., Aminabhavi, T. M., Kulkarni, A. R., & Rudzinski, W. E. (2001) · Journal of Controlled Release · doi:10.1016/s0168-3659(00)00339-4 · Cited by 3,549 · see citing works
A new one-trial test for neurobiological studies of memory in rats. 1: behavioral data
Ennaceur, A., & Delacour, J. (1988) · Behavioural Brain Research · doi:10.1016/0166-4328(88)90157-x · Cited by 3,223 · see citing works
Pathways towards and Away from Alzheimer’s Disease
Mattson, M. P. (2004) · Nature · doi:10.1038/nature02621 · Cited by 3,052 · see citing works
The blood-brain barrier: Bottleneck in brain drug development
Pardridge, W. M. (2005) · NeuroRX · doi:10.1602/neurorx.2.1.3 · Cited by 2,798 · see citing works
Wnt signaling: a common theme in animal development
Cadigan, K. M., & Nusse, R. (1997) · Genes & Development · doi:10.1101/gad.11.24.3286 · Cited by 2,567 · see citing works
Control of β-Catenin Phosphorylation/Degradation by a Dual-Kinase Mechanism
Liu, C., Li, Y., Semënov, M. V., Han, C., Baeg, G., Tan, Y., Zhang, Z., Lin, X., & He, X. (2002) · Cell · doi:10.1016/s0092-8674(02)00685-2 · Cited by 2,066 · see citing works
Biodegradable nanoparticles for drug delivery and targeting
Hans, M. L., & Lowman, A. M. (2002) · Current Opinion in Solid State and Materials Science · doi:10.1016/s1359-0286(02)00117-1 · Cited by 1,324 · see citing works
Bevins, R. A., & Besheer, J. (2006) · Nature Protocols · doi:10.1038/nprot.2006.205 · Cited by 1,278 · see citing works
Lindsay, J. (2002) · American Journal of Epidemiology · doi:10.1093/aje/kwf074 · Cited by 1,261 · see citing works
Deciphering the Molecular Basis of Memory Failure in Alzheimer's Disease
Walsh, D. M., & Selkoe, D. J. (2004) · Neuron · doi:10.1016/j.neuron.2004.09.010 · Cited by 1,207 · see citing works
Review of the folin phenol protein quantitation method of lowry, rosebrough, farr and randall
Peterson, G. L. (1979) · Analytical Biochemistry · doi:10.1016/0003-2697(79)90222-7 · Cited by 1,147 · see citing works
Bioavailability of resveratrol
Walle, T. (2011) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2010.05842.x · Cited by 1,051 · see citing works
Hippocampal synaptic loss in early Alzheimer's disease and mild cognitive impairment
Scheff, S. W., Price, D. A., Schmitt, F. A., & Mufson, E. J. (2006) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2005.09.012 · Cited by 1,017 · see citing works
Neurotoxicity of Amyloid -Protein: Synaptic and Network Dysfunction
Mucke, L., & Selkoe, D. J. (2012) · Cold Spring Harbor Perspectives in Medicine · doi:10.1101/cshperspect.a006338 · Cited by 1,000 · see citing works
Resveratrol Promotes Clearance of Alzheimer's Disease Amyloid-β Peptides
Marambaud, P., Zhao, H., & Davies, P. J. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m508246200 · Cited by 750 · see citing works
Axonal Remodeling and Synaptic Differentiation in the Cerebellum Is Regulated by WNT-7a Signaling
Hall, A. C., Lucas, F. R., & Salinas, P. C. (2000) · Cell · doi:10.1016/s0092-8674(00)80689-3 · Cited by 687 · see citing works
Metabolism and bioavailability oftrans-resveratrol
Wenzel, E., & Somoza, V. (2005) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.200500010 · Cited by 677 · see citing works
Vingtdeux, V., Giliberto, L., Zhao, H., Chandakkar, P., Wu, Q., Simon, J. E., Janle, E. M., Lobo, J., Ferruzzi, M. G., Davies, P. J., et al. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.060061 · Cited by 648 · see citing works
Hughes, R. N. (2004) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2004.06.006 · Cited by 641 · cited 1× · see citing works
“Hippocampal-dependent memory performance was assessed by measuring spontaneous alternation performance during 8 min in the Y-maze test, which evaluates cognitive searching behavior, although it does not allow isolating memory performance (reviewed in [35]).”
MethodA local Wnt-3a signal is required for development of the mammalian hippocampus
Lee, S. M. K., Tole, S., Grove, E. A., & McMahon, A. P. (2000) · Development · doi:10.1242/dev.127.3.457 · Cited by 636 · see citing works
Administration of resveratrol: What formulation solutions to bioavailability limitations?
Amri, A., Chaumeil, J. C., Sfar, S., & Charrueau, C. (2011) · Journal of Controlled Release · doi:10.1016/j.jconrel.2011.09.083 · Cited by 622 · see citing works
Object recognition memory and the rodent hippocampus
Broadbent, N. J., Gaskin, S., Squire, L. R., & Clark, R. E. (2010) · Learning & Memory · doi:10.1101/lm.1650110 · Cited by 568 · see citing works
Resveratrol: A multitargeted agent for age-associated chronic diseases
Harikumar, K. B., & Aggarwal, B. B. (2008) · Cell Cycle · doi:10.4161/cc.7.8.5740 · Cited by 552 · see citing works
Passage of peptides through the blood-brain barrier with colloidal polymer particles (nanoparticles)
Kreuter, J., Alyautdin, R. N., Kharkevich, D. A., & Aa, I. (1995) · Brain Research · doi:10.1016/0006-8993(95)00023-j · Cited by 538 · see citing works
Wine consumption and dementia in the elderly: a prospective community study in the Bordeaux area.
Orgogozo, J. M., Dartigues, J. F., Lafont, S., Letenneur, L., Commenges, D., Salamon, R., Renaud, S., & Breteler, M. M. B. (1997) · PubMed · Cited by 525 · see citing works
Significant Transport of Doxorubicin into the Brain with Polysorbate 80-Coated Nanoparticles
Gulyaev, A. E., Gelperina, S. E., Skidan, I. N., Antropov, A. S., Kivman, G. Y., & Kreuter, J. (1999) · Pharmaceutical Research · doi:10.1023/a:1018983904537 · Cited by 521 · see citing works
Resolving controversies on the path to Alzheimer's therapeutics
Selkoe, D. J. (2011) · Nature Medicine · doi:10.1038/nm.2460 · Cited by 494 · see citing works
Karuppagounder, S. S., Pinto, J. T., Xu, H., Chen, H., Beal, M. F., & Gibson, G. E. (2008) · Neurochemistry International · doi:10.1016/j.neuint.2008.10.008 · Cited by 488 · see citing works
Klein, W. L., Stine, W. B., & Teplow, D. B. (2004) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2004.02.010 · Cited by 487 · see citing works
Cancer chemopreventive and therapeutic potential of resveratrol: Mechanistic perspectives
Kundu, J. K., & Surh, Y. (2008) · Cancer Letters · doi:10.1016/j.canlet.2008.03.057 · Cited by 472 · see citing works
Zensi, A., Begley, D., Pontikis, C., Legros, C., Mihoreanu, L., Wagner, S., Büchel, C., von Briesen, H., & Kreuter, J. (2009) · Journal of Controlled Release · doi:10.1016/j.jconrel.2009.03.002 · Cited by 438 · see citing works
Capiralla, H., Vingtdeux, V., Zhao, H., Sankowski, R., Al‐Abed, Y., Davies, P., & Marambaud, P. (2012) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2011.07594.x · Cited by 426 · see citing works
Hippocampus development and generation of dentate gyrus granule cells is regulated by LEF1
Galcerán, J., Miyashita-Lin, E. M., Devaney, E. J., Rubenstein, J. L. R., & Grosschedl, R. (2000) · Development · doi:10.1242/dev.127.3.469 · Cited by 399 · see citing works
Garwood, C. J., Pooler, A. M., Atherton, J., Hanger, D. P., & Noble, W. (2011) · Cell Death & Disease · doi:10.1038/cddis.2011.50 · Cited by 379 · see citing works
Canas, P. M., Porciúncula, L. O., Cunha, G. M. A., Silva, C. G., Machado, N. J., Oliveira, J. M. A., Oliveira, C. R., & Cunha, R. A. (2009) · Journal of Neuroscience · doi:10.1523/jneurosci.3728-09.2009 · Cited by 358 · see citing works
Alyautdin, R. N., Petrov, V. E., Langer, K., Berthold, A., Kharkevich, D. A., & Kreuter, J. (1997) · Pharmaceutical Research · doi:10.1023/a:1012098005098 · Cited by 352 · see citing works
Resveratrol—A boon for treating Alzheimer's disease?
Anekonda, T. S. (2006) · Brain Research Reviews · doi:10.1016/j.brainresrev.2006.04.004 · Cited by 341 · see citing works
Soluble protein oligomers as emerging toxins in Alzheimer’s and other amyloid diseases
Ferreira, S. T., Vieira, M. N. N., & De Felice, F. G. (2007) · IUBMB Life · doi:10.1080/15216540701283882 · Cited by 335 · see citing works
Ferrari, G. V. D., Chacón, M. A., Barría, M. I., Garrido, J., Godoy, J. A., Olivares, G. H., Reyes, A. E., Alvarez, A. R., Bronfman, M., & Inestrosa, N. C. (2003) · Molecular Psychiatry · doi:10.1038/sj.mp.4001208 · Cited by 331 · see citing works
Ladiwala, A. R. A., Lin, J. C., Bale, S. S., Marcelino, A. M. C., Bhattacharya, M., Dordick, J. S., & Tessier, P. M. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.133108 · Cited by 299 · see citing works
Dendritic Spine Loss and Synaptic Alterations in Alzheimer’s Disease
Knobloch, M., & Mansuy, I. M. (2008) · Molecular Neurobiology · doi:10.1007/s12035-008-8018-z · Cited by 296 · see citing works
Medeiros, R., Prediger, R. D. S., Passos, G. F., Pandolfo, P., Duarte, F. S., Franco, J. L., Dafre, A. L., Di Giunta, G., Figueiredo, C. P., Takahashi, R. N., et al. (2007) · The Journal of Neuroscience · doi:10.1523/jneurosci.5047-06.2007 · Cited by 292 · see citing works
Toledo, E. M., & Inestrosa, N. C. (2009) · Molecular Psychiatry · doi:10.1038/mp.2009.72 · Cited by 290 · see citing works
Delivery of peptide and protein drugs over the blood–brain barrier
Brasnjevic, I., Steinbusch, H. W. M., Schmitz, C., & Martinez-Martinez, P. (2009) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2008.12.002 · Cited by 279 · see citing works
Hensley, K. (2010) · Journal of Alzheimer s Disease · doi:10.3233/jad-2010-1414 · Cited by 250 · see citing works
Chitosan nanoparticles as a new delivery system for the anti-Alzheimer drug tacrine
Wilson, B., Samanta, M. K., Santhi, K., Kumar, K. P. S., Ramasamy, M., & Suresh, B. (2009) · Nanomedicine Nanotechnology Biology and Medicine · doi:10.1016/j.nano.2009.04.001 · Cited by 245 · see citing works
Therapeutic potential of resveratrol in Alzheimer's disease
Vingtdeux, V., Dreses‐Werringloer, U., Zhao, H., Davies, P. J., & Marambaud, P. (2008) · BMC Neuroscience · doi:10.1186/1471-2202-9-s2-s6 · Cited by 224 · see citing works
Selective Synthesis and Biological Evaluation of Sulfate-Conjugated Resveratrol Metabolites
Hoshino, J., Park, E., Kondratyuk, T. P., Marler, L., Pezzuto, J. M., van Breemen, R. B., Mo, S., Li, Y., & Cushman, M. (2010) · Journal of Medicinal Chemistry · doi:10.1021/jm100274c · Cited by 202 · see citing works
Mehan, S., Meena, H., Sharma, D., & Sankhla, R. (2010) · Journal of Molecular Neuroscience · doi:10.1007/s12031-010-9454-6 · Cited by 185 · see citing works
Pleiotropic mechanisms facilitated by resveratrol and its metabolites
Calamini, B., Ratia, K. M., Malkowski, M. G., Cuendet, M., Pezzuto, J. M., Santarsiero, B. D., & Mesecar, A. D. (2010) · Biochemical Journal · doi:10.1042/bj20091857 · Cited by 176 · see citing works
Microglia Activation and Anti-inflammatory Regulation in Alzheimer’s Disease
Lue, L., Kuo, Y., Beach, T. G., & Walker, D. G. (2010) · Molecular Neurobiology · doi:10.1007/s12035-010-8106-8 · Cited by 175 · see citing works
Resveratrol and novel potent activators of SIRT1: effects on aging and age-related diseases
Knutson, M. D., & Leeuwenburgh, C. (2008) · Nutrition Reviews · doi:10.1111/j.1753-4887.2008.00109.x · Cited by 175 · see citing works
Nanotechnological applications for the treatment of neurodegenerative disorders
Modi, G., Pillay, V., Choonara, Y. E., Ndesendo, V. M. K., du Toit, L. C., & Naidoo, D. (2009) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2009.05.002 · Cited by 172 · see citing works
Frozza, R. L., Bernardi, A., Paese, K., Hoppe, J. B., da Silva, T., Battastini, A. M. O., Pohlmann, A. R., Guterres, S. S., & Salbego, C. G. (2010) · Journal of Biomedical Nanotechnology · doi:10.1166/jbn.2010.1161 · Cited by 172 · see citing works
Self-citationGlycogen synthase kinase 3β and Alzheimer’s disease: pathophysiological and therapeutic significance
Balaraman, Y., Limaye, A. R., Levey, A. I., & Srinivasan, S. (2006) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-005-5597-y · Cited by 167 · see citing works
Protein kinase C inhibits amyloid β‐peptide neurotoxicity by acting on members of the Wnt pathway
Garrido, J., Godoy, J. A., Alvarez, A. R., Bronfman, M., & Inestrosa, N. C. (2002) · The FASEB Journal · doi:10.1096/fj.02-0327fje · Cited by 163 · see citing works
Indomethacin-loaded nanocapsules treatment reduces in vivo glioblastoma growth in a rat glioma model
Bernardi, A., Braganhol, E., Jäger, E., Figueiró, F., Edelweiss, M. I. A., Pohlmann, A. R., Guterres, S. S., & Battastini, A. M. O. (2009) · Cancer Letters · doi:10.1016/j.canlet.2009.02.018 · Cited by 161 · see citing works
Self-citationJäger, E., Venturini, C. G., Poletto, F. S., Colomé, L. M., Pohlmann, J. P. U., Bernardi, A., Battastini, A. M. O., Guterres, S. S., & Pohlmann, A. R. (2009) · Journal of Biomedical Nanotechnology · doi:10.1166/jbn.2009.1004 · Cited by 152 · see citing works
Self-citationJNK Plays a Key Role in Tau Hyperphosphorylation in Alzheimer's Disease Models
Ploia, C., Antoniou, X., Sclip, A., Grande, V., Cardinetti, D., Colombo, A., Canu, N., Benussi, L., Ghidoni, R., Forloni, G., et al. (2011) · Journal of Alzheimer's Disease · doi:10.3233/jad-2011-110320 · Cited by 145 · see citing works
Effects of indomethacin‐loaded nanocapsules in experimental models of inflammation in rats
Bernardi, A., Zilberstein, A., Jäger, E., Campos, M. M., Morrone, F. B., Calixto, J. Β., Pohlmann, A. R., Guterres, S. S., & Battastini, A. (2009) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.2009.00244.x · Cited by 135 · see citing works
Self-citationAnimal Models of Alzheimer's Disease: Therapeutic Implications
Woodruff‐Pak, D. S. (2008) · Journal of Alzheimer s Disease · doi:10.3233/jad-2008-15401 · Cited by 133 · see citing works
Albani, D., Polito, L., & Forloni, G. (2010) · Journal of Alzheimer s Disease · doi:10.3233/jad-2010-1215 · Cited by 122 · see citing works
Diffusion and mathematical modeling of release profiles from nanocarriers
Cruz, L., SOARES, L., Costa, T. D., Mezzalira, G., DASILVEIRA, N., Guterres, S. S., & Pohlmann, A. R. (2006) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2006.01.035 · Cited by 122 · see citing works
Self-citationThe binding of resveratrol to monomer and fibril amyloid beta
Ge, J., Qiao, J., Qi, C., Wang, C.-W., & Zhou, J. (2012) · Neurochemistry International · doi:10.1016/j.neuint.2012.08.012 · Cited by 105 · see citing works
Gao, N., Budhraja, A., Cheng, S., Liu, E.-H., Chen, J., Yang, Z., Chen, D., Zhang, Z., & Shi, X. (2011) · Cell Death and Disease · doi:10.1038/cddis.2011.22 · Cited by 102 · see citing works
Bernardi, A., Frozza, R. L., Meneghetti, Hoppe, Battastini, A. M. O., Pohlmann, Guterres, S. S., & Salbego (2012) · International Journal of Nanomedicine · doi:10.2147/ijn.s35333 · Cited by 90 · see citing works
Self-citationAntitumor Activity of Resveratrol and its Sulfated Metabolites against Human Breast Cancer Cells
Miksits, M., Wlcek, K., Svoboda, M., Kunert, O., Haslinger, E., Thalhammer, T., Szekeres, T., & Jäger, W. R. (2009) · Planta Medica · doi:10.1055/s-0029-1185533 · Cited by 84 · see citing works
Zamin, L. L., Dillenburg-Pilla, P., Comiran, R. A., Horn, A. P., Simão, F., Nassif, M., Gerhardt, D., Frozza, R. L., & Salbego, C. G. (2006) · Neurobiology of Disease · doi:10.1016/j.nbd.2006.06.002 · Cited by 81 · see citing works
Self-citationWNT5A Signaling Contributes to Aβ-Induced Neuroinflammation and Neurotoxicity
Li, B., Zhong, L., Yang, X., Andersson, T., Huang, M., & Tang, S.-J. (2011) · PLoS ONE · doi:10.1371/journal.pone.0022920 · Cited by 81 · see citing works
Synaptotoxicity in Alzheimer's Disease: The Wnt Signaling Pathway as a Molecular Target
Inestrosa, N. C., Varela‐Nallar, L., Grabowski, C. P., & Colombres, M. (2007) · IUBMB Life · doi:10.1080/15216540701242490 · Cited by 65 · see citing works
Passos, G. F., Figueiredo, C. P., Prediger, R. D., Pandolfo, P., Duarte, F. S., Medeiros, R., & Calixto, J. Β. (2009) · American Journal Of Pathology · doi:10.2353/ajpath.2009.081113 · Cited by 60 · see citing works
Neurodegenerative and physiological actions of c-Jun N-terminal kinases in the mammalian brain
Waetzig, V., & Herdegen, T. (2004) · Neuroscience Letters · doi:10.1016/j.neulet.2004.02.041 · Cited by 58 · see citing works
Beck, R. C. R., Pohlmann, A. R., Hoffmeister, C. R. D., Gallas, M. R., Collnot, E. M., Schaefer, U. F., Guterres, S. S., & Lehr, C. (2007) · European Journal of Pharmaceutics and Biopharmaceutics · doi:10.1016/j.ejpb.2007.01.007 · Cited by 51 · see citing works
Self-citationGuterres, V. S. S. (2000) · Drug Delivery · doi:10.1080/107175400455119 · Cited by 51 · see citing works
Pohlmann, A. R., Mezzalira, G., Venturini, C. D. G., Cruz, L., Bernardi, A., Jäger, E., Battastini, A. M. O., da Silveira, N. P., & Guterres, S. S. (2008) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2008.04.007 · Cited by 40 · see citing works
Self-citationPohlmann, A. R., Soares, L. U., Cruz, L., da Silveira, N. P., & Guterres, S. S. (2004) · Current Drug Delivery · doi:10.2174/1567201043479920 · Cited by 32 · see citing works
Self-citationBernardi, A., Frozza, R. L., Horn, A. P., Campos, M. M., Calixto, J. Β., Salbego, C. G., Pohlmann, A. R., Guterres, S. S., & Battastini, A. M. O. (2010) · Neurochemistry International · doi:10.1016/j.neuint.2010.07.012 · Cited by 30 · see citing works
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Singh, A. P., Biswas, A., Shukla, A., & Maiti, P. (2019) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-019-0068-3 · Cited by 645 · see citing works
Drug Delivery Systems, CNS Protection, and the Blood Brain Barrier
Upadhyay, R. K. (2014) · BioMed Research International · doi:10.1155/2014/869269 · Cited by 532 · see citing works
Neuroprotective action of resveratrol
Bastianetto, S., Ménard, C., & Quirion, R. (2014) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2014.09.011 · Cited by 411 · see citing works
Neuroprotective Mechanisms of Resveratrol in Alzheimer’s Disease: Role of SIRT1
Gomes, B. A. Q., Silva, J. P. B., Romeiro, C. F. R., dos Santos, S. M., Rodrigues, C. A., Gonçalves, P. R., Sakai, J. T., Mendes, P. F. S., Varela, E. L. P., & Monteiro, M. C. (2018) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2018/8152373 · Cited by 403 · see citing works
Anti-Inflammatory Effects of Resveratrol: Mechanistic Insights
Coutinho, D. D. S., Pacheco, M. T., Frozza, R. L., & Bernardi, A. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19061812 · Cited by 298 · see citing works
Self-citationReinisalo, M., Kårlund, A., Koskela, A. K. J., Kaarniranta, K., & Karjalainen, R. (2015) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2015/340520 · Cited by 285 · see citing works
Neuroprotective effects of resveratrol in Alzheimer disease pathology
Rege, S. D., Geetha, T., Griffin, G. D., Broderick, T. L., & Babu, J. R. (2014) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2014.00218 · Cited by 243 · see citing works
Neves, A. R., Queiroz, J. F., & Reis, S. (2016) · Journal of Nanobiotechnology · doi:10.1186/s12951-016-0177-x · Cited by 241 · see citing works
Protein Folding and Aggregation into Amyloid: The Interference by Natural Phenolic Compounds
Stefani, M., & Rigacci, S. (2013) · International Journal of Molecular Sciences · doi:10.3390/ijms140612411 · Cited by 239 · see citing works
Jurcău, M. C., Andronie-Cioara, F. L., Jurcău, A., Marcu, F., Ţiț, D. M., Pașcalău, N., & Nistor-Cseppentö, D. C. (2022) · Antioxidants · doi:10.3390/antiox11112167 · Cited by 226 · see citing works
Hoppe, J. B., Coradini, K., Frozza, R. L., de Oliveira, C. M., Meneghetti, A., Bernardi, A., Pires, E. N. S., Beck, R. C. R., & Salbego, C. G. (2013) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2013.08.001 · Cited by 207 · see citing works
Self-citationAgis-Torres, A., Sollhuber, M., Fernandez, M., & Sanchez-Montero, J. M. (2014) · Current Neuropharmacology · doi:10.2174/1570159x113116660047 · Cited by 202 · see citing works
Coradini, K., Lima, F. O., Oliveira, C. M., Chaves, P. S., Athayde, M. L., Carvalho, L. M., & Beck, R. C. R. (2014) · European Journal of Pharmaceutics and Biopharmaceutics · doi:10.1016/j.ejpb.2014.04.009 · Cited by 200 · see citing works
Zanotto‐Filho, A., Braganhol, E., Klafke, K., Figueiró, F., Terra, S. R., Paludo, F. J. D. O., Morrone, M. D. S., Bristot, I. J., Battastini, A. M. O., Forcelini, C. M., et al. (2014) · Cancer Letters · doi:10.1016/j.canlet.2014.12.044 · Cited by 197 · see citing works
Self-citationRole of phenolic acid, tannins, stilbenes, lignans and flavonoids in human health – a review
OLUWOLE, O. B., Fernando, W. M. A. D. B., Lumanlan, J. C., Ademuyiwa, O. H., & Jayasena, V. (2022) · International Journal of Food Science & Technology · doi:10.1111/ijfs.15936 · Cited by 184 · see citing works
Nanoformulations of Herbal Extracts in Treatment of Neurodegenerative Disorders
Moradi, S. Z., Momtaz, S., Bayrami, Z., Farzaei, M. H., & Abdollahi, M. R. (2020) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2020.00238 · Cited by 181 · see citing works
Resveratrol and Alzheimer’s Disease: Mechanistic Insights
Ahmed, T., Javed, S., Javed, S., Tariq, A., Šamec, D., Tejada, S., Nabavi, S. F., Braidy, N., & Nabavi, S. M. (2016) · Molecular Neurobiology · doi:10.1007/s12035-016-9839-9 · Cited by 179 · see citing works
Resveratrol Brain Delivery for Neurological Disorders Prevention and Treatment
Andrade, S., Ramalho, M. J., Pereira, M. D. C., & Loureiro, J. A. (2018) · Frontiers in Pharmacology · doi:10.3389/fphar.2018.01261 · Cited by 173 · see citing works
Molecular Mechanisms of Neuroinflammation in Aging and Alzheimer’s Disease Progression
Andronie-Cioară, F. L., Ardelean, A. I., Nistor-Cseppento, C. D., Jurcău, A., Jurcău, M. C., Pașcalău, N., & Marcu, F. M. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24031869 · Cited by 164 · see citing works
Mitochondrial membrane permeabilisation by amyloid aggregates and protection by polyphenols
Camilleri, A., Zarb, C., Caruana, M., Ostermeier, U., Ghio, S., Högen, T., Schmidt, F., Giese, A., & Vassallo, N. (2013) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/j.bbamem.2013.06.026 · Cited by 161 · see citing works
Putative Role of Red Wine Polyphenols against Brain Pathology in Alzheimer’s and Parkinson’s Disease
Caruana, M., Cauchi, R. J., & Vassallo, N. (2016) · Frontiers in Nutrition · doi:10.3389/fnut.2016.00031 · Cited by 162 · see citing works
Ortega, R. H., Cerezo, A. B., de Pablos, R. M., Krisa, S., Richard, T., García-Parrilla, M. C., & Troncoso, A. M. (2018) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2018.00373 · Cited by 130 · see citing works
Natural Antioxidant Compounds as Potential Pharmaceutical Tools against Neurodegenerative Diseases
Marino, A., Battaglini, M., Moles, N., & Ciofani, G. (2022) · ACS Omega · doi:10.1021/acsomega.2c03291 · Cited by 132 · see citing works
Lindner, G. D. R., Santos, D. B., Colle, D., Moreira, E. L. G., Prediger, R. D., Farina, M., Khalil, N. M., & Mainardes, R. M. (2015) · Nanomedicine · doi:10.2217/nnm.14.165 · Cited by 126 · see citing works
Paiva‐Santos, A. C., Pereira, I., Pereira‐Silva, M., Ferreira, L., Caldas, M., Collado-González, M., Magalhães, M., Figueiras, A., Ribeiro, A. J., & Veiga, F. (2019) · Colloids and Surfaces B Biointerfaces · doi:10.1016/j.colsurfb.2019.04.030 · Cited by 121 · see citing works
Nano-antioxidants: An emerging strategy for intervention against neurodegenerative conditions
Sandhir, R., Yadav, A., Sunkaria, A., & Singhal, N. K. (2015) · Neurochemistry International · doi:10.1016/j.neuint.2015.08.011 · Cited by 119 · see citing works
Ganesan, P., Ko, H.-M., Kim, I., & Choi, D. (2015) · International Journal of Nanomedicine · doi:10.2147/ijn.s93918 · Cited by 119 · see citing works
Dai, Y., Guo, Y., Tang, W., Chen, D., Xue, L., Chen, Y., Guo, Y., Wei, S., Wu, M., Dai, J., et al. (2024) · Journal of Nanobiotechnology · doi:10.1186/s12951-024-02501-9 · Cited by 116 · see citing works
Natural Products as a Potential Modulator of Microglial Polarization in Neurodegenerative Diseases
Jin, X., Liu, M.-Y., Zhang, D.-F., Zhong, X., Du, K., Qian, P., Gao, H., & Wei, M.-J. (2019) · Pharmacological Research · doi:10.1016/j.phrs.2019.104253 · Cited by 109 · see citing works
Giacomeli, R., Izoton, J. C., dos Santos, R. B., Boeira, S. P., Jessé, C. R., & Haas, S. E. (2019) · Brain Research · doi:10.1016/j.brainres.2019.146325 · Cited by 108 · see citing works
Pires, E. N. S., Frozza, R. L., Hoppe, J. B., Menezes, B. D. M., & Salbego, C. G. (2014) · Brain Research · doi:10.1016/j.brainres.2014.02.021 · Cited by 107 · see citing works
Self-citationCoradini, K., Friedrich, R. B., da Fonseca, F. N., Vencato, M., de Andrade, D. F., de Oliveira, C. M., Battistel, A. P., Guterres, S. S., da Rocha, M. I. D. U. M., Pohlmann, A. R., et al. (2015) · European Journal of Pharmaceutical Sciences · doi:10.1016/j.ejps.2015.07.012 · Cited by 105 · see citing works
Self-citationGuerrero‐Munoz, M. J., Castillo‐Carranza, D. L., & Kayed, R. (2014) · Biochemical Pharmacology · doi:10.1016/j.bcp.2013.12.023 · Cited by 103 · see citing works
Mohseni, R., Sadeghabadi, Z. A., Ziamajidi, N., Abbasalipourkabir, R., & Farimani, A. R. (2019) · Nanoscale Research Letters · doi:10.1186/s11671-019-3042-7 · Cited by 98 · see citing works
The Interaction of Polyphenols and the Gut Microbiota in Neurodegenerative Diseases
Zhang, Y., Yu, W., Zhang, L., Wang, M., & Chang, W. (2022) · Nutrients · doi:10.3390/nu14245373 · Cited by 95 · see citing works
Resveratrol induces dephosphorylation of Tau by interfering with the MID1-PP2A complex
Schweiger, S., Matthes, F., Posey, K. L., Kickstein, E., Weber, S. S., Hettich, M. M., Pfurtscheller, S., Ehninger, D., Schneider, R., & Krauß, S. (2017) · Scientific Reports · doi:10.1038/s41598-017-12974-4 · Cited by 92 · see citing works
The protective role of plant biophenols in mechanisms of Alzheimer's disease
Omar, S. H., Scott, C., Hamlin, A. S., & Obied, H. K. (2017) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2017.02.016 · Cited by 82 · see citing works
Ahmad, J., Akhter, S., Rizwanullah, M., Khan, M. A., Pigeon, L., Addo, R. T., Greig, N. H., Midoux, P., Pichon, C., & Kamal, M. A. (2017) · Current Alzheimer Research · doi:10.2174/1567205014666170508121031 · Cited by 81 · see citing works
Nanocarriers for resveratrol delivery: Impact on stability and solubility concerns
Paiva‐Santos, A. C., Pereira, I., Pereira‐Silva, M., Ferreira, L., Caldas, M., Magalhães, M., Figueiras, A., Ribeiro, A. J., & Veiga, F. (2019) · Trends in Food Science & Technology · doi:10.1016/j.tifs.2019.07.048 · Cited by 79 · see citing works
Yadav, E., Yadav, P. S., Khan, M. M. U., Singh, H., & Verma, A. (2022) · Frontiers in Pharmacology · doi:10.3389/fphar.2022.922232 · Cited by 81 · see citing works
Shi, D., Dong, C. M., Ho, L. C., Lam, C. T. W., Zhou, X., Wu, E. X., Zhou, Z., Wang, X., & Zhang, Z.-J. (2018) · Neurobiology of Disease · doi:10.1016/j.nbd.2018.03.006 · Cited by 79 · see citing works
Resveratrol reduces morphine tolerance by inhibiting microglial activation via AMPK signalling
Han, Y., Jiang, C., Tang, J., Wang, C., Wu, P., Zhang, G., Liu, W., Jamangulova, N., Wu, X., & Song, X. (2014) · European Journal of Pain · doi:10.1002/ejp.511 · Cited by 77 · see citing works
Therapeutic Potential of Phytoconstituents in Management of Alzheimer’s Disease
Singh, S. P., Nand, S., Maurya, A., Mishra, G., Awasthi, R., Shakya, A., Chellappan, D. K., Dua, K., Vamanu, E., Chaudhary, S. K., et al. (2021) · Evidence-based Complementary and Alternative Medicine · doi:10.1155/2021/5578574 · Cited by 75 · see citing works
Nanotechnology to improve the Alzheimer’s disease therapy with natural compounds
Ramalho, M. J., Andrade, S., Loureiro, J. A., & do Carmo Pereira, M. (2020) · Drug Delivery and Translational Research · doi:10.1007/s13346-019-00694-3 · Cited by 75 · see citing works
Zhou, H., Tai, J., Xu, H., Lu, X., & Meng, D. (2019) · Frontiers in Pharmacology · doi:10.3389/fphar.2019.01035 · Cited by 72 · see citing works
Nutraceuticals and amyloid neurodegenerative diseases: a focus on natural phenols
Rigacci, S., & Stefani, M. (2014) · Expert Review of Neurotherapeutics · doi:10.1586/14737175.2015.986101 · Cited by 69 · see citing works
Remião, M. H., Lucas, C. G., Domingues, W. B., da Silveira, T. L. R., Barther, N. N., Komninou, E. R., Basso, A. C., Jornada, D. S., Beck, R. C. R., Pohlmann, A. R., et al. (2016) · Reproductive Toxicology · doi:10.1016/j.reprotox.2016.05.016 · Cited by 69 · see citing works
Self-citationWang, M., Li, L., Zhang, X., Liu, Y., Zhu, R., Liu, L., Fang, Y., Gao, Z., & Gao, D. (2018) · ACS Sustainable Chemistry & Engineering · doi:10.1021/acssuschemeng.8b04507 · Cited by 69 · see citing works
Nanoparticle-mediated growth factor delivery systems: A new way to treat Alzheimer's disease
Lauzon, M.-A., Daviau, A., Marcos, B., & Faucheux, N. (2015) · Journal of Controlled Release · doi:10.1016/j.jconrel.2015.03.024 · Cited by 65 · see citing works
The Tragedy of Alzheimer’s Disease: Towards Better Management via Resveratrol-Loaded Oral Bilosomes
Abbas, H., Gad, H. A., Khattab, M. A., & Mansour, M. (2021) · Pharmaceutics · doi:10.3390/pharmaceutics13101635 · Cited by 62 · see citing works
Lin, Y., Wu, Y., Sun, G., Ho, C., Wong, T., Lin, C., Chen, H., Yeh, T., Li, C., Tseng, C., et al. (2018) · Journal of Clinical Medicine · doi:10.3390/jcm7100329 · Cited by 60 · see citing works
McCubrey, J. A., Lertpiriyapong, K., Steelman, L. S., Abrams, S. L., Cocco, L., Ratti, S., Martelli, A. M., Candido, S., Libra, M., Montalto, G., et al. (2017) · Advances in Biological Regulation · doi:10.1016/j.jbior.2017.05.005 · Cited by 59 · see citing works
Shati, A. A., & Alfaifi, M. Y. (2018) · Neurochemical Research · doi:10.1007/s11064-018-2683-8 · Cited by 58 · see citing works
TRPM2 in the Brain: Role in Health and Disease
Sita, G., Hrelia, P., Graziosi, A., Ravegnini, G., & Morroni, F. (2018) · Cells · doi:10.3390/cells7070082 · Cited by 57 · see citing works
Petry, F. D. S., Coelho, B. P., Gaelzer, M. M., Kreutz, F., Guma, F. T. C. R., Salbego, C. G., & Trindade, V. M. T. (2019) · Phytotherapy Research · doi:10.1002/ptr.6560 · Cited by 57 · see citing works
Self-citationNanotechnology-based herbal medicine: Preparation, synthesis, and applications in food and medicine
Awlqadr, F. H., Majeed, K. R., Altemimi, A. B., Hassan, A. M. A., Qadir, S. A., Saeed, M. N., Faraj, A. M., Salih, T. H., Al‐Manhel, A. J. A., Najm, M. A. A., et al. (2025) · Journal of Agriculture and Food Research · doi:10.1016/j.jafr.2025.101661 · Cited by 56 · see citing works
Неганова, М. Е., Aleksandrova, Y. R., Sukocheva, O. A., & Klochkov, S. G. (2022) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2022.06.011 · Cited by 56 · see citing works
Resveratrol Nanoparticles: A Promising Therapeutic Advancement over Native Resveratrol
Chung, I., Subramanian, U., Thirupathi, P., Venkidasamy, B., Samynathan, R., Gangadhar, B. H., Rajakumar, G., & Thiruvengadam, M. (2020) · Processes · doi:10.3390/pr8040458 · Cited by 51 · see citing works
D’Almeida, A. P. L., de Oliveira, M. P., de Souza, É., Coutinho, D. D. S., Ciambarella, B. T., Gomes, C., Terroso, T. F., Guterres, S. S., Pohlmann, A. R., Silva, P., et al. (2017) · International Journal of Nanomedicine · doi:10.2147/ijn.s130798 · Cited by 50 · see citing works
Self-citationResveratrol in Alzheimer's disease: a review of pathophysiology and therapeutic potential
Sousa, J. C. E., SANTANA, A. C. F., & MAGALHÃES, G. J. P. (2020) · Arquivos de Neuro-Psiquiatria · doi:10.1590/0004-282x20200010 · Cited by 49 · see citing works
The Role of Sirtuin 1 (SIRT1) in Neurodegeneration
Razick, D., Akhtar, M., Wen, J., Alam, M., Dean, N., Karabala, M., Ansari, U., Ansari, Z., Tabaie, E. A., & Siddiqui, S. (2023) · Cureus · doi:10.7759/cureus.40463 · Cited by 48 · see citing works
Advances in Nanomedicine for the Treatment of Alzheimer’s and Parkinson’s Diseases
Hernando, S., Gartziandia, O., Herrán, E., Pedraz, J. L., Igartúa, M., & Hernández, R. M. (2016) · Nanomedicine · doi:10.2217/nnm-2016-0019 · Cited by 48 · see citing works
Impaired autophagy: a link between neurodegenerative and neuropsychiatric diseases
Polajnar, M., & Žerovnik, E. (2014) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.12349 · Cited by 47 · see citing works
Neuroprotective effect of phytoconstituents via nanotechnology for treatment of Alzheimer diseases
Paramanick, D., Singh, V. D., & Singh, V. K. (2022) · Journal of Controlled Release · doi:10.1016/j.jconrel.2022.09.058 · Cited by 47 · see citing works
Bellaver, B., de Souza, D. G., Bobermin, L. D., Souza, D. O., Gonçalves, C., & Quincozes‐Santos, A. (2015) · Neurochemical Research · doi:10.1007/s11064-015-1636-8 · Cited by 46 · see citing works
Giacomeli, R., de Gomes, M. G., Reolon, J. B., Haas, S. E., Colomé, L. M., & Jessé, C. R. (2020) · Behavioural Brain Research · doi:10.1016/j.bbr.2020.112696 · Cited by 46 · see citing works
Petry, F. D. S., Hoppe, J. B., Klein, C. P., dos Santos, B. G., Hözer, R. M., Bifi, F., Matté, C., Salbego, C. G., & Trindade, V. M. T. (2020) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2020.108525 · Cited by 46 · see citing works
Self-citationKreutz, F., Scherer, E. B. D. S., Ferreira, A. G. K., Petry, F. D. S., Pereira, C. L., Santana, F., Wyse, Â. T. D. S., Salbego, C. G., & Trindade, V. M. T. (2013) · Neurochemical Research · doi:10.1007/s11064-013-1145-6 · Cited by 44 · see citing works
Self-citationDao, A. T., Zagaar, M. A., Levine, A. T., & Alkadhi, K. A. (2015) · Molecular Neurobiology · doi:10.1007/s12035-015-9612-5 · Cited by 43 · see citing works
JNK Activation in Alzheimer’s Disease Is Driven by Amyloid β and Is Associated with Tau Pathology
Solas, M., Vela, S., Smerdou, C., Martišová, E., Martínez-Valbuena, I., Luquín, M. R., & Ramírez, M. J. (2023) · ACS Chemical Neuroscience · doi:10.1021/acschemneuro.3c00093 · Cited by 42 · see citing works
Sun, L., Ju, T., Wang, T., Zhang, L., Ding, F., Zhang, Y., An, R., Sun, Y., Li, Y., Lu, Y., et al. (2019) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2019.00124 · Cited by 42 · see citing works
Non-Enzymatic Antioxidants against Alzheimer’s Disease: Prevention, Diagnosis and Therapy
Varesi, A., Campagnoli, L. I. M., Carrara, A., Pola, I., Floris, E., Ricevuti, G., Chirumbolo, S., & Pascale, A. (2023) · Antioxidants · doi:10.3390/antiox12010180 · Cited by 45 · see citing works
Bv8/prokineticin 2 is involved in Aβ-induced neurotoxicity
Severini, C., Lattanzi, R., Maftei, D., Marconi, V., Ciotti, M. T., Passeri, P. P., Florenzano, F., DUCA, E. D., Caioli, S., Zona, C., et al. (2015) · Scientific Reports · doi:10.1038/srep15301 · Cited by 40 · see citing works
Resveratrol-loaded nanoemulsion prevents cognitive decline after abdominal surgery in aged rats
Locatelli, F. M., Kawano, T., Iwata, H., Aoyama, B., Eguchi, S., Nishigaki, A., Yamanaka, D., Tateiwa, H., Shigematsu-Locatelli, M., & Yokoyama, M. (2018) · Journal of Pharmacological Sciences · doi:10.1016/j.jphs.2018.08.006 · Cited by 40 · see citing works
Zwart, S. R., Mulavara, A. P., Williams, T. J., George, K. A., & Smith, S. M. (2021) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2021.04.026 · Cited by 41 · see citing works
Wen, M., Ding, L., Zhang, L., Zhang, T., Yanagita, T., Wang, Y., & Xue, C. (2019) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.9b05947 · Cited by 39 · see citing works
Rathinavel, T., Bhuvaneswari, M., Haritha, S., Jeevarathna, S., Janani, K. S. S., & Suresh, K. (2022) · South African Journal of Botany · doi:10.1016/j.sajb.2022.06.027 · Cited by 38 · see citing works
Rakotondrabe, T. F., Fan, M., Muema, F. W., & Guo, M. (2023) · Pharmaceutics · doi:10.3390/pharmaceutics15020699 · Cited by 37 · see citing works
Glia and TRPM2 Channels in Plasticity of Central Nervous System and Alzheimer’s Diseases
Wang, J., Jackson, M. F., & Xie, Y. (2016) · Neural Plasticity · doi:10.1155/2016/1680905 · Cited by 35 · see citing works
New insights in drug development for Alzheimer's disease based on microglia function
Qiao, O., Ji, H., Zhang, Y., Zhang, X., Zhang, X., Liu, N., Huang, L., Liu, C., & Gao, W. (2021) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2021.111703 · Cited by 34 · see citing works
Kim, S. H., Adhikari, B. B., Cruz, S., Schramm, M. P., Vinson, J. A., & Narayanaswami, V. (2015) · PLoS ONE · doi:10.1371/journal.pone.0135130 · Cited by 33 · see citing works
Systems‐level thinking for nanoparticle‐mediated therapeutic delivery to neurological diseases
Curtis, C., Zhang, M., Liao, R., Wood, T. R., & Nance, E. A. (2016) · Wiley Interdisciplinary Reviews Nanomedicine and Nanobiotechnology · doi:10.1002/wnan.1422 · Cited by 32 · see citing works
Yee, Y. J., Benson, H. A., Dass, C. R., & Chen, Y. (2022) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2022.121499 · Cited by 32 · see citing works
Hernando, S., Santos‐Vizcaíno, E., Igartúa, M., & Hernández, R. M. (2023) · Wiley Interdisciplinary Reviews Nanomedicine and Nanobiotechnology · doi:10.1002/wnan.1898 · Cited by 32 · see citing works
Wen, M., Ding, L., Zhang, L., Cong, P., Zhang, T., Xu, J., Chang, Y., Wang, Y., & Xue, C. (2018) · Food & Function · doi:10.1039/c7fo01815k · Cited by 31 · see citing works
Baldissera, M. D., Souza, C. F., Grando, T. H., Moreira, K. L. S., Schafer, A. S., Cossetin, L. F., da Silva, A. P. T., da Veiga, M. L., da Rocha, M. I. D. U. M., Stefani, L. M., et al. (2016) · Naunyn-Schmiedeberg s Archives of Pharmacology · doi:10.1007/s00210-016-1313-8 · Cited by 30 · see citing works
Fouad, G. I., & Rizk, M. Z. (2019) · Bulletin of the National Research Centre/Bulletin of the National Research Center · doi:10.1186/s42269-019-0149-z · Cited by 29 · see citing works
Sun, D. I., Yue, Q., Guo, W., Li, T., Zhang, J., Li, G., Liu, Z., & Sun, J. (2015) · BioFactors · doi:10.1002/biof.1221 · Cited by 26 · see citing works
Delbreil, P., Rabanel, J., Banquy, X., & Brambilla, D. (2022) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2022.114397 · Cited by 25 · see citing works
Park, S., Kang, S., Kim, D. S., & Moon, B. R. (2016) · Nutritional Neuroscience · doi:10.1080/1028415x.2015.1135572 · Cited by 24 · see citing works
Ashrafizadeh, M., Zarrabi, A., Najafi, M., Samarghandian, S., Mohammadinejad, R., & Ahn, K. S. (2020) · Phytotherapy Research · doi:10.1002/ptr.6732 · Cited by 24 · see citing works
Zhang, Y., Lv, C., & Zhao, G. (2021) · Food Reviews International · doi:10.1080/87559129.2021.1888973 · Cited by 23 · see citing works
Klein, C. P., Cintra, M. R., Binda, N. S., Diniz, D. M., Gomez, M. V., Souto, A. A., & de Souza, A. H. (2016) · Pain Research and Treatment · doi:10.1155/2016/3191638 · Cited by 23 · see citing works
Nanobiotechnology in Neurodegenerative Diseases
Jampílek, J., Kráľová, K., Novák, P., & Novák, M. (2019) · Springer eBooks · doi:10.1007/978-3-030-30930-5_4 · Cited by 22 · see citing works
Pomegranate as a natural source of phenolic antioxidants: a review
de Oliveira, F. L., Arruda, T. Y. P., Lima, R. D. S., Casarotti, S. N., & Morzelle, M. C. (2020) · Journal of Food Bioactives · doi:10.31665/jfb.2020.9214 · Cited by 22 · see citing works
Sangsen, Y., Sooksawate, T., Likhitwitayawuid, K., Sritularak, B., & Wiwattanapatapee, R. (2018) · Planta Medica · doi:10.1055/s-0043-125337 · Cited by 21 · see citing works
Samie, S. M. A., & Nasr, M. (2020) · Elsevier eBooks · doi:10.1016/b978-0-12-821222-6.00011-7 · Cited by 20 · see citing works
Hussain, Z., Thu, H. E., Khan, S., Sohail, M. F., Sarfraz, R. M., Mahmood, A., & Abourehab, M. A. S. (2022) · Journal of Drug Delivery Science and Technology · doi:10.1016/j.jddst.2022.103895 · Cited by 20 · see citing works
Neuroprotective Effects of Curcumin-Loaded Emulsomes in a Laser Axotomy-Induced CNS Injury Model
Yılmaz, E. N., Bay, S., Öztürk, G., & Üçışık, M. H. (2020) · International Journal of Nanomedicine · doi:10.2147/ijn.s272931 · Cited by 20 · see citing works
Kanojia, N., Thapa, K., Kaur, G., Sharma, A., Puri, V., & Verma, N. (2022) · Journal of Drug Delivery Science and Technology · doi:10.1016/j.jddst.2022.104074 · Cited by 19 · see citing works
- Authors
- Frozza, R. L., Bernardi, A., Hoppe, J. B., Meneghetti, A. B., Matté, A., Battastini, A. M. O., Pohlmann, A. R., Guterres, S. S., & Salbego, C.
- Affiliations
- Universidade Federal do Rio Grande do Sul (BR)
- Corresponding author
- Frozza, Rudimar L.
- ORCID
- Venue
- Molecular Neurobiology
- Published
- 2013-01-12
- Volume
- 47
- Issue
- 3
- Pages
- 1066-1080
- ISSN
- 0893-7648 (ISSN-L)
- 1559-1182
- OpenAlex
- W2037132719
- Cited by
- 165
- References
- 81
- Citations by year
- 2026: 2 · 2025: 9 · 2024: 10 · 2023: 17 · 2022: 18 · 2021: 9 · 2020: 17 · 2019: 17 · 2018: 14 · 2017: 13 · 2016: 11 · 2015: 12 · 2014: 12 · 2013: 4
- FWCI
- 9.03
- Type
- journal article
- Language
- en
- Open access
- green
- hdl.handle.net
- Licence
- cc-by-nc-sa
- www.springer.com/tdm (tdm)
- Locations
- Molecular Neurobiology (publishedVersion)
- PubMed (publishedVersion)
- Lume (Universidade Federal do Rio Grande do Sul) (submittedVersion, cc-by-nc-sa)
- Funders
- Coordenação de Aperfeiçoamento de Pessoal de Nível Superior
- Conselho Nacional de Desenvolvimento Científico e Tecnológico
- Fundação de Amparo à Pesquisa do Estado do Rio Grande do Sul
- Topics
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Health Sciences › Medicine › Pharmacology › Cholinesterase and Neurodegenerative Diseases
- Keywords
- resveratrol, amyloid-beta 42, Alzheimer's disease, lipid-core nanocapsules, nanoparticle drug delivery, neuroprotection, learning and memory impairment, astrocyte activation, microglial activation, JNK, GSK3β, β-catenin, intracerebroventricular administration
- MeSH terms
- Glycogen Synthase Kinase 3 beta, Resveratrol, Animals, Astrocytes, Enzyme Activation, Hippocampus, Injections, Intraventricular, Lipids, Male, Memory Disorders, Stilbenes, Synapses, Tissue Distribution, Signal Transduction, Amyloid beta-Peptides, Rats, Wistar, Microglia, Neuroprotective Agents, Cytoprotection, Glycogen Synthase Kinase 3, JNK Mitogen-Activated Protein Kinases, beta Catenin, Rats, Nanocapsules, Protein Stability
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