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It takes two to tango: Understanding the interactions between engineered nanomaterials and the immune system

Farrera, Consol, Fadeel, Bengt·2015·European Journal of Pharmaceutics and Biopharmaceutics
DOI 10.1016/j.ejpb.2015.03.007
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Abstract

The immune system represents our primary defense system against foreign intrusion, including pathogens as well as particles. In order to understand the potential toxicity of engineered nanomaterials of ever increasing sophistication, it is necessary to understand the sophistication of the immune system with its multiple, specialized cell types and soluble mediators. Moreover, it is important to consider not only material-intrinsic properties of the pristine nanomaterial, but also the acquired, context-dependent 'identity' of a nanomaterial in a living system resulting from the adsorption of biomolecules on its surface. The immune system has evolved to recognize a vast array of microbes through so-called pattern recognition; we discuss in the present review whether engineered nanomaterials with or without a corona of biomolecules could also be sensed as 'pathogens' by immune-competent cells.

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Metadata

Authors
Farrera, C., & Fadeel, B.
Venue
European Journal of Pharmaceutics and Biopharmaceutics
Publisher
Elsevier BV
Published
2015-09
Volume
95
Pages
3-12
ISSN
0939-6411
DOI
10.1016/j.ejpb.2015.03.007
Cited by
92
References
10
Language
en
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Funders
  • Swedish Research Council
  • Swedish Research Council for Environment, Agricultural Sciences and Spatial Planning

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