Cited by 68biodegradable polymer synthesis and propertiesRadiopharmaceutical Chemistry and ApplicationsNanoparticle-Based Drug Delivery

Aliphatic polyesters for medical imaging and theranostic applications

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Nottelet, Benjamin, Darcos, Vincent, Coudane, Jean·2015·European Journal of Pharmaceutics and Biopharmaceutics

Abstract

Medical imaging is a cornerstone of modern medicine. In that context the development of innovative imaging systems combining biomaterials and contrast agents (CAs)/imaging probes (IPs) for improved diagnostic and theranostic applications focuses intense research efforts. In particular, the classical aliphatic (co)polyesters poly(lactide) (PLA), poly(lactide-co-glycolide) (PLGA) and poly(ɛ-caprolactone) (PCL), attract much attention due to their long track record in the medical field. This review aims therefore at providing a state-of-the-art of polyester-based imaging systems. In a first section a rapid description of the various imaging modalities, including magnetic resonance imaging (MRI), optical imaging, computed tomography (CT), ultrasound (US) and radionuclide imaging (SPECT, PET) will be given. Then, the two main strategies used to combine the CAs/IPs and the polyesters will be discussed. In more detail we will first present the strategies relying on CAs/IPs encapsulation in nanoparticles, micelles, dendrimers or capsules. We will then present chemical modifications of polyesters backbones and/or polyester surfaces to yield macromolecular imaging agents. Finally, opportunities offered by these innovative systems will be illustrated with some recent examples in the fields of cell labeling, diagnostic or theranostic applications and medical devices.

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Crossref · 10.1016/j.ejpb.2015.06.023

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  • Good biocompatibility ensures that there is no inflammatory reaction in the surrounding tissue due to rejection after PLA enters the human body.

    “Good biocompatibility also ensures that there is no inflammatory reaction in the surrounding tissue due to rejection after it enters the human body [75,76,77].”

    From Synthesis and Biological Application of Polylactic Acid (2020) · cites this paper as [76]

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Authors
Nottelet, B., Darcos, V., & Coudane, J.
Affiliations
Centre National de la Recherche Scientifique (FR)
Corresponding author
Nottelet, Benjamin
Venue
European Journal of Pharmaceutics and Biopharmaceutics
Publisher
Elsevier BV
Published
2015-11
Volume
97
Issue
Pt B
Pages
350-370
ISSN
0939-6411 (ISSN-L)
OpenAlex
W2211301183
Cited by
68
References
221
Citations by year
2025: 4 · 2024: 5 · 2023: 9 · 2022: 6 · 2021: 4 · 2020: 7 · 2019: 11 · 2018: 6 · 2017: 4 · 2016: 11 · 2015: 1
FWCI
0.44
Type
journal article
Language
en
Open access
Locations
  • European Journal of Pharmaceutics and Biopharmaceutics (publishedVersion)
  • PubMed (publishedVersion)
  • HAL (submittedVersion, cc-by-nc-nd)
Topics
  • Physical Sciences › Materials Science › Biomaterials › biodegradable polymer synthesis and properties
  • Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Radiopharmaceutical Chemistry and Applications
  • Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
Keywords
aliphatic polyesters, polylactic acid, poly(lactic-co-glycolic acid), polycaprolactone, contrast media, imaging agents, theranostics, magnetic resonance imaging, optical imaging, computed tomography, ultrasonography, SPECT, PET, nanoparticle encapsulation, micelles, dendrimers, capsules, surface modification, cell labeling, medical devices
MeSH terms
Theranostic Nanomedicine, Polylactic Acid-Polyglycolic Acid Copolymer, Contrast Media, Diagnostic Imaging, Magnetic Resonance Imaging, Polyesters, Polyglycolic Acid, Tomography, X-Ray Computed, Tomography, Emission-Computed, Single-Photon, Lactic Acid

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